Daniel Teupser

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 6:e29070. 2011
  2. ncbi request reprint Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
    Circ Cardiovasc Genet 3:331-9. 2010
  3. ncbi request reprint Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Arterioscler Thromb Vasc Biol 28:2009-15. 2008
  4. doi request reprint Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice
    Ralph Burkhardt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 31:775-84. 2011
  5. doi request reprint Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany
    Atherosclerosis 222:337-43. 2012
  6. pmc Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice
    Lesca M Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 28:1097-103. 2008
  7. ncbi request reprint Changes of vasoregulatory gene expression following hepatic ischemia/reperfusion and treatment with endothelin-A receptor blockade
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, Leipzig, Germany
    J Cardiovasc Pharmacol 44:S100-2. 2004
  8. doi request reprint Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque
    Lesca Miriam Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Atherosclerosis 214:264-70. 2011
  9. doi request reprint ANRIL expression is associated with atherosclerosis risk at chromosome 9p21
    Lesca M Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 30:620-7. 2010
  10. ncbi request reprint Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice
    Carsten Tennert
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Biochem Biophys Res Commun 361:574-9. 2007

Detail Information

Publications44

  1. pmc Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 6:e29070. 2011
    ..We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases...
  2. ncbi request reprint Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
    Circ Cardiovasc Genet 3:331-9. 2010
    ..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...
  3. ncbi request reprint Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Arterioscler Thromb Vasc Biol 28:2009-15. 2008
    ..The aim of the present study was to test whether transgenic expression of LXR-alpha might affect these mechanisms and result in a reduction of atherosclerosis...
  4. doi request reprint Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice
    Ralph Burkhardt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 31:775-84. 2011
    ..We sought to identify novel atherosclerosis-modifying loci and their potential functional links in a genome-wide approach using cosegregation analysis of atherosclerosis and related intermediate phenotypes in mice...
  5. doi request reprint Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany
    Atherosclerosis 222:337-43. 2012
    ..Proliferation signal inhibitors/mTOR-inhibitors have been shown to reduce de novo development of hypercholesterolemic atherosclerosis in animal models. However, their effect on pre-existing atherosclerosis has not yet been studied...
  6. pmc Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice
    Lesca M Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 28:1097-103. 2008
    ..The aim of the present study was to identify potentially causative genes at this locus...
  7. ncbi request reprint Changes of vasoregulatory gene expression following hepatic ischemia/reperfusion and treatment with endothelin-A receptor blockade
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, Leipzig, Germany
    J Cardiovasc Pharmacol 44:S100-2. 2004
    ....
  8. doi request reprint Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque
    Lesca Miriam Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Atherosclerosis 214:264-70. 2011
    ....
  9. doi request reprint ANRIL expression is associated with atherosclerosis risk at chromosome 9p21
    Lesca M Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 30:620-7. 2010
    ..We tested the hypothesis that expression of transcripts adjacent to the chromosome 9p21 (Chr9p21) locus of coronary artery disease was affected by the genotype at this locus and associated with atherosclerosis risk...
  10. ncbi request reprint Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice
    Carsten Tennert
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Biochem Biophys Res Commun 361:574-9. 2007
    ..We conclude that over-expression of ApoE in macrophages might be useful as a therapeutic principle for the prevention of atherosclerosis...
  11. ncbi request reprint Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia
    Marc A Mueller
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Atherosclerosis 198:39-48. 2008
    ..The significant reduction of atherosclerotic lesions was associated with a delayed transition from early macrophages enriched lesions to advanced atherosclerotic plaques...
  12. pmc Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks
    Lesca M Holdt
    LIFE Leipzig Research Center for Civilization Diseases, Universitat Leipzig, Leipzig, Germany
    PLoS Genet 9:e1003588. 2013
    ..Our study provides a molecular mechanism for pro-atherogenic effects of ANRIL at Chr9p21 and suggests a novel role for Alu elements in epigenetic gene regulation by long ncRNAs. ..
  13. pmc Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82
    Kathrin M Y Engel
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e29400. 2011
    ..GPR82 may represent a thrifty gene most probably representing an advantage during human expansion into new environments...
  14. ncbi request reprint Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathway
    Ivonne Haffner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    J Cell Biochem 103:520-7. 2008
    ..These data indicate that cAMP-dependent activation of ARG1 expression is mediated by PKAI and requires histone deacetylation...
