Dirk Taubert

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features
    Dirk Taubert
    Department of Pharmacology, University of Cologne, Cologne, Germany
    J Cardiovasc Pharmacol 40:701-13. 2002
  2. ncbi Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, D 50931 Cologne, Germany
    J Rheumatol 33:2139-45. 2006
  3. ncbi Pharmacokinetics of clopidogrel after administration of a high loading dose
    Dirk Taubert
    Department of Pharmacology, University Hospital, University of Cologne, Cologne, Germany
    Thromb Haemost 92:311-6. 2004
  4. ncbi The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Gleueler Str 24, D 50931 Cologne, Germany
    Toxicol Lett 164:1-5. 2006
  5. ncbi Impact of P-glycoprotein on clopidogrel absorption
    Dirk Taubert
    Institut fur Pharmakologie, Klinikum I für Innere Medizin, Cologne, and Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Clin Pharmacol Ther 80:486-501. 2006
  6. ncbi Influence of processing parameters on acrylamide formation during frying of potatoes
    Dirk Taubert
    Department of Pharmacology, University of Cologne, D 50931 Cologne, Germany
    J Agric Food Chem 52:2735-9. 2004
  7. ncbi Acute effects of glucose and insulin on vascular endothelium
    D Taubert
    Department of Pharmacology, Medical Hospital of the University of Cologne, Gleueler Str 24, 50931, Cologne, Germany
    Diabetologia 47:2059-71. 2004
  8. ncbi [Aspirin--a suitable drug for cancer prevention?]
    D Taubert
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Cologne
    Dtsch Med Wochenschr 129:439-42. 2004
  9. ncbi Reaction rate constants of superoxide scavenging by plant antioxidants
    Dirk Taubert
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Free Radic Biol Med 35:1599-607. 2003
  10. ncbi Effect of cocoa and tea intake on blood pressure: a meta-analysis
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Gleueler Strasse 24, D 50931 Cologne, Germany
    Arch Intern Med 167:626-34. 2007

