Holger Thiele

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial
    Holger Thiele
    University of Leipzig Heart Centre, Leipzig, Germany Electronic address
    Lancet 382:1638-45. 2013
  2. pmc Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial
    Madlen Uhlemann
    Sports Medicine, University Wuppertal, Wuppertal, Germany
    Trials 13:167. 2012
  3. doi [Diagnostic work-up of coronary artery disease: Clinical value of different imaging methods]
    H Thiele
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum, Strümpellstr 39, 04289, Leipzig, Deutschland
    Herz 37:887-99; quiz 900-1. 2012
  4. ncbi Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial)
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 33:2035-43. 2012
  5. doi Intraaortic balloon support for myocardial infarction with cardiogenic shock
    Holger Thiele
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    N Engl J Med 367:1287-96. 2012
  6. doi Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial
    Holger Thiele
    University of Leipzig Heart Center, Leipzig, Germany
    Am Heart J 163:938-45. 2012
  7. doi Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial
    Holger Thiele
    Universität Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Lancet 379:923-31. 2012
  8. ncbi Magnetic resonance imaging after percutaneous closure of a ventricular septal defect complicating myocardial infarction
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 27:1136. 2006
  9. ncbi Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: a 5-year follow-up
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circulation 112:3445-50. 2005
  10. ncbi Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 47:1641-5. 2006

Detail Information

Publications91

  1. doi Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial
    Holger Thiele
    University of Leipzig Heart Centre, Leipzig, Germany Electronic address
    Lancet 382:1638-45. 2013
    ..However, previous trials in cardiogenic shock showed a mortality benefit only at extended follow-up. The present analysis therefore reports 6 and 12 month results...
  2. pmc Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial
    Madlen Uhlemann
    Sports Medicine, University Wuppertal, Wuppertal, Germany
    Trials 13:167. 2012
    ..Until now, data demonstrating the positive effect of ET on the collateral blood flow and the functional capacity of the coronary collateral circulation are still lacking...
  3. doi [Diagnostic work-up of coronary artery disease: Clinical value of different imaging methods]
    H Thiele
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum, Strümpellstr 39, 04289, Leipzig, Deutschland
    Herz 37:887-99; quiz 900-1. 2012
    ..Recently developed hybrid imaging allows the coronary anatomy and simultaneous functional testing of ischemia to be depicted. The different imaging methods for ischemia and viability testing are described...
  4. ncbi Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial)
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 33:2035-43. 2012
    ..The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction...
  5. doi Intraaortic balloon support for myocardial infarction with cardiogenic shock
    Holger Thiele
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    N Engl J Med 367:1287-96. 2012
    ..However, evidence is based mainly on registry data, and there is a paucity of randomized clinical trials...
  6. doi Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial
    Holger Thiele
    University of Leipzig Heart Center, Leipzig, Germany
    Am Heart J 163:938-45. 2012
    ..The hypothesis of this trial is that IABP in addition to early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting will improve clinical outcome of patients in cardiogenic shock...
  7. doi Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial
    Holger Thiele
    Universität Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Lancet 379:923-31. 2012
    ..However, the safety and efficacy of intracoronary versus standard intravenous bolus application in patients with ST-elevation myocardial infarction (STEMI) undergoing this intervention has not been tested in a large-scale clinical trial...
  8. ncbi Magnetic resonance imaging after percutaneous closure of a ventricular septal defect complicating myocardial infarction
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 27:1136. 2006
  9. ncbi Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: a 5-year follow-up
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circulation 112:3445-50. 2005
    ..Long-term follow-up data are sparse...
  10. ncbi Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 47:1641-5. 2006
    ..The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI)...
  11. doi Immediate primary transcatheter closure of postinfarction ventricular septal defects
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Eur Heart J 30:81-8. 2009
    ..Primary transcatheter VSD closure in the acute setting may also offer advantages over surgery...
  12. ncbi ST-segment recovery and prognosis in patients with ST-elevation myocardial infarction reperfused by prehospital combination fibrinolysis, prehospital initiated facilitated percutaneous coronary intervention, or primary percutaneous coronary intervention
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Am J Cardiol 98:1132-9. 2006
    ..In addition, STR has been confirmed to predict prognosis in timely optimized reperfusion strategies...
