B Szabo

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. pmc Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex
    B Szabo
    Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University, Hermann Herder Strasse 5, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 134:295-304. 2001
  2. ncbi request reprint Imidazoline antihypertensive drugs: a critical review on their mechanism of action
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Pharmacol Ther 93:1-35. 2002
  3. ncbi request reprint Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
    B Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg, Germany
    J Pharmacol Exp Ther 297:819-26. 2001
  4. ncbi request reprint Role of I1 imidazoline receptors in the sympathoinhibition produced by intracisternally administered rilmenidine and moxonidine
    B Szabo
    Pharmakologisches Institut, Albert Ludwigs Universitat, Freiburg, Germany
    Arzneimittelforschung 47:1009-15. 1997
  5. ncbi request reprint Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine
    B Szabo
    Department of Pharmacology, University of Freiburg, Germany
    Ann N Y Acad Sci 881:253-64. 1999
  6. ncbi request reprint Cannabinoids depress excitatory neurotransmission between the subthalamic nucleus and the globus pallidus
    I Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Neuroscience 133:305-13. 2005
  7. ncbi request reprint Cannabinoids inhibit striatonigral GABAergic neurotransmission in the mouse
    I Wallmichrath
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104, Freiburg i Br, Germany
    Neuroscience 113:671-82. 2002
  8. doi request reprint Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex
    M J Urbanski
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg im Breisgau, Germany
    Neuroscience 169:1268-78. 2010
  9. pmc Effects of cannabinoids on adrenaline release from adrenal medullary cells
    N Niederhoffer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg i Br, Germany
    Br J Pharmacol 134:1319-27. 2001
  10. ncbi request reprint Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Eur J Neurosci 15:2057-61. 2002

Collaborators

Detail Information

Publications22

  1. pmc Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex
    B Szabo
    Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University, Hermann Herder Strasse 5, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 134:295-304. 2001
    ..The results argue against the hypothesis that rilmenidine and moxonidine, due to their selectivity for sympatho-inhibitory I(1) imidazoline receptors, do not suppress noradrenergic neurons in the central nervous system...
  2. ncbi request reprint Imidazoline antihypertensive drugs: a critical review on their mechanism of action
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Pharmacol Ther 93:1-35. 2002
    ..Peripheral presynaptic inhibition of transmitter release from postganglionic sympathetic neurons contributes to the overall sympathoinhibition...
  3. ncbi request reprint Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
    B Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg, Germany
    J Pharmacol Exp Ther 297:819-26. 2001
    ..The mechanism of the inhibition of vagal activity was not clarified: cannabinoids may have an inhibitory action on both pre- and postganglionic vagal neurons...
  4. ncbi request reprint Role of I1 imidazoline receptors in the sympathoinhibition produced by intracisternally administered rilmenidine and moxonidine
    B Szabo
    Pharmakologisches Institut, Albert Ludwigs Universitat, Freiburg, Germany
    Arzneimittelforschung 47:1009-15. 1997
    ..alpha 2-Adrenoceptors are responsible for the sympathoinhibition produced by guanabenz. In contrast, I1 imidazoline receptors are involved in the sympathoinhibition caused by rilmenidine and moxonidine...
  5. ncbi request reprint Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine
    B Szabo
    Department of Pharmacology, University of Freiburg, Germany
    Ann N Y Acad Sci 881:253-64. 1999
    ....
  6. ncbi request reprint Cannabinoids depress excitatory neurotransmission between the subthalamic nucleus and the globus pallidus
    I Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Neuroscience 133:305-13. 2005
    ..Cannabinoids elicit catalepsy in vivo. The observed inhibition of glutamatergic neurotransmission in the globus pallidus would favor catalepsy...
  7. ncbi request reprint Cannabinoids inhibit striatonigral GABAergic neurotransmission in the mouse
    I Wallmichrath
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104, Freiburg i Br, Germany
    Neuroscience 113:671-82. 2002
    ..Endocannabinoids released from SNR neurons can modulate striatonigral neurotransmission by inhibiting GABA release from terminals of striatonigral axons...
  8. doi request reprint Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex
    M J Urbanski
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg im Breisgau, Germany
    Neuroscience 169:1268-78. 2010
    ..The produced endocannabinoid, in turn, suppresses the GABAergic synaptic input to the neuron by activating CB(1) cannabinoid receptors...
  9. pmc Effects of cannabinoids on adrenaline release from adrenal medullary cells
    N Niederhoffer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg i Br, Germany
    Br J Pharmacol 134:1319-27. 2001
    ..The inhibition of adrenaline secretion in adrenal glands most probably accounts for the decrease in the plasma adrenaline concentration observed after cannabinoid administration in pithed rabbits...
  10. ncbi request reprint Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Eur J Neurosci 15:2057-61. 2002
    ..Depression of the GABAergic inhibitory input of dopaminergic neurons would increase their firing rate in vivo. Accordingly, dopamine release in the projection region of VTA neurons, the nucleus accumbens, would also increase...
  11. pmc Autoimmune hypertensive syndrome
    David C Kem
    Department of Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, USA
    Hypertension 50:829-34. 2007
  12. pmc Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universität Albertstrasse 25, D 79104 Freiburg im Breisgau, Germany
    J Physiol 577:263-80. 2006
    ....
  13. pmc Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice
    Ilka Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, D 79104 Freiburg i Br, Germany
    J Physiol 575:789-806. 2006
    ..The cannabinoids acted preferentially on axon terminals without effects on the somatodendritic region of the neurons...
  14. ncbi request reprint Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse
    Birgit Engler
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Freiburg, Germany
    J Pharmacol Exp Ther 316:608-17. 2006
    ..Depression of the action potential-evoked calcium influx into axon terminals is the probable mechanism of this inhibition...
  15. ncbi request reprint Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system
    Torsten Pfitzer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, 79104 Freiburg i Br, Germany
    Naunyn Schmiedebergs Arch Pharmacol 371:9-17. 2005
    ....
  16. pmc Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats
    Torsten Pfitzer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 142:943-52. 2004
    ..4 Our results show that activation of CB1 cannabinoid receptors in the brain stem depresses respiration and enhances sympathetic tone and cardiac vagal tone. Opioid mechanisms are not involved in these central cannabinoid effects...
  17. ncbi request reprint Analysis of the effects of cannabinoids on synaptic transmission between basket and Purkinje cells in the cerebellar cortex of the rat
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    J Pharmacol Exp Ther 310:915-25. 2004
    ..This was demonstrated under near-physiological conditions: transmitter release was elicited by action potentials generated by spontaneously firing intact presynaptic neurons...
  18. ncbi request reprint Analysis of the effect of cannabinoids on GABAergic neurotransmission in the substantia nigra pars reticulata
    Ilka Wallmichrath
    Institut für Experimentelle und Klinische Pharmakologie der Albert Ludwigs Universität, Albertstrasse 25, 79104 Freiburg i Br, Germany
    Naunyn Schmiedebergs Arch Pharmacol 365:326-34. 2002
    ..No direct actions of cannabinoids on SNR neurons were observed in addition to this synaptic effect...
  19. ncbi request reprint The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression
    Nathalie Niederhoffer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104 Freiburg i Br, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:434-43. 2003
    ..The cannabinoid-evoked cardiovascular depression depends strongly on the respiratory state of the animals...
  20. ncbi request reprint Analysis of the function of GABA(B) receptors on inhibitory afferent neurons of Purkinje cells in the cerebellar cortex of the rat
    Marta Than
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Eur J Neurosci 15:1575-84. 2002
    ....
  21. ncbi request reprint Analysis of the respiratory effects of cannabinoids in rats
    Karin Schmid
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104, Freiburg i Br, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:301-8. 2003
    ..The second major finding of the present study is that the respiratory depression evoked by cannabinoids largely amplifies the cardiovascular depression...
  22. ncbi request reprint The effects of thoracic epidural anesthesia on hepatic perfusion and oxygenation in healthy pigs during general anesthesia and surgical stress
    Dierk A Vagts
    Anaesthesiologische Universitätsklinik Freiburg, Freiburg im Breisgau, Germany
    Anesth Analg 97:1824-32. 2003
    ..We conclude that, despite decreased mean arterial blood pressure, TEA did not affect liver oxygenation. There was no clinically relevant effect of volume loading on total hepatic perfusion...