Research Topics
Genomes and GenesSpecies | Christian SteinhäuserSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction couplingChristian Steinhäuser
Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
Glia 60:1192-202. 2012..Recent work suggests that astrocyte dysfunction is causative of the generation or spread of seizure activity. Thus, astrocytes should be considered as promising targets for alternative antiepileptic therapies...- Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampusSusan Strohschein
Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
Glia 59:973-80. 2011..These findings highlight the role of AQP4 channels in the regulation of K(+) homeostasis... 
Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activityChristian Steinhäuser
Experimental Neurobiology, Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
Eur J Pharmacol 447:227-37. 2002..This review summarizes current knowledge of alterations of plasma membrane channels and receptors of macroglial cells in epilepsy and discusses the putative importance of these changes for the generation and spread of seizure activity...- Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysisKerstin Hüttmann
Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Eur J Neurosci 18:2769-78. 2003..We conclude that there is an early increase in proliferating radial glia-like astrocytes in the dentate after kainate-induced seizures, consistent with a recruitment of precursors for seizure-induced neurogenesis... - Role of astroglial connexin30 in hippocampal gap junction couplingDominic Gosejacob
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Glia 59:511-9. 2011..Employing tracer coupling analyses in acute slices of Cx30 deficient mice here we show that Cx30 makes a substantial contribution to interastrocytic gap junctional communication in the mouse hippocampus... - Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunitGerald Seifert
Institute of Cellular Neurosciences, University of Bonn, D 53105 Bonn, Germany
J Neurosci 29:7474-88. 2009..Together, our findings demonstrate that Kir4.1 constitutes the pivotal K+ channel subunit and that superposition of currents through Kir4.1 and TREK channels underlies the "passive" current pattern of hippocampal astrocytes... - Distinct types of astroglial cells in the hippocampus differ in gap junction couplingAnke Wallraff
Department of Neurosurgery, University of Bonn, Bonn, Germany
Glia 48:36-43. 2004..Since GluR cells do not participate in the astrocytic gap junctional network, their functional role must be different from spatial buffering of ions or signaling molecules, i.e., properties generally assigned to astrocytes... - Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneityJoachim Degen
Life and Medical Sciences Institute, Medical Faculty, University of Bonn, Bonn, Germany
FASEB J 26:4576-83. 2012..Analysis of a newly generated Cx43 knock-in ECFP mouse revealed an unexpected heterogeneity of Cx43-expressing astrocytes across brain areas... - The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampusAnke Wallraff
Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
J Neurosci 26:5438-47. 2006..In general, a surprisingly large capacity for K+ clearance was conserved in mice with coupling-deficient astrocytes, indicating that gap junction-dependent processes only partially account for K+ buffering in the hippocampus... 
Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrusAlbrecht Kunze
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Proc Natl Acad Sci U S A 106:11336-41. 2009..These findings strongly suggest the requirement of connexin expression by radial glia-like cells for intact neurogenesis in the adult brain and point to possible communication pathways of these cells...- Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activationRobert Pascal Requardt
Institute of Genetics, Division of Molecular Genetics, University of Bonn, D 53117 Bonn, Germany
Glia 57:680-92. 2009..We present several strategies to control for the fidelity of hGFAP-Cre mediated recombination. (c) 2008 Wiley-Liss, Inc... - Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon's horn sclerosisGerald Seifert
Experimental Neurobiology, Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
J Neurosci 24:1996-2003. 2004..These findings imply that in AHS, glutamate may lead to prolonged depolarization of astrocytes, thereby facilitating the generation or spread of seizure activity... - The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell deathPanos Theofilas
Department of Neuropathology, University of Bonn, Medical Center, Bonn, Germany
J Neuropathol Exp Neurol 68:102-10. 2009..These in vivo and histological data suggest that Bim is not critically involved in excitotoxicity-induced acute neuronal cell injury... - Synaptic transmission onto hippocampal glial cells with hGFAP promoter activityRonald Jabs
Experimental Neurobiology, Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
J Cell Sci 118:3791-803. 2005..These data demonstrate that a distinct type of glial cells is integrated into the synaptic circuit of the hippocampus, extending the finding that synapse-based brain information processing is not a property exclusive to neurons... - Astrocytic function and its alteration in the epileptic brainRonald Jabs
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany
Epilepsia 49:3-12. 2008..The goal is to provide an understanding of the current knowledge of these cells with the long-term view of providing a foundation for the development of novel hypotheses about the role of glia in epilepsy... - Molecular and functional properties of neurons in the human lateral amygdalaKerstin Hüttmann
Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Mol Cell Neurosci 31:210-7. 2006..The most striking difference relates to the expression of postsynaptic GABA(B) receptors coupled to Kir3 channels in projection neurons and the lack of functional GABA(B) receptors in interneurons... - Lack of P2X receptor mediated currents in astrocytes and GluR type glial cells of the hippocampal CA1 regionRonald Jabs
Institute of Cellular Neurosciences, Medical School, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Glia 55:1648-55. 2007..It is concluded that in acute preparations, astroglial cells of the hippocampal CA1 subfield do not express functional P2X receptors... - Changes in splice variant expression and subunit assembly of AMPA receptors during maturation of hippocampal astrocytesGerald Seifert
Experimental Neurobiology, Neurosurgery, Bonn University, Sigmund Freud Str 25, 53105, Bonn, Germany
Mol Cell Neurosci 22:248-58. 2003.... - Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampusKatja Matthias
Experimental Neurobiology, Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
J Neurosci 23:1750-8. 2003..The observed heterogeneity of cells with GFAP promoter-regulated EGFP expression and S100beta/GFAP immunoreactivity challenges the hitherto accepted definition of astrocytes... - Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction couplingOliver Braganza
Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Epilepsia 53:1898-906. 2012..1, the predominating astrocytic K(+) channel subunit, is altered by albumin... - Nanomolar ambient ATP decelerates P2X3 receptor kineticsAlexander Grote
Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
Neuropharmacology 55:1212-8. 2008..The observed modulation of the receptor kinetics could be considered as a physiological fine tuning mechanism of the nociceptive system, driven by the actual ambient agonist concentration... - Functional analysis of embryonic stem cell-derived glial cells after integration into hippocampal slice culturesLeila Husseini
Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
Stem Cells Dev 17:1141-52. 2008..These findings emphasize the need to carefully characterize ES cell-derived progeny aimed for neural repair and cell-mediated gene transfer strategies... - Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processesChristian Haberlandt
Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
PLoS ONE 6:e17575. 2011..Furthermore, we demonstrate that NG2 cell processes in situ are highly motile. Our findings demonstrate that gray matter NG2 cells are endowed with the cellular machinery for two-way communication with neighboring cells... - Changes in flip/flop splicing of astroglial AMPA receptors in human temporal lobe epilepsyGerald Seifert
Experimental Neurobiology, Dept of Neurosurgery, University of Bonn, Sigmund-Freud-Strasse 25, 53125 Bonn, Germany
Epilepsia 43:162-7. 2002.... - AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampusWolfgang Schroder
Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
Mol Cell Neurosci 19:447-58. 2002..A transient inhibition of I(Kir) in astrocytes in response to neuronal glutamate release and glial AMPA receptor activation represents a further, so far undetected mechanism to balance neuronal excitability... - Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brainTobias Mittelsteadt
Institute of Neuropathology, University of Bonn, 53105 Bonn, Germany
J Comp Neurol 512:514-28. 2009..This study therefore supports the hypothesis that the functional properties of individual neurons and astrocytes are conferred by the specific subset of synaptotagmins expressed in a cell... - Astrocyte dysfunction in epilepsyGerald Seifert
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Brain Res Rev 63:212-21. 2010..This review summarizes current evidence regarding astroglial dysfunction in epilepsy and discusses presumed underlying mechanisms... - Functional characterization of P2X3 receptors fused with fluorescent proteinsAlexander Grote
Experimental Neurobiology, Neurosurgery, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
Mol Membr Biol 22:497-506. 2005..We conclude that both fusion proteins tested here are suitable for generating transgenic mice, which can be expected to promote understanding of the physiological role of P2X3 receptors in CNS signaling... - Functional redundancy and compensation among members of gap junction protein families?Peter Bedner
University of Bonn, Bonn, Germany
Biochim Biophys Acta 1818:1971-84. 2012..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics... - Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycleMichael Hesse
Institute of Physiology I, Life and Brain Center, University of Bonn, 53105 Bonn, Germany
Nat Commun 3:1076. 2012..Thus, the enhanced green fluorescent protein-anillin system enables monitoring and measurement of cell division in vivo and markedly simplifies in vitro analysis in fixed cells... - Astrocyte dysfunction in neurological disorders: a molecular perspectiveGerald Seifert
Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
Nat Rev Neurosci 7:194-206. 2006..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders... - Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: role of astrogliaRichard Kovacs
Institute for Neurophysiology, Charité Medical University Berlin, Berlin, Germany
Epilepsia 53:53-9. 2012..In conclusion, astrocytic activation preceding alterations in neuronal function might critically contribute to epileptogenesis. Therefore, astrocytes represent a promising new target for the development of antiepileptic drugs...