  13. doi Randomized comparison of pre-hospital-initiated facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention in acute myocardial infarction very early after symptom onset: the LIPSIA-STEMI trial (Leipzig immediate preho
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:605-14. 2011
    ....
  14. doi Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention: design and rationale of the Abciximab Intracoronary versus intravenously Drug Application in ST-Elevation Myocardial Infarction (AIDA ST
    Holger Thiele
    Universität Leipzig Heart Center, Department of Internal Medicine Cardiology, Germany
    Am Heart J 159:547-54. 2010
    ..The hypothesis of this trial is that abciximab bolus intracoronary in comparison to standard intravenous application will improve the outcome of patients undergoing primary PCI in STEMI...
  15. ncbi Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 28:2057-63. 2007
    ..This review reports the current experience of percutaneous LVAD in CS complicating AMI...
  16. ncbi Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  17. ncbi Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 26:1956-63. 2005
    ..This approach has been compared with pre-hospital combination-fibrinolysis only to determine whether either one of these methods offer advantages with respect to final infarct size...
  18. doi Randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus-eluting stenting in isolated proximal left anterior descending coronary artery stenosis
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 53:2324-31. 2009
    ....
  19. doi Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 55:2201-9. 2010
    ....
  20. ncbi Effects of missing dynamic images on myocardial perfusion reserve index calculation: comparison between an every heartbeat and an alternate heartbeat acquisition
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Cardiovasc Magn Reson 5:343-52. 2003
    ..Furthermore, it may lead to false positive or negative results in individual cases. This effect is increased if data are acquired only every 2nd heartbeat...
  21. ncbi Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 28:1433-9. 2007
    ..Delayed enhancement magnetic resonance imaging (DE-MRI) has excellent spatial resolution to uncover these relations...
  22. ncbi Short- and long-term hemodynamic effects of intra-aortic balloon support in ventricular septal defect complicating acute myocardial infarction
    Holger Thiele
    Department of Internal Medicine, University of Leipzig, Heart Center, Germany
    Am J Cardiol 92:450-4. 2003
    ..In patients who can be stabilized or remain stable, there is no habituation to the effects of the intra-aortic balloon pump; thus, later surgical closure of the ventricular septal defect might be possible in some patients...
  23. ncbi Coronary artery bypass graft versus drug-eluting stent for high-risk proximal left anterior descending stenosis
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289, Leipzig, Germany
    Curr Treat Options Cardiovasc Med 12:36-45. 2010
    ..In this article, the current treatment options are reviewed and outlined...
  24. ncbi [Hypertension and exercise. Sports methods for the hypertensive patient]
    Holger Thiele
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum, Leipzig
    Herz 29:401-5. 2004
    ..Intensity of exercise should be monitored by the heart rate. The mean intensity should not exceed 70% of the maximal heart rate. An initial ergometry might be suitable for the planning of training recommendations...
  25. ncbi Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 26:1276-83. 2005
    ..A newly developed percutaneous left ventricular assist device (VAD) (Tandem Heart, Cardiac Assist, Pittsburgh, PA, USA) with active circulatory support might have positive haemodynamic effects and decrease mortality...
  26. ncbi Color-encoded semiautomatic analysis of multi-slice first-pass magnetic resonance perfusion: comparison to tetrofosmin single photon emission computed tomography perfusion and X-ray angiography
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Int J Cardiovasc Imaging 20:371-84; discussion 385-7. 2004
    ....
  27. doi Shock in acute myocardial infarction: the Cape Horn for trials?
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, Leipzig, Germany
    Eur Heart J 31:1828-35. 2010
    ....
  28. doi Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  29. doi Right ventricular injury in ST-elevation myocardial infarction: risk stratification by visualization of wall motion, edema, and delayed-enhancement cardiac magnetic resonance
    Matthias Grothoff
    Department of Radiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Cardiovasc Imaging 5:60-8. 2012
    ..Aims were to determine the predictors and the prognostic significance of RVI assessed by wall motion abnormalities, edema, myocardial salvage index, and delayed enhancement in acute reperfused STEMI...
  30. doi Incidence and distribution of occluded culprit arteries and impact of coronary collaterals on outcome in patients with non-ST-segment elevation myocardial infarction and early invasive treatment strategy
    Philipp Bahrmann
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, 04289, Leipzig, Germany
    Clin Res Cardiol 100:457-67. 2011
    ..In addition, coronary collaterals may have beneficial effects in patients with OCA...
  31. doi Reliability of myocardial salvage assessment by cardiac magnetic resonance imaging in acute reperfused myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiovasc Imaging 28:263-72. 2012
    ..Further validation studies and trials showing the prognostic value of myocardial salvage by CMRI are needed before routine implementation as a surrogate endpoint in STEMI trials...
  32. doi Sex differences in myocardial salvage and clinical outcome in patients with acute reperfused ST-elevation myocardial infarction: advances in cardiovascular imaging
    Ingo Eitel
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circ Cardiovasc Imaging 5:119-26. 2012
    ....
  33. doi Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trial
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:452-9. 2011
    ....
  34. doi Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation-myocardial infarction
    Ingo Eitel
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circ Cardiovasc Imaging 4:354-62. 2011
    ..The aim of this study was to evaluate determinants and prognostic impact of a hypointense infarct core in T2-weighted CMR images, studied in patients after acute, reperfused ST-elevation-myocardial infarction...
  35. ncbi Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction
    Ingo Eitel
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    J Am Coll Cardiol 55:2470-9. 2010
    ..The aim of the study was to determine the prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance (CMR) in reperfused ST-segment elevation myocardial infarction...
  36. ncbi Comparison of stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    Anno Diegeler
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    N Engl J Med 347:561-6. 2002
    ..Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these two procedures...
  37. doi Relationship and prognostic value of microvascular obstruction and infarct size in ST-elevation myocardial infarction as visualized by magnetic resonance imaging
    Suzanne de Waha
    Department of Internal Medicine, Cardiology, University of Leipzig Heart Center, Strümpellstr 39, Leipzig, 04289, Germany
    Clin Res Cardiol 101:487-95. 2012
    ..We hypothesized that a ratio of MO and infarct size (MO/infarct size) might be an even stronger predictor for outcome after STEMI, which has not been investigated yet...
  38. doi Diagnostic performance of CMR imaging compared with EMB in patients with suspected myocarditis
    Philipp Lurz
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Imaging 5:513-24. 2012
    ..The goal of this study was to assess the diagnostic performance of cardiac magnetic resonance (CMR) compared with endomyocardial biopsy in patients with suspected acute myocarditis (AMC) and chronic myocarditis (CMC)...
  39. doi Time-dependency, predictors and clinical impact of infarct transmurality assessed by magnetic resonance imaging in patients with ST-elevation myocardial infarction reperfused by primary coronary percutaneous intervention
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289, Leipzig, Germany
    Clin Res Cardiol 101:191-200. 2012
    ..However, transmural infarction was not predictive of death and congestive heart failure...
  40. doi Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty
    Michal Droppa
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Clin Res Cardiol 100:1037-43. 2011
    ....
  41. ncbi Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected]
    Peter B Sick
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Am Heart J 149:681-8. 2005
    ..The aim of this study was to compare a carbonized and high-grade stainless steel stent of identical design with regard to early and late adverse events...
  42. ncbi Effect of coronary collaterals on microvascular obstruction as assessed by magnetic resonance imaging in patients with acute ST-elevation myocardial infarction treated by primary coronary intervention
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 104:1204-9. 2009
    ..5% vs 12.2%, p = 0.07). In conclusion, well-developed collaterals before reperfusion by PCI in patients with STEMI are associated with a protective effect on coronary microcirculation...
  43. doi Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Leipzig, Germany
    Eur Heart J 31:2660-8. 2010
    ..Furthermore, it is unclear whether the assessment of MO by MRI adds incremental prognostic information independent of traditional outcome markers...
  44. doi Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Am Heart J 164:706-14. 2012
    ..The aims of this study were (1) to assess the relation between miR-133a and myocardial damage assessed by cardiovascular magnetic resonance (CMR) imaging and (2) to evaluate the prognostic value of miR-133a in reperfused STEMI...
  45. doi The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications
    Madlen Uhlemann
    Department of Internal Medicine Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    JACC Cardiovasc Interv 5:36-43. 2012
    ....
  46. ncbi Prevalence and clinical impact of left coronary dominance in patients with aortic stenosis
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Heart Valve Dis 20:23-8. 2011
    ....
  47. doi Intracoronary versus intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: 6-month effects on infarct size and left ventricular function. The randomised Leipzig I
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289, Leipzig, Germany
    Clin Res Cardiol 100:425-32. 2011
    ..Aim of this study was to investigate whether the early benefits of an IC abciximab administration in STEMI patients undergoing PCI are sustained at 6 months...
  48. doi Long-term prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction
    Ingo Eitel
    Department of Internal Medicine, University of Leipzig, Heart Center, Leipzig, Germany
    Heart 97:2038-45. 2011
    ....
  49. doi Diagnostic performance of prospectively ECG triggered versus retrospectively ECG gated 64-slice computed tomography coronary angiography in a heterogeneous patient population
    Lukas Lehmkuhl
    University of Leipzig Heart Center, Department of Diagnostic and Interventional Radiology, Strümpellstraße 39, D 04289 Leipzig, Germany
    Eur J Radiol 80:342-8. 2011
    ..retro-CTCA) in a heterogeneous patient population compared to invasive coronary angiography...
  50. doi Timing of invasive treatment after fibrinolysis in ST elevation myocardial infarction--a meta-analysis of immediate or early routine versus deferred or ischemia-guided randomised controlled trials
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, Leipzig 04289, Germany
    Heart 96:1695-702. 2010
    ..Controversy remains over the optimal timing of percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) who have initially been treated with fibrinolytic agents...
  51. ncbi Impact of diabetes mellitus type 2 on in-hospital outcome after cardiac catheterizations in a large cohort of octogenarians
    Josef Niebauer
    Department of Internal Medicine and Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiol 96:441-6. 2004
    ..To assess the impact of diabetes mellitus type 2 (DM) in 1085 octogenarians on in-hospital outcome after cardiac catheterization (CATH) and/or percutaneous coronary intervention (PCI)...
  52. doi Myocardium at risk in ST-segment elevation myocardial infarction comparison of T2-weighted edema imaging with the MR-assessed endocardial surface area and validation against angiographic scoring
    Georg Fuernau
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Imaging 4:967-76. 2011
    ....
  53. doi Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Eur Heart J 29:2651-9. 2008
    ..Precise magnetic resonance imaging (MRI) data are not yet available and there is little evidence for the differential diagnosis of ABS assessed by MRI...
  54. ncbi Prospective randomized comparison of early and late results of 4 different stent designs
    Peter B Sick
    Heart Center, Department for Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Am Heart J 146:134-41. 2003
    ..So far, few data are available addressing the effect of stent design on this crucial variable and on early and late adverse events after stent implantation...
  55. doi Low vs. higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients
    Steffen Desch
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Am J Hypertens 23:694-700. 2010
    ..higher doses of dark chocolate over the course of 3 months...
  56. doi Osteoprotegerin in ST-elevation myocardial infarction: prognostic impact and association with markers of myocardial damage by magnetic resonance imaging
    Georg Fuernau
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig Germany
    Int J Cardiol 167:2134-9. 2013
    ..In acute ST-elevation myocardial infarction (STEMI) data on the correlation to myocardial damage by cardiac magnetic resonance imaging (CMR) or clinical outcome are lacking...
  57. pmc Thrombus Aspiration in ThrOmbus containing culpRiT lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI): study protocol for a randomized controlled trial
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Struempellstr 39, Leipzig 04289, Germany
    Trials 14:110. 2013
    ..Current guidelines recommend thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI); however, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI)...
  58. ncbi Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  59. doi Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: 10-year follow-up of a randomized trial
    Stephan Blazek
    Department of Internal Medicine, Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, Leipzig, Germany
    JACC Cardiovasc Interv 6:20-6. 2013
    ....
  60. doi Percutaneous, transendocardial injection of bone marrow-derived mononuclear cells in heart failure patients following acute ST-elevation myocardial infarction: ALSTER-Stem Cell trial
    Christian H Heeger
    Department of Cardiology, Asklepios Clinic St Georg, Hamburg, Germany
    EuroIntervention 8:732-42. 2012
    ....
  61. doi Prognostic impact of hyperglycemia in nondiabetic and diabetic patients with ST-elevation myocardial infarction: insights from contrast-enhanced magnetic resonance imaging
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Cardiovasc Imaging 5:708-18. 2012
    ..001). In nondiabetic patients, the risk of severe myocardial injury started to rise once admission glucose exceeded 7.8 mmol/L, whereas the threshold was higher among patients with diabetes mellitus (≥11.1 mmol/L)...
  62. doi Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am Heart J 159:882-90. 2010
    ..The aim of our study was to assess the relationship between systemic ET-1 levels and the occurrence of no-reflow as well as to evaluate the prognostic value of ET-1 in a high-risk STEMI population...
  63. doi Prevalence and functional impact of lipomatous metaplasia in scar tissue following myocardial infarction evaluated by MRI
    Christian Lücke
    Department of Diagnostic and Interventional Radiology, Leipzig Heart Center University of Leipzig, Strümpellstr 39, 04289, Leipzig, Germany
    Eur Radiol 20:2074-83. 2010
    ....
  64. pmc Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
    Steffen Desch
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Trials 12:204. 2011
    ..Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented...
  65. doi Effect of cocoa products on blood pressure: systematic review and meta-analysis
    Steffen Desch
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Am J Hypertens 23:97-103. 2010
    ..Cocoa products such as dark chocolate and cocoa beverages may have blood pressure (BP)-lowering properties due to their high content of plant-derived flavanols...
  66. ncbi Incidence, time course, and predictors of early malignant ventricular arrhythmias after non-ST-segment elevation myocardial infarction in patients with early invasive treatment
    Kazem Rahimi
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur Heart J 27:1706-11. 2006
    ..With the limited intensive care facilities, knowledge of the total risk and predictors of acute life-threatening arrhythmias is of major interest to guide the decision on the intensity of care at the time of admission...
  67. ncbi Seven-year follow-up after minimally invasive direct coronary artery bypass: experience with more than 1300 patients
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 83:108-14. 2007
    ..Here we present the experience after more than 1300 MIDCAB procedures with up to 7 years of follow-up...
  68. ncbi Contemporary outcome of cardiac catheterizations in 1085 consecutive octogenarians
    Josef Niebauer
    Abteilung für Innere Medizin Kardiolgie, Universität Leipzig Herzzentrum GmbH, Strümpellstr 39, 04289 Leipzig, Germany
    Int J Cardiol 93:225-30. 2004
    ..Since little is known about the overall safety of these procedures in this population, we assessed the procedure-related risks and determined predictors for complications...
  69. doi Growth-differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, Leipzig 04289, Germany
    Heart 97:632-40. 2011
    ....
  70. doi Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centre
    Ulrike M Müller
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Centre, Strumpellstrasse 39, Leipzig, Germany
    Clin Res Cardiol 100:297-309. 2011
    ..We hypothesised that DBT of <30 min can be accomplished for the majority of patients...
  71. doi [Coronary artery bypass surgery for the treatment of acute coronary syndromes]
    Ardawan Julian Rastan
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum Leipzig, Leipzig, Germany
    Herz 35:70-8. 2010
    ..For all surgical candidates a close and direct communication between interventionalist and cardiac surgeon is mandatory to early identify the best treatment strategy and to achieve best possible revascularization results...
  72. doi Effect of coronary collaterals on long-term prognosis in patients undergoing primary angioplasty for acute ST-elevation myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 106:605-11. 2010
    ..In conclusion, the presence of a well-developed collateral network before mechanical reperfusion in patients with STEMI is associated with improved long-term survival and lower major adverse cardiovascular event rates...
  73. doi Platelet inhibition and GP IIb/IIIa receptor occupancy by intracoronary versus intravenous bolus administration of abciximab in patients with ST-elevation myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Strümpellstr 39, 04289, Leipzig, Germany
    Clin Res Cardiol 101:117-24. 2012
    ....
  74. ncbi Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infa
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Circulation 116:366-74. 2007
    ....
  75. ncbi Influence of residual stenosis after percutaneous coronary intervention with stent implantation on development of restenosis and stent thrombosis
    Peter Sick
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Am J Cardiol 91:148-53. 2003
    ..Oversizing of stents is no longer necessary with an adequate dosage of ticlopidine and aspirin...
  76. doi ST-segment resolution and prognosis after facilitated versus primary percutaneous coronary intervention in acute myocardial infarction: a meta-analysis
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289, Leipzig, Germany
    Clin Res Cardiol 99:1-11. 2010
    ..The objective of this meta-analysis was, therefore, to evaluate the extent of early STR and subsequent prognosis in facilitated versus primary PCI...
  77. ncbi High, but not moderate frequency and duration of exercise training induces downregulation of the expression of inflammatory and atherogenic adhesion molecules
    Thomas Peschel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Austria
    Eur J Cardiovasc Prev Rehabil 14:476-82. 2007
    ..We designed a study to examine the effects of a multifactorial intervention on atherogenic adhesion molecules on the surface of monocytes in patients with coronary artery disease...
  78. doi Covered rupture of the free left ventricular wall or "only" thrombus in a true aneurysm?
    Ulrike Müller
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strümpellstr 39, 04289, Leipzig, Germany
    Clin Res Cardiol 97:843-5. 2008
    ..Differentiation between these complications of AMI may be difficult as shown by the following case report but is of paramount importance because of the different management...
  79. doi High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Int J Cardiol 146:56-63. 2011
    ..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...
  80. doi Randomized comparison of percutaneous coronary intervention with sirolimus-eluting stents versus coronary artery bypass grafting in unprotected left main stem stenosis
    Enno Boudriot
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    J Am Coll Cardiol 57:538-45. 2011
    ..The purpose of this randomized study was to compare sirolimus-eluting stenting with coronary artery bypass grafting (CABG) for patients with unprotected left main (ULM) coronary artery disease...
  81. doi Prognostic significance and magnetic resonance imaging findings in aborted myocardial infarction after primary angioplasty
    Ingo Eitel
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am Heart J 158:806-13. 2009
    ..So far, the prognostic significance and magnetic resonance imaging (MRI) findings of an aborted MI after primary angioplasty have not been evaluated appropriately...
  82. ncbi Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel
    Thorsten Dill
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    Am Heart J 157:541-7. 2009
    ....
  83. ncbi Cardio navigation: planning, simulation, and augmented reality in robotic assisted endoscopic bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 79:2040-7. 2005
    ..The aim of this study is to optimize the set-up and port placement in robotic surgery and enhance intraoperative orientation by video overlay of the angiographic coronary tree...
  84. ncbi Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state free precession
    Holger Thiele
    Clinic of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    J Cardiovasc Magn Reson 4:327-39. 2002
    ..This may increase clinical utility of magnetic resonance by shorter acquisition and processing times...
  85. doi Cardiac autonomic diabetic neuropathy
    Martin Schönauer
    Academic Practice of University of Leipzig, Leipzig, Germany
    Diab Vasc Dis Res 5:336-44. 2008
    ..The following article offers a topical overview for those working or interested in the fields of diabetology and cardiology...
  86. ncbi Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure
    Thomas Peschel
    Herzzentrum der Universitat Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:609-14. 2003
    ..To test the hypothesis that during acute heart failure endotoxin might be increased in hepatic veins as a sign of bacterial or endotoxin translocation from the bowel into the blood stream...
  87. ncbi Comparison of right ventricular volume measurement between segmented k-space gradient-echo and steady-state free precession magnetic resonance imaging
    Khaled Alfakih
    BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK
    J Magn Reson Imaging 16:253-8. 2002
    ..To compare right ventricular volume measurements and their reproducibility between steady-state free precession (SSFP) and conventional turbo gradient-echo (TGE) imaging...
  88. ncbi Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura
    Christian Netzer
    Institute of Human Genetics, University of Cologne, Cologne, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:37-41. 2008
    ..In summary, we found no convincing evidence for an involvement of common SNPs at the GABA-A receptor cluster on 15q11-q12 in the pathophysiology of MA...
  89. ncbi Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences
    Khaled Alfakih
    British Heart Foundation Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK
    J Magn Reson Imaging 17:323-9. 2003
    ..To establish normal ranges of left ventricular (LV) and right ventricular (RV) dimensions as determined by the current pulse sequences in cardiac magnetic resonance imaging (MRI)...
  90. ncbi Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors
    Holger Andree
    Charite, Universitatsmedizin Berlin, Institut für Vegetative Physiologie, Tucholskystr 2, 10117 Berlin, Germany
    Gene 380:95-103. 2006
    ....
  91. ncbi HaploPainter: a tool for drawing pedigrees with complex haplotypes
    Holger Thiele
    Gene Mapping Center, Max Delbrueck Center MDC for Molecular Medicine, Berlin Buch, Germany
    Bioinformatics 21:1730-2. 2005
    ....