Jurgen Thiele

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Chronic myeloproliferative disorders with thrombocythemia: a comparative study of two classification systems (PVSG, WHO) on 839 patients
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, 50924 Cologne, Germany
    Ann Hematol 82:148-52. 2003
  2. ncbi request reprint Initial (latent) polycythemia vera with thrombocytosis mimicking essential thrombocythemia
    Jurgen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Acta Haematol 113:213-9. 2005
  3. ncbi request reprint Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients
    J Thiele
    Institutes of Pathology, University of Cologne, Germany
    Histopathology 46:540-50. 2005
  4. ncbi request reprint Bone marrow features of diagnostic impact in erythrocytosis
    Juergen Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, 50924, Cologne, Germany
    Ann Hematol 84:362-7. 2005
  5. ncbi request reprint Diagnostic impact of bone marrow histopathology in polycythemia vera (PV)
    J Thiele
    Institute of Pathology, Universities of Cologne, D 50924 Cologne, Germany
    Histol Histopathol 20:317-28. 2005
  6. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate (STI571) on bone marrow features in patients with chronic myelogenous leukemia
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:1277-88. 2004
  7. ncbi request reprint Megakaryocyte features and bcr/abl translocation in chronic myeloid leukemia following imatinib mesylate (STI571) therapy--a fluorescence in-situ hybridization study
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Lymphoma 45:1627-31. 2004
  8. ncbi request reprint Mixed chimerism of cardiomyocytes and vessels after allogeneic bone marrow and stem-cell transplantation in comparison with cardiac allografts
    Juergen Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, D 50924 Cologne, Germany
    Transplantation 77:1902-5. 2004
  9. ncbi request reprint [Regression of the Philadelphia chromosome (bcr/abl)-positive myelo- and megakaryopoiesis after Imatinib (STI571) therapy in chronic myelogenous leukemia (CML)]
    J Thiele
    Institut fur Pathologie, Universitat Koln
    Pathologe 25:428-35. 2004
  10. ncbi request reprint Acute panmyelosis with myelofibrosis: a clinicopathological study on 46 patients including histochemistry of bone marrow biopsies and follow-up
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, Cologne, Germany
    Ann Hematol 83:513-21. 2004

Detail Information

Publications88

  1. ncbi request reprint Chronic myeloproliferative disorders with thrombocythemia: a comparative study of two classification systems (PVSG, WHO) on 839 patients
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, 50924 Cologne, Germany
    Ann Hematol 82:148-52. 2003
    ..6% and 32.3 %. In conclusion, a more accurate classification of ET is warranted by regarding the WHO criteria that include histopathology as a major feature for diagnosis...
  2. ncbi request reprint Initial (latent) polycythemia vera with thrombocytosis mimicking essential thrombocythemia
    Jurgen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Acta Haematol 113:213-9. 2005
    ..Therefore, so-called masked PV in patients with ET or simultaneous PVR-1 gene expression and endogeneous erythroid colony growth in ET patients are probably in keeping with initial PV mimicking ET...
  3. ncbi request reprint Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients
    J Thiele
    Institutes of Pathology, University of Cologne, Germany
    Histopathology 46:540-50. 2005
    ..To carry out an immunohistochemical study on bone marrow (BM) biopsy specimens in 75 patients with chronic myelogenous leukaemia (CML) on long-term STI571 therapy...
  4. ncbi request reprint Bone marrow features of diagnostic impact in erythrocytosis
    Juergen Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, 50924, Cologne, Germany
    Ann Hematol 84:362-7. 2005
    ..In conclusion, certain sets of morphological parameters allow a distinction between autonomous and reactive polycythemias and therefore enhance significantly diagnostic validity...
  5. ncbi request reprint Diagnostic impact of bone marrow histopathology in polycythemia vera (PV)
    J Thiele
    Institute of Pathology, Universities of Cologne, D 50924 Cologne, Germany
    Histol Histopathol 20:317-28. 2005
    ..In conclusion, PV is characterized by a distinctive pattern of histopathology that has been gained in an independent and blind fashion and therefore, dissolves arguments about failing specificity...
