Frank Stuber

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Oxidoreductase Macrophage Migration Inhibitory Factor is simultaneously increased in leukocyte subsets of patients with severe sepsis
    Lutz E Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitat Bonn, Bonn, Germany
    Biofactors 33:281-91. 2008
  2. pmc Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis
    Stefan U Weber
    Department of Anesthesiology and Intensive Care Medicine, University Bonn Medical Center, Sigmund Freud Strasse 25, 53129 Bonn, Germany
    Crit Care 12:R128. 2008
  3. doi request reprint [Bench reaches the bedside. Rethinking pathogen diagnostics]
    F Stuber
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitat Bonn, Sigmund Freud Str 25, 53105, Bonn
    Anaesthesist 57:325. 2008
  4. ncbi request reprint Cytokine promoter polymorphisms in severe sepsis
    Frank Stuber
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Clin Infect Dis 41:S416-20. 2005
  5. doi request reprint Improved detection of blood stream pathogens by real-time PCR in severe sepsis
    Lutz Eric Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitätsklinik Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Intensive Care Med 36:49-56. 2010
  6. doi request reprint CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care
    Ulrike M Stamer
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Anesth Analg 113:48-54. 2011
  7. pmc Inducibility of the endogenous antibiotic peptide beta-defensin 2 is impaired in patients with severe sepsis
    Malte Book
    Department of Anaesthesiology and Intensive Care Medicine, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Crit Care 11:R19. 2007
  8. ncbi request reprint Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    Ulrike M Stamer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anesth Analg 107:926-9. 2008
  9. ncbi request reprint A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass
    Lutz E Lehmann
    Klinik und Poliklinik für Anästhesie und operative Intensivmedizin der Universität Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Cardiothorac Surg 30:59-63. 2006
  10. ncbi request reprint Real-time polymerase chain-reaction detection of pathogens is feasible to supplement the diagnostic sequence for urinary tract infections
    Lutz E Lehmann
    Clinic and Policlinic for Anaesthesia and Operative Intensive Care, Bonn University, Bonn, Germany
    BJU Int 106:114-20. 2010

Detail Information

Publications38

  1. ncbi request reprint Oxidoreductase Macrophage Migration Inhibitory Factor is simultaneously increased in leukocyte subsets of patients with severe sepsis
    Lutz E Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitat Bonn, Bonn, Germany
    Biofactors 33:281-91. 2008
    ..05). This finding underlines the role of intracellular MIF in inflammatory diseases. It suggests monitoring of intracellular MIF in further clinical and non-clinical research valuable...
  2. pmc Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis
    Stefan U Weber
    Department of Anesthesiology and Intensive Care Medicine, University Bonn Medical Center, Sigmund Freud Strasse 25, 53129 Bonn, Germany
    Crit Care 12:R128. 2008
    ..This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis...
  3. doi request reprint [Bench reaches the bedside. Rethinking pathogen diagnostics]
    F Stuber
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitat Bonn, Sigmund Freud Str 25, 53105, Bonn
    Anaesthesist 57:325. 2008
  4. ncbi request reprint Cytokine promoter polymorphisms in severe sepsis
    Frank Stuber
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Clin Infect Dis 41:S416-20. 2005
    ..Cytokine promoter variants may contribute substantially to studies of genetic predisposition of sepsis because they operate in a gene region of high regulatory activity...
  5. doi request reprint Improved detection of blood stream pathogens by real-time PCR in severe sepsis
    Lutz Eric Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitätsklinik Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Intensive Care Med 36:49-56. 2010
    ....
  6. doi request reprint CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care
    Ulrike M Stamer
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Anesth Analg 113:48-54. 2011
    ..Additionally, the effects of doubling the ondansetron dose on genotype-dependent plasma concentrations were investigated...
  7. pmc Inducibility of the endogenous antibiotic peptide beta-defensin 2 is impaired in patients with severe sepsis
    Malte Book
    Department of Anaesthesiology and Intensive Care Medicine, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Crit Care 11:R19. 2007
    ..This study investigated the basic expression levels and the ex vivo inducibility of hBD2 mRNA in peripheral whole blood cells from patients with severe sepsis in comparison to non-septic critically ill patients and healthy individuals...
  8. ncbi request reprint Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    Ulrike M Stamer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anesth Analg 107:926-9. 2008
    ....
  9. ncbi request reprint A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass
    Lutz E Lehmann
    Klinik und Poliklinik für Anästhesie und operative Intensivmedizin der Universität Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Cardiothorac Surg 30:59-63. 2006
    ....
  10. ncbi request reprint Real-time polymerase chain-reaction detection of pathogens is feasible to supplement the diagnostic sequence for urinary tract infections
    Lutz E Lehmann
    Clinic and Policlinic for Anaesthesia and Operative Intensive Care, Bonn University, Bonn, Germany
    BJU Int 106:114-20. 2010
    ..To evaluate, in a prospective pilot study, the feasibility of identifying pathogens in urine using real-time polymerase chain reaction (PCR), and to compare the results with the conventional urine culture-based procedures...
