A Storch

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells
    Alexander Storch
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Chem Neuroanat 26:133-42. 2003
  2. ncbi HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Germany
    Neurochem Int 35:393-403. 1999
  3. ncbi Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurochem 89:685-94. 2004
  4. ncbi Neural stem cells and neurodegeneration
    Alexander Storch
    Department of Neurology, University of Ulm, Germany
    Curr Opin Investig Drugs 3:774-81. 2002
  5. ncbi Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter
    Alexander Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Biochem Pharmacol 63:909-20. 2002
  6. ncbi Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Exp Neurol 170:317-25. 2001
  7. ncbi Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    J Neurochem 75:2259-69. 2000
  8. ncbi 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Federal Republic of Germany
    J Neural Transm 107:281-93. 2000
  9. ncbi Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Mol Pharmacol 57:589-94. 2000
  10. ncbi 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Brain Res 855:67-75. 2000

Collaborators

Detail Information

Publications53

  1. ncbi Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells
    Alexander Storch
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Chem Neuroanat 26:133-42. 2003
    ....
  2. ncbi HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Germany
    Neurochem Int 35:393-403. 1999
    ..This cell system may serve as a screening system for endogenous and exogenous compounds with similar effects compared to MPP+ as well as protective agents...
  3. ncbi Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurochem 89:685-94. 2004
    ..Our data suggest that DAT-mediated cellular uptake of 2[N]-methylated betaCs represents a potential mechanism for selective toxicity towards dopaminergic neurons and may be relevant for the pathogenesis of Parkinson's disease...
  4. ncbi Neural stem cells and neurodegeneration
    Alexander Storch
    Department of Neurology, University of Ulm, Germany
    Curr Opin Investig Drugs 3:774-81. 2002
    ..These cells can be grown in vitro while retaining the potential to differentiate into nervous tissue. This review focuses on regenerative therapy in neurodegenerative diseases using NSC...
  5. ncbi Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter
    Alexander Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Biochem Pharmacol 63:909-20. 2002
    ....
  6. ncbi Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Exp Neurol 170:317-25. 2001
    ....
  7. ncbi Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    J Neurochem 75:2259-69. 2000
    ..These results provide further impetus to explore the neuroprotective potential of riluzole in Parkinson's disease...
  8. ncbi 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Federal Republic of Germany
    J Neural Transm 107:281-93. 2000
    ..These results suggest that cell death induced by 6-OHDA is not due to an inhibition of mitochondrial energy supply, but probably involves production of free radicals...
  9. ncbi Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Mol Pharmacol 57:589-94. 2000
    ..These data demonstrate that COMT inhibition attenuates L-dopa toxicity toward DA neurons in vitro, but probably not by preventing 3-O-methyldopa production or cellular S-adenosyl-L-methionine depletion...
  10. ncbi 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Brain Res 855:67-75. 2000
    ..These results suggest that cell death induced by salsolinol is due to impairment of cellular energy supply, caused in particular by inhibition of mitochondrial complex II (succinate-Q reductase), but not complex I...
  11. ncbi Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells
    A Storch
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neural Transm 113:1895-901. 2006
    ..Our results suggest that TaClo and related analogs are strong cytotoxins without selectivity towards dopaminergic cells...
  12. ncbi Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration
    A Storch
    Department of Neurology, University of Ulm, Germany
    J Neural Transm 111:1267-86. 2004
    ..Taken together, there is large body of evidence from morphological, molecular biological and toxicological studies indicating that the DAT might be responsible for the selectivity of DA cell death in PD...
  13. ncbi Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro
    A G Ludolph
    Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany
    J Neural Transm 113:1927-34. 2006
    ..The neurotoxic effects of MPP(+) could be significantly reduced by co-application of MPH, an effect that is most likely explained by MPH blocking the DAT...
  14. doi Altered migration and adhesion potential of pro-neurally converted human bone marrow stromal cells
    H J Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    Cytotherapy 10:824-33. 2008
    ..We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free conditions...
  15. ncbi [Tauopathies--a new class of neurodegenerative diseases]
    A C Ludolph
    Abt für Neurologie, Universitat Ulm, Steinhovelstrasse 9, 89075 Ulm
    Nervenarzt 72:78-85. 2001
    ..In the future, it will be important to designate the diagnostic gold standard not by clinical description, but etiologic classification...
  16. doi Depression in Parkinson's disease
    J Schwarz
    Department of Neurology, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    J Neurol 258:S336-8. 2011
    ..Data on specific diagnostic tools or treatment for depressive symptoms in PD patients are still sparse. Here we summarize an expert opinion based on available data and clinical experience...
  17. ncbi Efficacy and safety of high-dose cabergoline in Parkinson's disease
    P Odin
    Department of Neurology, Central Hospital, D 27574 Bremerhaven, Germany
