Rainer H Straub

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Arthritis Rheum 54:2039-46. 2006
  2. pmc Evolutionary medicine and chronic inflammatory state--known and new concepts in pathophysiology
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    J Mol Med (Berl) 90:523-34. 2012
  3. doi request reprint Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases--the 10-year update
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany Electronic address
    Semin Arthritis Rheum 43:392-404. 2013
  4. pmc Energy metabolism and rheumatic diseases: from cell to organism
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 14:216. 2012
  5. pmc Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF
    Stefanie Haas
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, F, J, Strauss Allee 11, Regensburg, 93053, Germany
    Arthritis Res Ther 14:R122. 2012
  6. pmc Integrins and their ligands in rheumatoid arthritis
    Torsten Lowin
    Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Franz Josef Straus Allee 11, 93053 Regensburg, Germany
    Arthritis Res Ther 13:244. 2011
  7. pmc The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro
    Philipp Lechler
    Department of Orthopedic Surgery, University of Regensburg, Asklepios Klinikum Bad Abbach, Kaiser Karl V Allee 3, 93077 Bad Abbach, Germany
    BMC Musculoskelet Disord 12:150. 2011
  8. pmc Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens
    Martin Schmidt
    Institute of Biochemistry II, Hospital of the Friedrich Schiller University, Jena, Germany
    Arthritis Res Ther 7:R938-48. 2005
  9. pmc Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis
    Birgit Riepl
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, F, J, Strauss Allee 11, 93053 Regensburg, Germany
    Arthritis Res Ther 12:R110. 2010
  10. pmc Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls
    Klaus Stark
    Department of Internal Medicine II, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Arthritis Res Ther 11:R70. 2009

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Arthritis Rheum 54:2039-46. 2006
  2. pmc Evolutionary medicine and chronic inflammatory state--known and new concepts in pathophysiology
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    J Mol Med (Berl) 90:523-34. 2012
    ..This combination leads to a net increase of the systemic fluid volume, which is hypothesized to be the basis of essential hypertension (prevalence in adults 22-32%)...
  3. doi request reprint Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases--the 10-year update
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany Electronic address
    Semin Arthritis Rheum 43:392-404. 2013
    ..It deals with the aspects of efferent neuronal and neurohormonal bearing on the peripheral immune and musculoskeletal systems. This review aims to add new information that appeared since 2001...
  4. pmc Energy metabolism and rheumatic diseases: from cell to organism
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 14:216. 2012
    ..We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology...
  5. pmc Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF
    Stefanie Haas
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, F, J, Strauss Allee 11, Regensburg, 93053, Germany
    Arthritis Res Ther 14:R122. 2012
    ..The study was initiated to fill this gap and to study effects of interleukin (IL)-1β/tumor necrosis factor (TNF) on rhythmicity in synovial fibroblasts of RA and OA patients...
  6. pmc Integrins and their ligands in rheumatoid arthritis
    Torsten Lowin
    Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Franz Josef Straus Allee 11, 93053 Regensburg, Germany
    Arthritis Res Ther 13:244. 2011
    ..Furthermore, in analogy to invading tumors, synovial fibroblasts start invading and degrading cartilage, thereby generating extracellular matrix debris that can further activate integrins...
  7. pmc The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro
    Philipp Lechler
    Department of Orthopedic Surgery, University of Regensburg, Asklepios Klinikum Bad Abbach, Kaiser Karl V Allee 3, 93077 Bad Abbach, Germany
    BMC Musculoskelet Disord 12:150. 2011
    ..We analyzed survivin expression in osteoarthritic cartilage and its function in primary human chondrocytes in vitro...
  8. pmc Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens
    Martin Schmidt
    Institute of Biochemistry II, Hospital of the Friedrich Schiller University, Jena, Germany
    Arthritis Res Ther 7:R938-48. 2005
    ..Androgens were differentially converted to pro- and anti-inflammatory steroid hormones via diverse pathways...
  9. pmc Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis
    Birgit Riepl
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, F, J, Strauss Allee 11, 93053 Regensburg, Germany
    Arthritis Res Ther 12:R110. 2010
    ..In this study, we focused on noradrenergic and TNF regulation of human neutrophil peptides 1-3 (HNP1-3), which are proinflammatory bactericidal alpha-defensins...
