Christian Steinhäuser

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling
    Christian Steinhäuser
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 60:1192-202. 2012
  2. doi Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus
    Susan Strohschein
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 59:973-80. 2011
  3. ncbi Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity
    Christian Steinhäuser
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
    Eur J Pharmacol 447:227-37. 2002
  4. ncbi Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis
    Kerstin Hüttmann
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Neurosci 18:2769-78. 2003
  5. ncbi Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus
    Katja Matthias
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 23:1750-8. 2003
  6. doi Role of astroglial connexin30 in hippocampal gap junction coupling
    Dominic Gosejacob
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
    Glia 59:511-9. 2011
  7. doi Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity
    Joachim Degen
    Life and Medical Sciences Institute, Medical Faculty, University of Bonn, Bonn, Germany
    FASEB J 26:4576-83. 2012
  8. doi Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit
    Gerald Seifert
    Institute of Cellular Neurosciences, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 29:7474-88. 2009
  9. ncbi Distinct types of astroglial cells in the hippocampus differ in gap junction coupling
    Anke Wallraff
    Department of Neurosurgery, University of Bonn, Bonn, Germany
    Glia 48:36-43. 2004
  10. ncbi The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    Anke Wallraff
    Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 26:5438-47. 2006

Collaborators

Detail Information

Publications37

  1. doi Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling
    Christian Steinhäuser
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 60:1192-202. 2012
    ..Recent work suggests that astrocyte dysfunction is causative of the generation or spread of seizure activity. Thus, astrocytes should be considered as promising targets for alternative antiepileptic therapies...
  2. doi Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus
    Susan Strohschein
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 59:973-80. 2011
    ..These findings highlight the role of AQP4 channels in the regulation of K(+) homeostasis...
  3. ncbi Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity
    Christian Steinhäuser
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
    Eur J Pharmacol 447:227-37. 2002
    ..This review summarizes current knowledge of alterations of plasma membrane channels and receptors of macroglial cells in epilepsy and discusses the putative importance of these changes for the generation and spread of seizure activity...
  4. ncbi Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis
    Kerstin Hüttmann
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Neurosci 18:2769-78. 2003
    ..We conclude that there is an early increase in proliferating radial glia-like astrocytes in the dentate after kainate-induced seizures, consistent with a recruitment of precursors for seizure-induced neurogenesis...
  5. ncbi Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus
    Katja Matthias
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 23:1750-8. 2003
    ..The observed heterogeneity of cells with GFAP promoter-regulated EGFP expression and S100beta/GFAP immunoreactivity challenges the hitherto accepted definition of astrocytes...
  6. doi Role of astroglial connexin30 in hippocampal gap junction coupling
    Dominic Gosejacob
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
    Glia 59:511-9. 2011
    ..Employing tracer coupling analyses in acute slices of Cx30 deficient mice here we show that Cx30 makes a substantial contribution to interastrocytic gap junctional communication in the mouse hippocampus...
  7. doi Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity
    Joachim Degen
    Life and Medical Sciences Institute, Medical Faculty, University of Bonn, Bonn, Germany
    FASEB J 26:4576-83. 2012
    ..Analysis of a newly generated Cx43 knock-in ECFP mouse revealed an unexpected heterogeneity of Cx43-expressing astrocytes across brain areas...
  8. doi Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit
    Gerald Seifert
    Institute of Cellular Neurosciences, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 29:7474-88. 2009
    ..Together, our findings demonstrate that Kir4.1 constitutes the pivotal K+ channel subunit and that superposition of currents through Kir4.1 and TREK channels underlies the "passive" current pattern of hippocampal astrocytes...
  9. ncbi Distinct types of astroglial cells in the hippocampus differ in gap junction coupling
    Anke Wallraff
    Department of Neurosurgery, University of Bonn, Bonn, Germany
    Glia 48:36-43. 2004
