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Genomes and Genes | Daniel TeupserSummaryAffiliation: University of Leipzig Country: Germany Publications
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Publications
Genetic regulation of serum phytosterol levels and risk of coronary artery diseaseDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
Circ Cardiovasc Genet 3:331-9. 2010..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...- Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- miceRalph Burkhardt
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
Arterioscler Thromb Vasc Biol 31:775-84. 2011..We sought to identify novel atherosclerosis-modifying loci and their potential functional links in a genome-wide approach using cosegregation analysis of atherosclerosis and related intermediate phenotypes in mice... - Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient miceDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
Arterioscler Thromb Vasc Biol 28:2009-15. 2008..We conclude that overexpression of LXR-alpha in macrophages might be useful as a therapeutic principle for the prevention of atherosclerosis... - Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient miceFrank Beutner
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany
Atherosclerosis 222:337-43. 2012..Proliferation signal inhibitors/mTOR-inhibitors have been shown to reduce de novo development of hypercholesterolemic atherosclerosis in animal models. However, their effect on pre-existing atherosclerosis has not yet been studied... 
Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient miceLesca M Holdt
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
Arterioscler Thromb Vasc Biol 28:1097-103. 2008..The aim of the present study was to identify potentially causative genes at this locus...
Changes of vasoregulatory gene expression following hepatic ischemia/reperfusion and treatment with endothelin-A receptor blockadeDirk Uhlmann
Second Department of Surgery, University of Leipzig, Leipzig, Germany
J Cardiovasc Pharmacol 44:S100-2. 2004....- Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaqueLesca Miriam Holdt
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
Atherosclerosis 214:264-70. 2011.... - Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery diseaseFrank Beutner
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
PLoS ONE 6:e29070. 2011..We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases... - ANRIL expression is associated with atherosclerosis risk at chromosome 9p21Lesca M Holdt
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
Arterioscler Thromb Vasc Biol 30:620-7. 2010..We tested the hypothesis that expression of transcripts adjacent to the chromosome 9p21 (Chr9p21) locus of coronary artery disease was affected by the genotype at this locus and associated with atherosclerosis risk... - Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient miceCarsten Tennert
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
Biochem Biophys Res Commun 361:574-9. 2007..We conclude that over-expression of ApoE in macrophages might be useful as a therapeutic principle for the prevention of atherosclerosis... - Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82Kathrin M Y Engel
Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
PLoS ONE 6:e29400. 2011..GPR82 may represent a thrifty gene most probably representing an advantage during human expansion into new environments... - Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemiaMarc A Mueller
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
Atherosclerosis 198:39-48. 2008..The significant reduction of atherosclerotic lesions was associated with a delayed transition from early macrophages enriched lesions to advanced atherosclerotic plaques... - Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathwayIvonne Haffner
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
J Cell Biochem 103:520-7. 2008..These data indicate that cAMP-dependent activation of ARG1 expression is mediated by PKAI and requires histone deacetylation... - Comparison of Celsior and UW solution in experimental pancreas preservationDirk Uhlmann
2nd Department of Surgery, University of Leipzig, 04103 Leipzig, Germany
J Surg Res 105:173-80. 2002..Increased ET-1 immunostaining and reduced p(ti)O(2) in the CEL group indicate increased microcirculatory damage in the CEL group... - Robustness of single-base extension against mismatches at the site of primer attachment in a clinical assayHolger Kirsten
IKIT BBZ, Faculty of Medicine, Center for Biotechnology and Biomedicine, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany
J Mol Med (Berl) 85:361-9. 2007..Care should be taken when interpreting observed changes in the allelic ratio, which could be caused by nucleotide mismatches, sample mixtures, or copy number variation... - Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery diseaseSebastian Sixt
Department of Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
Eur Heart J 31:112-9. 2010.... - No reduction of atherosclerosis in C-reactive protein (CRP)-deficient miceDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig Research Center for Civilization Diseases, University Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
J Biol Chem 286:6272-9. 2011..In fact, our data suggest that mouse CRP may even mediate atheroprotective effects, adding a cautionary note to the idea of targeting CRP as therapeutic intervention against progressive cardiovascular disease... - Identification of mutations in the lipoprotein lipase (LPL) and apolipoprotein C-II (APOC2) genes using denaturing high performance liquid chromatography (DHPLC)Kathrin B Schuster
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
Clin Chim Acta 412:240-4. 2011..Mutations in the LPL gene or its cofactor APOC2 may result in a decrease or complete loss of enzyme function and subsequently to type I hyperlipoproteinemia... - Statins reduce macrophage inflammatory protein-1alpha expression in human activated monocytesMathias Bruegel
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
Clin Exp Pharmacol Physiol 33:1144-9. 2006..The present findings suggest that statin-mediated immunomodulation by inhibiting MIP-1alpha could contribute to the beneficial effects of statin therapy independent of lowering plasma cholesterol... - Alpha-tocopherol distribution in lipoproteins and anti-inflammatory effects differ between CHD-patients and healthy subjectsAlexander Leichtle
Institute of Laboratory Medicine, Clinical Chemistry, Leipzig University Hospital, Liebigstrasse 27, 04103 Leipzig, Germany
