Ivo Tews

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
    Ivo Tews
    Biochemiezentrum der Universität Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Science 308:1020-3. 2005
  2. ncbi request reprint On the significance of Toc-GTPase homodimers
    Patrick Koenig
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 283:23104-12. 2008
  3. ncbi request reprint The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid
    Felix Findeisen
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Mol Biol 369:1282-95. 2007
  4. pmc Conserved properties of polypeptide transport-associated (POTRA) domains derived from cyanobacterial Omp85
    Patrick Koenig
    Heidelberg University Biochemistry Center BZH, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 285:18016-24. 2010
  5. ncbi request reprint Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme
    Gabriela Guédez
    Heidelberg University Biochemistry Center BZH, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Structure 20:172-84. 2012
  6. doi request reprint The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures
    Patrick Koenig
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Structure 16:585-96. 2008
  7. doi request reprint A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2
    Koen Temmerman
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Traffic 9:1204-17. 2008
  8. ncbi request reprint Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv
    Amira Abdel Motaal
    Abteilung Pharmazeutische Biochemie, Fakultät für Chemie und Pharmazie, Universitat Tubingen, Germany
    FEBS J 273:4219-28. 2006
  9. ncbi request reprint Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights
    Martin Gengenbacher
    Abteilung für Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Biol Chem 281:3633-41. 2006
  10. pmc The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64
    Soumya Qbadou
    Botanik, LMU Munchen, Munchen, Germany
    EMBO J 25:1836-47. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
    Ivo Tews
    Biochemiezentrum der Universität Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Science 308:1020-3. 2005
    ..Two alpha helices serve as molecular switches. Mutagenesis is consistent with a regulatory role of the structural transition, and we suggest that the transition is regulated by pH...
  2. ncbi request reprint On the significance of Toc-GTPase homodimers
    Patrick Koenig
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 283:23104-12. 2008
    ....
  3. ncbi request reprint The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid
    Felix Findeisen
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Mol Biol 369:1282-95. 2007
    ..From these data, we conclude that the regulatory domain is a structural scaffold used for distinct regulatory purposes...
  4. pmc Conserved properties of polypeptide transport-associated (POTRA) domains derived from cyanobacterial Omp85
    Patrick Koenig
    Heidelberg University Biochemistry Center BZH, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 285:18016-24. 2010
    ....
  5. ncbi request reprint Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme
    Gabriela Guédez
    Heidelberg University Biochemistry Center BZH, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Structure 20:172-84. 2012
    ..The mutagenesis analysis allows defining the requirement for conservation of critical methionines, whereas there is also plasticity in ammonia tunnel construction as seen from comparison across different species...
  6. doi request reprint The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures
    Patrick Koenig
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Structure 16:585-96. 2008
    ..Potential binding sites for interactions within the Toc translocon or with precursor proteins can be derived from the structures...
  7. doi request reprint A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2
    Koen Temmerman
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Traffic 9:1204-17. 2008
    ..These data show that a transient interaction with PI(4,5)P(2) associated with the inner leaflet of plasma membranes represents the initial step of the unconventional secretory pathway of FGF-2...
  8. ncbi request reprint Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv
    Amira Abdel Motaal
    Abteilung Pharmazeutische Biochemie, Fakultät für Chemie und Pharmazie, Universitat Tubingen, Germany
    FEBS J 273:4219-28. 2006
    ..These regulatory properties open the possibility that novel modes of cAMP-mediated signal transduction exist in the pathogen...
  9. ncbi request reprint Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights
    Martin Gengenbacher
    Abteilung für Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Biol Chem 281:3633-41. 2006
    ..62 A. The obstruction of the oxyanion hole indicates that Pdx2 is in a resting state and that activation occurs upon Pdx1-Pdx2 complex formation...
  10. pmc The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64
    Soumya Qbadou
    Botanik, LMU Munchen, Munchen, Germany
    EMBO J 25:1836-47. 2006
    ..We propose that Toc64 acts as an initial docking site for Hsp90 associated precursor proteins. We outline a mechanism in which chaperones are recruited for a specific targeting event by a membrane-inserted receptor...
  11. ncbi request reprint The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre
    Götz Hofhaus
    Institut für Biochemie und Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat Dusseldorf, Germany
    Eur J Biochem 270:1528-35. 2003
    ..Variations in dimer formation and unique colour changes of mutant proteins argue in favour of an interaction between the N-terminal cysteine pair with the redox centre of the partner monomer...
  12. ncbi request reprint Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides
    Christian Schlieker
    ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, Heidelberg D 69120, Germany
    FEBS Lett 578:351-6. 2004
    ..These findings support a ClpB-dependent threading mechanism as an integral part of the disaggregation reaction...
  13. ncbi request reprint Structural and thermodynamic insights into the assembly of the heteromeric pyridoxal phosphate synthase from Plasmodium falciparum
    Karlheinz Flicker
    Technische Universitat Graz, Institut fur Biochemie, Petersgasse 12, A 8010 Graz, Austria
    J Mol Biol 374:732-48. 2007
    ..subtilis Pdx2. The swap mutant also partially elicits glutaminase activity in BsPdx2, demonstrating that formation of the protein complex interface via alphaN and catalytic activation of the glutaminase are linked processes...
  14. ncbi request reprint Two independent routes of de novo vitamin B6 biosynthesis: not that different after all
    Teresa B Fitzpatrick
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Biochem J 407:1-13. 2007
    ..Surprisingly, this comparison reveals that the key biosynthetic enzymes of both pathways are, in fact, very similar both structurally and mechanistically...
  15. pmc Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis
    Marina Tambasco-Studart
    Institute of Plant Sciences, Eidgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland
    Plant Physiol 144:915-25. 2007
    ..Based on a model of the PDX1/PDX2 complex, mutation of a single residue uncouples enzyme coordination and in turn provides tangible evidence for the existence of the recently proposed ammonia tunnel through the core of PDX1...
  16. ncbi request reprint Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
    Edward D Lowe
    Laboratory of Molecular Biophysics, University of Oxford, Rex Richards Building, Oxford OX1 3QU, UK
    Biochemistry 41:15625-34. 2002
    ..The observations have implications for the further identification of physiological substrates of CDK2/cyclin A and the design of specific inhibitors...