    Acta Neurol Scand 113:18-24. 2006
    ..To assess the efficacy and safety of high-dose (up to 20 mg/day) cabergoline in Parkinson's disease (PD) patients with motor fluctuations and/or dyskinesias...
  18. ncbi Multiple cerebral aneurysms as delayed complication of left cardiac myxoma: a case report and review
    M Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Acta Neurol Scand 111:345-50. 2005
    ..The clinical, radiological and pathological features of these aneurysms are summarized. The pathogenesis, including the role of IL-6 in the formation of myxomatous aneurysms, is discussed...
  19. ncbi Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects
    H J Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neural Transm 114:1395-406. 2007
    ....
  20. ncbi Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic culture
    Juliane Hamann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurochem 98:1185-99. 2006
    ..These data underline the preferential susceptibility of dopaminergic neurones to 2,9-Me(2)NH(+) as a potent, oxidative stress generating neurotoxin...
  21. ncbi Developmental perspectives on human midbrain-derived neural stem cells
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Neurodegener Dis 3:45-9. 2006
    ..Neural stem cells derived from human fetal midbrain tissue maintain a considerable capacity to self-renew and to differentiate into DA neurons. Therefore, these cells may be a promising source to generate functional human DA neurons...
  22. ncbi Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells
    Andreas Hermann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurochem 98:629-40. 2006
    ..Our findings reinforce the emerging view that the differentiation capacity of adult hNPCs is critically influenced by non-neuronal mesodermal feeder cells...
  23. ncbi Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 99:426-37. 2006
    ..3 by Psora-4, increased NPC proliferation. These findings underline the regulatory role of K(+) channels on the cell cycle and imply that K(+) channel modulators might be used therapeutically to activate endogenous NPCs...
  24. ncbi Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro
    Javorina Milosevic
    Translational Centre for Regenerative Medicine, Leipzig, 04103 Leipzig, Germany, Department of Neurology, University of Leipzig, 04103, Germany
    Stem Cells Dev 16:625-35. 2007
    ..Our data question the relevance of neuroregenerative effects of dopamine agonists for human predopaminergic cells as well as patients with Parkinson's disease...
  25. ncbi Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Neurochem 99:913-23. 2006
    ..We conclude that uracil nucleotides exert specific P2 receptor-mediated effects on midbrain-derived human NPCs, and may be used to enhance both proliferation and dopaminergic differentiation...
  26. ncbi Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling
    Javorina Milosevic
    Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 27:412-21. 2007
    ..In conclusion, HIF-1alpha seems to be a transcription factor relevant to the development and survival of substantia nigra dopaminergic neurons involving VEGF signaling...
  27. ncbi Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state
    Martina Maisel
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    Stem Cells 25:1231-40. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  28. ncbi Maturation of synaptic contacts in differentiating neural stem cells
    Stefan Liebau
    Institute of Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Stem Cells 25:1720-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  29. ncbi Dexamethasone blocks astroglial differentiation from neural precursor cells
    Michael Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Neuroreport 17:1719-23. 2006
    ....
  30. ncbi Formation of cellular projections in neural progenitor cells depends on SK3 channel activity
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 101:1338-1350. 2007
    ..Both effects could be prevented by the pre-incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels...
  31. doi Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxins
    Michael Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Neurotoxicology 29:714-21. 2008
    ..This cell system seems not suitable as a screening tool for selective dopaminergic toxicity...
  32. ncbi Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Neurol 64:938-44. 2007
    ..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons...
  33. ncbi Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro
    Vera Lehmensiek
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neuroreport 13:1279-83. 2002
    ..Our data suggest a new mechanism of MPP+-induced dopaminergic toxicity by an interaction between mutant alpha-synucleins and the DAT, which is independent of the function of the proteasome...
  34. ncbi Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Germany
    J Neurochem 92:718-29. 2005
    ..Gene regulation governed by low oxygen tension may be relevant to the normal development and survival of midbrain neurons...
  35. ncbi Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear decline
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Nucl Med 45:1694-7. 2004
    ..Most follow-up studies have provided data best fitted by a linear decline of their outcome measure. However, in these studies, patients were repeatedly scanned during their first years after a diagnosis had been established...
  36. ncbi Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells
    Andreas Hermann
    Department of Neurology, University of Ulm, Helmholtzstr 8 1, 89081 Ulm, Germany
    J Cell Sci 117:4411-22. 2004
    ..Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases...
  37. ncbi Transplantation of human neural precursor cells in the 6-OHDA lesioned rats: effect of immunosuppression with cyclosporine A
