N Teich

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Relevance of variants in serum antiproteinases for the course of chronic pancreatitis
    N Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Scand J Gastroenterol 37:360-5. 2002
  2. pmc The hole in the stomach
    Hans Bodeker
    Department of Internal Medicine II, University of Leipzig, 04103 Leipzig, Germany
    Diagn Ther Endosc 2008:257185. 2008
  3. pmc Cathepsin B cleavage of the trypsinogen activation peptide
    Niels Teich
    Universitatsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Gastroenterologie und Hepatologie, Philipp Rosenthal Str, 27 04103 Leipzig, Germany
    BMC Gastroenterol 2:16. 2002
  4. pmc Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Germany
    Hum Mutat 25:343-7. 2005
  5. ncbi request reprint [Sporadic acute hepatitis E in Germany: an underdiagnosed phenomenon?]
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Z Gastroenterol 41:419-23. 2003
  6. ncbi request reprint The WayStation: the novel way for the collection of pancreatitis-associated mutations
    Niels Teich
    Universitatsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    Pancreatology 4:249-50. 2004
  7. ncbi request reprint Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation
    N Teich
    Medizinische Klinik II, Universitat Leipzig, Leipzig, Germany
    Gastroenterology 119:461-5. 2000
  8. ncbi request reprint [Clinical implications of genetic risk factors of chronic pancreatitis]
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Internist (Berl) 46:123-30. 2005
  9. ncbi request reprint Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene
    V Keim
    German Registry of Hereditary Pancreatitis at the Medizinische Klinik und Poliklinik II, , Leipzig, Germany
    Am J Med 111:622-6. 2001
  10. ncbi request reprint The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis
    V Keim
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Pancreas 19:248-54. 1999

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Relevance of variants in serum antiproteinases for the course of chronic pancreatitis
    N Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Scand J Gastroenterol 37:360-5. 2002
    ..The aim of this study was to determine the role of genetic variants of the main serum antiproteinases alpha-1-antitrypsin (AAT) and alpha-2-macroglobulin (A2M) for the course of chronic pancreatitis...
  2. pmc The hole in the stomach
    Hans Bodeker
    Department of Internal Medicine II, University of Leipzig, 04103 Leipzig, Germany
    Diagn Ther Endosc 2008:257185. 2008
    ..Immediate laparotomy showed a 3 cm orifice of the diaphragm. The orifice was widened and a partial necrosis of the incarcerated fundus was resected. The patient recovered fully and was discharged 12 days after laparotomy...
  3. pmc Cathepsin B cleavage of the trypsinogen activation peptide
    Niels Teich
    Universitatsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Gastroenterologie und Hepatologie, Philipp Rosenthal Str, 27 04103 Leipzig, Germany
    BMC Gastroenterol 2:16. 2002
    ..Here we investigated the influence of the mutations D22G and K23R of the trypsinogen activation peptide on the cleavability by cathepsin B...
  4. pmc Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Germany
    Hum Mutat 25:343-7. 2005
    ..In conclusion, we have demonstrated that gene conversion between two functional paralogous trypsinogen genes can occur and cause genetically determined chronic pancreatitis...
  5. ncbi request reprint [Sporadic acute hepatitis E in Germany: an underdiagnosed phenomenon?]
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Z Gastroenterol 41:419-23. 2003
    ..These data indicate that community acquired hepatitis E virus infection may occur sporadically in Germany and should be considered as a cause of seronegative (non-A-non-B-non-C) hepatitis...
  6. ncbi request reprint The WayStation: the novel way for the collection of pancreatitis-associated mutations
    Niels Teich
    Universitatsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    Pancreatology 4:249-50. 2004
  7. ncbi request reprint Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation
    N Teich
    Medizinische Klinik II, Universitat Leipzig, Leipzig, Germany
    Gastroenterology 119:461-5. 2000
    ..Mutations of the cationic trypsinogen have been described in hereditary pancreatitis. We report a new trypsinogen mutation in the activation peptide of the proenzyme in a family with chronic pancreatitis...
  8. ncbi request reprint [Clinical implications of genetic risk factors of chronic pancreatitis]
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig
    Internist (Berl) 46:123-30. 2005
    ..We summarize interesting genetic and biochemical findings, point to clinical features and review recommendations for genetic analysis, follow-up and cancer prevention...