  6. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate (STI571) on bone marrow features in patients with chronic myelogenous leukemia
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:1277-88. 2004
    ..Data on proliferative activity and apoptosis in general supported in vitro findings concerning the inhibitory effect of this agent on growth associated with a tendency for stimulated apoptosis, at least in responding patients...
  7. ncbi request reprint Megakaryocyte features and bcr/abl translocation in chronic myeloid leukemia following imatinib mesylate (STI571) therapy--a fluorescence in-situ hybridization study
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Lymphoma 45:1627-31. 2004
    ..Because cytogenetic response and reduction of micromegakaryocytes seem to be linked, this feature may be useful to monitor therapeutic efficacy by evaluating BM morphology...
  8. ncbi request reprint Mixed chimerism of cardiomyocytes and vessels after allogeneic bone marrow and stem-cell transplantation in comparison with cardiac allografts
    Juergen Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, D 50924 Cologne, Germany
    Transplantation 77:1902-5. 2004
    ..A sprouting of vascular structures into the donor heart after orthotopic cardiac transplantation has to be assumed, as does a pivotal role of the mesenchymal stem cells of the BM in the development of mCh...
  9. ncbi request reprint [Regression of the Philadelphia chromosome (bcr/abl)-positive myelo- and megakaryopoiesis after Imatinib (STI571) therapy in chronic myelogenous leukemia (CML)]
    J Thiele
    Institut fur Pathologie, Universitat Koln
    Pathologe 25:428-35. 2004
    ..Because cytogenetic response and reduction of atypical micromegakaryocytes are linked, this feature may be useful to monitor therapeutic efficacy...
  10. ncbi request reprint Acute panmyelosis with myelofibrosis: a clinicopathological study on 46 patients including histochemistry of bone marrow biopsies and follow-up
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, Cologne, Germany
    Ann Hematol 83:513-21. 2004
    ..In conclusion, APMF may not be a distinct entity, but includes hyperfibrotic myelodysplastic syndromes (MDS) either primary or secondary, a rare form of initial AML with fibrosis, and even cases of toxic myelopathy...
  11. ncbi request reprint Acute panmyelosis with myelofibrosis
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Lymphoma 45:681-7. 2004
    ....
  12. ncbi request reprint Prefibrotic chronic idiopathic myelofibrosis--a diagnostic enigma?
    J Thiele
    Institute of Pathology, Universitiy of Cologne, Cologne, Germany
    Acta Haematol 111:155-9. 2004
    ..In CIMF progressive myelofibrosis occurred in more than 50% of patients according to the last biopsy specimen; however, this figure increased according to relevant clinical data in the follow-up period...
  13. ncbi request reprint Standardization of bone marrow features--does it work in hematopathology for histological discrimination of different disease patterns?
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 20:633-44. 2005
    ..Regarding these results, a schematic procedure is proposed to be used for daily routine diagnosis concerning the discrimination of MPDs...
  14. ncbi request reprint Therapy-related changes of the bone marrow in chronic idiopathic myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:239-50. 2004
    ..Development of myelofibrosis in IMF is obviously due to disease progression unrelated to stage at diagnosis and not significantly influenced by treatment modalities...
  15. ncbi request reprint Regeneration of heart muscle tissue: quantification of chimeric cardiomyocytes and endothelial cells following transplantation
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:201-9. 2004
    ..This phenomenon is more extensively expressed than previously expected and may be related to an enforced repair of the damaged myocardium during the post-transplant period as the sequel of myeloablative (cardiotoxic) conditioning...
  16. ncbi request reprint Bone marrow histopathology following cytoreductive therapy in chronic idiopathic myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histopathology 43:470-9. 2003
    ..To analyse systematically therapy-induced lesions of haematopoiesis in chronic idiopathic myelofibrosis (IMF)...
