Verena Steinke

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
    Inga Hinrichsen
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt a, M, Germany
    Mol Cancer 13:11. 2014
  2. pmc Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Germany
    Dtsch Arztebl Int 110:32-8. 2013
  3. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
  4. doi request reprint No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 16:587-92. 2008
  5. doi request reprint Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus
    Nils Rahner
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet A 146:1314-9. 2008
  6. doi request reprint Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Int J Cancer 135:69-77. 2014
  7. doi request reprint Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas
    Isabel Spier
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Int J Cancer 137:320-31. 2015
  8. doi request reprint Expanded extracolonic tumor spectrum in MUTYH-associated polyposis
    Stefanie Vogt
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Gastroenterology 137:1976-85.e1-10. 2009
  9. ncbi request reprint Nine novel pathogenic germline mutations in MLH1, MSH2, MSH6 and PMS2 in families with Lynch syndrome
    Nils Rahner
    Institute of Human Genetics, University of Bonn, Germany
    Acta Oncol 46:763-9. 2007
  10. doi request reprint FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer
    Lucia Gullotti
    Institute of Pathology, University of Bonn Medical School, Bonn, Germany
    Lab Invest 91:1695-705. 2011

Collaborators

Detail Information

Publications13

  1. pmc Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
    Inga Hinrichsen
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt a, M, Germany
    Mol Cancer 13:11. 2014
    ..In the current study, the interaction of MLH1 and SPTAN1 and its potential consequences for CRC metastasis was evaluated...
  2. pmc Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Germany
    Dtsch Arztebl Int 110:32-8. 2013
    ..Diagnostic evaluations for Lynch syndrome should be carried out with appropriate genetic counseling...
  3. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
    ..Accumulating evidence also indicates a role of ghrelin in cancer development...
  4. doi request reprint No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 16:587-92. 2008
    ..30) nor in different subgroups regarding mutation type. Our results do not support the association between MSH6 mutations and heterozygosity for MUTYH mutations...
  5. doi request reprint Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus
    Nils Rahner
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet A 146:1314-9. 2008
    ....
  6. doi request reprint Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families
    Verena Steinke
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Int J Cancer 135:69-77. 2014
    ..Familial clustering of Lynch syndrome-related tumors, early age of onset, and familial occurrence of small-bowel cancer were clinically relevant predictors for Lynch syndrome. ..
  7. doi request reprint Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas
    Isabel Spier
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Int J Cancer 137:320-31. 2015
    ..The present study broadens the phenotypic spectrum of PPAP to duodenal adenomas and carcinomas, and identified novel, potentially pathogenic variants in four polymerase genes. ..
  8. doi request reprint Expanded extracolonic tumor spectrum in MUTYH-associated polyposis
    Stefanie Vogt
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Gastroenterology 137:1976-85.e1-10. 2009
    ..MUTYH-associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation of extracolonic manifestations has been reported...
  9. ncbi request reprint Nine novel pathogenic germline mutations in MLH1, MSH2, MSH6 and PMS2 in families with Lynch syndrome
    Nils Rahner
    Institute of Human Genetics, University of Bonn, Germany
    Acta Oncol 46:763-9. 2007
    ..The findings underline the importance of a pre-screening of tumor tissue for an efficient definition of conspicuous cases...
  10. doi request reprint FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer
    Lucia Gullotti
    Institute of Pathology, University of Bonn Medical School, Bonn, Germany
    Lab Invest 91:1695-705. 2011
    ..These findings are absent in HNPCC-associated colon cancers in vivo and may contribute to a less invasive and more protruding tumour margin of microsatellite instable carcinomas...
  11. doi request reprint Functional testing strategy for coding genetic variants of unclear significance in MLH1 in Lynch syndrome diagnosis
    Inga Hinrichsen
    Biomedical Research Laboratory, Department of Internal Medicine 1 and Department of Human Genetics, Universitatsklinikum Frankfurt, Frankfurt D 60590, Germany, Institute of Human Genetics, University of Bonn, Bonn D 53127, Germany and Department of Internal Medicine 1, Universitätsklinikum Frankfurt D 60590, Frankfurt, Germany
    Carcinogenesis 36:202-11. 2015
    ..Leu507Phe and p.Gln689Arg, and the results were consistent with available clinical data. We finally discuss the improved sensitivity and efficiency of the applied strategy and its limitations in analyzing unclear coding MLH1 variants. ..
  12. doi request reprint Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors
    Nils Rahner
    Institute of Human Genetics, BMZ, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Fam Cancer 11:19-26. 2012
    ..The present results suggest that neither rare nor common genetic variants in ESR1, ESR2, MAX, PCNA, or KAT2A contribute to the development of Lynch syndrome...
  13. doi request reprint Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis
    Sukanya Horpaopan
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Int J Cancer 136:E578-89. 2015
    ....