  15. ncbi request reprint Comparison of Celsior and UW solution in experimental pancreas preservation
    Dirk Uhlmann
    2nd Department of Surgery, University of Leipzig, 04103 Leipzig, Germany
    J Surg Res 105:173-80. 2002
    ..Recently, experimental and clinical experience has been reported on the application of CEL to abdominal organs. In this animal study, pancreas preservation with CEL was compared with that in UW solution...
  16. doi request reprint Risk factor management: antiatherogenic therapies
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009
    ..In addition, it is essential not just to treat CV risk factors, but also to treat them to achieve the target values as set by the guidelines of European Society of Cardiology...
  17. doi request reprint Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease
    Sebastian Sixt
    Department of Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    Eur Heart J 31:112-9. 2010
    ....
  18. ncbi request reprint Robustness of single-base extension against mismatches at the site of primer attachment in a clinical assay
    Holger Kirsten
    IKIT BBZ, Faculty of Medicine, Center for Biotechnology and Biomedicine, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany
    J Mol Med (Berl) 85:361-9. 2007
    ..Care should be taken when interpreting observed changes in the allelic ratio, which could be caused by nucleotide mismatches, sample mixtures, or copy number variation...
  19. pmc No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig Research Center for Civilization Diseases, University Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    J Biol Chem 286:6272-9. 2011
    ..In fact, our data suggest that mouse CRP may even mediate atheroprotective effects, adding a cautionary note to the idea of targeting CRP as therapeutic intervention against progressive cardiovascular disease...
  20. ncbi request reprint Leptin inhibits cell growth of human vascular smooth muscle cells
    Felix Bohlen
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15, 04103 Leipzig, Germany
    Vascul Pharmacol 46:67-71. 2007
    ..Our findings suggest a role for leptin in vascular smooth muscle cell growth, associated to a downregulation of leptin receptor isoforms...
  21. pmc Quantitative trait loci mapping of the mouse plasma proteome (pQTL)
    Lesca M Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
    Genetics 193:601-8. 2013
    ..Taken together, we show that genome-wide plasma proteome profiling in combination with genome-wide genetic screening aids in the identification of causal genetic variants affecting abundance of plasma proteins...
  22. ncbi request reprint Statins reduce macrophage inflammatory protein-1alpha expression in human activated monocytes
    Mathias Bruegel
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Exp Pharmacol Physiol 33:1144-9. 2006
    ..The present findings suggest that statin-mediated immunomodulation by inhibiting MIP-1alpha could contribute to the beneficial effects of statin therapy independent of lowering plasma cholesterol...
  23. doi request reprint Identification of mutations in the lipoprotein lipase (LPL) and apolipoprotein C-II (APOC2) genes using denaturing high performance liquid chromatography (DHPLC)
    Kathrin B Schuster
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    Clin Chim Acta 412:240-4. 2011
    ..Mutations in the LPL gene or its cofactor APOC2 may result in a decrease or complete loss of enzyme function and subsequently to type I hyperlipoproteinemia...
  24. ncbi request reprint Alpha-tocopherol distribution in lipoproteins and anti-inflammatory effects differ between CHD-patients and healthy subjects
    Alexander Leichtle
    Institute of Laboratory Medicine, Clinical Chemistry, Leipzig University Hospital, Liebigstrasse 27, 04103 Leipzig, Germany
    J Am Coll Nutr 25:420-8. 2006
    ....
  25. doi request reprint Prenatal stress programs lipid metabolism enhancing cardiovascular risk in the female F1, F2, and F3 generation in the primate model common marmoset (Callithrix jacchus)
    Ulrike Buchwald
    Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
    J Med Primatol 41:231-40. 2012
    ..Many human diseases are modulated by intrauterine environment, which is called prenatal programming. This study investigated effects of prenatal glucocorticoids on the lipid metabolism of three filial generations of common marmosets...
  26. ncbi request reprint Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations
    Lesca M Holdt
    Institute of Laboratory Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Arterioscler Thromb Vasc Biol 32:196-206. 2012
    ..Here, we review the current clinical, mechanistic, and diagnostic implications of the Chr9p21 locus in cardiovascular disease...
  27. ncbi request reprint Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans
    Frank W Albert
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Horm Behav 53:413-21. 2008
    ..Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness...
