Olaf Strauss

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Ca2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease
    Rita Rosenthal
    Institut für Klinische Physiologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Mol Vis 13:443-56. 2007
  2. ncbi request reprint The retinal pigment epithelium in visual function
    Olaf Strauss
    Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Physiol Rev 85:845-81. 2005
  3. ncbi request reprint [Morbus Best]
    O Strauss
    Abteilung für Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Eppendorf, Hamburg
    Ophthalmologe 102:109-10. 2005
  4. ncbi request reprint [Function of bestrophin]
    O Strauss
    Abteilung für Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Hamburg Eppendorf, Hamburg
    Ophthalmologe 102:122-6. 2005
  5. ncbi request reprint The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
  6. doi request reprint Heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion
    Sönke Cordeiro
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Invest Ophthalmol Vis Sci 51:6001-8. 2010
  7. doi request reprint Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium
    Mike O Karl
    University Eye Hospital Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Cell Signal 20:1159-68. 2008
  8. doi request reprint Expression profile of voltage-dependent Ca2+ channel subunits in the human retinal pigment epithelium
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 246:685-92. 2008
  9. ncbi request reprint Functional studies of synthetic gramicidin hybrid ion channels in CHO cells
    Ryszard Wesolowski
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Chembiochem 8:513-20. 2007
  10. doi request reprint The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER
    Rudgar Neussert
    Experimental Eye Research, Eye Hospital, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Pflugers Arch 460:163-75. 2010