J Am Coll Nutr 25:420-8. 2006..CONCLUSION: Our data demonstrate that CHD-patients require lower dosages of alpha-tocopherol supplementation than healthy subjects to exert biological effects on plasma lipoproteins and acute phase response... - Prenatal stress programs lipid metabolism enhancing cardiovascular risk in the female F1, F2, and F3 generation in the primate model common marmoset (Callithrix jacchus)Ulrike Buchwald
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
J Med Primatol 41:231-40. 2012..Many human diseases are modulated by intrauterine environment, which is called prenatal programming. This study investigated effects of prenatal glucocorticoids on the lipid metabolism of three filial generations of common marmosets... - Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populationsLesca M Holdt
Institute of Laboratory Medicine, Ludwig Maximilians University Munich, Munich, Germany
Arterioscler Thromb Vasc Biol 32:196-206. 2012..Here, we review the current clinical, mechanistic, and diagnostic implications of the Chr9p21 locus in cardiovascular disease... - Risk factor management: antiatherogenic therapiesStephan Gielen
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009..In addition, it is essential not just to treat CV risk factors, but also to treat them to achieve the target values as set by the guidelines of European Society of Cardiology... - Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistanceDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
Arterioscler Thromb Vasc Biol 26:365-71. 2006..CONCLUSIONS: High expression of arginase I in macrophages may contribute to atherosclerosis resistance of LAR rabbits, possibly by conferring antiinflammatory effects in the vessel wall... - Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humansFrank W Albert
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Horm Behav 53:413-21. 2008..Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness... - Leptin inhibits cell growth of human vascular smooth muscle cellsFelix Bohlen
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15, 04103 Leipzig, Germany
Vascul Pharmacol 46:67-71. 2007..Our findings suggest a role for leptin in vascular smooth muscle cell growth, associated to a downregulation of leptin receptor isoforms... - Quantitative trait loci mapping of the mouse plasma proteome (pQTL)Lesca M Holdt
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
Genetics 193:601-8. 2013..Taken together, we show that genome-wide plasma proteome profiling in combination with genome-wide genetic screening aids in the identification of causal genetic variants affecting abundance of plasma proteins... - Altered immune response in mice deficient for the G protein-coupled receptor GPR34Ines Liebscher
Institute of Biochemistry, Medical Faculty, University Leipzig, 04103 Leipzig, Germany
J Biol Chem 286:2101-10. 2011..Our data point toward a functional role of GPR34 in the cellular response to immunological challenges... - Endothelin(A) receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantationHelmut Witzigmann
Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
Ann Surg 238:264-74. 2003..The effect of prophylactic administration of a selective endothelin(A) receptor antagonist (ET(A)-RA) on ischemia/reperfusion injury in an experimental model of graft pancreatitis after pancreas transplantation was evaluated... - Rapid detection of the prion protein M129V polymorphism with the LightCyclerDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
J Neurosci Methods 115:93-6. 2002..The calculated allele frequency for the M-allele was 0.66. Thus, we have established a rapid, reliable fluorescent assay for high-throughput detection of the prion protein M129V polymorphism... - Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in GermanyAnke Tonjes
Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
Eur J Hum Genet 18:104-10. 2010.... - P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivoAndrej Khandoga
Institute for Surgical Research, University of Munich, Germany
Shock 18:529-35. 2002..P-selectin deficiency prevents microvascular injury and apoptosis after warm hepatic I/R... - Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic rootDaniel Teupser
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:17795-800. 2004..LDLR(-/-) backgrounds were less complex and contained significantly fewer macrophages than controls. In conclusion, the major reduction of atherosclerosis in fractalkine-deficient mice appears to be at the BCA rather than the aortic root... - Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- miceDaniel Teupser
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 103:123-8. 2006..Awareness of these complexities may have major consequences for the identification of atherosclerosis susceptibility genes by quantitative trait locus mapping... - Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)Daniel Teupser
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
Arterioscler Thromb Vasc Biol 23:1907-13. 2003..CONCLUSIONS: These results should aid investigations of atherosclerosis in LDLR-/- mice by informing the selection of diet to be used and the location of lesions to be scored... - High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson diseaseDominik Huster
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 282:8343-55. 2007..The identification of the network of specific copper-responsive targets facilitates further mechanistic analysis of human disorders of copper misbalance... - A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorptionEphraim Sehayek
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
J Lipid Res 47:2291-6. 2006.... - Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humansYvonne Bottcher
Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
J Clin Endocrinol Metab 91:2725-31. 2006..Visfatin is a peptide suggested to play a role in glucose homeostasis. In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM)... - Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistanceTobias A Beyer
Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
EMBO J 27:212-23. 2008..These findings may provide the basis for the development of new strategies to improve regeneration in patients with acute or chronic liver damage... - Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regenerationHeike Steiling
Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
Oncogene 22:4380-8. 2003..These data demonstrate a key role of FGFR signalling in repair after liver injury... - The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genesSusanne Wolfrum
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065
Proc Natl Acad Sci U S A 104:18601-6. 2007..These findings suggest that A20 diminishes atherosclerosis by decreasing NF-kappaB activity, thereby modulating the proinflammatory state associated with lesion development...