    Sigrid C Schwarz
    Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Saxony, Germany
    Parkinsonism Relat Disord 12:302-8. 2006
    ..There was no evidence for tumor formation. Immunosuppression of rats, xenotransplanted with human NPC did not improve graft survival or function...
  38. ncbi Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons
    Andreas Hermann
    Department of Neurology, University of Ulm, Germany
    Stem Cells 24:949-64. 2006
    ..Here, we demonstrate the existence of adult tNSCs with functional neurogenic and dopaminergic potential, a prerequisite for future endogenous cell replacement strategies in Parkinson's disease...
  39. ncbi Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease
    Vera Lehmensiek
    Department of Neurology, University of Ulm, Germany
    Neurochem Int 48:329-40. 2006
    ....
  40. ncbi Neural stem cells and Parkinson's disease
    Alexander Storch
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 249:III/30-2. 2002
    ..These cells will hopefully enable restorative treatment of patients with Parkinson's disease in the near future...
  41. ncbi Low extracellular calcium is sufficient for survival and proliferation of murine mesencephalic neural precursor cells
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Cell Tissue Res 324:377-84. 2006
    ..0 mM) are not required, a concentration of 0.5 mM being adequate for cell maintenance...
  42. ncbi Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity
    Heike Blessing
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Int 42:139-51. 2003
    ..In addition, we demonstrate a second mechanism of L-DOPA toxicity in vitro mediated by a COMT- and glia-dependent pathway, which is blocked by COMT inhibitors, most likely due to enhanced glial uptake of L-DOPA...
  43. ncbi Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols
    Andreas Hermann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurosci Res 83:1502-14. 2006
    ..Analysis of marker gene expression for characterization of neural cells derived from MSCs has to take into account that several early and late neuroectodermal genes are already expressed in undifferentiated MSCs...
  44. ncbi Midbrain-derived neural stem cells: from basic science to therapeutic approaches
    Alexander Storch
    Department of Neurology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 318:15-22. 2004
    ..This review discusses new data concerning the cell biology and therapeutic potential of NSCs derived from the midbrain region of the central nervous system...
  45. ncbi Spontaneous apoptosis in murine free-floating neurospheres
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Exp Cell Res 294:9-17. 2004
    ..Pro-apoptotic proteins of the Bcl-2 family, Bax and Bak, exhibited conformational changes in neural precursors expanding in vitro. Key molecules such as executioner caspase-3 may be useful targets to reduce the amount of apoptosis...
  46. ncbi Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneration
    Andreas Hermann
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Expert Opin Biol Ther 4:131-43. 2004
    ..However, one major problem is the control of growth and differentiation of these cells. This review discusses new data on stem cell technology in cell replacement strategies in PD as well as endogenous dopaminergic regeneration...
  47. ncbi Cryopreservation does not affect proliferation and multipotency of murine neural precursor cells
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Stem Cells 23:681-8. 2005
    ..We conclude that cryopreservation (up to 1 month at -70 degrees C and up to 1 year in liquid nitrogen) does not markedly alter the rate of proliferation and multipotency of murine neural precursor cells...
  48. ncbi Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: a reader-blinded monocenter echocardiography study
    Susann Junghanns
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    Mov Disord 22:234-8. 2007
    ..Our data suggest that ergot DAs are associated with higher prevalence of VHD compared to non-ergot DAs and controls. Standard echocardiography seems sufficient to detect VHD in PD patients treated with DAs...
  49. ncbi High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    Parkinsonism Relat Disord 11:393-8. 2005
    ..Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy...
  50. ncbi High doses of pergolide improve clinical global impression in advanced Parkinson's disease:- a preliminary open label study
    Guy Arnold
    Department of Neurology, Charite, University Hospital Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Arch Gerontol Geriatr 41:239-53. 2005
    ..A possible relationship to the study medication was assumed for two serious adverse events reporting psychosis. We conclude that high doses of pergolide are efficacious in advanced stages of PD if given in appropriate regimens...
  51. ncbi Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders
    Andreas Hermann
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    Expert Opin Biol Ther 6:653-70. 2006
    ..These cells provide a powerful tool for investigating the molecular mechanisms of neural differentiation, and might serve as an autologous cell source to treat acute and chronic neurodegenerative diseases...
  52. ncbi Increased periodontal pathology in Parkinson's disease
    Johannes Schwarz
    Dept of Neurology, University of Leipzig, Liebigstr 22a, 04103, Leipzig, Germany
    J Neurol 253:608-11. 2006
    ..We believe that problems in oral hygiene contribute to this increased periodontal pathology in patients with Parkinson's disease, which may further compromise the quality of life...
  53. ncbi New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications
    Alexander Storch
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neurol 251:VI/33-8. 2004
    ..Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials...