Reiner Strick

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets
    Pamela L Strissel
    University Clinic Erlangen, Department of Gynecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    Oncotarget 3:1204-19. 2012
  2. pmc Malformations in a cohort of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH)
    Patricia G Oppelt
    Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstrasse 21 23, Erlangen 91054, Germany
    Reprod Biol Endocrinol 10:57. 2012
  3. doi request reprint Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    J Cell Biochem 113:2383-96. 2012
  4. doi request reprint HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina
    Arif B Ekici
    Institute for Human Genetics, University Clinic Erlangen, D 91054 Erlangen, Germany
    Gene 518:267-72. 2013
  5. ncbi request reprint Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk
    Stefan P Renner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Laboratory for Molecular Medicine, Erlangen, Germany
    Am J Obstet Gynecol 199:648.e1-9. 2008
  6. doi request reprint Expression of the human endogenous retroviruse-W envelope gene syncytin in endometriosis lesions
    Peter Oppelt
    Department of Gynecology and Obstetrics, University of Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:741-7. 2009
  7. doi request reprint Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 88:1143-56. 2010
  8. pmc Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region
    Matthias Ruebner
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    PLoS ONE 8:e56145. 2013
  9. doi request reprint Regulation of murine placentogenesis by the retroviral genes Syncytin-A, Syncytin-B and Peg10
    Christine Henke
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Universitaetsstr 21 23, D 91054 Erlangen, Germany
    Differentiation 85:150-60. 2013
  10. doi request reprint Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis
    Stefan P Renner
    Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:726-33. 2009

Collaborators

Detail Information

Publications29

  1. pmc Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets
    Pamela L Strissel
    University Clinic Erlangen, Department of Gynecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    Oncotarget 3:1204-19. 2012
    ..Functional analyses showed that 10 env genes were regulated by methylation in EnCa using the RL95-2 cell line. In conclusion, over-expressed env genes could serve as indicators for pathological pre-stages and EnCa...
  2. pmc Malformations in a cohort of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH)
    Patricia G Oppelt
    Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstrasse 21 23, Erlangen 91054, Germany
    Reprod Biol Endocrinol 10:57. 2012
    ....
  3. doi request reprint Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    J Cell Biochem 113:2383-96. 2012
    ..Our study characterized PPARγ/RXRα signaling in human CT and cell fusions identifying Syncytin-1 as a new target gene. Based on these results, a disturbed PPARγ/RXRα pathway could contribute to pathological human pregnancies...
  4. doi request reprint HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina
    Arif B Ekici
    Institute for Human Genetics, University Clinic Erlangen, D 91054 Erlangen, Germany
    Gene 518:267-72. 2013
    ..Rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia...
  5. ncbi request reprint Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk
    Stefan P Renner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Laboratory for Molecular Medicine, Erlangen, Germany
    Am J Obstet Gynecol 199:648.e1-9. 2008
    ..This investigation analyzed the +331G/A and the V600L single nucleotide polymorphisms in the progesterone receptor, and correlated their incidence with clinical and tumor parameters as well as disease risk...
  6. doi request reprint Expression of the human endogenous retroviruse-W envelope gene syncytin in endometriosis lesions
    Peter Oppelt
    Department of Gynecology and Obstetrics, University of Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:741-7. 2009
    ..This study investigated the influence of HERV-W gene expression in endometriosis foci (EM) quantitatively at the RNA level...
  7. doi request reprint Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 88:1143-56. 2010
    ..Fusogenic and non-fusogenic envelope genes are dysregulated in IUGR placentae and may contribute to the etiology of growth restriction in utero...
  8. pmc Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region
    Matthias Ruebner
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    PLoS ONE 8:e56145. 2013
    ..Based on our findings we are predicting a broad aberrant epigenetic DNA-methylation pattern in pathological placentae affecting placentogenesis, but also the development of the fetus and the mother during pregnancy...
  9. doi request reprint Regulation of murine placentogenesis by the retroviral genes Syncytin-A, Syncytin-B and Peg10
    Christine Henke
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Universitaetsstr 21 23, D 91054 Erlangen, Germany
    Differentiation 85:150-60. 2013
    ..Due to the expression of Peg10 in TGCs, we propose an essential functional role in the fetal-maternal blood system. ..
  10. doi request reprint Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis
    Stefan P Renner
    Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:726-33. 2009
    ..Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis...
  11. ncbi request reprint Early aberrant insulin-like growth factor signaling in the progression to endometrial carcinoma is augmented by tamoxifen
    Pamela L Strissel
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Erlangen, Germany
    Int J Cancer 123:2871-9. 2008
    ....
  12. ncbi request reprint Impaired cytotrophoblast cell-cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction
    Manuela Langbein
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    Mol Reprod Dev 75:175-83. 2008
    ..These processes could contribute to the development and severity of PE and HELLP-associated IUGR...
  13. pmc Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts
    Fabian B Fahlbusch
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Reprod Biol Endocrinol 10:80. 2012
    ..Intrauterine growth restriction (IUGR) is accompanied by an increase in placental CRH, which could be of pathophysiological relevance for the dysregulation in syncytialisation seen in IUGR placentas...
  14. doi request reprint Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions
    Peter Oppelt
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    Fertil Steril 93:1778-86. 2010
    ..To investigate whether sexually transmitted viruses or prokaryotes, like human papilloma viruses (HPV), herpes viruses, and Chlamydia trachomatis, are associated with endometriosis lesions...
  15. ncbi request reprint Female genital malformations and their associated abnormalities
    Peter Oppelt
    Department of Gynecology and Obstetrics, University Hospital, Erlangen, Germany
    Fertil Steril 87:335-42. 2007
    ..The aim of this study was to assess whether a connection could be demonstrated between various degrees of severity of genital malformations and associated abnormalities...
  16. pmc Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection
    Michael G Schrauder
    Department of Obstetrics and Gynaecology, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e29770. 2012
    ..We investigated whether microarray-based miRNA profiling on whole blood could discriminate between early stage breast cancer patients and healthy controls...
  17. pmc High incidence of recurrent copy number variants in patients with isolated and syndromic Müllerian aplasia
    Serena Nik-Zainal
    Department of Obstetrics and Gynecology, University Clinic Erlangen, Erlangen, Germany
    J Med Genet 48:197-204. 2011
    ..Previous reports have suggested that a proportion of cases, especially syndromic cases, are caused by variation in copy number at different genomic loci...
  18. pmc Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients
    Alexander Hein
    Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    Biomed Res Int 2014:842452. 2014
    ..The effect of rs1054016(RANKL) adds to the evidence that the RANK pathway plays a role in BC pathogenesis and progression with respect to BMFS, emphasizing the connection between BC and bone health. ..
  19. ncbi request reprint Transcriptional analysis of steroid hormone receptors in smooth muscle uterine leiomyoma tumors of postmenopausal patients
    Pamela L Strissel
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine at the University of Erlangen Nuremberg, University Street 21 23, D 91054 Erlangen, Germany
    J Steroid Biochem Mol Biol 107:42-7. 2007
    ..In addition, a role for steroid hormones, specifically ERbeta, is discussed in terms of benign tumor regression or tumor maintenance in postmenopausal leiomyomas...
  20. ncbi request reprint Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients
    Peter Andreas Fasching
    University Breast Center for Franconia, Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Breast Cancer Res Treat 112:89-98. 2008
    ..The aim of this study was to examine the effect of single nucleotide polymorphisms (SNPs) in the aromatase gene, CYP19A1, on the prognosis, and in relation to tumor and patient characteristics in a cohort of breast cancer patients...
  21. doi request reprint Activation and regulation of endogenous retroviral genes in the human pituitary gland and related endocrine tumors
    Rolf Buslei
    Institute of Neuropathology, University Clinic Erlangen, Lab for Molecular Medicine, Germany
    Neuropathol Appl Neurobiol . 2014
    ..g. the ERVW-1 envelope gene Syncytin-1, essential for placentogenesis, but also deregulated in human tumors. Data concerning ERV expression in the AH and related endocrine tumors are missing...
  22. ncbi request reprint Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
    Juergen Kindla
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Cancer Biol Ther 11:584-91. 2011
    ....
  23. doi request reprint Estrogen and progesterone receptors: from molecular structures to clinical targets
    Stephan Ellmann
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054 Erlangen, Germany
    Cell Mol Life Sci 66:2405-26. 2009
    ....
  24. ncbi request reprint Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome
    Helge Binder
    Department of Obstetrics and Gynaecology, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054 Erlangen, Germany
    Reproduction 135:107-16. 2008
    ..The other FSHR coding gene variations and CYP19A1 rs10046 investigated are most likely not involved in the aetiology of iatrogenic OHSS or sterility...
  25. ncbi request reprint Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction
    Wenzel Wallner
    Department of Obstetrics and Gynaecology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Sci (Lond) 112:51-7. 2007
    ..Umbilical artery blood was unaffected in IUGR, indicating that the fetus does not contribute to changes in angiogenic growth factor concentrations...
  26. doi request reprint Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
    Tamme W Goecke
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Acta Obstet Gynecol Scand 89:7-14. 2010
    ..To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting...
  27. ncbi request reprint Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
    ..Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors...
  28. ncbi request reprint Clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging
    Peter Oppelt
    Department of Gynecology and Obstetrics, University Hospital, Universitätsstrasse 21 23, D 91054 Erlangen, Germany
    Hum Reprod 21:792-7. 2006
    ..This retrospective study examined the issue of associated malformations, subtyping, and the frequency distribution of subtypes in MRKH syndrome...
  29. ncbi request reprint The VCUAM (Vagina Cervix Uterus Adnex-associated Malformation) classification: a new classification for genital malformations
    Peter Oppelt
    Department of Gynecology and Obstetrics, University Hospital, Erlangen, Germany
    Fertil Steril 84:1493-7. 2005
    ..The aim of the present study was to produce a simple, systematic, and reproducible classification system...