C A Stuermer

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. pmc Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking
    Gonzalo P Solis
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Mol Biol Cell 24:2689-702. 2013
  2. doi request reprint How reggies regulate regeneration and axon growth
    Claudia A O Stuermer
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Cell Tissue Res 349:71-7. 2012
  3. pmc Evolution of prokaryotic SPFH proteins
    Markus Hinderhofer
    Department of Biology, Neurobiology, University of Konstanz, Konstanz, Germany
    BMC Evol Biol 9:10. 2009
  4. doi request reprint Microdomain-forming proteins and the role of the reggies/flotillins during axon regeneration in zebrafish
    Claudia A O Stuermer
    University of Konstanz, Department of Biology, Konstanz, Germany
    Biochim Biophys Acta 1812:415-22. 2011
  5. doi request reprint The reggie/flotillin connection to growth
    Claudia A O Stuermer
    University of Konstanz, Department of Biology, 78457 Konstanz, Germany
    Trends Cell Biol 20:6-13. 2010
  6. ncbi request reprint The retinal axon's pathfinding to the optic disk
    C A Stuermer
    Department of Biology, Developmental Neurobiology, University of Konstanz, 78457, Konstanz, Germany
    Prog Neurobiol 62:197-214. 2000
  7. ncbi request reprint PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction
    Claudia A O Stuermer
    Department of Biology University of Konstanz, 78457 Konstanz, Germany
    FASEB J 18:1731-3. 2004
  8. doi request reprint Reggie/flotillin and the targeted delivery of cargo
    Claudia A O Stuermer
    Department of Biology, University of Konstanz, Konstanz, Germany
    J Neurochem 116:708-13. 2011
  9. pmc Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2
    C A Stuermer
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Mol Biol Cell 12:3031-45. 2001
  10. ncbi request reprint E587 antigen is upregulated by goldfish oligodendrocytes after optic nerve lesion and supports retinal axon regeneration
    R Ankerhold
    Division of Biology, University of Konstanz, Germany
    Glia 23:257-70. 1998

Collaborators

  • M F Langhorst
  • Edward Malaga-Trillo
  • Martin E Schwab
  • Lawrence Rajendran
  • Helmut Plattner
  • Gonzalo P Solis
  • Andreas H Guse
  • Daniel F Legler
  • M Jung
  • John S Taylor
  • Thomas Oertle
  • Dirk M Lang
  • Birgit Oidtmann
  • A Meyer
  • Yi Zhou
  • V L Katanaev
  • Heike Diekmann
  • Michael Klinger
  • Eric Rivera-Milla
  • Alexander Reuter
  • H Ott
  • Markus Hinderhofer
  • Houari Abdesselem
  • Nathalie M Veith
  • Yvonne Schrock
  • Vsevolod Bodrikov
  • Christina Munderloh
  • Harald Illges
  • Martin Hoehne
  • Anne C von Philipsborn
  • Christina Haenisch
  • Dietmar Heinz
  • Carolin Neumann-Giesen
  • M Bastmeyer
  • Soeren Oliver Deininger
  • Samuel Solomon
  • Hua Shen
  • S H Bauer
  • Marianne Wiechers
  • Anke Friemel
  • Alexander Burkle
  • Heiko M Möller
  • Aleksandra Shypitsyna
  • Christina A Walker
  • Friederike A Jaeger
  • Walter J Schulz-Schaeffer
  • Theodoros Sklaviadis
  • Cynthia H Panagiotidis
  • Rudolf Hoffmann
  • Michael Baier
  • R Ankerhold
  • H Gert de Couet
  • Anna Ferrer-Vaquer
  • John Y Kuwada
  • Gianfranco Gennarini
  • Karl Friedrich Fischbach
  • Hans Martin Pogoda
  • Barbara Petrausch
  • Bianca Falkenbach
  • Peter Beicht
  • Sylvia Hannbeck von Hanwehr
  • Stephanie Claasen
  • Volker Herzog
  • Cordula Hirsch
  • Georg Lüers
  • Ritva Tikkanen
  • Friedrich Lottspeich
  • Michael Przybylski
  • Martin Bastmeyer
  • Madhan Masilamani
  • U Laessing
  • M F Wiechers
  • M Przybylski
  • H Diekmann
  • K Bruns
  • C A Leppert

Detail Information

Publications45

  1. pmc Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking
    Gonzalo P Solis
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Mol Biol Cell 24:2689-702. 2013
    ..Together our results identify reggie-1 as a regulator of the Rab11a/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved. ..
  2. doi request reprint How reggies regulate regeneration and axon growth
    Claudia A O Stuermer
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Cell Tissue Res 349:71-7. 2012
    ....