  17. ncbi request reprint Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. an immunohistochemical and morphometric study of sequential trephine biopsies
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Haematologica 88:1130-8. 2003
    ..Contrasting the wealth of clinical data, bone marrow (BM) changes during therapy have been relatively rarely studied; information is particularly lacking regarding specific features of megakaryocytopoiesis...
  18. doi request reprint Essential thrombocythemia versus early primary myelofibrosis: a multicenter study to validate the WHO classification
    Jurgen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Blood 117:5710-8. 2011
    ..Comparison of clinical and survival data of the Vienna cohort with the historical Cologne series revealed an overall congruence. This study highlights the impact of BM morphology for the differentiation between true vs false ET...
  19. ncbi request reprint Dynamics of bone marrow changes in patients with chronic idiopathic myelofibrosis following allogeneic stem cell transplantation
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, D 50924 Cologne, Germany
    Histol Histopathol 20:879-89. 2005
    ..Proliferative activity and apoptosis showed an increase until one year after SCT that implied a still regenerating hematopoiesis in keeping with an enhanced cell turnover...
  20. ncbi request reprint Bone marrow CD34+ progenitor cells in Philadelphia chromosome-negative chronic myeloproliferative disorders--a clinicopathological study on 575 patients
    Juergen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Leuk Lymphoma 46:709-15. 2005
    ..This putative pathomechanism is significantly associated with the evolution of MMM...
  21. doi request reprint The 2008 WHO diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis
    Juergen Thiele
    Institute for Pathology, University of Cologne, Kerpener Strasse 62, D 50924, Cologne, Germany
    Curr Hematol Malig Rep 4:33-40. 2009
    ..As with PMF, morphology plays a distinctive role in diagnosis, particularly for its differentiation from early-stage PV or prodromal PMF associated with thrombocytosis...
  22. doi request reprint Is it justified to perform a bone marrow biopsy examination in sustained erythrocytosis?
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Curr Hematol Malig Rep 1:87-92. 2006
    ..Finally, an increase in dysplastic changes and immaturity of cell lineages signals a transition into blastic crisis...
  23. ncbi request reprint Myelofibrosis--what's in a name? Consensus on definition and EUMNET grading
    Jurgen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Pathobiology 74:89-96. 2007
    ..Myelofibrosis (MF) implies an increase in the bone marrow (BM) fiber content without referring to quantity or quality (reticulin vs. collagen)...
  24. ncbi request reprint Dualism of mixed chimerism between hematopoiesis and stroma in chronic idiopathic myelofibrosis after allogeneic stem cell transplantation
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 22:365-72. 2007
    ..The non-transplantable stromal compartment includes the vascular endothelium with a predominance of recipient cells. The minimal mCh of this population implies probably a donor-derived origin (endothelial progenitor cells)...
  25. ncbi request reprint Myelofibrosis in chronic myeloproliferative disorders--dynamics and clinical impact
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 21:1367-78. 2006
    ..In conclusion, more elaborate evaluations including standardized grading of MF is warranted by regarding bone marrow biopsy specimens in association with clinical parameters including follow-up examinations...
  26. ncbi request reprint Effects of anagrelide on megakaryopoiesis and platelet production
    Juergen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Semin Thromb Hemost 32:352-61. 2006
    ..On the other hand, in follow-up examinations of BM specimens, ANA failed to show a stimulation of myelofibrosis in ET, provided diagnosis was established according to the World Health Organization criteria...
  27. ncbi request reprint Bone marrow histopathology in the diagnosis of chronic myeloproliferative disorders: a forgotten pearl
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Best Pract Res Clin Haematol 19:413-37. 2006
    ..In conclusion, BM biopsy should be considered as major diagnostic tool for evaluation and follow-up of patients enrolled in prospective studies...
  28. ncbi request reprint Clinicopathological criteria for differential diagnosis of thrombocythemias in various myeloproliferative disorders
    Juergen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Semin Thromb Hemost 32:219-30. 2006
    ..A scrutinized discrimination of thrombocythemias resulting in a clear-cut diagnosis of true versus false ET is warranted by a professional evaluation of BM biopsies in ongoing and prospective clinical trials...