  9. ncbi request reprint Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene
    V Keim
    German Registry of Hereditary Pancreatitis at the Medizinische Klinik und Poliklinik II, , Leipzig, Germany
    Am J Med 111:622-6. 2001
    ..CONCLUSIONS: Symptoms of patients with the N29I or R122H trypsinogen mutation were generally similar. The majority of subjects with trypsinogen mutations had mild disease or was asymptomatic...
  10. ncbi request reprint The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis
    V Keim
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Pancreas 19:248-54. 1999
    ..We conclude that there is a lack of PAP polymorphism in hereditary and alcoholic pancreatitis and that expression of the PAP in both groups of patients is related to the degree of cellular damage of the pancreas...
  11. doi request reprint [Nutrition in acute pancreatitis]
    N Teich
    Internistische Gemeinschaftspraxis für Verdauungs und Stoffwechselkrankheiten, Leipzig, Germany
    Dtsch Med Wochenschr 135:1979-81. 2010
    ..First trials suggest early oral refeeding as nutritional treatment of choice in patients with mild acute pancreatitis. In this review, we summarise the current knowledge on nutrition in acute pancreatitis and discuss future developments...
  12. ncbi request reprint [Pathogenetic concepts of chronic pancreatitis]
    N Teich
    Medizinische Klinik und Poliklinik II, , Germany
    Zentralbl Chir 126:884-8. 2001
    ..Investigation of these mutations may significantly contribute to a better understanding of the pathogenesis of chronic pancreatitis...
  13. ncbi request reprint [A 32-year-old patient with diarrhoea and acute kidney failure]
    A Hoffmeister
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Ph Rosenthal Strasse 27, 04103, Leipzig, Germany
    Internist (Berl) 47:1063-7. 2006
    ..MRI examination of the small bowel revealed inflammatory alterations typical for Crohn's disease, even without histological verification. We describe haemolytic-waemic syndrome as manifestation of Crohn's disease for the first time...
  14. ncbi request reprint Mutations of the cationic trypsinogen in hereditary pancreatitis
    N Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Hum Mutat 12:39-43. 1998
    ..As a model of pathogenesis, we hypothesize that mutation of trypsinogen in exon 2 could lead to premature cleavage of the activation peptide of trypsinogen or to altered intracellular transport...
  15. doi request reprint [Acute pancreatitis]
    N Teich
    Internistische Gemeinschaftspraxis für Verdauungs und Stoffwechselerkrankungen, Funkenburgstrasse 19, Leipzig, Germany
    Chirurg 80:245-52; quiz 253-4. 2009
    ..Surgery and endoscopic interventions may be necessary and beneficial in carefully selected patients. In this review we summarize clinically relevant issues of acute pancreatitis...
  16. ncbi request reprint [First aid regulations: generally unknown in Germany]
    N Teich
    Universitat Leipzig, Medizinische Klinik und Poliklinik II
    Versicherungsmedizin 58:37-8. 2006
  17. doi request reprint [Prevention of gastrointestinal malignancies]
    A Hoffmeister
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, AöR, Philipp Rosenthal Strasse 27, 04103 Leipzig
    Internist (Berl) 49:178-84. 2008
    ..Preneoplastic adenomas can be endoscopically removed during the same session. We here review simple prevention strategies and effective screening methods in gastrointestinal cancers of relevance in daily practice...
  18. doi request reprint A man with two pylori
    M Wiedmann
    Department of Internal Medicine II, University of Leipzig, Philipp Rosenthal Str 27, D 04103 Leipzig, Germany
    Gut 57:305, 351. 2008
  19. ncbi request reprint Endoluminal gastroplication: what are the predictors of outcome?
    I Schiefke
    Depts of Internal Medicine II and Radiology, University of Leipzig, Leipzig, Germany
    Scand J Gastroenterol 39:1296-303. 2004
    ..The aim of this study was to evaluate the major determinants to predict outcome in patients treated with EndoCinch...
  20. doi request reprint Treatment of massive cecal bleeding in a 28-Year-old patient with homozygous factor V deficiency with activated factor VII
    S Petros
    Haemophilia Centre, Medical Clinic I, University of Leipzig, Leipzig, Germany
    Z Gastroenterol 46:271-3. 2008
    ..We conclude that massive cecal mucosal bleeding is a possible manifestation of homozygous factor V deficiency and rFVIIa could be a successful therapy...