Detail Information

Publications31

  1. ncbi Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features
    Dirk Taubert
    Department of Pharmacology, University of Cologne, Cologne, Germany
    J Cardiovasc Pharmacol 40:701-13. 2002
    ....
  2. ncbi Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, D 50931 Cologne, Germany
    J Rheumatol 33:2139-45. 2006
    ..We investigated the association between ET concentrations in peripheral blood erythrocytes and the occurrence of RA...
  3. ncbi Pharmacokinetics of clopidogrel after administration of a high loading dose
    Dirk Taubert
    Department of Pharmacology, University Hospital, University of Cologne, Cologne, Germany
    Thromb Haemost 92:311-6. 2004
    ....
  4. ncbi The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Gleueler Str 24, D 50931 Cologne, Germany
    Toxicol Lett 164:1-5. 2006
    ..This may be relevant to human health since the suggested carcinogenic risk of dietary acrylamide may be reduced by concomitant intake of garlic...
  5. ncbi Impact of P-glycoprotein on clopidogrel absorption
    Dirk Taubert
    Institut fur Pharmakologie, Klinikum I für Innere Medizin, Cologne, and Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Clin Pharmacol Ther 80:486-501. 2006
    ..We tested the hypothesis that the intestinal efflux transporter P-glycoprotein (P-gp) limits the oral bioavailability of clopidogrel and that variance in the MDR1 gene encoding P-gp predicts absorption variability...
  6. ncbi Influence of processing parameters on acrylamide formation during frying of potatoes
    Dirk Taubert
    Department of Pharmacology, University of Cologne, D 50931 Cologne, Germany
    J Agric Food Chem 52:2735-9. 2004
    ..Moreover, browning levels were not a reliable measure of acrylamide content in large-surface products...
  7. ncbi Acute effects of glucose and insulin on vascular endothelium
    D Taubert
    Department of Pharmacology, Medical Hospital of the University of Cologne, Gleueler Str 24, 50931, Cologne, Germany
    Diabetologia 47:2059-71. 2004
    ..The aim of this study was to examine whether elevated glucose itself stimulates endothelial NO formation or enhances insulin-mediated endothelial NO release...
  8. ncbi [Aspirin--a suitable drug for cancer prevention?]
    D Taubert
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Cologne
    Dtsch Med Wochenschr 129:439-42. 2004
  9. ncbi Reaction rate constants of superoxide scavenging by plant antioxidants
    Dirk Taubert
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Free Radic Biol Med 35:1599-607. 2003
    ..Compounds with pyrogallol or catechol moieties were revealed as the most rapid superoxide scavengers, and the gallate moiety was found to be the minimal essential structure for maximal reaction rate constants with superoxide...
  10. ncbi Effect of cocoa and tea intake on blood pressure: a meta-analysis
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Gleueler Strasse 24, D 50931 Cologne, Germany
    Arch Intern Med 167:626-34. 2007
    ..We undertook a meta-analysis of randomized controlled trials to determine changes in systolic and diastolic blood pressure due to the intake of cocoa products or black and green tea...
  11. ncbi Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons
    Dirk Taubert
    Department of Pharmacology, Medical Hospital of the University of Cologne, Cologne, Germany
    PLoS ONE 2:e385. 2007
    ....
  12. ncbi Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial
    Dirk Taubert
    Department of Pharmacology, University Hospital of Cologne, Cologne, Germany
    JAMA 298:49-60. 2007
    ....
  13. ncbi Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action
    D Taubert
    Department of Pharmacology, Medical Hospital of the University of Cologne, Gleueler Str 24, D 50931 Cologne, Germany
    Br J Pharmacol 143:159-65. 2004
    ..This effect appears to be due to a direct acetylation of the eNOS protein, but is independent of COX inhibition or inhibition of superoxide-mediated NO degradation...
  14. ncbi Different antioxidative potencies of dihydropyridine calcium channel modulators in various models
    Reinhard Berkels
    Department of Pharmacology, University Hospital Cologne, Gleueler Str 24, 50931 Cologne, Germany
    Vascul Pharmacol 42:145-52. 2005
    ..We conclude that it seems necessary to access antioxidative properties of substances in physiological models in which we could demonstrate that nifedipine exhibits ROS-quenching properties in a therapeutic concentration range...
  15. ncbi Amlodipine increases endothelial nitric oxide by dual mechanisms
    Reinhard Berkels
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Cologne, Germany
    Pharmacology 70:39-45. 2004
    ..This may result in an improved endothelial function...
  16. ncbi Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect)
    Nicolas von Beckerath
    Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Circulation 112:2946-50. 2005
    ..It is unknown, though, whether loading doses higher than 600 mg exert additional suppression of platelet function...
  17. ncbi In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans
    Oxana Doroshyenko
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Cancer Epidemiol Biomarkers Prev 18:433-43. 2009
    ..No obvious genetic risks or protective factors in xenobiotic-metabolizing enzymes could be determined for exposed subjects...
  18. ncbi Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients
    Clara Lehmann
    First Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Acquir Immune Defic Syndr 48:522-30. 2008
    ..On the other hand, high IFN alpha serum levels in HIV-1-infected individuals have been proposed to promote immune hyper-activation and disease progression...
  19. ncbi Vascular protective effects of dihydropyridine calcium antagonists. Involvement of endothelial nitric oxide
    Reinhard Berkels
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Koln, Deutschland
    Pharmacology 69:171-6. 2003
    ..These pleiotropic effects of dihydropyridine calcium antagonists may underlie or contribute to antiatherosclerotic effects of this substance class...
  20. ncbi Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity
    Uwe Fuhr
    Department of Pharmacology, University Hospital, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany
    Cancer Epidemiol Biomarkers Prev 15:266-71. 2006
    ..This should be considered for quantitative cancer risk assessment...
  21. ncbi The localisation of the extraneuronal monoamine transporter (EMT) in rat brain
    Christine Haag
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Koln, Germany
    J Neurochem 88:291-7. 2004
    ....
  22. ncbi Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis
    Tim Bauer
    Department of Pharmacology, University Hospital of Cologne, D 50931 Cologne, Germany
    BMJ 343:d4588. 2011
    ..To evaluate the accumulated information from genetic association studies investigating the impact of variants of the cytochrome P450 (CYP) 2C19 genotype on the clinical efficacy of clopidogrel...
  23. ncbi Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection
    Norma Jung
    Department of Internal Medicine I, University of Cologne, Josef Stelzmannstr 6, 50924 Cologne, Germany
    Drug Metab Dispos 36:1616-23. 2008
    ..These data suggest that drug interactions about the OCTs may be relevant for the ARV therapy, in particular by influencing drug accession to infected tissues and hepatic or renal elimination...
  24. ncbi Dietary sources and antioxidant effects of ergothioneine
    Janine Ey
    Department of Pharmacology, University of Cologne, Gleueler Strasse 24, D 50931 Cologne, Germany
    J Agric Food Chem 55:6466-74. 2007
    ..Ergothioneine exhibited cell protection only against copper(II)-induced toxicity but was far less potent than glutathione, indicting that ergothioneine is not involved in the intracellular antioxidant thiol defense system...
  25. ncbi Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3)
    Andreas Lazar
    Department of Pharmacology, School of Medicine and Dentistry, University of Cologne, Gleueler Strasse 24, 50931, Cologne, German
    J Hum Genet 48:226-30. 2003
    ....
  26. ncbi Agmatine signaling: odds and threads
    Reinhard Berkels
    Institut fur Pharmakologie, Klinikum der Universität zu Köln, Gleueler Str 24, D 50931 Köln, Germany
    Cardiovasc Drug Rev 22:7-16. 2004
    ..Although the precise function of endogenously released agmatine is presently still unclear, this review will summarize several aspects concerning the biological function of agmatine...
  27. ncbi The HMG-CoA reductase inhibitor cerivastatin enhances the nitric oxide bioavailability of the endothelium
    Reinhard Berkels
    Institut fuer Pharmakologie, Universitaet zu Koeln, Germany
    J Cardiovasc Pharmacol 42:356-63. 2003
    ..Therefore, there seems to be an acute and a long-term effect of cerivastatin that results in enhanced endothelial NO bioavailability...
  28. ncbi Organic cation transporters and their roles in antiretroviral drug disposition
    Norma Jung
    University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany
    Expert Opin Drug Metab Toxicol 5:773-87. 2009
    ....
  29. ncbi Upregulation and activation of eNOS by resveratrol
    Dirk Taubert
    Circulation 107:e78-9; author reply e78-9. 2003
  30. ncbi A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite
    Nicolas von Beckerath
    Deutsches Herzzentrum, , Lazarettstr. 36, 80636 Munich, Germany
    Thromb Haemost 93:789-91. 2005
  31. ncbi Chocolate and blood pressure in elderly individuals with isolated systolic hypertension
    Dirk Taubert
    JAMA 290:1029-30. 2003