    ..Since GluR cells do not participate in the astrocytic gap junctional network, their functional role must be different from spatial buffering of ions or signaling molecules, i.e., properties generally assigned to astrocytes...
  10. ncbi The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    Anke Wallraff
    Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 26:5438-47. 2006
    ..In general, a surprisingly large capacity for K+ clearance was conserved in mice with coupling-deficient astrocytes, indicating that gap junction-dependent processes only partially account for K+ buffering in the hippocampus...
  11. ncbi Changes in flip/flop splicing of astroglial AMPA receptors in human temporal lobe epilepsy
    Gerald Seifert
    Experimental Neurobiology, Dept of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, 53125 Bonn, Germany
    Epilepsia 43:162-7. 2002
    ..This study sought to identify and functionally characterize AMPA receptors expressed by astrocytes in human hippocampal tissue resected from patients with intractable temporal lobe epilepsy...
  12. ncbi Polarized distribution of AMPA, but not GABAA , receptors in radial glia-like cells of the adult dentate gyrus
    Roland Renzel
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 61:1146-54. 2013
    ....
  13. pmc Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus
    Albrecht Kunze
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Proc Natl Acad Sci U S A 106:11336-41. 2009
    ..These findings strongly suggest the requirement of connexin expression by radial glia-like cells for intact neurogenesis in the adult brain and point to possible communication pathways of these cells...
  14. doi Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation
    Robert Pascal Requardt
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, D 53117 Bonn, Germany
    Glia 57:680-92. 2009
    ..We present several strategies to control for the fidelity of hGFAP-Cre mediated recombination. (c) 2008 Wiley-Liss, Inc...
  15. doi The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death
    Panos Theofilas
    Department of Neuropathology, University of Bonn, Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 68:102-10. 2009
    ..These in vivo and histological data suggest that Bim is not critically involved in excitotoxicity-induced acute neuronal cell injury...
  16. ncbi Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon's horn sclerosis
    Gerald Seifert
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 24:1996-2003. 2004
    ..These findings imply that in AHS, glutamate may lead to prolonged depolarization of astrocytes, thereby facilitating the generation or spread of seizure activity...
  17. doi Expression of the γ2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus
    Stefan Passlick
    Institute of Cellular Neurosciences, University of Bonn, 53105 Bonn, Germany
    J Neurosci 33:12030-40. 2013
    ..GABA-induced depolarization in NG2 cells might trigger Ca²⁺ influx through voltage-activated Ca²⁺ channels...
  18. ncbi Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity
    Ronald Jabs
    Experimental Neurobiology, Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Cell Sci 118:3791-803. 2005
    ..These data demonstrate that a distinct type of glial cells is integrated into the synaptic circuit of the hippocampus, extending the finding that synapse-based brain information processing is not a property exclusive to neurons...
  19. doi Astrocytic function and its alteration in the epileptic brain
    Ronald Jabs
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany
    Epilepsia 49:3-12. 2008
    ..The goal is to provide an understanding of the current knowledge of these cells with the long-term view of providing a foundation for the development of novel hypotheses about the role of glia in epilepsy...
  20. ncbi Functional characterization of P2X3 receptors fused with fluorescent proteins
    Alexander Grote
    Experimental Neurobiology, Neurosurgery, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Mol Membr Biol 22:497-506. 2005
    ..We conclude that both fusion proteins tested here are suitable for generating transgenic mice, which can be expected to promote understanding of the physiological role of P2X3 receptors in CNS signaling...
  21. doi Functional redundancy and compensation among members of gap junction protein families?
    Peter Bedner
    University of Bonn, Bonn, Germany
    Biochim Biophys Acta 1818:1971-84. 2012
    ..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics...
  22. ncbi Lack of P2X receptor mediated currents in astrocytes and GluR type glial cells of the hippocampal CA1 region
    Ronald Jabs
    Institute of Cellular Neurosciences, Medical School, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Glia 55:1648-55. 2007
    ..It is concluded that in acute preparations, astroglial cells of the hippocampal CA1 subfield do not express functional P2X receptors...
  23. ncbi Changes in splice variant expression and subunit assembly of AMPA receptors during maturation of hippocampal astrocytes
    Gerald Seifert
    Experimental Neurobiology, Neurosurgery, Bonn University, Sigmund Freud Str 25, 53105, Bonn, Germany
    Mol Cell Neurosci 22:248-58. 2003
    ....
  24. ncbi Molecular and functional properties of neurons in the human lateral amygdala
    Kerstin Hüttmann
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Mol Cell Neurosci 31:210-7. 2006
    ..The most striking difference relates to the expression of postsynaptic GABA(B) receptors coupled to Kir3 channels in projection neurons and the lack of functional GABA(B) receptors in interneurons...
  25. pmc Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling
    Oliver Braganza
    Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Epilepsia 53:1898-906. 2012
    ..1, the predominating astrocytic K(+) channel subunit, is altered by albumin...
  26. pmc Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes
    Christian Haberlandt
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    PLoS ONE 6:e17575. 2011
    ..Furthermore, we demonstrate that NG2 cell processes in situ are highly motile. Our findings demonstrate that gray matter NG2 cells are endowed with the cellular machinery for two-way communication with neighboring cells...
  27. ncbi Functional analysis of embryonic stem cell-derived glial cells after integration into hippocampal slice cultures
    Leila Husseini
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Stem Cells Dev 17:1141-52. 2008
    ..These findings emphasize the need to carefully characterize ES cell-derived progeny aimed for neural repair and cell-mediated gene transfer strategies...
  28. doi Nanomolar ambient ATP decelerates P2X3 receptor kinetics
    Alexander Grote
    Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Neuropharmacology 55:1212-8. 2008
    ..The observed modulation of the receptor kinetics could be considered as a physiological fine tuning mechanism of the nociceptive system, driven by the actual ambient agonist concentration...
  29. ncbi AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampus
    Wolfgang Schroder
    Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    Mol Cell Neurosci 19:447-58. 2002
    ..A transient inhibition of I(Kir) in astrocytes in response to neuronal glutamate release and glial AMPA receptor activation represents a further, so far undetected mechanism to balance neuronal excitability...
  30. doi Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain
    Tobias Mittelsteadt
    Institute of Neuropathology, University of Bonn, 53105 Bonn, Germany
    J Comp Neurol 512:514-28. 2009
    ..This study therefore supports the hypothesis that the functional properties of individual neurons and astrocytes are conferred by the specific subset of synaptotagmins expressed in a cell...
  31. pmc Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes
    Jiong Zhang
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany
    PLoS ONE 8:e82818. 2013
    ..Such control is essential to avoid pleiotropic effects due to germ-line deletion of loxP-flanked target genes and to maintain the CNS-restricted deletion status in transgenic mouse colonies. ..
  32. ncbi Astrocyte dysfunction in neurological disorders: a molecular perspective
    Gerald Seifert
    Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
    Nat Rev Neurosci 7:194-206. 2006
    ..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders...
  33. doi Neuron-astrocyte signaling and epilepsy
    Gerald Seifert
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Exp Neurol 244:4-10. 2013
    ..In this review, we will summarize current knowledge of astrocyte dysfunction in temporal lobe epilepsy and discuss putative mechanisms underlying these alterations...
  34. doi Astrocyte dysfunction in epilepsy
    Gerald Seifert
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
    Brain Res Rev 63:212-21. 2010
    ..This review summarizes current evidence regarding astroglial dysfunction in epilepsy and discusses presumed underlying mechanisms...
  35. ncbi Altered Kir and gap junction channels in temporal lobe epilepsy
    Peter Bedner
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany Electronic address
    Neurochem Int 63:682-7. 2013
    ..Dysfunctional astrocytes should be considered promising targets for new therapeutic strategies...
  36. pmc Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle
    Michael Hesse
    Institute of Physiology I, Life and Brain Center, University of Bonn, 53105 Bonn, Germany
    Nat Commun 3:1076. 2012
    ..Thus, the enhanced green fluorescent protein-anillin system enables monitoring and measurement of cell division in vivo and markedly simplifies in vitro analysis in fixed cells...
  37. doi Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia
    Richard Kovacs
    Institute for Neurophysiology, Charité Medical University Berlin, Berlin, Germany
    Epilepsia 53:53-9. 2012
    ..In conclusion, astrocytic activation preceding alterations in neuronal function might critically contribute to epileptogenesis. Therefore, astrocytes represent a promising new target for the development of antiepileptic drugs...