  29. ncbi request reprint Trisomy 8 in prefibrotic early stages of chronic idiopathic myelofibrosis: a fluorescence in situ study of bone marrow biopsies
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Acta Haematol 115:97-101. 2006
    ..In conclusion, trisomy 8 has been demonstrated already in the prodromal stages of CIMF and therefore is not limited to classical fibro-osteosclerotic manifestations...
  30. ncbi request reprint Grade of bone marrow fibrosis is associated with relevant hematological findings-a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis
    J Thiele
    Institute for Pathology, University of Cologne, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Ann Hematol 85:226-32. 2006
    ..In conclusion, the dynamics of the disease process in CIMF are characterized by evolving MF in the BM and closely associated changes of relevant hematological findings...
  31. ncbi request reprint A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders
    Juergen Thiele
    Institute of Pathology, University Cologne, Cologne, Germany
    Leuk Lymphoma 47:381-96. 2006
    ..A comparison of clinical data and BM morphology reveals that biomarkers (EPO, EECs, PRV-1, JAK2) show an overlapping pattern of positivity between the different subtypes of MPDs...
  32. ncbi request reprint Bone marrow histopathology in myeloproliferative disorders--current diagnostic approach
    Juergen Thiele
    Institute of Pathology, Cologne University, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
    Semin Hematol 42:184-95. 2005
    ....
  33. ncbi request reprint Hematopathologic findings in chronic idiopathic myelofibrosis
    Juergen Thiele
    Institute of Pathology, University of Cologne, Germany
    Semin Oncol 32:380-94. 2005
    ..Regarding prognosis, early CIMF is associated with a significantly more favorable survival than advanced stages...
  34. ncbi request reprint Anagrelide does not exert a myelodysplastic effect on megakaryopoiesis: a comparative immunohistochemical and morphometric study with hydroxyurea
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 20:1071-6. 2005
    ..However, contrasting ANA, HU generated defects of differentiation consistent with significant dysplastic changes. In conclusion, concern about a possible leukemogenic capacity following long-term HU therapy is supported by our findings...
  35. ncbi request reprint European consensus on grading bone marrow fibrosis and assessment of cellularity
    Jurgen Thiele
    Institute for Pathology, University of Cologne, Germany
    Haematologica 90:1128-32. 2005
    ..The consensus for measuring myelofibrosis by clear and reproducible guidelines achieved by our group should allow for precise grading during the disease process and after therapy...
  36. ncbi request reprint Dynamics of fibrosis in chronic idiopathic (primary) myelofibrosis during therapy: a follow-up study on 309 patients
    J Thiele
    Institutes of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Leuk Lymphoma 44:949-53. 2003
    ..In conclusion, persuasive evidence has been produced that myelofibrosis in IMF is characterized by a stepwise progression and that this process is not significantly influenced by current treatment strategies...
  37. ncbi request reprint Mixed chimerism of erythro- and megakaryopoiesis following allogeneic bone marrow transplantation
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Acta Haematol 109:176-83. 2003
    ..A striking conversion of MCh to a recipient cell type was found in leukemic relapse with a more than 90% host-derived erythroid and megakaryocytic cell population in 4 patients approximately 643 days after BMT...
  38. pmc Focal lymphoid aggregates (nodules) in bone marrow biopsies: differentiation between benign hyperplasia and malignant lymphoma--a practical guideline
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    J Clin Pathol 52:294-300. 1999
    ....
  39. ncbi request reprint Therapy-related changes of CD34+ progenitor cells in chronic myeloid leukemia: a morphometric study on sequential trephine biopsies
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    J Hematother Stem Cell Res 10:827-36. 2001
    ....