  10. pmc Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls
    Klaus Stark
    Department of Internal Medicine II, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Arthritis Res Ther 11:R70. 2009
    ..This study was initiated to investigate the association between defined genetic markers and RA in a Slovak population. In contrast to recent studies, we included intensively-characterized osteoarthritis (OA) patients as controls...
  11. pmc Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis
    Matthias Wahle
    Department of Internal Medicine IV, University Hospital Leipzig, Liebigstrasse 22, 04103 Leipzig, Germany
    Arthritis Res Ther 8:R138. 2006
    ..Such an unfavorable situation is a perpetuating factor for inflammation...
  12. ncbi request reprint Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy
    Rainer H Straub
    Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Medical Center, Regensburg, Germany
    J Rheumatol 32:1253-8. 2005
    ..Since tumor necrosis factor (TNF) alters production of these hormones, we investigated changes of these hormones during anti-TNF antibody (anti-TNF) therapy with adalimumab in longstanding RA...
  13. ncbi request reprint Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    J Infect Dis 192:560-72. 2005
    ..These results show the dual role of the sympathetic nervous system in sepsis. It can be favorable or unfavorable, depending on the innate immune effector mechanisms necessary to overcome infection...
  14. ncbi request reprint Adrenal and gonadal hormone variations during a febrile attack in a woman with tumor necrosis factor receptor-associated periodic syndrome
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    J Clin Endocrinol Metab 90:5884-7. 2005
    ..It is characterized by periodic fever, arthralgia, abdominal pain, myalgia, headache, and skin lesions...
  15. ncbi request reprint Bottom-up and top-down signaling of IL-6 with and without habituation?
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Brain Behav Immun 20:37-9. 2006
  16. ncbi request reprint [Stress, hormones, and neuronal signals in the pathophysiology of rheumatoid arthritis. The negative impact on chronic inflammation]
    Rainer H Straub
    Labor für Experimentelle Rheumatologie und Neuroendokrino Immunologie, Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg, 93042 Regensburg
    Med Klin (Munich) 100:794-803. 2005
    ..In the said two chronic inflammatory diseases, it is obvious that apart from the immune system also the endocrine and nervous system play an essential role in the stress-induced initiation and aggravation of these diseases...
  17. ncbi request reprint Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study
    Rainer H Straub
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 54:1778-85. 2006
    ..This study investigated the influence on steroidogenesis of an interleukin-6 (IL-6)-neutralizing strategy using IL-6 receptor monoclonal antibodies (referred to as MRA)...
  18. ncbi request reprint Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    FASEB J 17:2176-83. 2003
    ....
  19. pmc Benefit of pregnancy in inflammatory arthritis
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 64:801-3. 2005
  20. pmc Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa
    R H Straub
    Laboratory of Neuro Endocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 54:1098-106. 2005
    ..In the intestinal tract, the role of sympathetic neurotransmitters has been largely ignored in mucosal neuroimmunology...
  21. pmc Anti-tumour necrosis factor antibody treatment does not change serum levels of cortisol binding globulin in patients with rheumatoid arthritis but it increases androstenedione relative to cortisol
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg 93042, Germany
    Ann Rheum Dis 64:1353-6. 2005
    ..CBG serum levels are typically low during prolonged inflammatory processes. Thus, observed changes of cortisol during anti-tumour necrosis factor (TNF) treatment may be related to changes of CBG in rheumatoid arthritis (RA)...
  22. ncbi request reprint How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Division of Rheumatology, Dept of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Arthritis Rheum 52:16-26. 2005
  23. ncbi request reprint Autonomic dysfunction in rheumatic diseases
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Rheum Dis Clin North Am 31:61-75, viii. 2005
    ....
  24. ncbi request reprint Sympathetic neurotransmitters in joint inflammation
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, FJS Allee 11, 93042 Regensburg, Germany
    Rheum Dis Clin North Am 31:43-59, viii. 2005
    ..Because patients who have rheumatoid arthritis most often present in the chronic phase of the disease, support of anti-inflammatory sympathetic pathways can be a promising therapeutic option...
  25. ncbi request reprint Complexity of the bi-directional neuroimmune junction in the spleen
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Trends Pharmacol Sci 25:640-6. 2004
    ..Activation of the sympathetic nervous system and also the resting sympathetic nervous tone are important for controlling innate and adaptive immune responses...
  26. pmc Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus
    R H Straub
    Department of Internal Medicine I, University Hospital Regensburg, D 93042 Regensburg, Germany
    Ann Rheum Dis 63:961-8. 2004
    ..In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones...
  27. doi request reprint Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    J Endocrinol 199:61-8. 2008
    ..Since androgens inhibit IL6 secretion, the activity-induced increase of these hormones might be an anti-atherogenic signal...
  28. pmc The role of the sympathetic nervous system in intestinal inflammation
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 55:1640-9. 2006
    ..This review attempts to integrate the different perspectives of the pro- and anti-inflammatory effects of the SNS on inflammatory disease of the gut...
  29. ncbi request reprint Alterations of the hypothalamic-pituitary-adrenal axis in systemic immune diseases - a role for misguided energy regulation
    R H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Clin Exp Rheumatol 29:S23-31. 2011
    ....
  30. doi request reprint [Neuroendocrine immunology: new pathogenetic aspects and clinical application]
    R H Straub
    Labor für experimentelle Rheumatologie und Neuroendokrinoimmunologie, Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum Regensburg, Deutschland
    Z Rheumatol 70:767-74. 2011
    ..These considerations might help to deviate focus from pure anti-inflammatory treatment to adequate diagnosis and therapy of systemic disease sequelae...
  31. doi request reprint Sympathetic inhibition of IL-6, IFN-γ, and KC/CXCL1 and sympathetic stimulation of TGF-β in spleen of early arthritic mice
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Brain Behav Immun 25:1708-15. 2011
    ..This study investigated the influence of neuronally released neurotransmitters on IFN-γ, KC (CXCL1), IL-6, and TGF-β in spleen of mice shortly after outbreak of collagen type II-induced arthritis...
  32. doi request reprint Rheumatoid arthritis recapitulates events relevant in blastocyst implantation and embryogenesis: a pathogenetic theory
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Semin Arthritis Rheum 41:382-92. 2011
    ..Importantly, blastocyst implantation and embryogenesis are NOLTIES. We hypothesized that factors relevant in blastocyst implantation and embryogenesis are also found in active tissue inflammation of a CID...
  33. doi request reprint Increased density of sympathetic nerve fibers in metabolically activated fat tissue surrounding human synovium and mouse lymph nodes in arthritis
    Rainer H Straub
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 63:3234-42. 2011
    ..To investigate the density of sympathetic nerve fibers in and the metabolic activation of fat tissue surrounding human synovium in rheumatoid arthritis (RA)/osteoarthritis (OA) and in the draining lymph nodes of arthritic and normal mice...
  34. doi request reprint Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Brain Behav Immun 25:1-5. 2011
    ..In CIDs, a continuous energy appeal reaction triggers systemic detrimental consequences for the rest of the body...
  35. doi request reprint Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases
    R H Straub
    From the Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Intern Med 267:543-60. 2010
    ..We propose that the presented pathophysiological framework may lead to new therapeutical approaches and to a better understanding of CID sequence...
  36. doi request reprint Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis
    Rainer H Straub
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:3450-60. 2008
    ..This study aimed to identify the role of sympathetic neurotransmitters in splenic secretion of IFNgamma and KC shortly after the onset of CIA...
  37. doi request reprint Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:976-84. 2008
    ..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy...
  38. ncbi request reprint Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    R H Straub
    Laboratory of Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Gut 57:911-21. 2008
    ..Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. Aim and..
  39. doi request reprint Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant-induced polyarthritis
    Rainer H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Arthritis Rheum 58:456-66. 2008
    ..In contrast, endogenous opioids such as the recently discovered endomorphins (EMs) are antiinflammatory. However, the role of endogenous EMs such as EM-1 and EM-2 has never been investigated in OA and RA...
  40. ncbi request reprint [Why are there analogous disease mechanisms in chronic inflammatory diseases?]
    Rainer H Straub
    Labor für Neuro Endokrino Immunologie, Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg, Regensburg, Germany
    Wien Klin Wochenschr 119:444-54. 2007
  41. ncbi request reprint The complex role of estrogens in inflammation
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Endocr Rev 28:521-74. 2007
    ..It also explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems...