  11. ncbi request reprint A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples
    Lutz Eric Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:313-24. 2008
    ..8%. The analytical specificity in 102 healthy blood donors was 100%. Although further evaluation is warranted, our assay holds promise for more rapid pathogen identification in clinical sepsis...
  12. ncbi request reprint Low serum alpha-tocopherol and selenium are associated with accelerated apoptosis in severe sepsis
    Stefan U Weber
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Bonn, Germany
    Biofactors 33:107-19. 2008
    ..Accelerated apoptosis in sepsis is associated with low alpha-tocopherol and selenium. The results support the investigation of micronutrient supplementation strategies in severe sepsis...
  13. pmc CYP2D6 genotype dependent oxycodone metabolism in postoperative patients
    Ulrike M Stamer
    Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern, Bern, Switzerland
    PLoS ONE 8:e60239. 2013
    ..However, there are only spare data from postoperative settings. The hypothesis of this study is that genotype dependent CYP2D6 activity influences plasma concentrations of oxycodone and its metabolites and impacts analgesic consumption...
  14. ncbi request reprint TNF-alpha promoter polymorphism in relation to TNF-alpha production and clinical status in cystic fibrosis
    Sabina Schmitt-Grohe
    Department of Pediatrics, University of Bonn, Bonn, Germany
    Lung 184:99-104. 2006
    ..There were no significant differences for TNF values after LPS stimulation and the incidence of diabetes mellitus. The TNF-308 promoter polymorphism does not seem to influence TNF-alpha release in whole blood cells and clinical status...
  15. doi request reprint Hyperbaric oxygen induces apoptosis via a mitochondrial mechanism
    Stefan U Weber
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Apoptosis 14:97-107. 2009
    ..Regulation of Fas and Bcl-2 may be regarded as protective measures of the cell in response to hyperbaric oxygen...
  16. ncbi request reprint Genomic variations and transcriptional regulation of the human mu-opioid receptor gene
    Bettina Bayerer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Pain 11:421-7. 2007
    ..Individuals presenting these variations may have an altered level of MOR expression. A possible association of these genomic variants on efficacy and side effects of opioid treatment in different ethnic groups has to be elucidated...
  17. ncbi request reprint Screening of copy number polymorphisms in human beta-defensin genes using modified real-time quantitative PCR
    Qixing Chen
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, 53105 Bonn, Germany
    J Immunol Methods 308:231-40. 2006
    ..This method proved to be a reliable and fast tool to genotype gene copy number variations in projects associating genomic variations with gene expression or with population phenotypes in epidemiologic studies...
  18. ncbi request reprint Comparison of different decontamination methods for reagents to detect low concentrations of bacterial 16S DNA by real-time-PCR
    Sven Klaschik
    Klinik und Poliklinik fur Anasthesiologie und spezielle Intensivmedizin, Universitat Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Mol Biotechnol 22:231-42. 2002
    ..However, decontamination with DNAse may help, together with the use of highly purified PCR reagents, in detecting small amounts of bacterial DNA in clinical specimens...
  19. doi request reprint Is detection of bacterial DNA in ascitic fluid of clinical relevance?
    Beate Appenrodt
    Departments of aInternal Medicine I, University of Bonn, Bonn, Germany
    Eur J Gastroenterol Hepatol 22:1487-94. 2010
    ..However, the clinical relevance of this finding is ill-defined especially compared with the standard diagnostics for detection of spontaneous bacterial peritonitis (SBP). Furthermore, other DNA tests have not been sufficiently evaluated...
  20. doi request reprint Antagonistic effects of ondansetron and tramadol? A randomized placebo and active drug controlled study
    Neele I Rauers
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    J Pain 11:1274-81. 2010
    ..Co-administration of ondansetron neither increased tramadol consumption nor frequency of PONV in this postoperative setting...
  21. ncbi request reprint Personalized therapy in pain management: where do we stand?
    Ulrike M Stamer
    Department of Anaesthesiology and Intensive Care Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Pharmacogenomics 11:843-64. 2010
    ..Although pharmacogenetics as a diagnostic tool has the potential to improve patient therapy, well-designed studies are needed to demonstrate superiority to conventional dosing regimes...
  22. doi request reprint Comparison of multiplex ligation-dependent probe amplification and real-time PCR accuracy for gene copy number quantification using the beta-defensin locus
    Andrea Perne
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany
    Biotechniques 47:1023-8. 2009
    ..In addition, the consistency between MLPA and PPRT is higher than either PCR/MLPA or PCR/PPRT consistency. In summary, these results suggest that MLPA is superior to real-time PCR in beta-defensin copy number quantification...