  40. ncbi request reprint [Chronic myeloproliferative disorders. The new WHO classification]
    J Thiele
    Zentrum für Pathologie der Universität zu Köln
    Pathologe 22:429-43. 2001
    ..e., in CML regarding erythropoiesis and myelofibrosis and in IMF extent of myeloid metaplasia...
  41. ncbi request reprint Comparative effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous leukemia
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Lymphoma 42:855-62. 2001
    ..In addition, patients showing a rapid progression of myelofibrosis during IFN and HU treatment of Ph1+-CML are generally associated with a poor risk outcome and a significant worsening of survival...
  42. ncbi request reprint The value of bone marrow histology in differentiating between early stage Polycythemia vera and secondary (reactive) Polycythemias
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Haematologica 86:368-74. 2001
    ....
  43. ncbi request reprint Clinical and morphological criteria for the diagnosis of prefibrotic idiopathic (primary) myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstrasse 9, 50924 Cologne, Germany
    Ann Hematol 80:160-5. 2001
    ..In conclusion, morphological and clinical parameters have been validated by this study, which are consistent with a set of diagnostic criteria to recognize initial or prefibrotic precursor stages of IMF...
  44. ncbi request reprint Clinicopathology and histochemistry on bone marrow biopsies in chronic myeloproliferative disorders--a clue to diagnosis and classification
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Pathol Biol (Paris) 49:140-7. 2001
    ..Only in a small proportion not a failing methodology, but initial stages of the disease process requires sequential examinations to reach a correct diagnosis...
  45. ncbi request reprint Bone marrow engraftment: histopathology of hematopoietic reconstitution following allogeneic transplantation in CML patients
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 16:213-26. 2001
    ..Moreover, quantity of erythropoiesis and amount of reticulin fibers (myelofibrosis) exerted a significant impact on engraftment status...
  46. ncbi request reprint Relevance of bone marrow features in the differential diagnosis between essential thrombocythemia and early stage idiopathic myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Haematologica 85:1126-34. 2000
    ..In this context the updated diagnostic criteria of the Polycythemia Vera Study Group (PVSG) are generally accepted, although histopathologic features of the bone marrow were only marginally considered...
  47. ncbi request reprint Changing patterns of histological subgroups during therapy of Ph1+ chronic myelogenous leukaemia
    J Thiele
    Department of Pathology, Universities of Cologne, Freiburgand Essen, Germany
    Histopathology 37:355-62. 2000
    ..However, little information exists on whether these groups represent stable categories of the different classification systems and whether therapeutic regimes exert any influence on the putative shift of histological patterns...
  48. ncbi request reprint Macrophages and their subpopulations following allogenic bone marrow transplantation for chronic myeloid leukaemia
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Virchows Arch 437:160-6. 2000
    ....
  49. ncbi request reprint Therapy-related changes of CD20+ and CD45RO+ lymphocyte subsets in chronic myeloid leukemia (CML): an immunohistochemical and morphometric study on sequential trephine biopsies of the bone marrow
    J Thiele
    Institutes of Pathology, University of Cologne, Germany
    Mod Pathol 13:888-96. 2000
    ..Opposed to a repeatedly discussed pathomechanism, we failed to demonstrate any quantitative relationships between the extent of lymphocyte proliferations and occurrence or progression of myelofibrosis...
  50. ncbi request reprint [Histologic and hematological findings in CML. A comparative immunohistochemical-morphometric and clinical study on bone marrow biopsies from 604 patients derived from two institutes of pathology (Cologne/Freiburg)]
    J Thiele
    Zentrum für Pathologie der Universität zu Köln
    Pathologe 21:39-54. 2000
    ....
  51. ncbi request reprint Effect of IFN-alpha on normal human hematopoiesis: an immunohistochemical and morphometric study on trephine biopsy specimens
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    J Interferon Cytokine Res 18:247-53. 1998
    ..This feature was assumed to contribute to a maintenance of steady-state hematopoiesis expressed by a nonaltered bone marrow cellularity in our specimens...
