Holger Stepan

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Obesity as an obstetric risk factor: does it matter in a perinatal center?
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 14:770-3. 2006
  2. doi request reprint Angiogenic factors and pre-eclampsia: an early marker is needed
    Holger Stepan
    Department of Obstetrics, Leipzig University, Liebigstr 20a, 04103 Leipzig, Germany
    Clin Sci (Lond) 116:231-2. 2009
  3. doi request reprint [Use of angiogenic factors (sFlt-1/PlGF ratio) to confirm the diagnosis of preeclampsia in clinical routine: first experience]
    H Stepan
    Abteilung für Geburtsmedizin, Universitatsklinikum Leipzig, Liebigstrasse 20a, Leipzig
    Z Geburtshilfe Neonatol 214:234-8. 2010
  4. ncbi request reprint Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Philipp Rosenthalstr 55, 04103 Leipzig, Germany
    Eur J Obstet Gynecol Reprod Biol 122:172-6. 2005
  5. ncbi request reprint Proteinuria in hypertensive pregnancy diseases is associated with a longer persistence of hypertension postpartum
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Hum Hypertens 20:125-8. 2006
  6. doi request reprint Circulatory soluble endoglin and its predictive value for preeclampsia in second-trimester pregnancies with abnormal uterine perfusion
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig Faculty of Medicine, Leipzig, Germany
    Am J Obstet Gynecol 198:175.e1-6. 2008
  7. doi request reprint [Angiogenic factors and their role in pathogenesis and prediction of preeclampsia]
    H Stepan
    Abteilung für Geburtsmedizin, Universitatsklinikum Leipzig
    Z Geburtshilfe Neonatol 213:101-5. 2009
  8. ncbi request reprint Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Hypertension 49:818-24. 2007
  9. ncbi request reprint Maternal plasma concentrations of soluble endoglin in pregnancies with intrauterine growth restriction
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 92:2831-4. 2007
  10. doi request reprint Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
    Holger Stepan
    University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany
    Cytokine 62:322-6. 2013

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Obesity as an obstetric risk factor: does it matter in a perinatal center?
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 14:770-3. 2006
    ..Obesity before and during pregnancy is associated with several obstetrics risk factors for both mother and fetus. The aim of this retrospective study was to analyze the influence of BMI before pregnancy on distinct perinatal parameters...
  2. doi request reprint Angiogenic factors and pre-eclampsia: an early marker is needed
    Holger Stepan
    Department of Obstetrics, Leipzig University, Liebigstr 20a, 04103 Leipzig, Germany
    Clin Sci (Lond) 116:231-2. 2009
    ..Thus this protein could serve (alone or in combination with other parameters) as a new marker for risk assessment in terms of pre-eclampsia...
  3. doi request reprint [Use of angiogenic factors (sFlt-1/PlGF ratio) to confirm the diagnosis of preeclampsia in clinical routine: first experience]
    H Stepan
    Abteilung für Geburtsmedizin, Universitatsklinikum Leipzig, Liebigstrasse 20a, Leipzig
    Z Geburtshilfe Neonatol 214:234-8. 2010
    ..Not all pregnant women with signs and symptoms of preeclampsia develop the disease. Recently, the assessment of the sFlt-1/PlGF ratio in the serum of pregnant women has been proposed as an aid in the diagnosis of preeclampsia...
  4. ncbi request reprint Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Philipp Rosenthalstr 55, 04103 Leipzig, Germany
    Eur J Obstet Gynecol Reprod Biol 122:172-6. 2005
    ..The aim of the study was to analyze placental expression of BNip3 and Nix in pregnancies complicated by preeclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome and IUGR...
  5. ncbi request reprint Proteinuria in hypertensive pregnancy diseases is associated with a longer persistence of hypertension postpartum
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Hum Hypertens 20:125-8. 2006
    ..A high percentage of these women are discharged from hospital with persisting hypertension and proteinuria. These observations demand a more specific and long-term PP care for these women...
  6. doi request reprint Circulatory soluble endoglin and its predictive value for preeclampsia in second-trimester pregnancies with abnormal uterine perfusion
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig Faculty of Medicine, Leipzig, Germany
    Am J Obstet Gynecol 198:175.e1-6. 2008
    ..The aim of this study was to investigate whether the sEng increase was present already in second-trimester pregnancies with abnormal uterine perfusion and whether the pregnancy was at risk for preeclampsia...