  21. ncbi request reprint [Resuscitation by laypersons: lack of knowledge of first-aid measures in Germany]
    N Teich
    Medizinische Klinik und Poliklinik II, 04103 Leipzig
    Dtsch Med Wochenschr 130:2759-62. 2005
    ..Sudden cardiac death is a leading cause of death. In Germany, only 10% of patients will survive reanimation. The prognosis is mainly determined by the first-aid skills of accidental witnesses...
  22. doi request reprint [Nutrition in acute pancreatitis]
    J MOssner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig
    Z Gastroenterol 46:784-9. 2008
    ..In an recently published study, prebiotics were associated with a high complication rate. In this review, we summarise the current knowledge on nutrition in acute pancreatitis and discuss future developments...
  23. ncbi request reprint Genetic aspects of chronic pancreatitis
    Niels Teich
    University of Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    Med Sci Monit 10:RA325-8. 2004
    ..In this review, we summarize interesting clinical and biochemical features of genetic variants in these genes which are associated with chronic pancreatitis...
  24. ncbi request reprint Compound heterozygous mutations of the SBDS gene in a patient with Shwachman-Diamond syndrome, type 1 diabetes mellitus and osteoporosis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    Pancreatology 6:549-54. 2006
    ....
  25. ncbi request reprint UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer
    Johann Ockenga
    Department of Gastroenterology, Hepatology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Gastroenterology 124:1802-8. 2003
    ..Uridine 5'-diphosphate glucuronosyltransferases are phase II detoxifying enzymes capable of tobacco-borne toxicant inactivation and cellular protection. This study analyzes UGT1A7 gene polymorphisms in pancreatic diseases...
  26. ncbi request reprint Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    ..6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer...
  27. ncbi request reprint Evaluation of Pankrin, a new serum test for diagnosis of acute pancreatitis
    Volker Keim
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Philipp Rosenthal Strasse 27, D 04103, Leipzig, Germany
    Clin Chim Acta 332:45-50. 2003
    ..Evaluation of a new serum test for diagnosis of acute pancreatitis...
  28. pmc Hereditary chronic pancreatitis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Orphanet J Rare Dis 2:1. 2007
    ..The disease course and prognosis of patients with HCP is unpredictable. Pancreatic cancer risk is elevated. Therefore, HCP patients should strongly avoid environmental risk factors for pancreatic cancer...
  29. doi request reprint Hereditary chronic pancreatitis
    Niels Teich
    Medizinische Klinik and Poliklinik II, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    Best Pract Res Clin Gastroenterol 22:115-30. 2008
    ..The disease course and prognosis of patients with HCP is unpredictable. The risk of pancreatic cancer is elevated. Therefore, HCP patients should strongly avoid environmental risk factors for pancreatic cancer...
  30. ncbi request reprint Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Am J Gastroenterol 97:341-6. 2002
    ..After mutational screening of a cohort of patients with nonalcoholic chronic pancreatitis, we report three novel variants of the trypsinogen molecule and the clinical characteristics of the carriers...
  31. ncbi request reprint N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Deutschland
    Pancreatology 3:67-8. 2003
    ..The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer...
  32. ncbi request reprint Idiopathic vs hereditary pancreatitis
    Volker Keim
    JAMA 289:983-4; author reply 985. 2003
  33. ncbi request reprint Genetic disorders in pancreatitis: Implications in the pathogenesis of acute and chronic pancreatitis
    Joachim Mossner
    University of Leipzig, Medizinische Klinik und Poliklinik II, Germany
    Surgery 132:421-3. 2002
  34. ncbi request reprint Genetic risk factors in chronic pancreatitis
    Niels Teich
    Medizinische Klinik and Poliklinik II, University of Leipzig, Germany
    J Gastroenterol 37:1-9. 2002
  35. pmc Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Hum Mutat 27:721-30. 2006
    ..The clinical presentation is highly variable, but most affected mutation carriers have relatively mild disease. In this review, we summarize the current knowledge on trypsinogen mutations and their role in pancreatic diseases...
  36. pmc A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
    ..In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis...
  37. ncbi request reprint Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis
    Helen Beranek
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Kinderklinik, Charite Berlin, Berlin, Germany
    Eur J Gastroenterol Hepatol 15:1223-7. 2003
    ..We investigated the influence of interleukin 10 (IL10) and tumour necrosis factor alpha (TNFalpha) promotor variants on the manifestation of chronic pancreatitis of different underlying causes and in pancreatic cancer...
