Sebastian Strieth

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Neovascular targeting chemotherapy: encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Int J Cancer 110:117-24. 2004
  2. ncbi [Piercing complications in the facial area]
    S Strieth
    Klinik fur Hals, Nasen, Ohrenheilkunde, Klinikum Grosshadern und Innenstadt, LMU Munchen
    MMW Fortschr Med 148:41-3. 2006
  3. doi Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin
    Sebastian Strieth
    Department of Otorhinolaryngology, Campus Grosshadern, University of Munich, Munich, Germany
    Clin Cancer Res 14:4603-11. 2008
  4. ncbi Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels
    Sebastian Strieth
    Department of Otorhinolaryngology, Universityof Munich LMU, Marchioninistr 15, Munich 81377 Germany
    Cancer Biol Ther 7:814-9. 2008
  5. ncbi Tumor-selective vessel occlusions by platelets after vascular targeting chemotherapy using paclitaxel encapsulated in cationic liposomes
    Sebastian Strieth
    Institute for Surgical Research, University of Munich LMU, Germany
    Int J Cancer 122:452-60. 2008
  6. doi Biocompatibility of porous polyethylene implants tissue-engineered by extracellular matrix and VEGF
    Sebastian Strieth
    Walter Brendel Center for Experimental Medicine WBex, University of Munich LMU, Marchioninistr 27, Munich 81377, Germany
    J Biomed Mater Res A 93:1566-73. 2010
  7. ncbi Antiangiogenic combination tumor therapy blocking alpha(v)-integrins and VEGF-receptor-2 increases therapeutic effects in vivo
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Int J Cancer 119:423-31. 2006
  8. ncbi A new animal model to assess angiogenesis and endocrine function of parathyroid heterografts in vivo
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Transplantation 79:392-400. 2005
  9. ncbi Static magnetic fields impair angiogenesis and growth of solid tumors in vivo
    Donata Strelczyk
    Walter Brendel Center for Experimental Medicine WBex, Campus Grosshadern, University of Munich LMU, Munich, Germany
    Cancer Biol Ther 8:1756-62. 2009
  10. doi TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo
    Warangkana Arpornchayanon
    Walter Brendel Centre of Experimental Medicine WBex, University of Munich LMU, Germany
    Int J Audiol 52:545-52. 2013

Collaborators

Detail Information

Publications37

  1. ncbi Neovascular targeting chemotherapy: encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Int J Cancer 110:117-24. 2004
    ..Remarkable microcirculatory changes indicate that encapsulation of paclitaxel in cationic liposomes resulted in a mechanistic switch from tumor cell toxicity to an antivascular therapy...
  2. ncbi [Piercing complications in the facial area]
    S Strieth
    Klinik fur Hals, Nasen, Ohrenheilkunde, Klinikum Grosshadern und Innenstadt, LMU Munchen
    MMW Fortschr Med 148:41-3. 2006
    ..Through specific advice, early detection and treatment of complications, serious health damage to the wearer of piercing jewelry can be avoided...
  3. doi Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin
    Sebastian Strieth
    Department of Otorhinolaryngology, Campus Grosshadern, University of Munich, Munich, Germany
    Clin Cancer Res 14:4603-11. 2008
    ....
  4. ncbi Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels
    Sebastian Strieth
    Department of Otorhinolaryngology, Universityof Munich LMU, Marchioninistr 15, Munich 81377 Germany
    Cancer Biol Ther 7:814-9. 2008
    ..These reversible changes may have implications for functional measurements of tumor microcirculation by MRI and new therapeutic strategies using strong SMFs...
  5. ncbi Tumor-selective vessel occlusions by platelets after vascular targeting chemotherapy using paclitaxel encapsulated in cationic liposomes
    Sebastian Strieth
    Institute for Surgical Research, University of Munich LMU, Germany
    Int J Cancer 122:452-60. 2008
    ..Significantly disbalancing the coagulation system within tumors by targeted induction of microthromboses within the tumor microcirculation appears to be an important mechanism of EndoTAG-1 therapy...