  42. ncbi request reprint Autoimmune disease and innervation
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Brain Behav Immun 21:528-34. 2007
    ..It might well be that nerve repellent factors specific for the sympathetic nerve fiber might play an important role for the observed differential loss. Whether, or not, a therapy can be based on these findings remains to be established...
  43. ncbi request reprint Circadian rhythms in rheumatoid arthritis: implications for pathophysiology and therapeutic management
    Rainer H Straub
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 56:399-408. 2007
  44. doi request reprint Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6
    R H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Ann Rheum Dis 68:572-8. 2009
    ..Acute stress in patients with rheumatoid arthritis (RA) should stimulate a strong stress response. After cryotherapy, we expected to observe an increase of hormones of the adrenal gland and the sympathetic nervous system...
  45. ncbi request reprint Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 146:365-74. 2002
    ..Furthermore, the behaviour of serum levels of these hormones during an acute inflammatory stressful disease state is not well known...
  46. ncbi request reprint Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Leukoc Biol 67:553-8. 2000
    ..These findings may explain the close association of nerves and macrophages in tissue and lymphoid organs and may thus be of functional relevance in neuroimmunomodulation...
  47. ncbi request reprint A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-alpha and IL-6 secretion in the spleen
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University of Regensburg, Germany
    FASEB J 14:1380-8. 2000
    ..This suggests that activation of the sympathetic nervous system may be a forerunner for accumulation of bacteria in tissue and consecutively sepsis due to intensified inhibition of TNF-alpha secretion...
  48. ncbi request reprint The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    J Endocrinol 175:467-74. 2002
    ..As in chronic inflammatory diseases, during an acute inflammatory response with endotoxin, these physiological hormone changes are probably necessary to achieve adequate cortisol levels at the expense of adrenal androgens...
  49. ncbi request reprint Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis
    Rainer H Straub
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    J Rheumatol 29:1659-64. 2002
    ..To investigate the pituitary and adrenal hormone response after an intravenous epinephrine challenge in patients with rheumatoid arthritis (RA) and controls...
  50. doi request reprint [Neuroendocrine immune interactions in rheumatic diseases]
    R H Straub
    Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum Regensburg, 93042, Regensburg, Deutschland
    Z Rheumatol 69:340-8. 2010
    ..These considerations could lead to novel therapeutic strategies for rheumatic diseases in the future...
  51. ncbi request reprint Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Z Rheumatol 59:II/108-18. 2000
    ..The importance of DHEAS deficiency will be demonstrated with respect to osteoporosis. As a consequence, we suggest a combined therapy with corticosteroids plus DHEA in chronic inflammatory diseases...
  52. ncbi request reprint [Neuroendocrine-immunologic mechanisms in rheumatic diseases--a congress report]
    R H Straub
    Labor für Neuroendokrinoimmunologie Klinik und Poliklinik für Innere Medizin I Universitätsklinikum Regensburg, 93042 Regensburg, Germany
    Z Rheumatol 61:195-200. 2002
    ..Moreover, hyperexcitability of sensory nerves due to peripheral and central neuronal sensitization can support the local inflammatory process...
  53. ncbi request reprint Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  54. ncbi request reprint Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    J Neuroimmunol 125:73-81. 2002
    ..This study further expands our earlier description of the complexity of the local dialogue of sympathetic nerves and macrophages in lymphoid organs...
  55. ncbi request reprint The process of aging changes the interplay of the immune, endocrine and nervous systems
    R H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Regensburg, Germany
    Mech Ageing Dev 122:1591-611. 2001
    ..Furthermore, it is demonstrated that chronic inflammatory diseases may accelerate the aging process. This review also reveals that new statistical and computational methods are necessary to unravel the complexity of the aging process...
  56. ncbi request reprint Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion
    Rainer H Straub
    Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 48:1504-12. 2003
    ..Beyond local effects, anti-TNF treatment may modulate systemic antiinflammatory pathways such as the hypothalamic-pituitary-adrenal (HPA) axis. This longitudinal anti-TNF therapy study was designed to assess these effects in RA patients...
