R Thimme

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint T cell responses in hepatitis C: the good, the bad and the unconventional
    Paul Klenerman
    NIHR Biomedical Research Centre, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
    Gut 61:1226-34. 2012
  2. doi request reprint [Hepatology 2008]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Hugstetter Strasse 55, 79106 Freiburg
    Dtsch Med Wochenschr 133:1366-9. 2008
  3. doi request reprint Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma
    Robert Thimme
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Hepatology 48:1821-33. 2008
  4. ncbi request reprint [Hepatology 2007]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Freiburg, Germany
    Dtsch Med Wochenschr 132:1392-5. 2007
  5. doi request reprint [Hepatitis B viral load as a risk factor for liver cirrhosis]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Dtsch Med Wochenschr 133:1589-91. 2008
  6. ncbi request reprint [The role of the virus specific T-cell response in acute and chronic HBV and HCV infection]
    E Panther
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg, Germany
    Z Gastroenterol 42:39-46. 2004
  7. doi request reprint [Chronic hepatitis B]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II, Hugstetter Strasse 55, 79106 Freiburg
    Dtsch Med Wochenschr 133:135-8. 2008
  8. ncbi request reprint [The hepatocellular carcinoma: alternative therapeutical strategies]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Zentralbl Chir 132:322-7. 2007
  9. ncbi request reprint [Cholestatic liver diseases]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II
    Ther Umsch 61:521-7. 2004
  10. ncbi request reprint [Diagnosis and treatment of hepatocellular carcinoma]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Dtsch Med Wochenschr 129:368-72. 2004