  52. ncbi request reprint [Thrombocytosis versus thrombocythemia--differential diagnosis of elevated platelet count]
    J Thiele
    Zentrum für Pathologie der Universität zu Köln
    Pathologe 21:31-8. 2000
    ..Similar results are exhibited regarding reticulin fibrosis, which is usually not present in ET, rarely observed in PV and detectable to a variable degree in CML and IMF...
  53. ncbi request reprint Histochemistry and morphometry on bone marrow biopsies in chronic myeloproliferative disorders - aids to diagnosis and classification
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Ann Hematol 78:495-506. 1999
    ..Furthermore, it may even warrant follow-up studies and repeated bone marrow examinations in initially unclassifiable cases...
  54. ncbi request reprint Resident bone marrow macrophages in idiopathic (primary) myelofibrosis (IMF): a histochemical and morphometric study on sequential trephine biopsies
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Res 23:983-5. 1999
    ..The latter feature may be triggered by increased degradation of senescent megakaryocytes, frequently occurring as endstages of growth factors-releasing fibrogenetic megakaryopoiesis...
  55. ncbi request reprint Bone marrow histopathology in chronic myelogenous leukemia (CML)--evaluation of distinctive features with clinical impact
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 14:1241-56. 1999
    ..For this reason, it should be mandatory to enter morphological criteria into prospective clinical trials on CML, not only for diagnostic purpose, but also for a proper evaluation of different survival patterns...
  56. ncbi request reprint CD34+ stem cells in chronic myeloproliferative disorders
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 17:507-21. 2002
    ..For this reason, a presumptive defect in the recovery of normal and clonally transformed stem cells is speculated to add to the worsening of prognosis by causing the well-known bone marrow insufficiency in terminal stage PV and IMF...
  57. ncbi request reprint Diagnostic differentiation of essential thrombocythaemia from thrombocythaemias associated with chronic idiopathic myelofibrosis by discriminate analysis of bone marrow features--a clinicopathological study on 272 patients
    J Thiele
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Histol Histopathol 18:93-102. 2003
    ..Discrimination between these entities is warranted, because of a significant difference in presenting haematological data, follow-up and life expectancy...
  58. ncbi request reprint [Chimerism of cardiomyocytes and endothelial cells after allogeneic bone marrow transplantation in chronic myeloid leukemia. An autopsy study]
    J Thiele
    Zentrum für Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Pathologe 23:405-10. 2002
    ..However, further investigations are necessary to identify, isolate and enrich the cardiomyocytic stem cells more specifically for future curative therapeutic options in patients with severe ischemic cardiomyopathy...
  59. ncbi request reprint Follow-up examinations including sequential bone marrow biopsies in essential thrombocythemia (ET): a retrospective clinicopathological study of 120 patients
    Juergen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Am J Hematol 70:283-91. 2002
    ..A neglectable proportion of life loss according to a sex- and age-matched general population was found in true ET (less than 11%) opposed to IMF without or mild fibrosis (range 21% to 32%)...
  60. ncbi request reprint Dynamics of CD34+ progenitor cells following allogeneic bone marrow transplantation in Ph1+CML--an immunohistochemical study on 113 patients with sequential trephine biopsies
    Juergen Thiele
    Institute of Pathology, University of Cologne, D 50924 Cologne, Germany
    J Hematother Stem Cell Res 11:565-74. 2002
    ....
  61. ncbi request reprint Early-stage idiopathic (primary) myelofibrosis--current issues of diagnostic features
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    Leuk Lymphoma 43:1035-41. 2002
    ..Moreover, characterization of early stage IMF probably exerts an impact on survival and may influence the decision to perform a BM transplantation...
  62. ncbi request reprint [Anagrelide-induced changes of megakaryopoiesis during therapy of chronic myeloproliferative disorders with thrombocythemia]
    J Thiele
    Zentrum für Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Pathologe 23:426-32. 2002
    ..Finally, no significant influence of Agrylin((R)) on the evolution of myelofibrosis is detectable and there is a general improvement of hematological data especially in cIMF...