  6. doi Biocompatibility of porous polyethylene implants tissue-engineered by extracellular matrix and VEGF
    Sebastian Strieth
    Walter Brendel Center for Experimental Medicine WBex, University of Munich LMU, Marchioninistr 27, Munich 81377, Germany
    J Biomed Mater Res A 93:1566-73. 2010
    ..Therefore, novel tissue- engineered constructs of PPE implants providing ECM and VEGF in high local concentrations can increase biocompatibility especially under unfavorable conditions for implantation...
  7. ncbi Antiangiogenic combination tumor therapy blocking alpha(v)-integrins and VEGF-receptor-2 increases therapeutic effects in vivo
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Int J Cancer 119:423-31. 2006
    ....
  8. ncbi A new animal model to assess angiogenesis and endocrine function of parathyroid heterografts in vivo
    Sebastian Strieth
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Transplantation 79:392-400. 2005
    ..We provide a new animal model allowing simultaneous and repetitive in vivo assessment of angiogenesis and endocrine function of parathyroid transplants...
  9. ncbi Static magnetic fields impair angiogenesis and growth of solid tumors in vivo
    Donata Strelczyk
    Walter Brendel Center for Experimental Medicine WBex, Campus Grosshadern, University of Munich LMU, Munich, Germany
    Cancer Biol Ther 8:1756-62. 2009
    ..Hence, SMF therapy appears as a promising new anticancer strategy-as an inhibitor of tumor growth and angiogenesis and as a potential sensitizer to chemotherapy...
  10. doi TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo
    Warangkana Arpornchayanon
    Walter Brendel Centre of Experimental Medicine WBex, University of Munich LMU, Germany
    Int J Audiol 52:545-52. 2013
    ..It was the aim of this experimental study to analyse the effects of the TNF-α inhibitor etanercept on cochlear microcirculation and hearing threshold shift in NIHL in vivo...
  11. doi Vascular targeting by EndoTAG-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer
    Martin E Eichhorn
    Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Cancer 126:1235-45. 2010
    ..Therefore, this combination represents a promising novel strategy for clinical cancer therapy...
  12. ncbi Static magnetic fields increase tumor microvessel leakiness and improve antitumoral efficacy in combination with paclitaxel
    Donata Gellrich
    Walter Brendel Center for Experimental Medicine WBex, University of Munich LMU, Germany Department of Otorhinolaryngology, University of Munich LMU, Germany Electronic address
    Cancer Lett 343:107-14. 2014
    ..Further, SMF increased the effectiveness of paclitaxel-chemotherapy significantly. These findings support that SMF possibly open the blood-tumor-barrier to small molecular therapeutics...
  13. doi Validation of contrast-enhanced ultrasound-derived intensity-time gradients in submandibular gland sialolithotomy patients
    Vanessa Siedek
    Department of Otorhinolaryngology, University of Munich LMU, Marchioninistr 15, 81377 Munich, Germany
    Eur Arch Otorhinolaryngol 270:1941-6. 2013
    ..In addition, ITG ratios were significantly increased after sialolithotomy. In conclusion, CE-US-derived ITGs and ITG ratios appear as independent and valid quantitative parameters of sialolithotomy efficacy...
  14. ncbi Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy
    Marcus Schmitt-Sody
    Institute for Surgical Research, Department of Otorhinolaryngology, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany
    Clin Cancer Res 9:2335-41. 2003
    ..It was the aim of our study to evaluate tumor selectivity and antitumoral efficacy of paclitaxel encapsulated in cationic liposomes in comparison with the free drug paclitaxel (Taxol(R)) in vivo...
  15. doi Modeling the measurements of cochlear microcirculation and hearing function after loud noise
    Warangkana Arpornchayanon
    Walter Brendel Center for Experimental Medicine, University of Munich, Munich, Germany
    Otolaryngol Head Neck Surg 145:463-9. 2011
    ..The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo...
  16. ncbi Automated assessment of tumour microvascular architecture in vivo
    Sven Becker
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Anticancer Res 30:2597-602. 2010
    ..The aim of this study was to develop an automated analysis technique enabling quantitative assessment of complete tumour vascular networks non-invasively in vivo...
