Stefan J Teipel

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. pmc Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Psychiatry Res 221:187-94. 2014
  2. ncbi request reprint Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease
    Stefan Teipel
    Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Disorders, Rostock, Germany Electronic address
    Neurobiol Aging 35:482-91. 2014
  3. doi request reprint Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
  4. doi request reprint Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
  5. doi request reprint Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Germany
    Psychiatry Res 194:363-71. 2011
  6. ncbi request reprint Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 31:S33-47. 2012
  7. doi request reprint Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Prog Neurobiol 95:547-56. 2011
  8. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
  9. doi request reprint White matter microstructure in relation to education in aging and Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Restock, Restock, Germany
    J Alzheimers Dis 17:571-83. 2009
  10. doi request reprint Regional networks underlying interhemispheric connectivity: an EEG and DTI study in healthy ageing and amnestic mild cognitive impairment
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 30:2098-119. 2009

Detail Information

Publications54

  1. pmc Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany Electronic address
    Psychiatry Res 221:187-94. 2014
    ..Our findings may enhance understanding of the role of cholinergic degeneration for the regional specificity of the cortical destruction leading to the syndrome of PPA...
  2. ncbi request reprint Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease
    Stefan Teipel
    Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Disorders, Rostock, Germany Electronic address
    Neurobiol Aging 35:482-91. 2014
    ..Our findings suggest that BFCS atrophy is more closely associated with cortical amyloid burden than hippocampus atrophy in predementia AD. ..
  3. doi request reprint Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    Stefan J Teipel
    University Medicine Rostock, Rostock, Germany
    Med Clin North Am 97:399-424. 2013
    ....
  4. doi request reprint Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...
  5. doi request reprint Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Germany
    Psychiatry Res 194:363-71. 2011
    ..Our findings suggest that a clinical and physical phantom study involving more than two scanners is indispensable to detect potential sources of bias and to reliably estimate effect size in multicenter diagnostic trials using DTI...
  6. ncbi request reprint Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 31:S33-47. 2012
    ....
  7. doi request reprint Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Prog Neurobiol 95:547-56. 2011
    ..It will become ever more valuable with the introduction of new diagnostic standards and novel treatment approaches which will require valid and reliable biological markers to improve the diagnosis and early treatment of AD patients...
  8. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
    ..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies...
  9. doi request reprint White matter microstructure in relation to education in aging and Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Restock, Restock, Germany
    J Alzheimers Dis 17:571-83. 2009
    ....
  10. doi request reprint Regional networks underlying interhemispheric connectivity: an EEG and DTI study in healthy ageing and amnestic mild cognitive impairment
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 30:2098-119. 2009
    ..05). The study provides a methodology to access specific networks of subcortical fiber tracts subserving the maintenance of interhemispheric resting state coherence in the human brain...
  11. ncbi request reprint The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
    ..05, corrected for multiple comparisons). Our findings suggest that a multimodal MRI-DTI approach is supportive to determine atrophy of cholinergic nuclei and its effect on intracortical projecting fiber tracts in AD...
  12. doi request reprint Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  13. ncbi request reprint Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
    ..Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF)...
  14. ncbi request reprint Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    J Alzheimers Dis 22:507-22. 2010
    ..The underlying mechanisms for these changes are unknown...
  15. ncbi request reprint Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurobiol Aging 27:10-5. 2006
    ..Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD...
  16. ncbi request reprint CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University Munich, Germany
    Brain 129:3035-41. 2006
    ..There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease...
  17. ncbi request reprint Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
    Harald Hampel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Neurol 62:770-3. 2005
    ..We hypothesized that these variations partially reflect differences in the degree of neuronal damage and therefore may be used to predict structural disease progression...
  18. ncbi request reprint Fiber connections between the cerebral cortex and the corpus callosum in Alzheimer's disease: a diffusion tensor imaging and voxel-based morphometry study
    Djyldyz Sydykova
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, D 80366 Munich, Germany
    Cereb Cortex 17:2276-82. 2007
    ..In control subjects, no correlations were detected. Our findings suggest that decline of FA in the corpus callosum may be related to neuronal degeneration in corresponding cortical areas...
  19. ncbi request reprint Multivariate network analysis of fiber tract integrity in Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Neuroimage 34:985-95. 2007
    ..In agreement with post-mortem evidence, our study demonstrates dissociation between intracortical and extracortical projecting fiber systems in AD in the living human brain...
  20. ncbi request reprint Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurosci Lett 391:48-50. 2005
    ..Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects...
  21. ncbi request reprint Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    Michael Ewers
    Department of Psychiatry, Alzheimer Memorial Center, Ludwig Maximilian University, Munich, Germany
    Brain 131:1252-8. 2008
    ..The assessment of BACE 1 in CSF may provide a sensitive measure to detect in vivo alterations in the amyloidogenic processing potentially modified by the ApoE genotype...