  63. ncbi request reprint Mixed chimerism of bone marrow CD34+ progenitor cells (genotyping, bcr/abl analysis) after allogeneic transplantation for chronic myelogenous leukemia
    Juergen Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Transplantation 74:982-6. 2002
    ..Although CD34 progenitors play a crucial role during bone marrow transplantation (BMT), there is only scant knowledge concerning their lineage-restricted mixed chimerism (MCh)...
  64. ncbi request reprint Dynamics of lineage-restricted mixed chimerism following sex-mismatched allogeneic bone marrow transplantation
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 18:557-74. 2003
    ..These findings point towards a CD34+ progenitor cell origin of the (leukemic) endothelial cell layer and suggests that their dysfunction may contribute to an expansion of the neoplastic clone...
  65. ncbi request reprint Mixed chimerism of the resident macrophage population after allogeneic bone marrow transplantation for chronic myeloid leukemia
    Claudia Wickenhauser
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Transplantation 73:104-11. 2002
    ..So far, no information is available about a persistence of host-type macrophages after allogeneic bone marrow transplantation (BMT) implicating a lineage-specific mixed chimerism...
  66. ncbi request reprint Essential thrombocythemia with ringed sideroblasts: a heterogeneous spectrum of diseases, but not a distinct entity
    Annette Schmitt-Graeff
    Institutes of Pathology, Universities of Freiburg, Germany
    Haematologica 87:392-9. 2002
    ..Because until now only case reports or very small series of patients have been described, a more systematically performed study is warranted...
  67. ncbi request reprint MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
    ..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data...
  68. ncbi request reprint Structural, antigenetic and transcriptional characteristics in peripheral blood CD34+ progenitor cells from polycythemia vera patients: evidence for delayed determination
    Claudia Wickenhauser
    Institute for Pathologie, University of Cologne, Germany
    Int J Oncol 23:437-43. 2003
    ....
  69. ncbi request reprint Classification of Ph-negative chronic myeloproliferative disorders--morphology as the yardstick of classification
    Hans Michael Kvasnicka
    Institute of Pathology, University of Cologne, Cologne, Germany
    Pathobiology 74:63-71. 2007
    ....
  70. ncbi request reprint Mixed chimerism of bone marrow vessels (endothelial cells, myofibroblasts) following allogeneic transplantation for chronic myelogenous leukemia
    Hans M Kvasnicka
    Institute of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Leuk Lymphoma 44:321-8. 2003
    ..Evolution of leukemic relapse was characterized by conversion of MCh with almost total loss of donor type ECs and increase in number of bcr/abl+ ECs...
  71. doi request reprint Prodromal myeloproliferative neoplasms: the 2008 WHO classification
    Hans Michael Kvasnicka
    Institute of Pathology, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Am J Hematol 85:62-9. 2010
    ..The revised WHO classification incorporates hematological, morphological, and molecular-genetic parameters to generate a consensus-based working diagnosis...
  72. pmc Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Am J Pathol 163:819-26. 2003
    ..Thus, overexpression of bcl-2 and bcl-xL leading to prolonged survival of mast cells may contribute to the pathogenesis of mastocytosis. Our findings may help to develop new strategies for the treatment of this disease...
  73. ncbi request reprint Bone marrow manifestation of Lyme disease (Lyme Borreliosis)
    Hans M Kvasnicka
    Institute of Pathology, University of Cologne, Cologne, Germany
    Br J Haematol 120:723. 2003
  74. ncbi request reprint Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy
    Hans Michael Kvasnicka
    Institute of Pathology and First Clinic of Medicine, University of Cologne, Germany
    Blood 103:3549-51. 2004
    ..In conclusion, our data support the anti-angiogenic capacity of imatinib by normalization of vascularity. In contrast, hematologic response following IFN treatment is independent from BM angiogenesis...
