Affiliation: University of Munich
Ring L, Neth P, Weber C, Steffens S, Faussner A. ?-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency. Cell Signal. 2014;26:260-7 pubmed publisher
..These data and extension of this experimental setup to the poorly characterized other WNTs should facilitate deeper insight into the complex WNT/FZD signalling system and its function. ..
Rami M, Guillamat Prats R, Rinne P, Salvermoser M, Ring L, Bianchini M, et al
. Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018;38:1007-1019 pubmed publisher
..SSRI intake may promote atherosclerosis and therefore potentially increase the risk for acute cardiovascular events by a mechanism that is independent of 5-HT depletion. ..
Steffens S, Pacher P. The activated endocannabinoid system in atherosclerosis: driving force or protective mechanism?. Curr Drug Targets. 2015;16:334-41 pubmed
..This is followed by an outlook on emerging targets for possible therapeutic intervention. ..
Schloss M, Horckmans M, Nitz K, Duchene J, Drechsler M, Bidzhekov K, et al
. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Mol Med. 2016;8:937-48 pubmed publisher
..Limiting exaggerated neutrophilic inflammation at this time point significantly reduced the infarct size and improved cardiac function. ..
Steffens S, Winter C, Schloss M, Hidalgo A, Weber C, Soehnlein O. Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications. Arterioscler Thromb Vasc Biol. 2017;37:1022-1028 pubmed publisher
Schloss M, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, et al
. Ly6Chigh Monocytes Oscillate in the Heart During Homeostasis and After Myocardial Infarction-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1640-1645 pubmed publisher
..CCR2 surface expression on Ly6Chigh monocytes changes in a time-of-day-dependent manner, which crucially affects cardiac monocyte recruitment after an acute ischemic event. ..
Horckmans M, Bianchini M, Santovito D, Megens R, Springael J, Negri I, et al
. Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction. Circulation. 2018;137:948-960 pubmed publisher
..Our findings unveil a new mechanism by which the pericardial AT coordinates immune cell activation, granulopoiesis, and outcome after MI. ..