Srinivasa Subramaniam

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death
    S Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, D 69120, Heidelberg, Germany
    Neuroscience 138:1055-65. 2006
  2. pmc ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 2 OG, D 69120 Heidelberg, Germany
    J Cell Biol 165:357-69. 2004
  3. ncbi request reprint Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 25:2838-52. 2005
  4. ncbi request reprint Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    J Biol Chem 278:8904-12. 2003
  5. doi request reprint Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death
    K Lakshmi Narayanan
    Interdisciplinary Centerfor Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurosci Lett 446:117-22. 2008
  6. ncbi request reprint Glutamate activates NF-kappaB through calpain in neurons
    Marion N Scholzke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Neurosci 18:3305-10. 2003
  7. ncbi request reprint GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, 69120, Heidelberg, Germany
    Cell Tissue Res 331:373-83. 2008
  8. pmc Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat, Heidelberg, Germany
    Neural Dev 4:11. 2009
  9. ncbi request reprint TGF-beta induces cell death in the oligodendroglial cell line OLI-neu
    Norbert Schuster
    Department of Anatomy and Cell Biology, Medical Faculty, University of Saarland, Homburg Saar, Germany
    Glia 40:95-108. 2002
  10. ncbi request reprint Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices
    Neelam Shahani
    Department of Neurobiology, University of Osnabruck, 49076 Osnabruck, Germany
    J Neurosci 26:6103-14. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death
    S Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, D 69120, Heidelberg, Germany
    Neuroscience 138:1055-65. 2006
    ..Further, we discuss the mechanisms and the putative molecular inter-players associated with ERK-mediated neuronal death...
  2. pmc ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 2 OG, D 69120 Heidelberg, Germany
    J Cell Biol 165:357-69. 2004
    ..Antioxidants that reduced ERK activation and PM damage showed no effect on caspase-3 activation or DNA damage. These data identify ERK as an important executor of neuronal damage involving a caspase-3-independent mechanism...
  3. ncbi request reprint Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 25:2838-52. 2005
    ..Together, these data demonstrate that IGF-1 can positively and negatively regulate the ERK pathway in the same neuronal cell, and provide new insights into the PI3K/Akt/PKA signaling pathways in IGF-1-mediated neuronal survival...
  4. ncbi request reprint Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    J Biol Chem 278:8904-12. 2003
    ..Furthermore, we show that GDF-15 prevented generation of reactive oxygen species, a known activator of ERK. Together, our data suggest that GDF-15 prevents apoptosis in CGN by activating Akt and inhibiting endogenously active ERK...
  5. doi request reprint Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death
    K Lakshmi Narayanan
    Interdisciplinary Centerfor Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurosci Lett 446:117-22. 2008
    ..Thus, TRPC1 may represent a promising target for pharmacological interventions to prevent or reduce glutamate-induced neuronal damage...
  6. ncbi request reprint Glutamate activates NF-kappaB through calpain in neurons
    Marion N Scholzke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Neurosci 18:3305-10. 2003
    ..NF-kappaB activation by calpain may mediate the long-term effects of glutamate on neuron survival or memory formation...
  7. ncbi request reprint GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, 69120, Heidelberg, Germany
    Cell Tissue Res 331:373-83. 2008
    ..GDNF inhibits caspase-3-dependent DNA fragmentation but does not affect ERK-dependent PM damage. However, GDNF can attenuate TGF-beta-induced p38-MAPK-dependent PM damage via the PI3K pathway...
  8. pmc Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat, Heidelberg, Germany
    Neural Dev 4:11. 2009
    ....
  9. ncbi request reprint TGF-beta induces cell death in the oligodendroglial cell line OLI-neu
    Norbert Schuster
    Department of Anatomy and Cell Biology, Medical Faculty, University of Saarland, Homburg Saar, Germany
    Glia 40:95-108. 2002
    ....
  10. ncbi request reprint Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices
    Neelam Shahani
    Department of Neurobiology, University of Osnabruck, 49076 Osnabruck, Germany
    J Neurosci 26:6103-14. 2006
    ..Furthermore, they demonstrate that targeted expression of tau in hippocampal slices provides a novel model to analyze tau modification and spatiotemporal dynamics of tau-dependent neurodegeneration in an authentic CNS environment...