  17. pmc Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity
    Manuela Schneider
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University, Marchioninistrasse 15, Munich, Germany
    Neoplasia 12:254-63. 2010
    ..Thus, we conclude that GPx4, through controlling 12/15-LOX activity, is an important regulator of tumor angiogenesis as well as vessel maturation...
  18. doi Quantitative estimation of minor conductive hearing loss with distortion product otoacoustic emissions in the guinea pig
    Bernhard Olzowy
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, Marchioninistr 15, 81377 Munich, Germany
    J Acoust Soc Am 128:1845-52. 2010
    ..CHL(DPOAE) correlated well with CHL(CAP) (R=0.741, p=0.0142). Mean difference between CHL(DPOAE) and CHL(CAP) was 4.2±2.6 dB. Estimation of minor CHL from DPOAE measurements might help to increase the diagnostic value of DPOAEs...
  19. ncbi Anti-vascular tumor therapy: recent advances, pitfalls and clinical perspectives
    Martin E Eichhorn
    Department of Surgery, Klinikum Grosshadern, University of Munich, Germany
    Drug Resist Updat 7:125-38. 2004
    ..Conceptual differences between anti-angiogenic and vascular targeting therapies will be discussed with emphasis on specific problems and pitfalls in the conversion into the clinic...
  20. doi Acute hyperfibrinogenemia impairs cochlear blood flow and hearing function in guinea pigs in vivo
    Fritz Ihler
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen Hospital, Robert Koch Strasse 40, Gottingen, Germany
    Int J Audiol 51:210-5. 2012
    ..Fibrinogen is known as a risk factor for both microvascular dysfunction and SSNHL. Therefore, the aim of this study was to investigate the effect of elevated serum levels of fibrinogen on cochlear blood flow and hearing function in vivo...
  21. ncbi Vascular targeting tumor therapy: non-invasive contrast enhanced ultrasound for quantitative assessment of tumor microcirculation
    Martin E Eichhorn
    Department of Surgery, Campus Grosshadern, Walter Brendel Centre of Experimental Medicine WBex, University of Munich, Munich, Germany
    Cancer Biol Ther 9:794-802. 2010
    ..Bimodal tumor imaging by intravital microscopy and CEUS represents an experimental tool to further develop molecular imaging of tumor microcirculation by CEUS...
  22. pmc Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling
    Elias Q Scherer
    Hals Nasen Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Stroke 41:2618-24. 2010
    ..We sought to demonstrate that tumor necrosis factor (TNF)-α, via sphingosine-1-phosphate signaling, has the potential to alter cochlear blood flow and thus, cause ischemic hearing loss...
  23. ncbi Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer
    Sebastian Strieth
    Department of Otorhinolaryngology, Goethe University, Frankfurt M, Germany
    Head Neck 36:976-84. 2014
    ..The purpose of this phase I/II clinical trial was to test safety and effectiveness of 2 doses of vascular targeting cationic liposomes encapsulating paclitaxel (EndoTAG-1 [ET]) in human head and neck squamous cell carcinoma (HNSCC)...
  24. doi Phase I clinical study of vascular targeting fluorescent cationic liposomes in head and neck cancer
    Sebastian Strieth
    Department of Otorhinolaryngology, Goethe University Frankfurt M, Theodor Stern Kai 7, 60590 Frankfurt M, Germany
    Eur Arch Otorhinolaryngol 270:1481-7. 2013
    ..Detailed analysis of targeting properties of LDF01 has to be performed in upcoming clinical phase II trials...
  25. pmc Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo
    Fritz Ihler
    Department of Otorhinolaryngology, Head and Neck Surgery, Goettingen University Medical School, Gottingen, Germany
    PLoS ONE 7:e39086. 2012
    ..This study investigated the effect of betahistine on guinea pigs at dosages corresponding to clinically used doses for cochlear microcirculation...