  7. doi request reprint [Angiogenic factors and their role in pathogenesis and prediction of preeclampsia]
    H Stepan
    Abteilung für Geburtsmedizin, Universitatsklinikum Leipzig
    Z Geburtshilfe Neonatol 213:101-5. 2009
    ..The next step will be the development of therapeutic tools that have positive impact on the clinical symptoms via the inhibition of sFlt1 and or sEng...
  8. ncbi request reprint Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Hypertension 49:818-24. 2007
    ..We conclude that the concurrent measurement of uterine perfusion and angiogenic factors allows an efficient prediction of early onset pregnancy complications, particularly preeclampsia...
  9. ncbi request reprint Maternal plasma concentrations of soluble endoglin in pregnancies with intrauterine growth restriction
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 92:2831-4. 2007
    ..Pregnant women with preeclampsia show increased sEng concentrations in circulation, whereas the sEng increase is detectable months before the clinical onset of the disease...
  10. doi request reprint Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
    Holger Stepan
    University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany
    Cytokine 62:322-6. 2013
    ..Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo...
  11. ncbi request reprint Endogenous soluble receptor for advanced glycation endproducts is increased in preeclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Strasse 27, Leipzig, Germany
    J Hypertens 26:1824-8. 2008
    ..In the current study, we investigated esRAGE serum levels in patients with preeclampsia as compared to healthy gestational age-matched controls...
  12. doi request reprint Preliminary report: Serum levels of retinol-binding protein 4 in preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig 04103, Germany
    Metabolism 58:275-7. 2009
    ..Furthermore, RBP4 did not correlate to clinical and biochemical measures of pregnancy outcome, renal function, glucose, and lipid metabolism, as well as inflammation. Our results do not support a role of RBP4 in the pathogenesis of PE...
  13. doi request reprint Serum levels of the adipokine adipocyte fatty acid-binding protein are increased in preeclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Am J Hypertens 21:582-6. 2008
    ..In this study, we investigated serum concentrations of the adipokine AFABP in patients with PE as compared to healthy controls of similar gestational age...
  14. doi request reprint Circulating levels of the adipokine chemerin in gestational diabetes mellitus
    Dörte Pfau
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Horm Res Paediatr 74:56-61. 2010
    ..In the current study, we investigated circulating chemerin levels in patients with gestational diabetes mellitus (GDM) as compared to healthy pregnant controls matched for gestational age and fasting insulin...
  15. ncbi request reprint Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Metabolism 59:1054-6. 2010
    ..Circulating vaspin levels are not significantly different between GDM, PE, and control subjects and do not correlate with insulin sensitivity in pregnant subjects...
  16. ncbi request reprint Secretory products from human adipocytes stimulate proinflammatory cytokine secretion from human endothelial cells
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    J Cell Biochem 106:729-37. 2009
    ..Our findings suggest that endothelial cell secretion is significantly influenced towards a proinflammatory pattern by adipocyte-secreted factors...
  17. doi request reprint Serum levels of angiopoietin-related growth factor are increased in preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Am J Hypertens 22:314-8. 2009
    ..In the current study, we hypothesized that serum levels of AGF would be lower in preeclamptic patients as compared to healthy controls...
  18. doi request reprint Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia
    Sebastian Stein
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 59:33-7. 2010
    ..Fibroblast growth factor 21 is independently associated with markers of insulin resistance and an adverse lipid profile but is not dysregulated in GDM if patients are matched with controls for fasting insulin...
  19. doi request reprint New gestational phase-specific cutoff values for the use of the soluble fms-like tyrosine kinase-1/placental growth factor ratio as a diagnostic test for preeclampsia
    Stefan Verlohren
    Department of Obstetrics, Charite University Medicine Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Hypertension 63:346-52. 2014
    ..6%/73.1% and 58.2%/95.5%, respectively. The approach to use multiple cutoffs for the early and late gestational phase enhances the diagnostic accuracy of the sFlt-1/PlGF ratio as a diagnostic tool for preeclampsia. ..
  20. ncbi request reprint Serum levels of the adipokine visfatin are increased in pre-eclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Clin Endocrinol (Oxf) 69:69-73. 2008
    ..In the current study, we investigated visfatin serum levels in pre-eclamptic patients as compared to healthy gestational age-matched controls...
  21. doi request reprint Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus
    Susan Kralisch
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Eur J Endocrinol 160:33-8. 2009
    ..In the current study, we investigated serum concentrations of AFABP in patients with gestational diabetes mellitus (GDM) as compared with healthy pregnant controls matched for gestational age and fasting insulin...
  22. doi request reprint Relation between maternal angiogenic factors and utero-placental resistance in normal first- and second-trimester pregnancies
    Katrin Petzold
    Department of Obstetrics, University Hospital of Leipzig, Leipzig, Germany
    Hypertens Pregnancy 30:401-7. 2011
    ....
  23. doi request reprint An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia
    Stefan Verlohren
    Department of Obstetrics, Campus Virchow Clinic, Charite University Medicine, Berlin, Germany
    Am J Obstet Gynecol 202:161.e1-161.e11. 2010
    ..This study evaluates a newly developed Elecsys (Roche, Penzberg, Germany) assay for sFlt-1 and PIGF and tests the value of the sFlt-1/PIGF ratio in the assessment of PE...
  24. ncbi request reprint Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Reprod Immunol 73:130-4. 2007
    ..We find parvovirus IgG-positive pregnant women in all subgroups without relation to AT1-AA presence. This favors AT1-AA generation to be independent of epitope mimicry between parvovirus B19 capsid proteins and the AT1 receptor...
  25. doi request reprint Serum levels of growth arrest specific protein 6 are increased in preeclampsia
    Holger Stepan
    University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany
    Regul Pept 182:7-11. 2013
    ..Taken together, maternal Gas6 serum concentrations are significantly increased in PE during pregnancy. Furthermore, the adipokines leptin and adiponectin are independent predictors of circulating Gas6 in pregnant women...
  26. doi request reprint The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients
    Stefan Verlohren
    Department of Obstetrics, Campus Virchow Clinic, Charite University Medicine, Berlin, Germany
    Am J Obstet Gynecol 206:58.e1-8. 2012
    ..We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders...
  27. doi request reprint Serum levels of the adipokine chemerin are increased in preeclampsia during and 6 months after pregnancy
    Holger Stepan
    University of Leipzig, Department of Obstetrics, Germany
    Regul Pept 168:69-72. 2011
    ..4] μg/l). Taken together, maternal chemerin serum concentrations are significantly increased in preeclampsia during and after pregnancy. Furthermore, TG and leptin are independent predictors of circulating chemerin during pregnancy...
  28. doi request reprint Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery
    Thomas Ebert
    University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany Electronic address
    Cytokine 65:153-8. 2014
    ..However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far...
  29. ncbi request reprint Pathological uterine perfusion in the second trimester is not associated with neutrophil activation
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Hypertens Pregnancy 22:239-45. 2003
    ....
  30. doi request reprint Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Eur J Endocrinol 158:197-201. 2008
    ..Furthermore, high-molecular-weight (HMW) adiponectin has been suggested as the biologically active form of this adipokine...
  31. ncbi request reprint New insights into the biology of preeclampsia
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    Biol Reprod 74:772-6. 2006
    ..This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia...
  32. doi request reprint Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia
    Stefan Verlohren
    Department of Obstetrics, Campus Virchow Clinic, Charite University Medicine Berlin, Germany
    Clin Sci (Lond) 122:43-52. 2012
    ..Furthermore, we review studies with a clinical focus in which the sFlt-1/PlGF ratio has been analysed along with other candidates for routine clinical assessment of pre-eclampsia...
  33. doi request reprint Glucose tolerance in women 24 h postpartum is related to blood pressure, anthropometric data, and adipokine serum levels
    Sabine Nickisch
    Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Hypertens Pregnancy 31:228-39. 2012
    ..To characterize glucose tolerance and adipokine serum levels in a cohort of women shortly after delivery...
  34. ncbi request reprint Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
    Renaldo Faber
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Perinat Med 32:538-40. 2004
    ....
  35. ncbi request reprint Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function
    M Fasshauer
    Department of Internal Medicine III, University of Leipzig, Germany
    Clin Endocrinol (Oxf) 66:434-9. 2007
    ..As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregnancy disorders...
  36. ncbi request reprint Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Ultrasound Obstet Gynecol 23:579-83. 2004
    ....
  37. ncbi request reprint Baroreflex sensitivity, heart rate, and blood pressure variability in hypertensive pregnancy disorders
    R Faber
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Hum Hypertens 18:707-12. 2004
    ..Thus, distinct clinical manifestations of hypertension in pregnancy have different pathophysiological, regulatory, and compensatory mechanisms...
  38. ncbi request reprint Gestational regulation of the gene expression of C-type natriuretic peptide in mouse reproductive and embryonic tissue
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Philipp Rosenthalstr 55, 04103, Leipzig, Germany
    Regul Pept 102:9-13. 2001
    ..CNP-mRNA concentrations in embryos are gestational age-dependent with a high level at day 9.5 pc in head and trunk. These results indicate that CNP has a regulatory function in pregnancy and embryonic development...
  39. ncbi request reprint [Accuracy of prenatal diagnoses in terminated pregnancies--a retrospective analysis of results and influences]
    R Faber
    Universitatsfrauenklinik, Universitat Leipzig
    Z Geburtshilfe Neonatol 205:54-9. 2001
    ....
  40. ncbi request reprint [Abnormal uterine perfusion in the second trimester--current pathophysiological, diagnostic and therapeutic aspects]
    H Stepan
    Universitätsfrauenklinik Leipzig
    Z Geburtshilfe Neonatol 208:205-9. 2004
    ..Therapeutic approaches may improve clinical course and outcome of those high-risk pregnancies but do not target the cause of the disturbed placental development...
  41. ncbi request reprint Umbilical cord entanglement in monoamniotic twins
    R Faber
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    Ultrasound Obstet Gynecol 24:592-3. 2004
  42. ncbi request reprint Pre-eclampsia as a 'three stage problem'--a workshop report
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Philipp Rosenthalstr 55, 04103, Leipzig, Germany
    Placenta 25:585-7. 2004
  43. ncbi request reprint Detection of C-type natriuretic peptide in fetal circulation
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Perinat Med 28:118-21. 2000
    ..Moreover, fetal CNP-plasma levels are higher than previously measured maternal concentrations in normal pregnancies. Therefore, the fetus expresses CNP independently of the maternal circulation...
  44. ncbi request reprint C-type natriuretic peptide in maternal plasma in spontaneous labour, at elective cesarean section and during puerperium
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Perinat Med 26:396-9. 1998
    ..Its possible role in volume regulation with increased levels after rapid volume load but normal levels in puerperium with physiologically enhanced diuresis and natriuresis remains unclear...
  45. ncbi request reprint C-type natriuretic peptide levels in women with gestational hypertension and preeclampsia
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    Obstet Gynecol 93:199-202. 1999
    ..To measure plasma levels of C-type natriuretic peptide in women with normal pregnancies and those complicated by gestational hypertension and preeclampsia...
  46. ncbi request reprint Structure and regulation of the murine Mash2 gene
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, D 04103 Leipzig, Germany
    Biol Reprod 68:40-4. 2003
    ..0% +/- 69.7% on Day 12.5 p.c. The second half of gestation is marked by a more than 8-fold Mash2 decrease by Day 18.5 p.c. (77.0% +/- 28.4%). A 36.9% +/- 4.7% level of placental Mash2 mRNA is measurable at term...
  47. doi request reprint Application of tissue microarrays in placental research
    Lars Christian Horn
    Division of Gynecologic and Perintatal Pathology, Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 12:48-9. 2008
    ..Here we describe the technical details of the application of tissue microarray in placental research. Although the placenta represents a very inhomogeneous organ, this technique is also usable in placental research...
  48. doi request reprint Effect of terminated fetal circulation on maternal angiogenic factors in severe early preeclampsia
    Alexander Jank
    Department of Obstetrics, University Hospital of Leipzig, Leipzig, Germany
    Hypertens Pregnancy 31:201-6. 2012
    ....
  49. doi request reprint A case of maternal PKU syndrome despite intensive patient counseling
    Susette Unger
    Department of Medicine, University Hospital, Leipzig, Germany
    Wien Med Wochenschr 159:507-10. 2009
    ..However, a major factor in preventing Phe embryopathy is patient compliance in keeping the diet, which was insufficient in the case presented...
  50. ncbi request reprint Cervical immunoglobulin A and altered vaginal flora in pregnant women with threatened preterm delivery
    Simone Glasow
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Perinat Med 32:37-41. 2004
    ..0-189.7) mg/l. Patients with a pathological vaginal smear and preterm delivery had the lowest IgA levels (35.0; 0.0-187.9 mg/l). Measurement of cervical IgA concentration does not differentiate between women who deliver before or at term...