  3. pmc Evolution of prokaryotic SPFH proteins
    Markus Hinderhofer
    Department of Biology, Neurobiology, University of Konstanz, Konstanz, Germany
    BMC Evol Biol 9:10. 2009
    ..To gain better insight into this very diverse protein family, we have analyzed the genomes of 497 microorganisms and investigated the pattern of occurrence as well as the genomic vicinity of the prokaryotic SPFH members...
  4. doi request reprint Microdomain-forming proteins and the role of the reggies/flotillins during axon regeneration in zebrafish
    Claudia A O Stuermer
    University of Konstanz, Department of Biology, Konstanz, Germany
    Biochim Biophys Acta 1812:415-22. 2011
    ..Thus, reggies regulate the targeted delivery of cargo-a process which is required for process extension and growth. This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases...
  5. doi request reprint The reggie/flotillin connection to growth
    Claudia A O Stuermer
    University of Konstanz, Department of Biology, 78457 Konstanz, Germany
    Trends Cell Biol 20:6-13. 2010
    ....
  6. ncbi request reprint The retinal axon's pathfinding to the optic disk
    C A Stuermer
    Department of Biology, Developmental Neurobiology, University of Konstanz, 78457, Konstanz, Germany
    Prog Neurobiol 62:197-214. 2000
    ..This response requires the axonal netrin receptor DCC, laminin-1, beta-integrin and most likely the UNC5H netrin receptors which convert the growth encouraging signal into a repulsive one which drives growth cones into the nerve...
  7. ncbi request reprint PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction
    Claudia A O Stuermer
    Department of Biology University of Konstanz, 78457 Konstanz, Germany
    FASEB J 18:1731-3. 2004
    ....
  8. doi request reprint Reggie/flotillin and the targeted delivery of cargo
    Claudia A O Stuermer
    Department of Biology, University of Konstanz, Konstanz, Germany
    J Neurochem 116:708-13. 2011
    ....
  9. pmc Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2
    C A Stuermer
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Mol Biol Cell 12:3031-45. 2001
    ..Thus, reggie-1 and -2 define raft-related microdomain signaling centers in neurons and T cells, and the protein complex involved in signaling becomes subject to degradation...
  10. ncbi request reprint E587 antigen is upregulated by goldfish oligodendrocytes after optic nerve lesion and supports retinal axon regeneration
    R Ankerhold
    Division of Biology, University of Konstanz, Germany
    Glia 23:257-70. 1998
    ....
  11. ncbi request reprint Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk
    H Ott
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    J Neurosci 18:3363-72. 1998
    ..Because disrupted fascicles and errant axon routes were found only in the dorsal retinal half, a cooperation with so-called positional markers may be conceived...
  12. ncbi request reprint Topographic restriction of TAG-1 expression in the developing retinotectal pathway and target dependent reexpression during axon regeneration
    D M Lang
    Department of Biology, University of Konstanz, , Konstanz, 78467, Germany
    Mol Cell Neurosci 17:398-414. 2001
    ..The topographic restriction of TAG-1 expression and its target dependency during regeneration suggests that TAG-1 might play a role in the retinotopic organization and restoration of the retinotectal pathway...
  13. ncbi request reprint Isolation and identification of the plasma membrane-associated intracellular protein reggie-2 from goldfish brain by chromatography and Fourier-transform ion cyclotron resonance mass spectrometry
    S H Bauer
    Department of Biology, University of Konstanz, Konstanz, 78457, Germany
    Anal Biochem 298:25-31. 2001
    ....
  14. ncbi request reprint The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration
    Christina Haenisch
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Mol Cell Neurosci 28:361-74. 2005
    ..In adult goldfish, Cntn1b is expressed in oligodendrocytes and is upregulated in retinal ganglion cells after optic nerve transection, which is consistent with an additional role during regeneration...
  15. ncbi request reprint Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons
    Soeren Oliver Deininger
    Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany
    Mol Cell Neurosci 22:544-54. 2003
    ..These findings suggest a role of clustered M802 antigen/Thy-1 in reggie raft microdomains for cell growth and axon regeneration...
  16. ncbi request reprint Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    FASEB J 20:711-3. 2006
    ..Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation...
  17. ncbi request reprint Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons
    D M Lang
    Department of Biology, University of Konstanz, Germany
    J Neurobiol 37:502-23. 1998
    ..Thus, reggie-1 and reggie-2 identify sites where activated GPI-linked CAMs preferentially accumulate and which may represent noncaveolar micropatches (domains)...
  18. pmc Regulation of embryonic cell adhesion by the prion protein
    Edward Malaga-Trillo
    Department of Biology, University of Konstanz, Konstanz, Germany
    PLoS Biol 7:e55. 2009
    ..Altogether, our data uncover evolutionarily conserved roles of PrP in cell communication, which ultimately impinge on the stability of adherens cell junctions during embryonic development...
  19. doi request reprint Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:211-26. 2008
    ..Thus, regulated vesicular cycling might be a general feature of SPFH protein-dependent trafficking...
  20. ncbi request reprint Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons
    Eric Rivera-Milla
    Department of Biology, University of Konstanz, Konstanz, Germany
    FASEB J 20:317-9. 2006
    ....
  21. pmc Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
    Vladimir L Katanaev
    Department of Biology, TransRegio SFB11, University of Konstanz, Konstanz, Germany
    EMBO J 27:509-21. 2008
    ..In its action reggie-1 appears specific for Wnt and Hedgehog. These data suggest that reggie-1 is an important component of the Wnt and Hedgehog secretion pathway dedicated to formation of the mobile pool of these morphogens...
  22. ncbi request reprint Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Universitaetsstrasse 10, D 78457 Konstanz, Germany
    FEBS Lett 581:4697-703. 2007
    ....
  23. ncbi request reprint Analysis of the reticulon gene family demonstrates the absence of the neurite growth inhibitor Nogo-A in fish
    Heike Diekmann
    Department of Biology, University of Konstanz, Konstanz, Germany
    Mol Biol Evol 22:1635-48. 2005
    ..This result is in accordance with functional data showing that axon growth inhibitory molecules are less prominent in fish oligodendrocytes and CNS myelin compared to mammals...
  24. doi request reprint Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding
    Heike Diekmann
    Department of Biology, Universitat Konstanz, Konstanz, Germany
    J Comp Neurol 513:38-50. 2009
    ..Without Neurolin-b, RGC axons grow in highly aberrant routes along the optic tract and/or fail to reach the optic tectum. Thus, the zebrafish Neurolin paralogs are involved in distinct steps of retinotectal development...
  25. ncbi request reprint Evolution of duplicated reggie genes in zebrafish and goldfish
    Edward Malaga-Trillo
    Department of Biology, University of Konstanz, Germany
    J Mol Evol 54:235-45. 2002
    ..An evolutionary scenario for the evolution of reggie intron-exon structure, where loss of introns appears to be a distinctive trait in invertebrate reggie genes, is presented...
  26. ncbi request reprint Function of Neurolin (DM-GRASP/SC-1) in guidance of motor axons during zebrafish development
    H Ott
    Department of Biology, University of Konstanz, Fach M626, Konstanz, D-78457, Germany
    Dev Biol 235:86-97. 2001
    ..Consistent with this idea is the binding pattern of a soluble Neurolin-Fc construct showing that putative ligands are distributed along the common path, the ventral projection, and in the area where the rostral projection develops...
  27. doi request reprint Reggies/flotillins regulate retinal axon regeneration in the zebrafish optic nerve and differentiation of hippocampal and N2a neurons
    Christina Munderloh
    Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    J Neurosci 29:6607-15. 2009
    ....
  28. doi request reprint Reggies/flotillins regulate cytoskeletal remodeling during neuronal differentiation via CAP/ponsin and Rho GTPases
    Matthias F Langhorst
    Department of Biology, University of Konstanz, Developmental Neurobiology Group, Universitatsstrasse 10, D 78457 Konstanz, Germany
    Eur J Cell Biol 87:921-31. 2008
    ..Thus, the reggies/flotillins are crucial for coordinated assembly of signaling complexes regulating cytoskeletal remodeling...
  29. doi request reprint No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve
    Houari Abdesselem
    Developmental Neurobiology, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    J Neurosci 29:15489-98. 2009
    ..Thus, not only was the NogoA-specific domain lost in fish, but Nogo66, the second inhibitory domain in mammals, and its signaling upon binding to NgR, was modified so that ZF-Nogo/RTN-4 does not impair axon regeneration...
  30. ncbi request reprint An evolutionary basis for scrapie disease: identification of a fish prion mRNA
    Eric Rivera-Milla
    Department of Biology, University of Konstanz, 78457, Konstanz, Germany
    Trends Genet 19:72-5. 2003
    ..We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals...
  31. pmc Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells
    Lawrence Rajendran
    Division of Immunology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Proc Natl Acad Sci U S A 100:8241-6. 2003
    ..We present evidence that the asymmetric concentration of these microdomain resident proteins is built up during cytokinesis...
  32. ncbi request reprint Restricted expression of reggie genes and proteins during early zebrafish development
    Anne C von Philipsborn
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    J Comp Neurol 482:257-72. 2005
    ..Upon segmentation, a second phase of expression shows distinctly localized expression patterns, indicating tissue-specific roles and an involvement of re-1a/re-2a in neural development...
  33. ncbi request reprint Identification of Nogo-66 receptor (NgR) and homologous genes in fish
    Michael Klinger
    Department of Biology, University of Konstanz, Konstanz, Germany
    Mol Biol Evol 21:76-85. 2004
    ..Expression of zebrafish NgR homologs was detected relatively early in development and prominently in the adult brain, suggesting functions in axon growth, guidance, or plasticity...
  34. ncbi request reprint Spatiotemporal pattern of retinal ganglion cell differentiation revealed by the expression of neurolin in embryonic zebrafish
    U Laessing
    Faculty of Biology, University of Konstanz, Germany
    J Neurobiol 29:65-74. 1996
    ..The spatiotemporal expression pattern of neurolin suggests a functional significance of this cell adhesion molecule in RGC recognition and RGC axon growth...
  35. ncbi request reprint Cloning, expression, and alternative splicing of neogenin1 in zebrafish
    Hua Shen
    Department of Biology, University of Konstanz, P O Box M662, D 78457 Konstanz, Germany
    Mech Dev 118:219-23. 2002
    ..Alternative splicing generates several isoforms of zneo1. Most of them are developmentally regulated, showing distinct distribution in brain and other tissues...
  36. ncbi request reprint Cellular roles of the prion protein in association with reggie/flotillin microdomains
    Gonzalo P Solis
    University of Konstanz, Department of Biology, 78457 Konstanz, Germany
    Front Biosci (Landmark Ed) 15:1075-85. 2010
    ....
  37. ncbi request reprint Identification of two NOGO/RTN4 genes and analysis of Nogo-A expression in Xenopus laevis
    Michael Klinger
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Mol Cell Neurosci 25:205-16. 2004
    ..Nogo-A in Xenopus myelin might therefore contribute to the failure of spinal cord regeneration in frogs-a feature that may have evolved during the transition from fish to land vertebrates...
  38. doi request reprint Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy
    Nathalie M Veith
    Molecular Toxicology, Department of Biology, University of Konstanz, Box X911, D 78457 Konstanz, Germany
    Eur J Cell Biol 88:45-63. 2009
    ..Finally, we observed the release of PrPC/PrPSc via exocytotic pathways, i.e. via exosomes and as an opaque electron-dense mass which may represent a mechanism of intercellular spreading of infectious prions...
  39. ncbi request reprint The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs
    Samuel Solomon
    Faculty of Sciences, Department of Biology, University of Konstanz, Germany
    Immunobiology 205:108-19. 2002
    ..Since reggie/flotillin proteins co-cluster with the T cell receptor and fyn kinases upon T cell stimulation, our findings of reggie-1/flotillin-2 in B cells suggest a similar role in B cell function...
  40. pmc Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains
    Gonzalo P Solis
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Biochem J 403:313-22. 2007
    ..Our data indicate that the basic structural units of reggie microdomains are reggie homo- and hetero-tetramers, which are dependent on the presence of reggie-1...
  41. ncbi request reprint Accumulation of FlAsH/Lumio Green in active mitochondria can be reversed by beta-mercaptoethanol for specific staining of tetracysteine-tagged proteins
    Matthias F Langhorst
    Developmental Neurobiology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457, Konstanz, Germany
    Histochem Cell Biol 125:743-7. 2006
    ..Furthermore, we show that staining efficiency was greatly enhanced by introducing a second tetracysteine sequence in tandem...
  42. doi request reprint Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)
    Yvonne Schrock
    Department of Biology, University of Konstanz, Universitaetsstrasse 10, 78464 Konstanz, Germany
    FEBS Lett 583:389-93. 2009
    ..Altogether, PrP modulates process formation and FA dynamics, possibly via signal transduction involving FAK and Src...
  43. ncbi request reprint Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development
    Martin Hoehne
    Institut fur Biologie III, Schänzlestr 1, 79104 Freiburg, Germany
    Mol Cell Neurosci 30:326-38. 2005
    ..Our data support the notion that Reggie/Flotillin proteins are implicated in signaling processes at cellular contact sites...
  44. ncbi request reprint A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    FASEB J 17:1238-47. 2003
    ..These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons...
  45. pmc Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression
    Carolin Neumann-Giesen
    Institute of Biochemistry II, Medical School, University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Biochem J 378:509-18. 2004
    ..Overexpression of reggie-1 resulted in the induction of numerous filopodia-like protrusions in various cell lines, suggesting a role for reggie-1 as a signalling protein in actin-dependent processes...