Collaborators

Detail Information

Publications33

  1. doi request reprint T cell responses in hepatitis C: the good, the bad and the unconventional
    Paul Klenerman
    NIHR Biomedical Research Centre, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
    Gut 61:1226-34. 2012
    ..Specifically, we will emphasise recent new insights into the effector functions of T cells, possible mechanisms of their failure and the host-virus interactions occurring at the site of the disease, the liver...
  2. doi request reprint [Hepatology 2008]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Hugstetter Strasse 55, 79106 Freiburg
    Dtsch Med Wochenschr 133:1366-9. 2008
  3. doi request reprint Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma
    Robert Thimme
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Hepatology 48:1821-33. 2008
    ..Our results provide support for strategies to boost AFP-specific CD8(+) T cell responses in patients with HCC but also demonstrate a diversity of immune responses that may be needed for protection...
  4. ncbi request reprint [Hepatology 2007]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Freiburg, Germany
    Dtsch Med Wochenschr 132:1392-5. 2007
  5. doi request reprint [Hepatitis B viral load as a risk factor for liver cirrhosis]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Dtsch Med Wochenschr 133:1589-91. 2008
  6. ncbi request reprint [The role of the virus specific T-cell response in acute and chronic HBV and HCV infection]
    E Panther
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg, Germany
    Z Gastroenterol 42:39-46. 2004
    ..In case of viral persistence virus specific T-cells contribute to liver inflammation. In this article we summarize the current concepts about the role of the virus specific T-cell response in acute and chronic HBV and HCV infection...
  7. doi request reprint [Chronic hepatitis B]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II, Hugstetter Strasse 55, 79106 Freiburg
    Dtsch Med Wochenschr 133:135-8. 2008
  8. ncbi request reprint [The hepatocellular carcinoma: alternative therapeutical strategies]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Zentralbl Chir 132:322-7. 2007
    ..This review should give an overview of possible alternative therapies in HCC treatment...
  9. ncbi request reprint [Cholestatic liver diseases]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II
    Ther Umsch 61:521-7. 2004
    ..Cirrhosis may ultimately develop in PBC and PCS. In progressed PBC or PSC liver transplantation is indicated...
  10. ncbi request reprint [Diagnosis and treatment of hepatocellular carcinoma]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Dtsch Med Wochenschr 129:368-72. 2004
  11. ncbi request reprint [Systemic treatment for hepatocellular carcinoma]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitätsklinik Albert Ludwigs Universität Freiburg, Germany
    Zentralbl Chir 128:906-10. 2003
    ..Efficient strategies for the primary prevention of HCC are available and promising concepts in the secondary prevention have been reported...
  12. ncbi request reprint [Best supportive care of hepatocellular carcinoma]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Internist (Berl) 45:777-85. 2004
    ....
  13. ncbi request reprint Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection
    C Neumann-Haefelin
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Genes Immun 8:181-92. 2007
    ..A better understanding of these host-virus interactions is essential not only to gain better insights into the mechanisms of viral clearance and persistence but also for the development of new antiviral vaccine strategies...
  14. ncbi request reprint T cell response in hepatitis C virus infection
    C Neumann-Haefelin
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Clin Virol 32:75-85. 2005
    ..Recent studies, however, have provided new insights into the mechanisms of viral clearance and persistence that will be discussed in detail...
  15. ncbi request reprint [Suppressor T-cells: immunologic regulator cells and clinical perspectives]
    C Neumann-Haefelin
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Dtsch Med Wochenschr 129:1627-30. 2004
    ..Regulatory T cells modulate immune responses in different clinical settings. Here, we summarize the role of CD4(+)CD25(+) regulatory T cells in autoimmunity, transplantation, infectious diseases and tumor immunity...
  16. ncbi request reprint [T cell response to hepatitis B and C: from viral elimination to hepatocellular carcinoma]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitätsklinik Freiburg i Br, Germany
    Dtsch Med Wochenschr 127:2277-9. 2002
  17. doi request reprint [Hepatic resection for hepatocellular carcinoma--results and analysis of the current literature]
    H Neeff
    Universitat Freiburg, Allgemein und Viszeralchirurgie, Freiburg, Germany
    Zentralbl Chir 134:127-35. 2009
    ..In this context, we present our results on liver resection for HCC and a discussion of the current literature about (potentially curative) treatment for HCC...
  18. ncbi request reprint [Acute hepatitis C. Therapy with interferon alpha-2b]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Internist (Berl) 43:1148-50. 2002
  19. ncbi request reprint Serum markers of hepatocellular carcinoma
    H C Spangenberg
    Department of Medicine II, University Hospital, Freiburg, Germany
    Semin Liver Dis 26:385-90. 2006
    ..For all such proposed markers, however, the clinical usefulness has to be carefully evaluated and validated...
  20. doi request reprint [RNA interference as antiviral strategy]
    C Neumann-Haefelin
    Abteilung Innere Medizin II, Universitatsklinikum Freiburg
    Dtsch Med Wochenschr 133:2407-9. 2008
    ..The understanding of the mechanisms of action of miRNA might lead to new antiviral and preventive strategies...
  21. doi request reprint [Jaundice in an HIV-positive pregnant woman]
    E Panther
    Abteilung Innere Medizin II, Universitatsklinikum Freiburg
    Dtsch Med Wochenschr 133:1560-2. 2008
    ..During a routine pregnancy check-up six months previously, an HIV infection had been diagnosed and antiretroviral therapy was initiated. The patient had moved from Nigeria to Germany two years before and has not been abroad since then...
  22. ncbi request reprint [Therapy of hepatitis B]
    R Thimme
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Praxis (Bern 1994) 95:1383-8. 2006
    ..The efficacy ot the respective antivirals is affected by virological and clinical parameters, thus requiring individual treatment strategies that will be discussed in detail...
  23. ncbi request reprint [The patient as partner -- observations regarding a respectful relationship with sick people]
    K Rosler
    Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg
    Dtsch Med Wochenschr 130:2937-9. 2005
  24. doi request reprint [Perspectives on immunotherapy for hepatocellular carcinoma]
    N Schmidt
    Abteilung Innere Medizin II, Universitatsklinikum Freiburg, Freiburg
    Dtsch Med Wochenschr 138:740-4. 2013
    ..Thus, the aim of immunotherapeutic strategies is to address these mechanisms of T-cell failure and to induce new or to boost existing antitumoral immune responses...
  25. ncbi request reprint [Cholestatic liver diseases: diagnosis and therapy of primary sclerosing cholangitis]
    O G Opitz
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg, Germany
    Dtsch Med Wochenschr 127:1827-30. 2002
  26. ncbi request reprint [Cholestatic liver diseases: diagnosis and therapy of primary biliary cirrhosis]
    R Thimme
    Medizinische Universitatsklinik Freiburg, Abteilung Innere Medizin II, Medizinische Universitatsklinik Freiburg, Germany
    Dtsch Med Wochenschr 127:1823-6. 2002
  27. pmc Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency
    Julia Schmidt
    University Hospital Freiburg, Department of Medicine II, Hugstetter Str 55, 79106 Freiburg, Germany
    J Virol 85:5232-6. 2011
    ..These results indicate for the first time that immunodominance in a human viral infection is linked to naïve-precursor frequency...
  28. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
    ....
  29. ncbi request reprint Immune responses against HCV-NS3 after accidental infection with HCV-NS3 recombinant vaccinia virus
    C Eisenbach
    J Viral Hepat 14:817-9. 2007
  30. ncbi request reprint [Viral anti-interferon strategies: mechanisms and clinical impact]
    F Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universität Freiburg i Br
    Dtsch Med Wochenschr 128:323-5. 2003
  31. ncbi request reprint [Immunopathogenesis of viral hepatitis]
    C Neumann-Haefelin
    Abteilung Innere Medizin II, Medizinische Universitätsklinik Freiburg i Br
    Praxis (Bern 1994) 96:545-51. 2007
    ..The exact knowledge of the mechanisms contributing to viral clearance and persistence are prerequisite to the successful development of prophylactic and therapeutic immunostrategies...
  32. doi request reprint [Hepatology]
    R Thimme
    Dtsch Med Wochenschr 133:1559. 2008
  33. pmc Degenerate immunogenicity of an HLA-A2-restricted hepatitis B virus nucleocapsid cytotoxic T-lymphocyte epitope that is also presented by HLA-B51
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:3984-7. 2001
    ..In addition, they could facilitate the development of an epitope-based therapeutic vaccine to terminate chronic HBV infection that could provide a broad and diverse population coverage with a single peptide...