  22. ncbi request reprint Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Neurol 253:794-800. 2006
    ..Early pathological involvement of specific medial temporal lobe areas is characteristic for Alzheimer's disease (AD)...
  23. ncbi request reprint Diagnostic utility of novel MRI-based biomarkers for Alzheimer's disease: diffusion tensor imaging and deformation-based morphometry
    Uwe Friese
    Department of Psychiatry, University of Rostock, Germany Institute of Psychology, University of Osnabrueck, D 49076 Osnabrueck, Germany
    J Alzheimers Dis 20:477-90. 2010
    ..86 after leave-one-out cross-validation. It remains to be shown if this automated multivariate analysis of DTI-measures can improve early diagnosis of AD in predementia stages...
  24. doi request reprint Decreased activation along the dorsal visual pathway after a 3-month treatment with galantamine in mild Alzheimer disease: a functional magnetic resonance imaging study
    Arun L W Bokde
    Dementia and Neuroimaging Research Section, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Clin Psychopharmacol 29:147-56. 2009
    ..A visual perception task recruiting the dorsal visual system may be useful as a biomarker of treatment effects...
  25. ncbi request reprint Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Am J Psychiatry 160:376-9. 2003
    ..The authors asked whether p-tau(231) levels improve the differential diagnosis between geriatric major depression and Alzheimer's disease...
  26. ncbi request reprint Measurement of basal forebrain atrophy in Alzheimer's disease using MRI
    Stefan J Teipel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Ludwig Maximilian University, Munich, Germany
    Brain 128:2626-44. 2005
    ..If replicated in an independent sample, our technique may be useful to detect degeneration of basal forebrain cholinergic neurones in vivo...
  27. ncbi request reprint Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Brain 127:811-24. 2004
    ..The most likely substrate of these changes is alterations or loss of allocortical and neocortical neurons due to Alzheimer's disease-type pathology...
  28. ncbi request reprint Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment
    Stefan J Teipel
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Neuroimage 38:13-24. 2007
    ..Our findings indicate that multivariate network analysis of deformation maps detects typical features of AD pathology and provides a powerful tool to predict conversion into AD in non-demented at risk patients...
  29. ncbi request reprint Morphological substrate of face matching in healthy ageing and mild cognitive impairment: a combined MRI-fMRI study
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Brain 130:1745-58. 2007
    ..These findings support the notion that the functional segregation within the visual system is based on the distribution of cortical grey matter volumes, possibly reflecting the spatial distribution of neuron density...
  30. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
    ..However, there is a controversy regarding how the cholinergic lesion in AD relates to early and incipient stages of the disease. In vivo imaging studies on the structural integrity of the BFCS in normal and pathologic aging are rare...
  31. doi request reprint Structural and functional cortical disconnection in Alzheimer's disease: a combined study using diffusion tensor imaging and transcranial magnetic stimulation
    Martin Wegrzyn
    DZNE, German Centre for Neurodegenerative Diseases, Rostock, Germany
    Psychiatry Res 212:192-200. 2013
    ..Therefore, we argue that beside the direct degeneration of the underlying fibre tracts, other pathophysiological mechanisms may account for the observation of decreased transcallosal inhibition and increased motor excitability in AD...
  32. ncbi request reprint Progression of corpus callosum atrophy in Alzheimer disease
    Stefan J Teipel
    and Harald Hampel, MD, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Arch Neurol 59:243-8. 2002
    ..Atrophy of the corpus callosum in the absence of primary white matter degeneration reflects loss of intracortical projecting neocortical pyramidal neurons in Alzheimer disease (AD)...
  33. ncbi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
    ..Thus, our data support a role of SORL1 polymorphisms in AD...
  34. doi request reprint Prediction of Alzheimer's disease using midregional proadrenomedullin and midregional proatrial natriuretic peptide: a retrospective analysis of 134 patients with mild cognitive impairment
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Clin Psychiatry 72:556-63. 2011
    ....
  35. ncbi request reprint Fractional anisotropy changes in Alzheimer's disease depend on the underlying fiber tract architecture: a multiparametric DTI study using joint independent component analysis
    Stefan J Teipel
    Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany
    J Alzheimers Dis 41:69-83. 2014
    ..Supporting this interpretation, we found three populations of fiber tracts, namely cortico-petal and cortico-fugal, commissural, and intrahemispherically projecting fiber tracts, in the peak area of parallel FA and Mode increase. ..
  36. doi request reprint White matter microstructure underlying default mode network connectivity in the human brain
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Neuroimage 49:2021-32. 2010
    ....
  37. pmc Robust automated detection of microstructural white matter degeneration in Alzheimer's disease using machine learning classification of multicenter DTI data
    Martin Dyrba
    German Center for Neurodegenerative Diseases DZNE, Rostock, Germany
    PLoS ONE 8:e64925. 2013
    ..Our findings support the notion that machine learning classification allows robust classification of DTI data sets arising from multiple scanners, even if a new data set comes from a scanner that was not part of the training sample...
  38. ncbi request reprint Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease
    Harald Hampel
    Dementia Research and Neuroimaging Section, Memory Clinic, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Neurol Sci 194:15-9. 2002
    ..We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD...
  39. ncbi request reprint Reliable manual segmentation of the frontal, parietal, temporal, and occipital lobes on magnetic resonance images of healthy subjects
    Arun L W Bokde
    Dementia and Neuro imaging Research Section, Alzheimer s Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, Station D2, 80336 Munich, Germany
    Brain Res Brain Res Protoc 14:135-45. 2005
    ..It is a challenge to reliably measure the lobar volumes from magnetic resonance imaging (MRI) data...
  40. doi request reprint Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt Main, Germany
    Nat Rev Drug Discov 9:560-74. 2010
    ..Biomarkers that achieve these characteristics should enable objective business decisions in portfolio management and facilitate regulatory approval of new therapies...
  41. doi request reprint Novel MRI techniques in the assessment of dementia
    Stefan J Teipel
    Dementia and Neuroimaging Section, Department of Psychiatry, Alzheimer Memorial Center, Ludwig Maximilian University, Nussbaumstrasse 7, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:S58-69. 2008
    ..In the near future, these markers will be of high relevance for the selection of at-risk subjects in secondary preventive trials...
  42. ncbi request reprint Long-term cost-effectiveness of donepezil for the treatment of Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, Munich, 80336, Germany
    Eur Arch Psychiatry Clin Neurosci 257:330-6. 2007
    ..However, use of ChE inhibitors is limited by budget constraints and disincentives on the side of health insurances and nursing care insurances...
  43. ncbi request reprint Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study
    Ingo Kilimann
    German Center for Neurodegenerative Diseases DZNE Rostock Greifswald, Rostock, Germany Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
    J Alzheimers Dis 40:687-700. 2014
    ..The data of our study suggest that BFCS morphometry may provide an emerging biomarker in AD. ..
  44. ncbi request reprint Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 187:86-94. 2006
    ..Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) by measuring cortical metabolic response to activation assesses integrity of neuronal transmission in vivo...
  45. ncbi request reprint Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Arch Neurol 59:1267-72. 2002
    ....
  46. doi request reprint Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    Prog Neurobiol 95:570-8. 2011
    ..The network based approach provides a new independent method from previous ones to translate preclinical knowledge into the clinical domain...
  47. ncbi request reprint Pharmacological treatment of Alzheimer's dementia: state of the art and current dilemmas
    Muamer Omerovic
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 9:69-75. 2008
    ..Furthermore, we discuss current difficulties regarding AD treatment by looking for explanations for a still unsatisfying rate of state-of-the-art treatment of AD-patients...
  48. ncbi request reprint Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Behav Genet 36:405-15. 2006
    ..This has major implications for our understanding of the onset and progression of AD-type pathology both in DS and in sporadic AD...
  49. ncbi request reprint Total and phosphorylated tau proteins: evaluation as core biomarker candidates in frontotemporal dementia
    Harald Hampel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Maximilian University, Munich, Germany
    Dement Geriatr Cogn Disord 17:350-4. 2004
    ..Therefore, p-tau is a core biological marker candidate for future evaluation in large national and international multicenter networks...
  50. ncbi request reprint Decreased serum amyloid beta(1-42) autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid beta(1-42) peptide
    Sylvia Brettschneider
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Biol Psychiatry 57:813-6. 2005
    ..Autoantibodies against amyloid beta (A beta) peptide found in patients with Alzheimer's disease (AD) also occur naturally in the general population independently of the cognitive status...
  51. ncbi request reprint White matter pathology in ALS and lower motor neuron ALS variants: a diffusion tensor imaging study using tract-based spatial statistics
    Johannes Prudlo
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 259:1848-59. 2012
    ..The statistically identical findings of white matter lesions in classical ALS and LMN variants as ascertained by DTI further underline that these variants should be regarded as part of the ALS spectrum...
  52. ncbi request reprint Decline of fiber tract integrity over the adult age range: A diffusion spectrum imaging study
    Stefan J Teipel
    Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany
    J Magn Reson Imaging 40:348-59. 2014
    ..We applied a novel diffusion spectrum imaging (DSI) acquisition to determine associations between aging and subcortical fiber tract integrity...
  53. doi request reprint Isolated motor neglect following infarction of the posterior limb of the right internal capsule: a case study with diffusion tensor imaging-based tractography
    Yuttachai Likitjaroen
    Department of Aging Science and Humanities, University of Rostock, Rostock, Germany
    J Neurol 259:100-5. 2012
    ....
  54. pmc Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 23:221-37. 2011
    ....