  23. ncbi request reprint The pharmacogenetics of analgesia
    Ulrike M Stamer
    Rheinische Friedrich Wilhelms Universitat Bonn, Department of Anaesthesiology and Intensive Care Medicine, Sigmund Freud Str 25, 53105 Bonn, Germany
    Expert Opin Pharmacother 8:2235-45. 2007
    ..Pharmacogenetics as a diagnostic tool has the potential to improve patient therapy and care, and it is hoped that pharmacogenetics will individualise drug treatment to a greater extent in the near future...
  24. doi request reprint Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma
    Heiko Lier
    Department of Anaesthesiology and Intensive Care Medicine, University of Cologne, Cologne, Germany
    J Trauma 65:951-60. 2008
    ..Beside the often discussed topics of consumption and dilution coagulopathy, additional perioperative impairments of coagulation are caused by acidosis, hypocalcemia, anemia, hypothermia, and combinations...
  25. ncbi request reprint [Spinal and epidural anaesthesia for caesarean section in patients with pre-eclampsia]
    Ulrike M Stamer
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 42:200-7. 2007
    ..spinal anaesthesia for pre-eclampsia are not supported by recent study data. Spinal and epidural anaesthesia are both safe in patients presenting with pre-eclampsia, if contraindications for neuraxial anaesthesia are taken into account...
  26. pmc Real-time PCR for detection and differentiation of gram-positive and gram-negative bacteria
    Sven Klaschik
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    J Clin Microbiol 40:4304-7. 2002
    ..All tested bacteria were identified correctly, and none gave a false-positive signal with the opposite Gram probe...
  27. ncbi request reprint A tumor necrosis factor gene polymorphism influences the inflammatory response after cardiac operation
    Stefan Schroeder
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Ann Thorac Surg 75:534-7. 2003
    ....
  28. ncbi request reprint Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography- mass spectrometry and application to postoperative patients receiving tramadol
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Anal Toxicol 30:463-7. 2006
    ..The 7.7% of the samples that revealed negative results for ODT are likely explained by genetic polymorphisms resulting in absent enzyme activity of CYP2D6...
  29. ncbi request reprint Genomics and critical care: do the right thing!
    Frank Stuber
    Crit Care Med 31:1869-70. 2003
  30. ncbi request reprint Impact of CYP2D6 genotype on postoperative tramadol analgesia
    Ulrike M Stamer
    Klinik und Poliklinik fur Anasthesiologie und spezielle Intensivmedizin, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strass 25, 53105 Bonn, Germany
    Pain 105:231-8. 2003
    ..Therefore, CYP2D6 genotype has an impact on analgesia with tramadol. Pharmacogenetics may explain some of the varying response to pain medication in postoperative patients...
  31. ncbi request reprint IL-10 polymorphism is associated with increased incidence of severe sepsis
    Qiang Shu
    Department of Cardiovascular Surgery, Children s Hospital, Medical College of Zhejiang University, 310016 Hangzhou, China
    Chin Med J (Engl) 116:1756-9. 2003
    ..To investigate whether three biallelic polymorphisms at positions -592, -819 and -1082 in the promoter region of the IL-10 gene are associated with increased incidence of severe sepsis...
  32. ncbi request reprint Postoperative analgesia in children--current practice in Germany
    Ulrike M Stamer
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Eur J Pain 9:555-60. 2005
    ..In the future, additional education of the medical staff considering analgesic techniques and measurement of pain scores has to be emphasized...
  33. ncbi request reprint Pharmacogenetics of anesthetic and analgesic agents: CYP2D6 genetic variations
    Ulrike M Stamer
    Anesthesiology 103:1099; author reply 1101. 2005
  34. ncbi request reprint Epidemiology of sepsis in Germany: results from a national prospective multicenter study
    Christoph Engel
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107, Leipzig, Germany
    Intensive Care Med 33:606-18. 2007
    ..To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size...
  35. doi request reprint Practice and perception--a nationwide survey of therapy habits in sepsis
    Frank M Brunkhorst
    Anesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Germany
    Crit Care Med 36:2719-25. 2008
    ..To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock...
  36. ncbi request reprint Human genotyping
    Frank Stuber
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Crit Care Med 33:S453-6. 2005
  37. ncbi request reprint Interleukin 10.G microsatellite in the promoter region of the interleukin-10 gene in severe sepsis
    Qiang Shu
    Department of Cardiovascular Surgery, Children s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Chin Med J (Engl) 119:197-201. 2006
    ..This study was conducted to investigate whether IL10.G microsatellite is associated with the incidence and/or the outcome of severe sepsis...
  38. ncbi request reprint Protection against Pseudomonas aeruginosa pneumonia and sepsis-induced lung injury by overexpression of beta-defensin-2 in rats
    Qiang Shu
    Children s Hospital, School of Medicine and National Key Laboratory of Infection Disease, Zhejiang University, Hangzhou, China
    Shock 26:365-71. 2006
    ..aeruginosa pneumonia and 2CLP-induced lung injury based on its antimicrobial and anti-inflammatory activities, respectively. Modulating the expression level of BD-2 may serve as an approach to attenuate lung injury...