  26. doi Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease
    Sebastian Strieth
    Department of Otorhinolaryngology, University of Munich LMU, Marchioninistr 15, 81377, Munich, Germany
    Eur Arch Otorhinolaryngol 271:163-9. 2014
    ....
  27. doi An animal model for the analysis of cochlear blood flow [corrected] disturbance and hearing threshold in vivo
    Martin Canis
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich LMU, Campus Grosshadern, Munich, Germany
    Eur Arch Otorhinolaryngol 267:197-203. 2010
    ..This technique can be used to evaluate effects of treatments aimed at cochlear microcirculation in inner ear pathologies...
  28. ncbi [Antivascular strategies--a new concept for diagnosis and therapy of head and neck cancer. A review]
    M Dellian
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkranke der Ludwig Maximilians Universität München, Klinikum Grosshadern
    Laryngorhinootologie 81:509-15. 2002
    ..While antiangiogenic therapy prevents neovascularisation by inhibiting new blood vessel growth, the aim of vascular targeting is the destruction of already existing tumor vasculature...
  29. ncbi Cationic lipid complexed camptothecin (EndoTAG-2) improves antitumoral efficacy by tumor vascular targeting
    M E Eichhorn
    Department of Surgery and Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Cancer Biol Ther 6:920-9. 2007
    ..In conclusion this study shows that cationic lipid complexed camptothecin (EndoTag-2) is a markedly active antitumor agent based on an innovative vascular targeting approach...
  30. ncbi Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study
    M Suckfuell
    Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Acta Otolaryngol 127:938-42. 2007
    ..Intratympanic administration of a cell-permeable JNK ligand has been shown to prevent hearing loss after acute acoustic trauma in animal models...
  31. ncbi Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment
    M E Eichhorn
    Department of Surgery, Klinikum Grosshadern, University of Munich LMU, Germany
    Cancer Biol Ther 7:1006-13. 2008
    ....
  32. ncbi Porous polyethylene implants in revision rhinoplasty: chances and risks
    Klaus Stelter
    Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Centre, Ludwig Maximilians University, Munich, Germany
    Rhinology 45:325-31. 2007
    ..The material is being used more frequently in nasal surgery. In this study we describe possibilities and limitations in the use of PE in rhino-surgery...
  33. doi Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency
    Bernhard Olzowy
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, Marchioninistr 15, 81377 Munchen, Germany
    Eur Arch Otorhinolaryngol 267:351-5. 2010
    ..16 kHz). DPOAE level alterations due to hypoxia depend on the frequency in guinea pigs. Studies in human are warranted to improve non-invasive ICP monitoring with DPOAE by the detection of hypoxia-related changes...
  34. ncbi Paclitaxel encapsulated in cationic lipid complexes (MBT-0206) impairs functional tumor vascular properties as detected by dynamic contrast enhanced magnetic resonance imaging
    M E Eichhorn
    Department of Surgery, Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Cancer Biol Ther 5:89-96. 2006
    ..In conclusion, antivascular tumor therapy with MBT-0206 significantly impairs functional tumor microcirculation. DCE-MRI is a promising tool to quantify the antivascular effects of MBT-0206 during treatment...
  35. doi Contrast-enhanced ultrasound for monitoring effects of extracorporeal shock wave sialolithotripsy in sialolithiasis
    Vanessa Siedek
    Department of Otorhinolaryngology, University of Munich, Munich, Germany
    Laryngoscope 122:1301-5. 2012
    ..The aim of this investigator-initiated clinical trial was the evaluation of CE-US as a quantitative monitoring technique during gland-preserving extracorporeal shock wave sialolithotripsy (ESWL)...
  36. ncbi Protamine enhances uptake of cationic liposomes in angiogenic microvessels
    M E Eichhorn
    Department of Surgery, Klinikum Grosshadern, University of Munich, Germany
    Angiogenesis 7:133-41. 2004
    ....
  37. ncbi Static magnetic fields affect capillary flow of red blood cells in striated skin muscle
    Gunnar Brix
    Federal Office for Radiation Protection, Department of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany
    Microcirculation 15:15-26. 2008
    ....