  75. ncbi request reprint Impact of bone marrow morphology on multivariate risk classification in chronic myelogenous leukemia
    Hans Michael Kvasnicka
    Institute of Pathology, University of Cologne, Cologne, Germany
    Acta Haematol 109:53-6. 2003
  76. ncbi request reprint The impact of clinicopathological studies on staging and survival in essential thrombocythemia, chronic idiopathic myelofibrosis, and polycythemia rubra vera
    Hans Michael Kvasnicka
    Institute of Pathology, University of Cologne, Cologne, Germany
    Semin Thromb Hemost 32:362-71. 2006
    ..It has been shown that examination of bone marrow specimens enhances the diagnostic reliability and also enables the recognition of evolving myelofibrotic transformation in MPDs...
  77. ncbi request reprint Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Ann Surg Oncol 9:887-93. 2002
    ..MUC5AC represents a mucin peptide core expressed in normal gastric epithelia. Its presence in gastric carcinomas was previously described as a characteristic of gastric differentiation...
  78. ncbi request reprint Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    Gastroenterology 129:1042-6. 2005
    ..Our studies identify a new regulatory region in the KIT molecule and strongly suggest that patients with extracellular KIT mutations respond to tyrosine kinase inhibitors...
  79. pmc Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification
    Paul M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 242:684-92. 2005
    ..We sought to quantitatively and objectively evaluate histomorphologic tumor regression and establish a relevant prognostic regression classification system for esophageal cancer patients receiving neoadjuvant radiochemotherapy...
  80. ncbi request reprint Differences in proportion and dynamics of recipient hematopoiesis following hematopoietic cell transplantation in CML and IMF
    Udo Siebolts
    Institute of Pathology, University of Cologne, D 50924 Cologne, Germany
    Oncol Rep 19:287-92. 2008
    ....
  81. ncbi request reprint Co-expression of CDX2 and MUC2 in gastric carcinomas: correlations with clinico-pathological parameters and prognosis
    Kristina Roessler
    Institute of Pathology, University of Cologne, Joseph Stelzmann Strasse 9, D 50931 Cologne, Germany
    World J Gastroenterol 11:3182-8. 2005
    ..CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia...
  82. doi request reprint Philadelphia chromosome-negative chronic myeloproliferative disease
    Juergen Thiele
    Institute for Pathology, University of Cologne, Kerpener Str 62, Cologne D 50924, Germany
    Am J Clin Pathol 132:261-80. 2009
    ..Although novel genetic and molecular approaches have significantly improved the way we classify Ph- MPD, a combined clinicopathologic approach, including representative bone marrow specimens, still remains the yardstick for diagnosis...
  83. ncbi request reprint Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
    Stephan E Baldus
    Haematologica 89:1525-7. 2004
    ..An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis...
  84. ncbi request reprint Quantifying chimeric cardiomyocytes
    Hans Michael Kvasnicka
    Circulation 108:e60; author reply e60. 2003
  85. ncbi request reprint Clinical and pathological criteria for the diagnosis of essential thrombocythemia, polycythemia vera, and idiopathic myelofibrosis (agnogenic myeloid metaplasia)
    Jan Jacques Michiels
    Department of Hematology, University Hospital Antwerp, University of Antwerp, Belgium
    Int J Hematol 76:133-45. 2002
    ..On the other hand, survival is substantially shortened in IMF/AMM, even for patients with thrombocythemia as a frequent finding of prefibrotic and early stage IMF/AMM...
  86. ncbi request reprint Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel
    Ayalew Tefferi
    Mayo Clinic, Rochester, MN 55905, USA
    Blood 110:1092-7. 2007
    ....
  87. ncbi request reprint Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and
    Ruben A Mesa
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 31:737-40. 2007
    ....
  88. ncbi request reprint International Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT)
    Ayalew Tefferi
    Mayo Clinic, 200 First Street SW, Rochester MN 55905, USA
    Blood 108:1497-503. 2006
    ..Bone marrow histologic and hematologic remissions characterize CR and CR/PR, respectively. The panel agreed that the CI response category is applicable only to patients with moderate to severe cytopenia or splenomegaly...