Holger Thiele

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation
    Arian Mobascher
    Department of Psychiatry, Johannes Gutenberg University, Untere Zahlbacher Str 8, 55131, Germany
    Mol Pain 6:32. 2010
  2. ncbi request reprint HaploPainter: a tool for drawing pedigrees with complex haplotypes
    Holger Thiele
    Gene Mapping Center, Max Delbrueck Center MDC for Molecular Medicine, Berlin Buch, Germany
    Bioinformatics 21:1730-2. 2005
  3. ncbi request reprint Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Biol Chem 386:61-7. 2005
  4. ncbi request reprint Mutations in the WFS1 gene that cause low-frequency sensorineural hearing loss are small non-inactivating mutations
    Kim Cryns
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Hum Genet 110:389-94. 2002
  5. pmc A 4-bp insertion in the eya-homologous region (eyaHR) of EYA4 causes hearing impairment in a Hungarian family linked to DFNA10
    Markus Pfister
    Department of Otolaryngology, University of Tubingen, Tubingen, Germany
    Mol Med 8:607-11. 2002
  6. pmc Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
    Birgit Uhlenberg
    Department of Neuropediatrics, Charite, University Medical School of Berlin, Berlin, Germany
    Am J Hum Genet 75:251-60. 2004
  7. ncbi request reprint Color-encoded semiautomatic analysis of multi-slice first-pass magnetic resonance perfusion: comparison to tetrofosmin single photon emission computed tomography perfusion and X-ray angiography
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Int J Cardiovasc Imaging 20:371-84; discussion 385-7. 2004
  8. ncbi request reprint Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura
    Christian Netzer
    Institute of Human Genetics, University of Cologne, Cologne, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:37-41. 2008
  9. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008

Collaborators

  • Richard J Smith
  • Jan Freudenberg
  • R C Betz
  • Dieter E Jenne
  • Gerhard Schlenvoigt
  • Timea Toth
  • Susan Kupka
  • Guy Van Camp
  • R J E Pennings
  • M Schuelke
  • J Michael Schröder
  • W Reardon
  • Astrid Golla
  • Peter Nurnberg
  • Arian Mobascher
  • Mohammad R Toliat
  • Christian Netzer
  • Axel M Hillmer
  • Markus Pfister
  • Birgit Uhlenberg
  • Nikolaus Blin
  • Kim Cryns
  • Alfons Schnitzler
  • Juergen Brinkmeyer
  • Francesco Musso
  • Michael Steffens
  • Andreas Saleh
  • Tracy Warbrick
  • Hans Joerg Wittsack
  • Georg Winterer
  • Louis J Ptacek
  • Anne Katrin Kortüm
  • Christine Metzen
  • Hans Christian Hennies
  • Unda Todt
  • Axel Heinze
  • Ingrid Goebel
  • Thomas Ruzicka
  • Sibylle Eigelshoven
  • Markus M Nothen
  • Christian Kubisch
  • Susanne Kolberg
  • Felix F Brockschmidt
  • Katja Heinze-Kuhn
  • Roland Kruse
  • Antonia Flaquer
  • Roman Reinartz
  • Sandra Hanneken
  • Hartmut Gobel
  • Marco Henneke
  • Jutta Gartner
  • Bernhard Weschke
  • Haluk Topaloglu
  • Nico Ruf
  • Franz Ruschendorf
  • Gisela Stoltenburg-Didinger
  • Christoph Hübner
  • Fuat Aksu
  • Angela M Kaindl
  • Steven J H Bom
  • Goele Caethoven
  • Dafydd Stephens
  • Paul H Van de Heyning
  • Cor W R J Cremers
  • Istvan Sziklai
  • Hannie Kremer
  • Kris Flothmann
  • Karen A Köln
  • Birgit Haack
  • Hans Peter Zenner
  • Isabelle Schatteman

Detail Information

Publications9

  1. pmc The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation
    Arian Mobascher
    Department of Psychiatry, Johannes Gutenberg University, Untere Zahlbacher Str 8, 55131, Germany
    Mol Pain 6:32. 2010
    ..In the present fMRI study we therefore sought to investigate the impact of the COMT val158met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation...
  2. ncbi request reprint HaploPainter: a tool for drawing pedigrees with complex haplotypes
    Holger Thiele
    Gene Mapping Center, Max Delbrueck Center MDC for Molecular Medicine, Berlin Buch, Germany
    Bioinformatics 21:1730-2. 2005
    ....
  3. ncbi request reprint Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Biol Chem 386:61-7. 2005
    ..We conclude that the structural motif around the Ser606 residue represents an important functional site that may regulate the transient activation and limited proteolysis of calpain 3...
  4. ncbi request reprint Mutations in the WFS1 gene that cause low-frequency sensorineural hearing loss are small non-inactivating mutations
    Kim Cryns
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Hum Genet 110:389-94. 2002
    ..In contrast, 64% of the Wolfram syndrome mutations are inactivating. Our results indicate that only non-inactivating mutations in WFS1 are responsible for non-syndromic low-frequency hearing impairment...
  5. pmc A 4-bp insertion in the eya-homologous region (eyaHR) of EYA4 causes hearing impairment in a Hungarian family linked to DFNA10
    Markus Pfister
    Department of Otolaryngology, University of Tubingen, Tubingen, Germany
    Mol Med 8:607-11. 2002
    ..EYA4 is orthologous to the Drosophila gene eya ("eyes absent"), a key regulator of eye formation. EYA4 plays an important role in several developmental processes...
  6. pmc Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
    Birgit Uhlenberg
    Department of Neuropediatrics, Charite, University Medical School of Berlin, Berlin, Germany
    Am J Hum Genet 75:251-60. 2004
    ..In this study, we demonstrate that GJA12 plays a key role in central myelination and is involved in peripheral myelination in humans...
  7. ncbi request reprint Color-encoded semiautomatic analysis of multi-slice first-pass magnetic resonance perfusion: comparison to tetrofosmin single photon emission computed tomography perfusion and X-ray angiography
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Int J Cardiovasc Imaging 20:371-84; discussion 385-7. 2004
    ....
  8. ncbi request reprint Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura
    Christian Netzer
    Institute of Human Genetics, University of Cologne, Cologne, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:37-41. 2008
    ..In summary, we found no convincing evidence for an involvement of common SNPs at the GABA-A receptor cluster on 15q11-q12 in the pathophysiology of MA...
  9. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008
    ..97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss...