D R Thal

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi The development of amyloid beta protein deposits in the aged brain
    Dietmar R Thal
    Department of Neuropathology, University of Bonn, D 53105 Bonn, Germany
    Sci Aging Knowledge Environ 2006:re1. 2006
  2. ncbi [Post-mortem diagnosis of Alzheimer's disease]
    D R Thal
    Institut für Neuropathologie, Medizinische Einrichtungen der Universität Bonn
    Pathologe 26:201-13. 2005
  3. ncbi The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology
    D R Thal
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    Neuropathol Appl Neurobiol 31:270-9. 2005
  4. doi Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, University of Ulm, Albert Einstein Allee 7, 89081 Ulm, Germany
    Acta Neuropathol 115:599-609. 2008
  5. ncbi Phases of A beta-deposition in the human brain and its relevance for the development of AD
    Dietmar R Thal
    Department of Anatomy, J W Goethe University, Frankfurt am Main, Germany
    Neurology 58:1791-800. 2002
  6. pmc Nuclear localization of Annexin A7 during murine brain development
    Michaela Rick
    Center for Biochemistry, Institute of Biochemistry I, Medical Faculty and Center for Molecular Medicine Cologne, University of Cologne, Joseph Stelzmann Str, 52, 50931 Koln, Germany
    BMC Neurosci 6:25. 2005
  7. ncbi Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 62:1287-301. 2003
  8. ncbi UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain
    D R Thal
    Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Neuropathol 21:35-40. 2002
  9. ncbi Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Acta Neuropathol 110:459-71. 2005
  10. ncbi Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Neurobiol Aging 28:1221-30. 2007

Collaborators

Detail Information

Publications31

  1. ncbi The development of amyloid beta protein deposits in the aged brain
    Dietmar R Thal
    Department of Neuropathology, University of Bonn, D 53105 Bonn, Germany
    Sci Aging Knowledge Environ 2006:re1. 2006
    ..The role of intracellular Abeta in Abeta deposition and the mechanism of Abeta toxicity are also discussed...
  2. ncbi [Post-mortem diagnosis of Alzheimer's disease]
    D R Thal
    Institut für Neuropathologie, Medizinische Einrichtungen der Universität Bonn
    Pathologe 26:201-13. 2005
    ..According to these stages a dementing disorder can be diagnostically attributed to Alzheimer's disease...
  3. ncbi The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology
    D R Thal
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    Neuropathol Appl Neurobiol 31:270-9. 2005
    ....
  4. doi Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, University of Ulm, Albert Einstein Allee 7, 89081 Ulm, Germany
    Acta Neuropathol 115:599-609. 2008
    ..Thus, blood flow alterations with subsequent hypoperfusion induced by CAA-related capillary occlusion presumably point to a second mechanism in which A beta adversely affects the brain in AD in addition to its direct neurotoxic effects...
  5. ncbi Phases of A beta-deposition in the human brain and its relevance for the development of AD
    Dietmar R Thal
    Department of Anatomy, J W Goethe University, Frankfurt am Main, Germany
    Neurology 58:1791-800. 2002
    ..The deposition of the amyloid beta protein (Abeta) is a histopathologic hallmark of AD. The regions of the medial temporal lobe (MTL) are hierarchically involved in Abeta-deposition...
  6. pmc Nuclear localization of Annexin A7 during murine brain development
    Michaela Rick
    Center for Biochemistry, Institute of Biochemistry I, Medical Faculty and Center for Molecular Medicine Cologne, University of Cologne, Joseph Stelzmann Str, 52, 50931 Koln, Germany
    BMC Neurosci 6:25. 2005
    ....
  7. ncbi Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 62:1287-301. 2003
    ..A combination of both CAA and AS/LH may, therefore, contribute to neurodegeneration in AD. These data also suggest that small vessel disease due to arteriosclerosis and fibrolipohyalinosis is a potential target for the treatment of AD...
  8. ncbi UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain
    D R Thal
    Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Neuropathol 21:35-40. 2002
    ....
  9. ncbi Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Acta Neuropathol 110:459-71. 2005
    ..Moreover, apoE-positive newly formed plaques were seen more frequently in APOE epsilon4/4 cases than in non-APOE epsilon4/4 individuals, thereby underlining the potentially crucial role of apoE for the development of Abeta deposits...
  10. ncbi Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Neurobiol Aging 28:1221-30. 2007
    ..In so doing, our results strengthen the hypothesis that an alteration of perivascular drainage supports Abeta-deposition and the development of AD...
  11. ncbi Neurodegeneration in normal brain aging and disease
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Sci Aging Knowledge Environ 2004:pe26. 2004
    ..Aging is, therefore, a major risk factor for these diseases but does not necessarily lead to age-related diseases...
  12. ncbi The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 26:553-67. 2000
    ....
  13. ncbi Gender and age modify the association between APOE and AD-related neuropathology
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
    Neurology 56:1696-701. 2001
    ..To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP)...
  14. ncbi Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
    I Sassin
    Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Acta Neuropathol 100:259-69. 2000
    ..The considerable morphological diversity of cytoskeletal alterations is typical of stages III and IV. These results indicate that individual neurons of the bnM enter the sequence of cytoskeletal deterioration at different times...
  15. ncbi Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex
    D R Thal
    Department of Anatomy, J W Goethe University, Frankfurt, Germany
    Acta Neuropathol 100:608-17. 2000
    ....
  16. ncbi The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology
    U Rüb
    Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 101:555-64. 2001
    ..This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons...
  17. ncbi Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 28:308-13. 2002
    ..9% vs. 13.2%, P=0.93). This association, however, is only apparent in the presence of the LRP CC genotype. In conclusion, the present study shows that AGD is associated with the LRP, A2M and ApoE genes...
  18. ncbi Mutant valosin-containing protein causes a novel type of frontotemporal dementia
    Rolf Schroder
    Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Ann Neurol 57:457-61. 2005
    ..We demonstrate that mutant VCP causes a novel type of frontotemporal dementia characterized by neuronal nuclear inclusions containing ubiquitin and VCP...
  19. ncbi Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
    Estifanos Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Neurosci Lett 320:25-8. 2002
    ..036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE...
  20. pmc Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 103:443-8. 2006
    ....
  21. ncbi Giant cell arteritis in a 19-year-old woman associated with vertebral artery aneurysm and subarachnoid hemorrhage
    D R Thal
    Department of Neuropathology, University of Frankfurt Main, Germany
    Clin Neuropathol 20:80-6. 2001
    ..This case demonstrates that GCA is not necessarily restricted to elderly people. Moreover, this case shows that a GCA-induced aneurysm is a very rare reason for subarachnoid hemorrhage even in young adults...
  22. pmc Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease
    Sadanand Gaikwad
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Am J Pathol 175:2528-39. 2009
    ..Thus, SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis...
  23. ncbi Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis
    Irfan Y Tamboli
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 28:12097-106. 2008
    ..Thus, these data demonstrate a functional link between two major genetic factors that cause early-onset and late-onset Alzheimer's disease...
  24. ncbi GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide
    Tina Wahle
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:12838-46. 2006
    ..Thus, GGA proteins might be involved in the pathogenesis of AD...
  25. doi Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neuropathol Exp Neurol 69:442-8. 2010
    ..05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke...
  26. ncbi Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages
    Estifanos Ghebremedhin
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 114:359-63. 2007
    ..These findings suggest that homozygosity, but not heterozygosity, for BCHE-K is a potential risk factor for the development of NFT pathology in young individuals implicating BCHE-K in the pathogenesis of early AD...
  27. pmc Tracing of temporo-entorhinal connections in the human brain: cognitively impaired argyrophilic grain disease cases show dendritic alterations but no axonal disconnection of temporo-entorhinal association neurons
    Dietmar Rudolf Thal
    Department of Pathology, Laboratory of Neuropathology, University of Ulm, Ulm, Germany
    Acta Neuropathol 115:175-83. 2008
    ..Our findings in three cognitively impaired AGD cases suggest that AGD-related dementia constitutes a distinct disorder with a characteristic pattern of degeneration in the neuronal network...
  28. doi Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
    Sabrina Utter
    Department of Neuropathology, University of Bonn, Bonn, Germany
    J Neuropathol Exp Neurol 67:842-56. 2008
    ..It is therefore tempting to speculate that apoE represents a pathogenetic link between SVD and AD...
  29. ncbi Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
    Estibaliz Capetillo-Zarate
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Brain 129:2992-3005. 2006
    ..The vulnerability of different types of neurons to Abeta, thereby, is presumably related to the complexity of their dendritic morphology...
  30. ncbi Two types of sporadic cerebral amyloid angiopathy
    Dietmar Rudolf Thal
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:282-93. 2002
    ..CAA-Type 2 is not associated with the epsilon4 allele as a risk factor but shows a higher epsilon2 allele frequency than CAA-Type 1 cases and controls in our sample...
  31. ncbi Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression
    Heike Kolsch
    Stroke 38:2847-50. 2007
    ..The objective of this study is to address the question of whether common vessel disorders known to cause vascular dementia are modified in their severity by this polymorphism...