  57. ncbi request reprint Favorable role of interleukin 10 in patients with polymyalgia rheumatica
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Rheumatol 26:1318-25. 1999
    ..To determine the relationship between the antiinflammatory molecule interleukin 10 (IL-10) and disease symptoms, IL-1beta, tumor necrosis factor (TNF), and IL-1 receptor antagonist (IL-1ra) in patients with polymyalgia rheumatica (PMR)...
  58. ncbi request reprint Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 83:2012-7. 1998
    ..Immunosenescence may be directly related to endocrinosenescence, which, in turn, may be a significant cofactor for the manifestation of inflammatory and age-related diseases...
  59. ncbi request reprint Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 85:1340-4. 2000
    ..As IL-6 may be a pathogenetic factor in age-related diseases, HRT-related inhibition of IL-6 secretion could be an important element for the favorable effects of HRT in postmenopausal women...
  60. ncbi request reprint Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Neuroimmunol 80:149-57. 1997
    ..05). Autonomic hyperreflexia was significantly associated with more severe inflammation and systemic disease in IBD. Hyperreflexia may be a response to inflammation or a pathogenetic element that drives mucosal inflammation...
  61. ncbi request reprint The multiple facets of premature aging in rheumatoid arthritis
    Rainer H Straub
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 48:2713-21. 2003
  62. doi request reprint Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis
    Alexander Fassold
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 60:2892-901. 2009
    ..The aim of this study was to investigate the role of neuropilin-2 in the synovial tissue of patients with RA and patients with osteoarthritis (OA) and in experimental arthritis...
  63. doi request reprint Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target
    Silvia Capellino
    Department of Internal Medicine I, Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 69:1853-60. 2010
    ..The presence of tyrosine hydroxylase (TH)-positive cells in RA and osteoarthritis (OA) has been determined, but the role of these cells in inflammation is still unclear...
  64. ncbi request reprint Anti-inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro
    Rainer H Straub
    Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    FASEB J 16:993-1000. 2002
    ..These results underscore that coupling of an efficient secretion of systemic cortisol together with local production of NE is important in order to lower synovial inflammation...
  65. ncbi request reprint An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis
    Peter Härle
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 52:1305-13. 2005
    ..The purpose of this study was to examine the effects of the SNS on late-stage chronic arthritis in mice with type II collagen-induced arthritis (CIA)...
  66. ncbi request reprint During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH
    Selda Kizildere
    Department of Internal Medicine I, University Hospital of Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 148:45-53. 2003
    ..g. in patients with heart failure, fibromyalgia, or cancer cachexia). We aimed to identify the influence of the SNS tone on stimulated adrenal steroid secretion in 16 male and 12 female healthy subjects...
  67. ncbi request reprint Via beta-adrenoceptors, stimulation of extrasplenic sympathetic nerve fibers inhibits lipopolysaccharide-induced TNF secretion in perfused rat spleen
    Martin G Kees
    Laboratory of Neuro Endocrino Immunology, Department of Internal Medicine I, University Hospital, Regensberg 93042, Germany
    J Neuroimmunol 145:77-85. 2003
    ..This study corroborates the idea that splenic sympathetic nerves are able to inhibit important activators of the innate immune system when stimulation happens very early or even prior to their induction by LPS...
  68. ncbi request reprint Corticotropin-releasing factor modulates cardiovascular and pupillary autonomic reflexes in man: is there a link to inflammation-induced autonomic nervous hyperreflexia?
    Georg Pongratz
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    Ann N Y Acad Sci 966:373-83. 2002
    ..It is obvious that CRF can regulate autonomic reflexes. Possibly, central CRF status may also influence autonomic reflexes during chronic inflammation due to chronically changed central CRF concentration...
  69. ncbi request reprint Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis
    Luitpold E Miller
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 50:1156-63. 2004
    ..This study was undertaken to investigate the presence of different semaphorins in synovial tissue of patients with RA, patients with osteoarthritis (OA), and control subjects without inflammation...
  70. ncbi request reprint Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis
    Luitpold E Miller
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    J Rheumatol 29:427-35. 2002
    ..This was accompanied by norepinephrine (NE) release from synovial tyrosine hydroxylase positive cells (TH+ cells). We investigated the role of TH+ cells and NE in synovial inflammation...
