Götz J Thomalla

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi [EU-funded treatment study: WAKE-UP : A randomized, placebo-controlled MRI-based trial of thrombolysis in wake-up stroke]
    G Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Nervenarzt 83:1241-51. 2012
  2. ncbi DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Lancet Neurol 10:978-86. 2011
  3. ncbi Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging
    G Thomalla
    NeuroImage Nord, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Neurol Neurosurg Psychiatry 76:266-8. 2005
  4. ncbi Two tales: hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia: MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hours
    Gotz Thomalla
    Neuro Zentrum, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Stroke 38:313-8. 2007
  5. ncbi Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational study
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 68:435-45. 2010
  6. ncbi Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less
    Gotz Thomalla
    Department of Neurology, Center for Clinical Neurosciences, University Medical Center Hamburg, Eppendorf, Hamburg, Germany
    Ann Neurol 65:724-32. 2009
  7. ncbi Prediction of malignant middle cerebral artery infarction by early perfusion- and diffusion-weighted magnetic resonance imaging
    Götz J Thomalla
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Martinistrabetae 52, D 20246 Hamburg, Germany
    Stroke 34:1892-9. 2003
  8. ncbi Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome
    Gotz Thomalla
    Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Brain 132:765-77. 2009
  9. ncbi [Effective acute stroke treatment beyond approval limitations: intravenous thrombolysis within an extended time window (3-6 h) and in old patients (aged 80 or older)]
    G Thomalla
    Klinik und Poliklinik fur Neurologie, Neuro Zentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Fortschr Neurol Psychiatr 75:343-50. 2007
  10. ncbi Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Neuroimage 22:1767-74. 2004

Detail Information

Publications18

  1. ncbi [EU-funded treatment study: WAKE-UP : A randomized, placebo-controlled MRI-based trial of thrombolysis in wake-up stroke]
    G Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Nervenarzt 83:1241-51. 2012
    ..If positive the WAKE-UP trial is expected to change clinical practice and to make effective and safe treatment available for a large group of acute stroke patients currently excluded from specific acute treatment...
  2. ncbi DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Lancet Neurol 10:978-86. 2011
    ....
  3. ncbi Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging
    G Thomalla
    NeuroImage Nord, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Neurol Neurosurg Psychiatry 76:266-8. 2005
    ..These signal changes reflect the progressive disintegration of fibre structures resulting from WD...
  4. ncbi Two tales: hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia: MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hours
    Gotz Thomalla
    Neuro Zentrum, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Stroke 38:313-8. 2007
    ..We studied whether perfusion-weighted imaging and diffusion-weighted imaging has the potential to identify patients at risk of severe intracerebral hemorrhage after treatment with intravenous tissue plasminogen activator...
  5. ncbi Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational study
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 68:435-45. 2010
    ..We tested the hypothesis that acute stroke magnetic resonance imaging (MRI) predicts MMI within 6 hours of stroke onset...
  6. ncbi Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less
    Gotz Thomalla
    Department of Neurology, Center for Clinical Neurosciences, University Medical Center Hamburg, Eppendorf, Hamburg, Germany
    Ann Neurol 65:724-32. 2009
    ..To evaluate the use of fluid-attenuated inversion recovery (FLAIR) imaging as surrogate marker of lesion age within the first 6 hours of ischemic stroke...
  7. ncbi Prediction of malignant middle cerebral artery infarction by early perfusion- and diffusion-weighted magnetic resonance imaging
    Götz J Thomalla
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Martinistrabetae 52, D 20246 Hamburg, Germany
    Stroke 34:1892-9. 2003
    ..We tested the hypothesis that early diffusion- and perfusion-weighted MRI (DWI and PWI, respectively) allows the prediction of malignant middle cerebral artery (MCA) infarction (MMI)...
  8. ncbi Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome
    Gotz Thomalla
    Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Brain 132:765-77. 2009
    ..The negative correlation between higher regional FA values and fewer tics suggests that these alterations of white matter microstructure represent adaptive reorganization of somatosensory processing in GTS...
  9. ncbi [Effective acute stroke treatment beyond approval limitations: intravenous thrombolysis within an extended time window (3-6 h) and in old patients (aged 80 or older)]
    G Thomalla
    Klinik und Poliklinik fur Neurologie, Neuro Zentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Fortschr Neurol Psychiatr 75:343-50. 2007
    ..To summarize, we recommend experienced stroke centres to treat acute stroke patients with thrombolysis up to 6 hours using MRI criteria for patient selection, and to treat also patients aged 80 years or older...
  10. ncbi Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Neuroimage 22:1767-74. 2004
    ..We demonstrated for the first time a correlation of early DTI findings of pyramidal tract damage with the motor deficit. DTI can help prognosing recovery of motor function after stroke within the early subacute phase...
  11. ncbi Outcome and symptomatic bleeding complications of intravenous thrombolysis within 6 hours in MRI-selected stroke patients: comparison of a German multicenter study with the pooled data of ATLANTIS, ECASS, and NINDS tPA trials
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Stroke 37:852-8. 2006
    ....
  12. ncbi [Vertebrobasilar occlusions : Pathophysiology, diagnostics and treatment]
    J Fiehler
    Klinik und Poliklinik für neuroradiologische Diagnostik und Intervention, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Radiologe 49:319-27. 2009
    ..This review paper focuses on the clinical and pathophysiological details that are crucial for decision-making...
  13. ncbi Thrombolysis targeting MRI defined tissue at risk in minor stroke
    A Kruetzelmann
    Neuro Zentrum, Klinik und Poliklinik fur Neurologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Neurol Neurosurg Psychiatry 80:1156-8. 2009
    ..Treatment with intravenous tissue plasminogen activator (IV-tPA) is usually not recommended in patients with minor stroke. Clinical and imaging outcome were studied after IV-tPA treatment based on MRI criteria in patients with minor stroke...
  14. ncbi Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study
    T Baumer
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Neurophysiol 120:1724-31. 2009
    ..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)...
  15. ncbi [Visual rating of T2'-blood-oxygen-level-dependent magnetic resonance imaging in acute stroke patients--a pilot study]
    J Fiehler
    Neuroradiology, University Hospital Hamburg Eppendorf, Hamburg
    Rofo 179:17-20. 2007
    ..Metabolic characterization of the penumbra might be able to be achieved using blood-oxygen-level-dependent (BOLD) imaging...
  16. ncbi Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke
    F C Hummel
    Department of Neurology, University Medical Center Hamburg Eppendorf, Germany
    Neurology 72:1766-72. 2009
    ..Poor control of intracortical inhibitory function in the primary motor cortex (M1) might contribute to persistent abnormal motor behavior in the paretic hand after chronic stroke...
  17. ncbi Altered modulation of intracortical excitability during movement preparation in Gilles de la Tourette syndrome
    K F Heise
    Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Brain 133:580-90. 2010
    ....
  18. ncbi [Patient selection for thrombolysis using perfusion and diffusion MRI. An overview]
    G Thomalla
    Klinik und Poliklinik fur Neurologie, Neuro Zentrum, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Deutschland
    Nervenarzt 80:119-20, 122-4, 126 passim. 2009
    ..At the moment MRI-based thrombolysis can be performed after 3 h based on individual benefit:risk assessment in experienced stroke centers...