  38. ncbi request reprint Transforming growth factor-beta-1 variants are not associated with chronic nonalcoholic pancreatitis
    Kerstin Böhm
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Germany
    Pancreatology 5:75-80. 2005
    ..PSC activation and collagen synthesis are highly controlled by transforming growth factor-beta-1 (TGF-beta1). We evaluated whether functionally relevant genetic variants of TGF-beta1 are associated with chronic nonalcoholic pancreatitis...
  39. pmc Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen
    Zsofia Nemoda
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    Pancreatology 5:273-8. 2005
    ....
  40. ncbi request reprint Molecular analysis of pancreatic juice: a helpful tool to differentiate benign and malignant pancreatic tumors?
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Deutschland
    Dig Dis 22:235-8. 2004
    ....
  41. ncbi request reprint Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Leipzig, Germany
    Hum Mutat 23:22-31. 2004
    ....
  42. ncbi request reprint [The value of iron determination. Comment on Hermann Heimpel, Martin Riedel, Roman Wennauder, Lothar Thomas: Plasma iron determination--useful, unnecessary or misleading?]
    Niels Teich
    Med Klin (Munich) 98:398-9. 2003
  43. ncbi request reprint Chronic pancreatitis with pancreaticolithiasis and pseudocyst in a 5-year-old boy with homozygous SPINK1 mutation
    Axel C Kühn
    Department of Diagnostic Radiology Pediatric Radiology, Faculty of Medicine, University of Leipzig, Oststr 21 25, 04317 Leipzig, Germany
    Pediatr Radiol 35:902-5. 2005
    ..Successful endoscopic papillotomy and stent implantation were performed. Genetic testing showed homozygous SPINK1-N34S mutation, which is an established risk factor for chronic pancreatitis...
  44. pmc The presence of the proteolysis-inducing factor in urine does not predict the malignancy of a pancreatic tumour
    Niels Teich
    Universitat Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    BMC Gastroenterol 5:20. 2005
    ..We hypothesized that PIF could be a useful marker to exclude benign pancreatic tumors, as chronic pancreatitis with a pancreatic mass...
  45. ncbi request reprint Expression of mutated cationic trypsinogen reduces cellular viability in AR4-2J cells
    Sebastian Gaiser
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig AoR, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 334:721-8. 2005
    ..Expression of trypsin and R122H trypsinogen induced caspase-3 activity. Acinar cells might react to intracellular trypsin activity by triggering apoptosis...
  46. ncbi request reprint Clinical value of a new fecal elastase test for detection of chronic pancreatitis
    Volker Keim
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Clin Lab 49:209-15. 2003
    ..Several pancreatic function tests exist, but their role in the diagnosis of chronic pancreatitis is controversial. Here we analyzed the clinical value of a newly available fecal elastase assay...
  47. ncbi request reprint The course of genetically determined chronic pancreatitis
    Volker Keim
    Medizinische Klinik II, Universitatsklinikum Leipzig, Germany
    JOP 4:146-54. 2003
    ..The clinical course of chronic pancreatitis in patients with mutations of cationic trypsinogen and the trypsin inhibitor SPINK1 has not yet been characterized...
  48. ncbi request reprint Chronic parotitis: not another SPINKosis
    Felix Gundling
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Deutschland
    Dig Dis 22:292-5. 2004
    ..We tested the hypothesis that the pancreatitis-associated N34S mutation of SPINK1 is also a risk factor for chronic parotitis...
  49. doi request reprint Pancreatic cancer: cause and result of diabetes mellitus
    Niels Teich
    Gastroenterology 134:344-5. 2008
  50. pmc Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Philipp Rosenthal Strasse 27, 04103 Leipzig, Germany
    Nat Genet 40:78-82. 2008
    ..The results indicate that loss-of-function alterations in CTRC predispose to pancreatitis by diminishing its protective trypsin-degrading activity...
  51. ncbi request reprint The ways of realization of high specificity and efficiency of enteropeptidase
    Anna G Mikhailova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russian Federation
    Protein Pept Lett 14:227-32. 2007
    ....
  52. ncbi request reprint Regression of pancreatic diabetes in chronic hereditary pancreatitis
    Holm H Uhlig
    Diabetes Care 29:1981-2. 2006