  71. ncbi request reprint Increased chromogranin A levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus
    Silvia Capellino
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    J Rheumatol 35:91-9. 2008
    ..We aimed to identify a serum marker of the sympathetic nervous system, the adrenal chromogranin A (CHGA), in order to study sympathetic hyperactivity in RA and SLE...
  72. doi request reprint An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells
    Peter Härle
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:2347-55. 2008
    ..The aim of the present study was to determine whether CD4+CD25+ T cells are influenced by the SNS of mice and play a disease-modifying role in the early symptomatic phase of the disease...
  73. pmc Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension
    Lukas Moleda
    Department of Internal Medicine I, University Medical Center, D 93042 Regensburg, Germany
    World J Gastroenterol 16:1837-44. 2010
    ..To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension...
  74. pmc Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems
    P Harle
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Germany
    Ann Rheum Dis 65:51-6. 2006
    ..To study in parallel the outflow of the sympathetic nervous system (SNS) and the hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  75. doi request reprint Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion
    Torsten Lowin
    Department of Internal Medicine I, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany
    Arthritis Rheum 60:3623-32. 2009
    ..The aim of this study was to investigate whether hormones such as cortisol or other steroids can influence integrin expression and function in the synovial cells of patients with RA...
  76. pmc Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3
    P Sarzi-Puttini
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 65:301-5. 2006
    ..IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation...
  77. pmc Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis
    P Harle
    Laboratory of Neuro Endocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, D 93042 Regensburg, Germany
    Ann Rheum Dis 63:809-16. 2004
    ..Leptin is stimulated by TNF and is associated with hypoandrogenicity in non-inflammatory conditions...
  78. doi request reprint Neuroendocrine immune pathways in chronic arthritis
    Silvia Capellino
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Best Pract Res Clin Rheumatol 22:285-97. 2008
    ....
  79. ncbi request reprint Cardiovascular and pupillary autonomic nervous dysfunction in patients with rheumatoid arthritis - a cross-sectional and longitudinal study
    S Schwemmer
    Dept of Internal Medicine I, University Hospital of Regensburg, Germany
    Clin Exp Rheumatol 24:683-9. 2006
    ..Patients with inflammatory diseases often demonstrate autonomic nervous dysfunction. This study was initiated to investigate cardiovascular (CAD) or pupillary autonomic dysfunction (PAD) in patients with rheumatoid arthritis (RA)...
  80. pmc Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    S Capellino
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Ann Rheum Dis 66:53-8. 2007
    ..Steroid hormone receptors such as glucocorticoid receptors, androgen receptors, and oestrogen receptors alpha (ERalpha) and beta (ERbeta) have been identified in synovial cells of patients with rheumatoid arthritis and osteoarthritis...
  81. ncbi request reprint Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Neurochem 75:2464-71. 2000
    ..These experiments demonstrate the ambiguity of NPY, which functions as a cotransmitter of NE in the nerve-macrophage interplay...
  82. ncbi request reprint Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones
    Daniela Vogl
    Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Medical Center Regensburg, Regensberg, Germany
    J Rheumatol 30:269-75. 2003
    ..In both diseases, cortisol levels remain relatively stable at the expense of other adrenal hormones. This study revealed distinct changes of steroid pathways that are related to the disease entities...
  83. doi request reprint B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?
    Georg Pongratz
    Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Hospital Regensburg, Regensburg 93042, Germany
    Immunol Res 40:148-63. 2008
    ..Finally, the hypothesis is introduced that the sympathetic nervous system via modulating B-cell function, e.g., antibody production, influences the development and progression of RA...
  84. ncbi request reprint Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 46:654-62. 2002
    ....
  85. ncbi request reprint Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol
    David Janele
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann N Y Acad Sci 1069:168-82. 2006
    ..This study underlines the proinflammatory role of E2, which is probably dependent on conversion to a proinflammatory cocktail of downstream estrogens and the presence of cortisol...
  86. doi request reprint Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis
    Klaus Stark
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
    Ann N Y Acad Sci 1193:10-4. 2010
    ..Neuroendocrine factors are hypothesized to play an important role both in RA and OA etiology. Here, we discuss these findings and present an outlook for genetic association studies after GWAS...
  87. ncbi request reprint Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency
    Claudia Weidler
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 52:1721-9. 2005
    ..Because androgens are thought to inhibit immune responses, their presence in inflamed tissue is an additional important antiinflammatory factor...
  88. ncbi request reprint Differential age-related changes of hypothalamus - pituitary - adrenal axis hormones in healthy women and men - role of interleukin 6
    B Zietz
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:93-101. 2001
    ..This study underlines the hormone-like role of IL-6 in the aging process of the endocrine system in women...
  89. pmc Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium
    C Weidler
    Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 64:13-20. 2005
    ..To investigate the correlation between density of nerve fibres and the presence of BDNF(+) cells...
  90. ncbi request reprint Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential beta-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions
    R H Straub
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    J Neuroimmunol 71:37-43. 1996
    ..The study demonstrates two different beta-adrenergic effects on IL-6 secretion of murine spleen slices under bacteria-rich or bacteria-free conditions...
  91. ncbi request reprint In polymyalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers
    R H Straub
    Department of Internal Medicine, University Medical Centre Regensburg, D 93042 Regensburg, Germany
    Rheumatology (Oxford) 41:423-9. 2002
    ..In the present study, we investigated the role of prolactin (PRL) in relation to the number of typical symptoms and serum markers of systemic inflammation in patients with polymyalgia rheumatica (PMR)...
  92. doi request reprint Relevance of disease- and organ-specific endothelial cells for in vitro research
    Karla Lehle
    Department of Cardiothoracic Surgery, University Hospital Regensburg, 93042 Regensburg, Germany
    Cell Biol Int 34:1231-8. 2010
    ....
  93. doi request reprint The melanocortin system in articular chondrocytes: melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of alpha-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components
    Susanne Grassel
    Department of Orthopaedic Surgery and Centre for Medical Biotechnology, University of Regensburg, Regensburg, Germany
    Arthritis Rheum 60:3017-27. 2009
    ..This study was carried out to investigate the expression patterns of the MC system and the effects of alpha-MSH in human articular chondrocytes...
  94. ncbi request reprint Stress as a risk factor in the pathogenesis of rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genoa, Italy, and Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Neuroimmunomodulation 13:277-82. 2006
    ..Long-lasting (chronic) stress may lead to proinflammatory effects because no adequate long-term responses of stress axes (anti-inflammatory) are to be expected...
  95. doi request reprint Aggravation of DSS-induced colitis after chronic subordinate colony (CSC) housing is partially mediated by adrenal mechanisms
    Stefan O Reber
    Institute of Zoology, University of Regensburg, Regensburg, Germany
    Stress 11:225-34. 2008
    ..In conclusion, exposure to chronic psycho-social stress increases the severity of acute DSS colitis, an effect which is, at least partly, mediated by adrenal mechanisms...
  96. doi request reprint The B cell, arthritis, and the sympathetic nervous system
    Georg Pongratz
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Brain Behav Immun 24:186-92. 2010
    ....
  97. ncbi request reprint Myocardial IL-6 regulation by neurohormones--an in vitro superfusion study
    Andreas Jeron
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Brain Behav Immun 17:245-50. 2003
    ....
  98. ncbi request reprint Histopathological parameters as predictors for the course of Crohn's disease
    Frauke Bataille
    Department of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Virchows Arch 443:501-7. 2003
    ..Individual, clinical course-specific new treatment schemes would be highly desirable for different potentially divergent pathophysiological pathways (e.g., fistula vs stenosis)...
  99. ncbi request reprint Steroid hormones strongly support bovine articular cartilage integration in the absence of interleukin-1beta
    Carsten Englert
    University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 54:3890-7. 2006
    ..This study was undertaken to investigate effects on articular cartilage integration mediated by steroid hormones, interleukin-1beta (IL-1beta), and combinations thereof...
  100. ncbi request reprint Serum BAFF strongly correlates with PsA activity in male patients only--is there a role for sex hormones?
    G Pongratz
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Clin Exp Rheumatol 28:813-9. 2010
    ..To determine the relationship between serum levels of B cell activating factor belonging to the TNF family (BAFF) and disease activity (DAS28) in psoriatic arthritis (PsA) patients...