Ernst R Tamm

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection
    Roswitha Seitz
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053, Regensburg, Germany
    Adv Exp Med Biol 801:347-53. 2014
  2. ncbi request reprint [Functional morphology of the outflow pathways of aqueous humor and their changes in open angle glaucoma]
    E R Tamm
    Institut fur Anatomie, Universitat Regensburg, Universitätsstr 31, 93053, Regensburg, Deutschland
    Ophthalmologe 110:1026-35. 2013
  3. ncbi request reprint Status and perspectives of neuroprotective therapies in glaucoma: the European Glaucoma Society White Paper
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitatstrasse 31, 93053, Regensburg, Germany
    Cell Tissue Res 353:347-54. 2013
  4. ncbi request reprint [Development of the human eye]
    E R Tamm
    Institut fur Anatomie, Universitat Regensburg, Regensburg, Deutschland
    Ophthalmologe 109:911-28. 2012
  5. pmc Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
    Shuying He
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Epigenetics Chromatin 3:21. 2010
  6. pmc Rybp, a polycomb complex-associated protein, is required for mouse eye development
    Melinda K Pirity
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 7:39. 2007
  7. ncbi request reprint [Development of the iridocorneal angle and congenital glaucoma]
    E R Tamm
    Institut für Anatomie, Universität Regensburg, Universitätsstr 31, 93053, Regensburg, Deutschland
    Ophthalmologe 108:610-4, 616-7. 2011
  8. ncbi request reprint The trabecular meshwork outflow pathways: structural and functional aspects
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 88:648-55. 2009
  9. pmc Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application
    Klaus Pollinger
    Department of Pharmaceutical Technology, University of Regensburg, 93040 Regensburg, Germany
    Proc Natl Acad Sci U S A 110:6115-20. 2013
  10. pmc Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1020-32. 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection
    Roswitha Seitz
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053, Regensburg, Germany
    Adv Exp Med Biol 801:347-53. 2014
    ....
  2. ncbi request reprint [Functional morphology of the outflow pathways of aqueous humor and their changes in open angle glaucoma]
    E R Tamm
    Institut fur Anatomie, Universitat Regensburg, Universitätsstr 31, 93053, Regensburg, Deutschland
    Ophthalmologe 110:1026-35. 2013
    ..As a result there is an increase in cellular tone in the trabecular outflow pathways leading to an increase in rigidity and outflow resistance. ..
  3. ncbi request reprint Status and perspectives of neuroprotective therapies in glaucoma: the European Glaucoma Society White Paper
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitatstrasse 31, 93053, Regensburg, Germany
    Cell Tissue Res 353:347-54. 2013
    ..The results of the meetings are summarized in this EGS White Paper. ..
  4. ncbi request reprint [Development of the human eye]
    E R Tamm
    Institut fur Anatomie, Universitat Regensburg, Regensburg, Deutschland
    Ophthalmologe 109:911-28. 2012
    ..Examples are aqueous humor circulation, maturation of cones in the foveola, myelination of optic nerve axons and completion of the retinal vasculature...
  5. pmc Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
    Shuying He
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Epigenetics Chromatin 3:21. 2010
    ..Brg1 also controls neural stem cell maintenance, terminal differentiation of multiple cell lineages and organs including the T-cells, glial cells and limbs...
  6. pmc Rybp, a polycomb complex-associated protein, is required for mouse eye development
    Melinda K Pirity
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 7:39. 2007
    ..Here we investigated the requirement for Rybp in ocular development using four in vivo mouse models which resulted in either the ablation or overexpression of Rybp...
  7. ncbi request reprint [Development of the iridocorneal angle and congenital glaucoma]
    E R Tamm
    Institut für Anatomie, Universität Regensburg, Universitätsstr 31, 93053, Regensburg, Deutschland
    Ophthalmologe 108:610-4, 616-7. 2011
    ..More rarely, mutations in latent transforming growth factor beta binding protein 2 (LTBP2) or in the transcription factor FOXC1 have been described as causative for primary congenital glaucoma...
