Affiliation: University of Veterinary Medicine
Empl M, Kammeyer P, Ulrich R, Joseph J, Parr M, Willenberg I, et al
. The influence of chronic L-carnitine supplementation on the formation of preneoplastic and atherosclerotic lesions in the colon and aorta of male F344 rats. Arch Toxicol. 2015;89:2079-87 pubmed publisher
Nicken P, Willenberg I, Keutz A, Elsner L, Hamscher G, Vanhaecke L, et al
. Intestinal absorption and cell transforming potential of PhIP-M1, a bacterial metabolite of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Toxicol Lett. 2015;234:92-8 pubmed publisher
Nicken P, von Keutz A, Willenberg I, Ostermann A, Schebb N, Giovannini S, et al
. Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP. Arch Toxicol. 2016;90:1093-102 pubmed publisher
..The hypothesis that in the course of chronic colitis more PhIP is taken up by the intestinal epithelium, thereby increasing the risk of developing colorectal cancer, could not be confirmed in the present report. ..
Steinberg P. In Vitro-In Vivo Carcinogenicity. Adv Biochem Eng Biotechnol. 2017;157:81-96 pubmed publisher
..In the future, the development of human cell line-based transformation assays may contribute to increase further their relevance and the willingness to incorporate them into existing in vitro toxicity test batteries. ..
Zeljenková D, Aláčová R, Ondrejková J, Ambrusova K, Bartusova M, Kebis A, et al
. One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE). Arch Toxicol. 2016;90:2531-62 pubmed publisher
..The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure. ..
Steinberg P, Behnisch P, Besselink H, Brouwer A. Screening of molecular cell targets for carcinogenic heterocyclic aromatic amines by using CALUX® reporter gene assays. Cell Biol Toxicol. 2017;33:283-293 pubmed publisher
..Taken together, the results obtained show that the battery of CALUX® assays performed in the present study can successfully be used to screen for molecular cell targets of carcinogenic compounds such as HCAs. ..