  28. ncbi request reprint Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistance
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Arterioscler Thromb Vasc Biol 26:365-71. 2006
    ..The aim of the present study was to identify new genes of atherosclerosis susceptibility in macrophages from the 2 strains...
  29. ncbi request reprint S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases
    Benjamin Ondruschka
    1 Institute of Legal Medicine, Medical Faculty University of Leipzig, Leipzig, Germany
    J Neurotrauma 30:1862-71. 2013
    ..In conclusion, the present findings emphasize that S100B and NSE are useful markers in postmortem biochemistry in cases of suspected TBI. Further, S100B may be helpful to estimate the survival time of fatal injuries in legal medicine...
  30. pmc From genotype to phenotype in human atherosclerosis--recent findings
    Lesca M Holdt
    Institute of Laboratory Medicine, University Hospital Munich LMU and Ludwig Maximilians University Munich, Munich, Germany
    Curr Opin Lipidol 24:410-8. 2013
    ..The majority of these loci harbor genes previously not known to be involved in atherogenesis. In this review, we summarize the recent progress in understanding the pathophysiology of genetic variants in atherosclerosis...
  31. pmc Altered immune response in mice deficient for the G protein-coupled receptor GPR34
    Ines Liebscher
    Institute of Biochemistry, Medical Faculty, University Leipzig, 04103 Leipzig, Germany
    J Biol Chem 286:2101-10. 2011
    ..Our data point toward a functional role of GPR34 in the cellular response to immunological challenges...
  32. ncbi request reprint Rapid detection of the prion protein M129V polymorphism with the LightCycler
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    J Neurosci Methods 115:93-6. 2002
    ..The calculated allele frequency for the M-allele was 0.66. Thus, we have established a rapid, reliable fluorescent assay for high-throughput detection of the prion protein M129V polymorphism...
  33. pmc Endothelin(A) receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantation
    Helmut Witzigmann
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Ann Surg 238:264-74. 2003
    ..The effect of prophylactic administration of a selective endothelin(A) receptor antagonist (ET(A)-RA) on ischemia/reperfusion injury in an experimental model of graft pancreatitis after pancreas transplantation was evaluated...
  34. pmc Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
    Anke Tonjes
    Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
    Eur J Hum Genet 18:104-10. 2010
    ....
  35. ncbi request reprint Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 23:1907-13. 2003
    ..LDLR-/-) and FVB/NJ (FVB.LDLR-/-) backgrounds...
  36. ncbi request reprint P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo
    Andrej Khandoga
    Institute for Surgical Research, University of Munich, Germany
    Shock 18:529-35. 2002
    ..P-selectin deficiency prevents microvascular injury and apoptosis after warm hepatic I/R...
  37. pmc Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17795-800. 2004
    ..LDLR(-/-) backgrounds were less complex and contained significantly fewer macrophages than controls. In conclusion, the major reduction of atherosclerosis in fractalkine-deficient mice appears to be at the BCA rather than the aortic root...
  38. pmc Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:123-8. 2006
    ..Awareness of these complexities may have major consequences for the identification of atherosclerosis susceptibility genes by quantitative trait locus mapping...
  39. ncbi request reprint High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease
    Dominik Huster
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:8343-55. 2007
    ..The identification of the network of specific copper-responsive targets facilitates further mechanistic analysis of human disorders of copper misbalance...
  40. ncbi request reprint Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
    Heike Steiling
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 22:4380-8. 2003
    ..These data demonstrate a key role of FGFR signalling in repair after liver injury...
  41. ncbi request reprint Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 91:2725-31. 2006
    ..Visfatin is a peptide suggested to play a role in glucose homeostasis. In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM)...
  42. ncbi request reprint A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption
    Ephraim Sehayek
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
    J Lipid Res 47:2291-6. 2006
    ....
  43. pmc Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    Tobias A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 27:212-23. 2008
    ..These findings may provide the basis for the development of new strategies to improve regeneration in patients with acute or chronic liver damage...
  44. pmc The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes
    Susanne Wolfrum
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065
    Proc Natl Acad Sci U S A 104:18601-6. 2007
    ..These findings suggest that A20 diminishes atherosclerosis by decreasing NF-kappaB activity, thereby modulating the proinflammatory state associated with lesion development...