  8. ncbi request reprint The trabecular meshwork outflow pathways: structural and functional aspects
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 88:648-55. 2009
    ..The scleral spur contains axons that innervate scleral spur cells or that have the ultrastructural characteristics of mechanosensory nerve endings...
  9. pmc Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application
    Klaus Pollinger
    Department of Pharmaceutical Technology, University of Regensburg, 93040 Regensburg, Germany
    Proc Natl Acad Sci U S A 110:6115-20. 2013
    ..The presented strategy of targeting integrin receptors in the retina could be of utmost value for future intervention in pathologies of the posterior eye, which are to date only accessible with difficulty...
  10. pmc Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1020-32. 2009
    ..A therapeutic modulation of Smad7 might be a promising approach to influence ECM turnover in the TM and to treat POAG...
  11. pmc Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression
    Walter Paper
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 87:257-67. 2008
    ..Our findings support a role for myocilin in modulating cellular adhesion, and suggest functional processes that involve other proteins of the olfactomedin family...
  12. ncbi request reprint Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/beta-catenin signaling pathway and the induction of neuroprotective growth factors in Muller cells
    Roswitha Seitz
    Institute of Human Anatomy and Embryology, University of Regensburg, D 93053 Regensburg, Germany
    J Neurosci 30:5998-6010. 2010
    ..The effects of Norrin involve activation of Wnt/beta-catenin signaling and subsequent induction of neurotrophic growth factors in Müller cells...
  13. ncbi request reprint Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma
    Markus Kroeber
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Hum Mol Genet 19:3332-42. 2010
    ..Pax6 probably controls the expression of signaling molecules in lens cells that regulate the morphogenetic processes during iridocorneal angle formation...
  14. ncbi request reprint The role of plasmalemma vesicle-associated protein (PLVAP) in endothelial cells of Schlemm's canal and ocular capillaries
    Leonie Herrnberger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, D 93053 Regensburg, Germany
    Exp Eye Res 105:27-33. 2012
    ..PLVAP is expressed in endothelial cells of Schlemm's canal and is essential for the formation of diaphragms in vascular endothelial cells of the eye...
  15. ncbi request reprint Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage
    Barbara M Braunger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, D 93053 Regensburg, Germany
    Neurobiol Dis 50:1-12. 2013
    ..The findings suggest that Norrin and its associated signaling pathways have strong potentials to attenuate photoreceptor death following injury...
  16. ncbi request reprint Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins
    Christiane Sippl
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 93:669-80. 2011
    ..We propose that lack of neurotrophic support due to impaired secretion of neurotrophic proteins is a critical factor that causes or contributes to RGC or motor neuron death in patients with mutated optineurin...
  17. ncbi request reprint Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma
    Dirk D Konz
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1643-9. 2009
    ..In this study, we analyzed the localization of myocilin in the trabecular meshwork (TM) of eyes with primary open-angle glaucoma (POAG), and compared it with that of normal eyes...
  18. ncbi request reprint Modulation of extracellular matrix turnover in the trabecular meshwork
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 88:683-8. 2009
    ..The antagonizing effects of BMP-7 are mediated in trabecular meshwork cells through Smad7. Smad7 is a key molecular switch to inhibit TGF-beta2 signaling in the trabecular meshwork...
  19. ncbi request reprint Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Germany
    Histochem Cell Biol 136:301-19. 2011
    ....
  20. ncbi request reprint Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis
    Daniela C Bohr
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Nephrol Dial Transplant 26:83-92. 2011
    ..Here, we tested if the expression of both proteins is modified during puromycin aminonucleoside (PAN) nephrosis, which leads to structural changes in the actin cytoskeleton of podocytes...
  21. ncbi request reprint Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11
    Antje Wurm
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 86:895-907. 2008
    ..Our findings suggest that SOX11 might similarly be involved in the pathogenesis of ASD in human patients...
  22. ncbi request reprint Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells
    Benjamin Junglas
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1065-75. 2009
    ....
  23. ncbi request reprint Norrin: molecular and functional properties of an angiogenic and neuroprotective growth factor
    Andreas Ohlmann
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, D 93053 Regensburg, Germany
    Prog Retin Eye Res 31:243-57. 2012
    ....
  24. ncbi request reprint Heterozygote Wdr36-deficient mice do not develop glaucoma
    Martin Gallenberger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, D 93053 Regensburg, Germany
    Exp Eye Res 128:83-91. 2014
    ..Our data obtained in Wdr36(+/-) mice do not support the assumption of a causative role for WDR36 in the pathogenesis of POAG. ..
  25. ncbi request reprint Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice
    Andreas Ohlmann
    Institute of Human Anatomy and Embryology, University of Regensburg, D 93053 Regensburg, Germany
    J Neurosci 30:183-93. 2010
    ..The effects of Norrin appear to be mediated, at least partially, via the induction of Ang-2...
  26. ncbi request reprint N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage
    Roswitha Seitz
    Institute for Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Methods Mol Biol 935:99-109. 2013
    ..This chapter provides protocols for applying NMDA-induced excitotoxic damage to RGC of mouse eyes and for subsequent measuring of the extent of the resulting damage...
  27. ncbi request reprint Different collagen types define two types of idiopathic epiretinal membranes
    Michaela Kritzenberger
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Histopathology 58:953-65. 2011
    ..To identify differences in extracellular matrix contents between idiopathic epiretinal membranes (IEM) of cellophane macular reflex (CMRM) or preretinal macular fibrosis (PMFM) type...
  28. ncbi request reprint Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork
    Benjamin Junglas
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Am J Pathol 180:2386-403. 2012
    ..CTGF-overexpressing mice provide a model that mimics the essential functional and structural aspects of POAG and offer a molecular mechanism to explain the increase of its most critical risk factor...
  29. ncbi request reprint Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro
    Martin Gallenberger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitat, Regensburg, Germany
    Hum Mol Genet 20:422-35. 2011
    ..Our results provide evidence that WDR36 is an essential protein in mammalian cells which is involved in the nucleolar processing of SSU 18S rRNA...
  30. ncbi request reprint Programmed cell death during retinal development of the mouse eye
    Barbara M Braunger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053, Regensburg, Germany
    Adv Exp Med Biol 801:9-13. 2014
    ..Important signaling mechanisms that induce programmed cell death of retinal progenitors appear to involve nerve growth factor acting on the proapoptotic receptor to p75 neurotrophin receptor (p75(NTR)) and transforming growth factor-β. ..
  31. ncbi request reprint Ambiguous role of glucocorticoids on survival of retinal neurons
    Tembei K Forkwa
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053, Regensburg, Germany
    Adv Exp Med Biol 801:365-71. 2014
    ..Finally, we summarize potential protective and harmful GC-mediated mechanisms, which might be involved in the determination of neuronal fate in the retina following injury or during degeneration. ..
  32. ncbi request reprint The role of Müller glia and microglia in glaucoma
    Roswitha Seitz
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätstr 31, 93053, Regensburg, Germany
    Cell Tissue Res 353:339-45. 2013
    ..More research is needed to understand the homeostatic signaling network in which retinal glia cells are embedded to maintain or restore neuronal function after injury. ..
  33. ncbi request reprint What increases outflow resistance in primary open-angle glaucoma?
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Germany
    Surv Ophthalmol 52:S101-4. 2007
    ....
  34. ncbi request reprint Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway
    Tembei K Forkwa
    Institute of Human Anatomy and Embryology, University of Regensburg, 93053 Regensburg, Germany
    Exp Neurol 252:28-36. 2014
    ..In summary, we provide evidence that 1) short-term psychosocial stress protects photoreceptors from light-induced damage and 2) the protective effect is most likely mediated by GC-induced activation of the AKT signaling pathway. ..
  35. ncbi request reprint Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice
    Leonie Herrnberger
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053, Regensburg, Germany
    Histochem Cell Biol 138:709-24. 2012
    ..Plvap(-/-) mice provide an animal model to clarify the specific functional role of endothelial fenestrae and their contribution to passage of water and solutes in different organs...
  36. ncbi request reprint Identification of adult stem cells in Schwalbe's line region of the primate eye
    Barbara M Braunger
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Invest Ophthalmol Vis Sci 55:7499-507. 2014
    ..To identify stem cells in the chamber angle of the monkey eye by detection of 5-bromo-2'-deoxyuridine (BrdU) long-term retention...