  51. ncbi request reprint Umbilical cord hypercoiling and thinning: a rare cause of intrauterine death in the second trimester of pregnancy
    Lars Christian Horn
    Institute of Pathology, University Hospital of Leipzig, Leipzig, Germany
    Pediatr Dev Pathol 9:20-4. 2006
    ..Careful pathologic examination of the umbilical cord is recommended to detect TCS and to reduce the cases with unexplained intrauterine death...
  52. doi request reprint Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia
    Konstanze Miehle
    Department of Internal Medicine Endocrinology and Nephrology, University of Leipzig, Germany
    Clin Endocrinol (Oxf) 76:2-11. 2012
    ..This review gives an overview on the regulation and pathophysiology of leptin and adiponectin in GDM and PE. Furthermore, data on novel adipokines including resistin, visfatin, retinol-binding protein 4 and vaspin are summarized...
  53. ncbi request reprint Cells on a chip--the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling
    Andrée Rothermel
    Center for Biotechnology and Biomedicine, Department of Molecular Biological Biochemical Processing Technology, University of Leipzig, Germany
    Cell Physiol Biochem 16:51-8. 2005
    ..We developed a highly sensitive cardiomyocyte based screening system for the non-destructive electronic detection of chronotropic drugs and tissue-secreted factors involved in AT1 receptor-mediated cardiovascular diseases...
  54. ncbi request reprint Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    Fetal Diagn Ther 17:37-41. 2002
    ..Since CNP shows antimitogenic and vasodilatative properties, it was the aim of the study to investigate whether CNP expression is altered in placenta and myometrium from pregnancies complicated by intrauterine growth retardation...
  55. ncbi request reprint A rare case of congenital choroid plexus carcinoma
    Miriam Wilhelm
    Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Pediatr Hematol Oncol 29:643-6. 2012
    ..The parents opted for palliative treatment at this stage. The patient died at the age of one year. Ethical aspects have to be actively considered and addressed when caring for children with choroid plexus carcinoma...
  56. doi request reprint A mass spectrometric multicenter study supports classification of preeclampsia as heterogeneous disorder
    Ulrich Pecks
    Department of Obstetrics and Gynecology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Hypertens Pregnancy 31:278-91. 2012
    ..The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting...
  57. ncbi request reprint Secretory products from human adipocytes impair endothelial function via nuclear factor kappaB
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Atherosclerosis 196:523-31. 2008
    ..Adipo did not show cytotoxic effects. Taken together, we demonstrate that endothelial dysfunction is induced by adipocyte-secreted factors via NFkappaB partly dependent on TNFalpha...
  58. doi request reprint EXIT procedure in a neonate with a prenatally diagnosed granular cell tumor
    Steffi Mayer
    Department of Pediatric Surgery, University Hospital Leipzig, Leipzig, Germany
    Pediatr Surg Int 26:935-7. 2010
    ..The EXIT procedure is an elegant approach to optimize perinatal airway management in such tumors...
  59. ncbi request reprint PRL as a novel potent cofactor for platelet aggregation
    H Wallaschofski
    Department of Internal Medicine III, University of Leipzig, Germany
    J Clin Endocrinol Metab 86:5912-9. 2001
    ..Further studies of the interaction between PRL and platelets will clarify the clinical relevance of hyperprolactinemia as a potential risk factor for VTE...
  60. ncbi request reprint [Peripartum cardiomyopathy-the (un)known obstetricalcardiologic emergency situation]
    H Stepan
    Universitatsfrauenklinik, Philipp Rosenthalstr 55, 04103 Leipzig, Germany
    Z Kardiol 92:811-6. 2003
    ..The severity of the disease requires an interdisciplinary approach in a perinatal center with consequent follow-up of the patients for risk stratification including echocardiography...
  61. ncbi request reprint Detection of cervical immunoglobulin A in normal pregnancy
    S Abitzsch
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Perinat Med 29:36-41. 2001
    ..In normal pregnancy, cervical immunoglobulin A concentration does not change with advancing gestational age, but a pathological vaginal colonization seems to be associated with decreased immunoglobulin A levels...
  62. ncbi request reprint Cytomegalovirus-induced mirror syndrome associated with elevated levels of angiogenic factors
    Holger Stepan
    Obstet Gynecol 109:1205-6; author reply 1206. 2007
  63. ncbi request reprint Soluble fms-like tyrosine kinase 1
    Holger Stepan
    N Engl J Med 351:2241-2. 2004
  64. ncbi request reprint Autonomic cardiovascular control in pregnancies with abnormal uterine perfusion
    Andreas Voss
    Department of Medical Engineering, University of Applied Sciences, Jena, Germany
    Am J Hypertens 19:306-12. 2006
    ..based on blood pressure variability (BPV), baroreflex sensitivity (BRS), and heart rate variability (HRV) analyses...
  65. ncbi request reprint A combined technique for predicting pre-eclampsia: concurrent measurement of uterine perfusion and analysis of heart rate and blood pressure variability
    Thomas Walther
    Department of Cardiology, Charite, Campus Benjamin Franklin CBF, Berlin, Germany
    J Hypertens 24:747-50. 2006
    ..Although most pre-eclamptic patients have pathological uterine perfusion in the second trimester, perfusion disturbance has a positive predictive accuracy (PPA) only of approximately 30%...
  66. ncbi request reprint Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature
    Thomas Walther
    Department of Cardiology and Pneumology, Charite Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:1275-9. 2005
    ..The generation of this antibody seems to be associated with distinct types of pregnancy disorders resulting from impaired placental development. The AT1 autoantibody may thus be causative for pathological uteroplacental perfusion...
  67. ncbi request reprint Urinary angiogenic factors in preeclampsia
    Holger Stepan
    Am J Obstet Gynecol 193:2181-2; author reply 2182. 2005
  68. ncbi request reprint Longitudinal analysis of heart rate variability in chronic hypertensive pregnancy
    Thomas Walther
    Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Hypertens Res 28:113-8. 2005
    ..Thus, our data indicate that patients with long-term hypertension are still able to respond to the physiological changes occurring during pregnancy...
  69. ncbi request reprint Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders
    Thomas Walther
    Charite, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, Berlin, Germany
    Curr Hypertens Rep 9:128-32. 2007
    ..This review summarizes current knowledge about the generation, function, and clinical importance of AT1-AA...
  70. ncbi request reprint Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops
    Holger Stepan
    N Engl J Med 354:1857-8. 2006
  71. ncbi request reprint Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide
    Thomas Walther
    Department of Cardiology, Medical Center Benjamin Franklin, Free University of Berlin, D 12200 Berlin, Germany
    Biol Chem 385:179-84. 2004
    ..Moreover, the NEP-independent BNP degradation provides an effective means for achieving a beneficial BNP increase in cardiovascular pathology by inhibiting the assumed novel NP-degrading peptidase(s)...
  72. ncbi request reprint Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice
    Yong Wang
    Department Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Eur J Heart Fail 9:548-57. 2007
    ..Our study aimed to investigate the effect of cardiomyocyte-specific CNP over-expression on I/R injury and MI in transgenic mice...
  73. ncbi request reprint Fibrosis rather than blood pressure determines cardiac BNP expression in mice
    Thomas Walther
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Regul Pept 116:95-100. 2003
    ....
  74. ncbi request reprint Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase activity and resistance of BNP to neutral endopeptidase in the fetus
    Thomas Walther
    Department of Cardiology, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    BJOG 111:452-5. 2004
    ..To investigate the role of neutral endopeptidase in the turnover of atrial (ANP) and brain (BNP) natriuretic peptides and their N-terminal fragments in human fetal circulation...
  75. ncbi request reprint Questionable role of the angiotensin II receptor subtype 1 autoantibody in the pathogenesis of preeclampsia
    Holger Stepan
    Hypertension 50:e3; author reply e4. 2007
  76. ncbi request reprint Fetal, neonatal cord, and maternal plasma concentrations of angiotensin-converting enzyme (ACE)
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
    Prenat Diagn 22:111-3. 2002
    ..It was the aim of the present study to measure ACE activity in human fetal blood and to determine its changes with advancing gestational age...
  77. ncbi request reprint Natriuretic peptide system in fetal heart and circulation
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Germany
    J Hypertens 20:785-91. 2002
    ..In comparison with data on the relevance of natriuretic peptides in adults, those summarized here indicate a functional maturation of the natriuretic peptide system during ontogeny in mammals...