Collaborators

Detail Information

Publications29

  1. pmc Ca2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease
    Rita Rosenthal
    Institut für Klinische Physiologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Mol Vis 13:443-56. 2007
    ..Since RPE cells express neuroendocrine L-type Ca2+ channels we investigated their involvement in VEGF secretion in normal RPE cells and RPE cells from patients with CNV...
  2. ncbi request reprint The retinal pigment epithelium in visual function
    Olaf Strauss
    Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Physiol Rev 85:845-81. 2005
    ..On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other...
  3. ncbi request reprint [Morbus Best]
    O Strauss
    Abteilung für Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Eppendorf, Hamburg
    Ophthalmologe 102:109-10. 2005
  4. ncbi request reprint [Function of bestrophin]
    O Strauss
    Abteilung für Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Hamburg Eppendorf, Hamburg
    Ophthalmologe 102:122-6. 2005
    ..Further studies on either bestrophin-deficient mice or transgenic mice will show that either one of the hypotheses is right or maybe both will be proven correct, showing bestrophin as a Cl(-) channel and Ca(2+) channel regulator...
  5. ncbi request reprint The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  6. doi request reprint Heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion
    Sönke Cordeiro
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Invest Ophthalmol Vis Sci 51:6001-8. 2010
    ..The purpose of the study was to identify pathways that lead to increased VEGF secretion by the RPE...
  7. doi request reprint Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium
    Mike O Karl
    University Eye Hospital Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Cell Signal 20:1159-68. 2008
    ..These results suggest that L-type Ca(2+)-channels could be regulated downstream of both MerTK and alphavbeta5-integrin, indicating that the binding and uptake mechanisms of phagocytosis are part of a converging pathway...
  8. doi request reprint Expression profile of voltage-dependent Ca2+ channel subunits in the human retinal pigment epithelium
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 246:685-92. 2008
    ..In order to provide a better base for the understanding of the underlying Ca(2+) signalling in these cells, we investigated the expression profile of voltage-dependent Ca(2+) channel subunits in RPE cells...
  9. ncbi request reprint Functional studies of synthetic gramicidin hybrid ion channels in CHO cells
    Ryszard Wesolowski
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Chembiochem 8:513-20. 2007
    ..5 % that of the control. Thus, the synthetic hybrid channel 1 can function as a cation channel with some Cs(+) specificity, and as a water channel in CHO cells...
  10. doi request reprint The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER
    Rudgar Neussert
    Experimental Eye Research, Eye Hospital, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Pflugers Arch 460:163-75. 2010
    ..Therefore, bestrophin-1 possibly conducts Cl(-) as counter ion for Ca(2+) uptake into cytosolic Ca(2+) stores...
  11. doi request reprint Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium
    Sönke Cordeiro
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 249:47-54. 2011
    ..Despite the multitude of Ca²(+)-dependently regulated functions, only few Ca²(+) channels have been described so far in the RPE to couple Ca²(+) conductance and Ca²(+) signaling...
  12. ncbi request reprint Effects of unoprostone and endothelin 1 on L-type channel currents in human trabecular meshwork cells
    Hagen Thieme
    Augenklinik und Hochschulambulanz, Berlin, Germany
    Ophthalmic Res 37:293-300. 2005
    ..Since L-type channel currents are known to influence the contractility of TM, we examined the effects of unoprostone and ET-1 on L-type channel currents of TM cells...
  13. ncbi request reprint Ion channels in the RPE
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Prog Retin Eye Res 26:263-301. 2007
    ..Increasing knowledge about the properties of RPE ion channels has not only provided a new understanding of RPE function but has also provided greater understanding of RPE function in health and disease...
  14. ncbi request reprint Ca2+-channels in the RPE
    Rita Rosenthal
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Adv Exp Med Biol 514:225-35. 2002
    ..Thus, voltage-dependent Ca2+ channels in the retinal pigment epithelium are of importance for the function of photoreceptors...
  15. ncbi request reprint Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004
    ..Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization...
  16. ncbi request reprint Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice
    Guido Wollmann
    Institut fuer Klinische Physiologie, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
    Vision Res 46:688-98. 2006
    ..Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models...
  17. pmc Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cells
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Mol Vis 14:2340-8. 2008
    ..Many cellular functions of the retinal pigment epithelium (RPE) are coupled to changes in [Ca2+]i. The aim of this study was to identify which Ca2+-entry pathway leads to the activation of BK channels in the RPE...
  18. ncbi request reprint Insulin-like growth factor-1 increases intracellular calcium concentration in human primary neuroendocrine pancreatic tumor cells and a pancreatic neuroendocrine tumor cell line (BON-1) via R-type Ca2+ channels and regulates chromogranin a secretion in BO
    Stefan Mergler
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Interdisziplinares Stoffwechsel Centrum Endokrinologie, Diabetes und Stoffwechsel, Charite Universitatsmedizin Berlin, Germany
    Neuroendocrinology 82:87-102. 2005
    ....
  19. ncbi request reprint Electrophysiological response of cultured trabecular meshwork cells to synthetic ion channels
    Pawel Fidzinski
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Chem Biol 10:35-43. 2003
    ..Thus, THF-gramicidin hybrids form a basis for the use of synthetic ion channels in biological systems, which eventually may lead to new therapeutic approaches...
  20. ncbi request reprint Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 20:178-80. 2006
    ....
  21. ncbi request reprint Basal calcium entry in retinal pigment epithelial cells is mediated by TRPC channels
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitätsklinkikum Hamburg Eppendorf, Hamburg, Germany
    Invest Ophthalmol Vis Sci 48:5767-72. 2007
    ..Because Ca(2+) is permanently extruded from the cytosol, RPE cells need a basal Ca(2+) entry pathway that counteracts this Ca(2+) efflux. The purpose of this study was to identify the molecular basis of basal Ca(2+) entry into the RPE...
  22. doi request reprint [Oxidative stress at the retinal pigment epithelium - experimental implications for protection]
    O Zeitz
    Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Klin Monbl Augenheilkd 226:27-30. 2009
    ..This review summarises the current literature on cellular effects of free radicals and deduces potential therapeutic approaches to protect the RPE from oxidative damage...
  23. pmc PKC{alpha} is essential for the proper activation and termination of rod bipolar cell response
    Klaus Ruether
    Charité Eye Hospital, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Invest Ophthalmol Vis Sci 51:6051-8. 2010
    ..Protein kinase (PKC)-α is abundant in retinal bipolar cells. This study was performed to explore its role in visual processing...
  24. ncbi request reprint Lack of antioxidative properties of vitamin C and pyruvate in cultured retinal pigment epithelial cells
    Oliver Zeitz
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik ffir Augenheilkunde, Martinistr 52, 20246 Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 245:276-81. 2007
    ..The aim of the present study is to evaluate antioxidative properties of vitamin C and pyruvate at retinal pigment epithelial (RPE) cells exposed to oxidative stress...
  25. ncbi request reprint Stimulation of L-type Ca(2+) channels by increase of intracellular InsP3 in rat retinal pigment epithelial cells
    Stefan Mergler
    Universitätsklinikum Charité der Humboldt Universität zu Berlin, Medizinische Klinik, Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany
    Exp Eye Res 74:29-40. 2002
    ..This is enabled by depletion of cytosolic Ca(2+)stores and tyrosine kinase-dependent activation of L-type channels...
  26. ncbi request reprint Investigations of RPE cells of choriodal neovascular membranes from patients with age-related macula degeneration
    Rita Rosenthal
    Department of Clinical Physiology, Benjamin Franklin University Hospital, Free University Berlin, 12200 Berlin, Germany
    Adv Exp Med Biol 533:107-13. 2003
  27. pmc The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1)
    Lihua Y Marmorstein
    Department of Ophthalmology and Vision Science, University of Arizona, Tucson 85711, USA
    J Gen Physiol 127:577-89. 2006
    ..Furthermore, we suggest that the loss of vision associated with BMD is not caused by the same pathologic process as the diminished LP, but rather is caused by as yet unidentified effects of best-1 on other cellular processes...
  28. pmc The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium
    Vanda S Lopes
    Molecular and Cellular Medicine, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Traffic 8:486-99. 2007
    ....
  29. ncbi request reprint Effects of protein kinase C on delayed rectifier K+ channel regulation by tyrosine kinase in rat retinal pigment epithelial cells
    Olaf Strauss
    Institute for Clinical Physiology, Benjamin Franklin University Clinic, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Invest Ophthalmol Vis Sci 43:1645-54. 2002
    ..Investigation of the regulation of delayed rectifier potassium channels by protein kinases in retinal pigment epithelial (RPE) cells...