  37. ncbi request reprint Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage
    Leonie Herrnberger
    Department of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    PLoS ONE 9:e115005. 2014
    ..Lack of fenestrations caused by PLVAP deficiency substantially impairs the passage of chylomicron remnants between liver sinusoids and hepatocytes, and finally leads to liver damage. ..
  38. ncbi request reprint Optineurin associates with the podocyte Golgi complex to maintain its structure
    Christiane Sippl
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
    Cell Tissue Res 358:567-83. 2014
    ..Thus, optineurin appears to play an important role in the maintenance of the podocyte Golgi complex and in the trafficking of vesicles to focal contacts and lysosomes. ..
  39. ncbi request reprint Myocilin modulates programmed cell death during retinal development
    Marcus A Koch
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, D 93053 Regensburg, Germany
    Exp Eye Res 125:41-52. 2014
    ..Myocilin appears to modulate apoptotic death of retinal neurons likely by interacting with the intrinsic apoptotic pathway. ..
  40. pmc Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation
    Myriam Mirza
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany Department of Ophthalmology, University of Cologne, Cologne, Germany
    PLoS ONE 8:e75963. 2013
    ..Our results suggest that microglial reactivity closely accompanies disease progression in the CLN6 (nclf) retina and both processes can be attenuated with dietary supplemented immuno-modulating compounds. ..
  41. ncbi request reprint The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular meshwork cells
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    J Ocul Pharmacol Ther 30:237-45. 2014
    ..Here we studied whether treatment with the prostaglandin F2α analog fluprostenol modulates the CTGF-mediated increase of the TM extracellular matrix...
  42. ncbi request reprint TGF-β signaling protects retinal neurons from programmed cell death during the development of the mammalian eye
    Barbara M Braunger
    Institute of Human Anatomy and Embryology, University of Regensburg, D 93053 Regensburg, Germany
    J Neurosci 33:14246-58. 2013
    ....
  43. ncbi request reprint Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium
    Néstor Más Gómez
    Experimental Ophthalmology, Eye Hospital, University Medical Center Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Pflugers Arch 465:481-95. 2013
    ..In conclusion we found that a proportion of bestrophin-1 is functionally localized to ER Ca(2+) stores where it influences the amount of Ca(2+) and therefore Ca(2+) signals which result from activation of Orai-1 via Stim-1...
  44. ncbi request reprint The role of TGF-β in the pathogenesis of primary open-angle glaucoma
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Cell Tissue Res 347:279-90. 2012
    ....
  45. ncbi request reprint Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans?
    Susanne Schiffner
    University of Regensburg, Institute of Pathology, Molecular Pathology, Franz Joseph Strauss Allee 11, 93053 Regensburg, Germany
    Exp Eye Res 127:59-68. 2014
    ..Further, we showed that GRM1 is expressed in human UM, similar to skin melanoma. This study presents a new mouse model for spontaneous UM and suggests that the glutamate signaling pathway is a possible target for UM therapy. ..
  46. ncbi request reprint Transgenic studies on the role of optineurin in the mouse eye
    Markus Kroeber
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 82:1075-85. 2006
    ..Our results show that optineurin is a cytoplasmatic rather than a secretory protein that is preferentially expressed in retinal ganglion cells, and argue against a major role of optineurin for the modulation of apoptosis in vivo...
  47. pmc Differential angiogenic properties of lithium chloride in vitro and in vivo
    Ludwig F Zeilbeck
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    PLoS ONE 9:e95546. 2014
    ....
  48. ncbi request reprint Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Invest Ophthalmol Vis Sci 48:715-26. 2007
    ..The present study was undertaken to determine whether bone morphogenetic protein (BMP)-7 signaling antagonizes the effects of TGF-beta2 on TM cells...
  49. ncbi request reprint Kidney podocytes as specific targets for cyclo(RGDfC)-modified nanoparticles
    Klaus Pollinger
    Department of Pharmaceutical Technology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Small 8:3368-75. 2012
    ..This could be a highly promising approach for future therapy and diagnostics of podocyte-associated diseases...