Hermann Stefan

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint [Valproate sustained release in the treatment of epilepsy]
    H Stefan
    Epilepsiezentrum der Neurologischen Klinik der Universität Erlangen
    Fortschr Neurol Psychiatr 73:681-6. 2005
  2. ncbi request reprint Ictal fear in temporal lobe epilepsy: surgical outcome and focal hippocampal changes revealed by proton magnetic resonance spectroscopy imaging
    M Feichtinger
    Department of Neurology, University Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    Arch Neurol 58:771-7. 2001
  3. ncbi request reprint Magnetic brain source imaging of focal epileptic activity: a synopsis of 455 cases
    H Stefan
    Department of Neurology, Epilepsy Center, University of Erlangen Nuernberg, Germany
    Brain 126:2396-405. 2003
  4. ncbi request reprint Emerging drugs for epilepsy and other treatment options
    H Stefan
    Epilepsy Center ZEE Neurological Clinic, University Erlangen Nuernberg, Schwabachanlage, Erlangen, Germany
    Eur J Neurol 14:1154-61. 2007
  5. ncbi request reprint [Brain tumors and epilepsy]
    H Stefan
    Neurologische Klinik, Epilepsiezentrum ZEE, Erlangen
    Nervenarzt 76:1196, 1198-200, 1203-4, 1206-8. 2005
  6. ncbi request reprint [How to diagnose and treat epilepsy]
    H Stefan
    Epilepsiezentrum Universität Erlangen Nürnberg, Erlangen
    MMW Fortschr Med 146:41-4, 46. 2004
  7. pmc Magnetoencephalography (MEG) predicts focal epileptogenicity in cavernomas
    H Stefan
    Department of Neurology, Epilepsy and Neuro Center, University of Erlangen Nurnberg, Germany
    J Neurol Neurosurg Psychiatry 75:1309-13. 2004
  8. ncbi request reprint Autonomic phenomena of temperature regulation in temporal lobe epilepsy
    Hermann Stefan
    Department of Neurology, Epilepsy Center, University Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Epilepsy Behav 4:65-9. 2003
  9. ncbi request reprint Cavernous haemangiomas, epilepsy and treatment strategies
    H Stefan
    Department of Neurology, Epilepsy Center Erlangen ZEE, University Erlangen Nuernberg, Erlangen, Germany
    Acta Neurol Scand 110:393-7. 2004
  10. ncbi request reprint Periventricular nodular heterotopia: A challenge for epilepsy surgery
    H Stefan
    Epilepsy Center ZEE, University Erlangen Nuremberg, Germany
    Seizure 16:81-6. 2007

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint [Valproate sustained release in the treatment of epilepsy]
    H Stefan
    Epilepsiezentrum der Neurologischen Klinik der Universität Erlangen
    Fortschr Neurol Psychiatr 73:681-6. 2005
    ..These results confirm the excellent benefit-risk ratio of the valproate sustained release minitablets and underline the importance of a simple compliance-improving dose regimen for effective seizure control...
  2. ncbi request reprint Ictal fear in temporal lobe epilepsy: surgical outcome and focal hippocampal changes revealed by proton magnetic resonance spectroscopy imaging
    M Feichtinger
    Department of Neurology, University Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    Arch Neurol 58:771-7. 2001
    ..In addition, our data emphasize that multivoxel MRS is a valuable tool in the presurgical evaluation, as it may reveal different topographical patterns of hippocampal sclerosis...
  3. ncbi request reprint Magnetic brain source imaging of focal epileptic activity: a synopsis of 455 cases
    H Stefan
    Department of Neurology, Epilepsy Center, University of Erlangen Nuernberg, Germany
    Brain 126:2396-405. 2003
    ..Accuracy as well as contribution findings underlined MSI appropriateness even for extratemporal epilepsies, which otherwise frequently prove difficult with respect to focus localization...
  4. ncbi request reprint Emerging drugs for epilepsy and other treatment options
    H Stefan
    Epilepsy Center ZEE Neurological Clinic, University Erlangen Nuernberg, Schwabachanlage, Erlangen, Germany
    Eur J Neurol 14:1154-61. 2007
    ..The aim of this review is to highlight currently emerging different treatment approaches which may ameliorate the perspectives of patients with difficult-to-treat epilepsies...
  5. ncbi request reprint [Brain tumors and epilepsy]
    H Stefan
    Neurologische Klinik, Epilepsiezentrum ZEE, Erlangen
    Nervenarzt 76:1196, 1198-200, 1203-4, 1206-8. 2005
    ..These should consider possibilities of new techniques of co-registering imaging and electrophysiology, surgery, and the interaction of anticonvulsive and chemotherapeutic drugs, cognition, and mood...
  6. ncbi request reprint [How to diagnose and treat epilepsy]
    H Stefan
    Epilepsiezentrum Universität Erlangen Nürnberg, Erlangen
    MMW Fortschr Med 146:41-4, 46. 2004
    ..Difficult-to-treat and drug-resistant epilepsy should be treated surgically and the patients should be referred to an epilepsy center for a pre-operative diagnostic work-up...
  7. pmc Magnetoencephalography (MEG) predicts focal epileptogenicity in cavernomas
    H Stefan
    Department of Neurology, Epilepsy and Neuro Center, University of Erlangen Nurnberg, Germany
    J Neurol Neurosurg Psychiatry 75:1309-13. 2004
    ..The aim of this study was to identify the irritative epileptic zone in patients with cavernomas by means of magnetoencephalography (MEG)...
  8. ncbi request reprint Autonomic phenomena of temperature regulation in temporal lobe epilepsy
    Hermann Stefan
    Department of Neurology, Epilepsy Center, University Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Epilepsy Behav 4:65-9. 2003
    ..Our results suggest that phenomena of temperature dysregulation during epileptic seizures may be of value in the presurgical evaluation as they may be indicative of a left temporal lobe seizure focus...
  9. ncbi request reprint Cavernous haemangiomas, epilepsy and treatment strategies
    H Stefan
    Department of Neurology, Epilepsy Center Erlangen ZEE, University Erlangen Nuernberg, Erlangen, Germany
    Acta Neurol Scand 110:393-7. 2004
    ..To achieve optimal treatment of patients with cavernous haemangiomas and epilepsy both medical and surgical treatment have to be considered...
  10. ncbi request reprint Periventricular nodular heterotopia: A challenge for epilepsy surgery
    H Stefan
    Epilepsy Center ZEE, University Erlangen Nuremberg, Germany
    Seizure 16:81-6. 2007
    ..Postoperatively preservation of the visual fields was documented and the frequency of seizures was markedly reduced...
  11. ncbi request reprint [Epilepsy in the elderly: diagnostic and therapeutic problems]
    Hermann Stefan
    Universitatsklinikum Erlangen, Epilepsiezentrum ZEE
    MMW Fortschr Med . 2006
    ..Second generation antiepileptic drugs (lamotrigine, topiramate, levetiracetam) are tolerated better and should be used preferentially over antiepileptic drugs of the first generation (carbamazepine, phenytoin, phenobarbital, primidone)...
  12. ncbi request reprint [Diagnosis of sylvian and perisylvian epilepsies. Excitation symptomes of the insula reilii]
    H Stefan
    Epilepsiezentrum Erlangen ZEE Neurologische Klinik, Universitatsklinikum, Erlangen
    Nervenarzt 78:1175-81. 2007
    ..Magnetic source imaging as noninvasive treatment can deliver important information for the involvement of sylvian and perisylvian regions in focal pharmacoresistant epilepsies...
  13. ncbi request reprint Onset of action of levetiracetam: a RCT trial using therapeutic intensive seizure analysis (TISA)
    Hermann Stefan
    Epilepsy Center Erlangen, Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Epilepsia 47:516-22. 2006
    ..To correlate the onset of clinical effects of add-on levetiracetam (LEV) therapy with daily serum LEV concentration, in pharmaco-resistant focal epilepsies, using the TISA method...
  14. ncbi request reprint A new approach in anti-epileptic drug evaluation
    H Stefan
    Department of Neurology, Epilepsy Center ZEE, University of Erlangen Nurnberg, Erlangen, Germany
    Eur J Neurol 11:467-73. 2004
    ..In addition long-term effects can be evaluated by repeated video-EEG monitoring...
  15. ncbi request reprint [Supratentorial cavernoma and epileptic seizures. Are there predictors for postoperative seizure control?]
    H Stefan
    Neurologische Klinik Zentrum Epilepsie ZEE, Universitat Erlangen Nurnberg, Erlangen
    Nervenarzt 75:755-62. 2004
    ..None of the four patients harbouring multiple cavernomas became seizure-free after resection of one lesion, which was believed to be mostly attributable to the epileptic focus that was removed...
  16. ncbi request reprint Ictal pleasant sensations: cerebral localization and lateralization
    Hermann Stefan
    Neurologische Klinik, Zentrum Epilepsie der Universität Erlangen Nürnberg, Erlangen Nurnberg, Germany
    Epilepsia 45:35-40. 2004
    ..According to our findings ictal happiness is a localizing sign pointing to the ictal involvement of temporal mesiobasal areas. Lateralization to the right temporal lobe was found in seven and to the left temporal lobe in four patients...
  17. ncbi request reprint 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG
    Thilo Hammen
    Center Epilepsy Erlangen, Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Epilepsia 48:263-9. 2007
    ..In this study, hippocampal metabolite alterations in (1)H-MR spectroscopy ((1)H-MRS) were correlated to the findings of intensive video-EEG monitoring and duration of seizure symptoms in patients with temporal lobe epilepsy (TLE)...
  18. doi request reprint Computerized cognitive testing in epilepsy (CCTE): a new method for cognitive screening
    Katrin Kurzbuch
    Epilepsy Center, Department of Neurology, University of Erlangen Nurnberg, Germany
    Seizure 22:424-32. 2013
    ....
  19. doi request reprint Alterations of intracerebral γ-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies
    M Thorsten Doelken
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    Epilepsia 51:1477-82. 2010
    ..The objective of this study was to determine if levetiracetam (LEV) modulates brain γ-aminobutyric acid (GABA) in patients with epilepsy...
  20. ncbi request reprint Lobar localization information in epilepsy patients: MEG--a useful tool in routine presurgical diagnosis
    Andrea Paulini
    Epilepsy Center ZEE, Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Epilepsy Res 76:124-30. 2007
    ..In summary MEG is a useful tool in the routine workup for epilepsy surgery contributing information to focus hypothesis in addition to video-EEG...
  21. ncbi request reprint Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by (1)H-MRS and neuropathology
    Thilo Hammen
    Center Epilepsy Erlangen ZEE, Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    NMR Biomed 21:545-52. 2008
    ..The extent of tNAA reduction correlates with hippocampal neuronal cell density. Furthermore, m-Ins is associated with the extent of hippocampal astrogliosis...
  22. doi request reprint Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial
    Hermann Stefan
    Department of Neurology Epilepsy Center, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 53:e115-8. 2012
    ..The noninvasive t-VNS stimulation is a safe and well-tolerated method for relatively long periods, and might be an alternative treatment option for patients with epilepsy...
  23. doi request reprint MEG in frontal lobe epilepsies: localization and postoperative outcome
    Hermann Stefan
    Neurological Clinic, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 52:2233-8. 2011
    ..This study aimed to analyze magnetoencephalography (MEG) localizations of epileptic clusters in different cortical regions of the frontal lobe and relate these findings to postoperative outcomes associated with frontal lobe epilepsy (FLE)...
  24. doi request reprint Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies
    Ingmar Blumcke
    Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    Acta Neuropathol 117:535-44. 2009
    ..The association with long-term seizure histories and cognitive dysfunction is remarkable and may point to a compromised regenerative capacity of the DG in this cohort of TLE patients...
  25. ncbi request reprint Spatial relationship of source localizations in patients with focal epilepsy: Comparison of MEG and EEG with a three spherical shells and a boundary element volume conductor model
    Gabriela Scheler
    Epilepsy and Neurocenter, Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Hum Brain Mapp 28:315-22. 2007
    ....
  26. ncbi request reprint Drug withdrawal after successful epilepsy surgery: how safe is it?
    Frank Kerling
    Epilepsy Center ZEE, Department of Neurology, University Hospital of Erlangen, Schwabachanlage 6, Erlangen, Germany
    Epilepsy Behav 15:476-80. 2009
    ..5%) persons in the control group were seizure free 5 years after surgery. In this study, AED discontinuation 1 year after successful epilepsy surgery was not associated with a risk of seizure recurrence higher than that of controls...
  27. ncbi request reprint Post-apoplectic reorganization of cortical areas processing passive movement and tactile stimulation--a neuromagnetic case study
    Katrin Druschky
    Division of Neuroradiology, Department of Neurosurgery University of Erlangen Nuernberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroreport 13:2581-6. 2002
    ..The occurrence of ipsilateral SI activity following passive movement of only the impaired index finger might suggest a disinhibition of subthreshold, transcallosal excitatory pathways...
  28. doi request reprint Multi-voxel magnetic resonance spectroscopy of cerebral metabolites in healthy adults at 3 Tesla
    Marc Thorsten Doelken
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Acad Radiol 16:1493-501. 2009
    ..This study was implemented to create an internal reference database for patients with psychiatric disorders and epilepsy...
  29. doi request reprint Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy
    Katja Kobow
    Institute of Neuropathology, University Medical School Erlangen, Erlangen, Germany
    J Neuropathol Exp Neurol 68:356-64. 2009
    ..These data support a compromised Reelin-signaling pathway and identify promoter methylation as an epigenetic mechanism in the pathogenesis of TLE...
  30. doi request reprint Autobiographical memory in temporal lobe epilepsy: role of hippocampal and temporal lateral structures
    Kirsten Herfurth
    Department of Neurology, Epilepsy Centre ZEE, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Epilepsy Behav 19:365-71. 2010
    ..Both autobiographical memory aspects, episodic and personal semantic memory, were significantly intercorrelated, but both did not correlate with anterograde memory, indicating a structural dissociation between both functions...
  31. doi request reprint Increased spike frequency during general anesthesia with etomidate for magnetoencephalography in patients with focal epilepsies
    Hermann Stefan
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Erlangen, Germany
    Clin Neurophysiol 121:1220-6. 2010
    ..Magnetoencephalography (MEG) is used for focus localization in presurgical evaluation of patients with focal epilepsies. In this proof-of-concept study, general anesthesia with etomidate was used to improve effectiveness of MEG-recordings...
  32. doi request reprint 18Fluoroethyl-L-tyrosine-PET in long-term epilepsy associated glioneuronal tumors
    Burkhard S Kasper
    Department of Neurology, Epilepsy Center, Friedrich Alexander University Erlangen, Erlangen, Germany
    Epilepsia 52:35-44. 2011
    ..Herein we analyzed a large LEAT cohort investigated by 18fluoroethyl-L-tyrosine-positron emission tomography (FET-PET)...
  33. doi request reprint (1)H-MRS profile in MRI positive- versus MRI negative patients with temporal lobe epilepsy
    M T Doelken
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Seizure 17:490-7. 2008
    ....
  34. doi request reprint Long-term experience with fractionated stereotactic radiotherapy in pharmacoresistant epilepsy: neurological and MRI changes
    Christophe Rauch
    Epilepsy Center Erlangen, Department of Neurology, University of Erlangen Nuremberg, Germany
    Epilepsy Res 99:14-20. 2012
    ..Primary endpoint is tolerability concerning neurological and MRI findings, secondary endpoint seizure frequency...
  35. doi request reprint Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans
    Roland Coras
    University Hospital Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Brain 133:3359-72. 2010
    ..966; P = 0.001; linear regression: R²(adjusted) = 0.9). Our results suggest that encoding new memories is related to the regenerative capacity of the hippocampus in the human brain...
  36. doi request reprint MEG correlates of epileptic high gamma oscillations in invasive EEG
    Stefan Rampp
    University Hospital Erlangen, Epilepsy Center, Department of Neurology, Erlangen, Germany
    Epilepsia 51:1638-42. 2010
    ..Determination of sensitivity and specificity, as well as development of MEG-HGO analysis without the need of iEEG should be addressed in a larger study...
  37. doi request reprint White matter angiopathy is common in pediatric patients with intractable focal epilepsies
    Michelle Hildebrandt
    Neuropathological Reference Center for Epilepsy Surgery, Friedrich Alexander University Erlangen Nuremburg, Erlangen, Germany
    Epilepsia 49:804-15. 2008
    ..In the present study, we investigated pathomorphological abnormalities of blood vessels in a cohort of young patients with chronic intractable seizures submitted to an epilepsy surgery program...
  38. doi request reprint Monofocal MEG in lesional TLE: does video EEG monitoring add crucial information?
    Marcel Heers
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, D 91052 Erlangen, Germany
    Epilepsy Res 92:54-62. 2010
    ..To evaluate the additive effect of video-electroencephalography (vEEG), monofocal temporal lobe MEG findings were compared to electrophysiological findings from vEEGs of patients with lesional epilepsy...
  39. doi request reprint Clinical prediction of postoperative seizure control: structural, functional findings and disease histories
    H Stefan
    Epilepsy Centre, Department of Neurology, University Hospital Erlangen, Schwabachanalage 6, 91054 Erlangen, Germany
    J Neurol Neurosurg Psychiatry 80:196-200. 2009
    ..Mesial temporal lobe epilepsy (MTLE) constitutes a heterogenic entity with different clinical histories, pathomorphological hippocampal findings and varying postoperative outcome...
  40. ncbi request reprint Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy
    Roland Coras
    1 Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Brain 137:1945-57. 2014
    ....
  41. doi request reprint The correlation between ictal semiology and magnetoencephalographic localization in frontal lobe epilepsy
    Xintong Wu
    Neurological Clinic, University Hospital Erlangen, Erlangen, Germany
    Epilepsy Behav 22:587-91. 2011
    ..The aim of this study was to investigate the correlation of ictal semiology with localization and/or lateralization by magnetoencephalography (MEG)...
  42. ncbi request reprint When do patients forget their seizures? An electroclinical study
    Frank Kerling
    Epilepsy Center, Erlangen University Hospital, Erlangen, Germany
    Epilepsy Behav 9:281-5. 2006
    ..Subjects in whom events occurred during sleep or originated in (or propagated to) the left temporal lobe had a significantly higher percentage of unrecognized events...
  43. doi request reprint Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI
    Angelika Mühlebner
    Department of Neuropathology, University Hospital Erlangen, Germany
    Acta Neuropathol 123:259-72. 2012
    ..The systematic analysis of well-specified histopathological features could be helpful to improve sensitivity and specificity in MRI detection during pre-surgical work-up of patients with drug-resistant focal epilepsies...
  44. ncbi request reprint [Fractionated stereotactically guided radiotherapy for pharmacoresistant epilepsy]
    Gerhard G Grabenbauer
    Klinik und Poliklinik für Strahlentherapie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Strahlenther Onkol 179:1-7. 2003
    ..This prospective study evaluated the efficiency of fractionated stereotactically guided radiotherapy as a treatment of pharmacoresistant temporal lobe epilepsy...
  45. ncbi request reprint Automatic seizure detection in long-term scalp EEG using an adaptive thresholding technique: a validation study for clinical routine
    Rüdiger Hopfengärtner
    Department of Neurology, Epilepsy Center Erlangen, University Hospital Erlangen, Germany Electronic address
    Clin Neurophysiol 125:1346-52. 2014
    ..The goal of the current study was to validate an improved algorithm in a much larger group of patients in order to show its general applicability in clinical routine...
  46. ncbi request reprint Utilization of magnetoencephalography results to obtain favourable outcomes in epilepsy surgery
    Michael J M Fischer
    Department of Neurology, Epilepsy Neurocentre, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 128:153-7. 2005
    ..This study shows that MEG source localization can help to delineate epileptic activity and, along with other techniques, should be taken into account for epilepsy surgery...
  47. doi request reprint Effects of electrical stimulation in vestibular cortex areas in humans
    Christoph Best
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neurol Sci 290:157-62. 2010
    ..These findings support the hypothesis that the superior temporal gyrus is one of the regions of a multisensory network that plays a crucial role in the processing of vestibulo-ocular information...
  48. ncbi request reprint Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy
    Ying Wang-Tilz
    Department of Neurology, Epilepsy Center Erlangen, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Epilepsia 47:233-9. 2006
    ....
  49. ncbi request reprint Magnetoencephalography in presurgical epilepsy diagnosis
    Stefan Rampp
    Epilepsy Center ZEE, Department of Neurology, University Hospital, Schwabachanlage 6, 91054 Erlangen, Germany
    Expert Rev Med Devices 4:335-47. 2007
    ..This review gives an overview of the method and discusses advantages and limitations in the clinical context of presurgical epilepsy diagnosis...
  50. ncbi request reprint Cortical processing of brush-evoked allodynia
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroreport 14:785-9. 2003
    ..This study corroborates the concept of cortical reorganisation underlying chronic pain. Furthermore, it demonstrates that a remarkable early activation of the cingulate cortex may be involved in the cortical processing of allodynia...
  51. ncbi request reprint Fractionated stereotactically guided radiotherapy of pharmacoresistant temporal lobe epilepsy
    G G Grabenbauer
    Department of Radiation Therapy, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Acta Neurochir Suppl 84:65-70. 2002
    ..This prospective study evaluated the efficacy of fractionated stereotactically guided radiotherapy (SRT) as a treatment of pharmacoresistant temporal lobe epilepsy...
  52. doi request reprint Interictal triple ECoG characteristics of temporal lobe epilepsies: An intraoperative ECoG analysis correlated with surgical outcome
    H Stefan
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Neurophysiol 119:642-52. 2008
    ..We have systematically investigated different characteristic epileptiform activities in intraoperative ECoG and correlated them to postoperative outcome...
  53. ncbi request reprint Deficient memory acquisition in temporal lobe epilepsy is predicted by hippocampal granule cell loss
    E Pauli
    Department of Neuropathology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neurology 67:1383-9. 2006
    ..The hippocampal formation is essentially involved in the formation of conscious memories for facts and events and neurologic diseases affecting the hippocampus associate with severe memory deficits, i.e., temporal lobe epilepsies...
  54. pmc A new clinico-pathological classification system for mesial temporal sclerosis
    Ingmar Blumcke
    Department of Neuropathology, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 113:235-44. 2007
    ..Our classification system appears suitable for stratifying the clinically heterogeneous group of MTLE patients also with respect to postsurgical outcome studies...
  55. ncbi request reprint Use of intraoperative magnetic resonance imaging in tailored temporal lobe surgeries for epilepsy
    Michael Buchfelder
    Department of Neurosurgery, University of Erlangen Nurnberg, Erlangen, Germany
    Epilepsia 43:864-73. 2002
    ..The recently proposed concept of an individually tailored procedure, preserving tissue not involved in seizures, leads to a variety of differently shaped resections...
  56. ncbi request reprint Model based prognosis of postoperative object naming in left temporal lobe epilepsy
    Michael Schwarz
    Department of Neurology, Epilepsy Center Erlangen, ZEE, University of Erlangen Nuernberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Seizure 14:562-8. 2005
    ..It is hypothesized, that there is a strong connection between stable naming performance and deviant intrahemispheric speech representation as a result of early brain damage and/or chronic seizures...
  57. ncbi request reprint The vegetarian who ate a sausage with curry sauce
    Josef G Heckmann
    Department of Neurology, University of Erlangen Nuremberg, Germany
    Lancet Neurol 2:62. 2003
  58. doi request reprint Network characteristics of idiopathic generalized epilepsies in combined MEG/EEG
    Hermann Stefan
    University Hospital Erlangen, Epilepsy Center Department of Neurology, Schwabachanlage 6, 91054 Erlangen, Germany
    Epilepsy Res 85:187-98. 2009
    ....
  59. ncbi request reprint [Drug therapy before and after surgery for epilepsy. Critical review and recommendations]
    H Stefan
    Neurologische Klinik, Universitat Erlangen Nurnberg
    Nervenarzt 71:451-8. 2000
    ..In general, the less successful the operative therapy, the longer and more intensive the drug treatment...
  60. ncbi request reprint Pathophysiology of human epilepsy: imaging and physiologic studies
    H Stefan
    Neurologische Klinik der Universität Erlangen Nürnberg, Zentrum Epilepsie Erlangen, Germany
    Curr Opin Neurol 13:177-81. 2000
    ..The ability to correlate functional disturbances and lesions has been clarified, which has led to a better understanding of plasticity and epilepsy...
  61. doi request reprint Pitfalls in diagnosing limbic encephalitis - a case report
    F Kerling
    Epilepsy Center ZEE, Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Neurol Scand 118:339-42. 2008
    ..The syndrome of limbic encephalitis (LE) is characterized by subacute onset of temporal lobe epilepsy, loss of short-term memory, cognitive confusion and psychiatric symptoms...
  62. ncbi request reprint The significance of bilateral CSI changes for the postoperative outcome in temporal lobe epilepsy
    K E Eberhardt
    Department of Neurosurgery, University of Erlangen Nuremberg, Germany
    J Comput Assist Tomogr 24:919-26. 2000
    ....
  63. ncbi request reprint Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study
    W Graf
    Department of Neurology Epilepsy Center, University Erlangen Nurnberg, Erlangen, Germany
    Int J Clin Pharmacol Ther 47:439-43. 2009
    ..Chronopharmacological investigations concerning efficacy, side effects and circadian serum concentration are lacking for many antiepileptic drugs...
  64. ncbi request reprint Magnetic resonance spectroscopy and histopathological findings in temporal lobe epilepsy
    H Stefan
    Department of Neurology, University Erlangen Nurnberg, Schwabachanlange 6, 90154 Erlangen, Germany
    Epilepsia 42:41-6. 2001
    ....
  65. ncbi request reprint Pain-related somatosensory evoked magnetic fields induced by controlled ballistic mechanical impacts
    K Druschky
    Department of Neurology, University of Erlangen Nuernberg, Germany
    J Clin Neurophysiol 17:613-22. 2000
    ....
  66. ncbi request reprint Specific accumulation of 18F-deoxyglucose in three-dimensional long-term cultures of human and rodent brain tissue
    C Hocke
    Clinic of Nuclear Medicine, Krankenhausstrasse 12, 91054 Erlangen
    Nuklearmedizin 46:233-8. 2007
    ..Here, we report the use of (18)F-deoxyglucose (FDG) for evaluating the viability of brain slice preparations obtained either from postnatal rats or human hippocampal specimens...
  67. ncbi request reprint Multimodal coregistration in patients with temporal lobe epilepsy--results of different imaging modalities in lateralization of the affected hemisphere in MR imaging positive and negative subgroups
    M T Doelken
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    AJNR Am J Neuroradiol 28:449-54. 2007
    ....
  68. ncbi request reprint Therapeutic intensive seizure analysis (TISA) in presurgical evaluation of Losigamone
    H Stefan
    Department of Neurology, Epilepsy Center, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    Acta Neurol Scand 104:195-201. 2001
    ..The new method TISA was used to evaluate Losigamone efficacy...
  69. ncbi request reprint [Sports injuries of the nervous system]
    C Lang
    Neurologische Klinik, Friedrich Alexander Universitat Erlangen Nurnberg
    Fortschr Neurol Psychiatr 67:373-84. 1999
    ..The knowledge of typical traumata should enable the neurologist to rapidly and reliably recognize related lesions and to contribute to their prevention or improvement...
  70. ncbi request reprint Epilepsy surgery, resection volume and MSI localization in lesional frontal lobe epilepsy
    A Genow
    Neurological Clinic, Department of Neurology, Epilepsy Center, University Erlangen Nurnberg, D 91054, Erlangen, Germany
    Neuroimage 21:444-9. 2004
    ..Our results in five cases with lesional frontal lobe epilepsy showed that good surgical outcome could be achieved in those patients where the majority of MEG spike localizations were located within the resected brain volume...
  71. ncbi request reprint Somatosensory evoked magnetic fields following passive movement compared with tactile stimulation of the index finger
    K Druschky
    Department of Neurology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Exp Brain Res 148:186-95. 2003
    ....
  72. ncbi request reprint Recent advances in the diagnosis and treatment of epilepsy
    H Stefan
    Neurologische Klinik der Universität Erlangen Nürnberg ZEE, Germany
    Eur J Neurol 8:519-39. 2001
    ..A constructive approach from multicenter studies requires homologous definitions, documentations and standardization of procedures of trials for European multicenter studies...
  73. ncbi request reprint Ictal onset localization of epileptic seizures by magnetoencephalography
    C Tilz
    Department of Neurology, Epilepsy Center, Friedrich Alexander University of Erlangen Nuernberg, Germany
    Acta Neurol Scand 106:190-5. 2002
    ....
  74. ncbi request reprint Short TE single-voxel 1H-MR spectroscopy of hippocampal structures in healthy adults at 1.5 Tesla--how reproducible are the results?
    T Hammen
    Department of Neurology, Epilepsy Center, University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    NMR Biomed 18:195-201. 2005
    ..857), and Ins (p=0.826). Rescan led to the same results and gave proof of good reproducibility. Scan-rescan testing in one subject showed comparable results: tNAA (CV=4.8%), followed by Cr, Ins, Glu+Gln and Cho (all CV above 10%)...
  75. ncbi request reprint Progressive cognitive decline in epilepsy: an indication of ongoing plasticity
    H Stefan
    Department of Neurology, Epilepsy Center University Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Prog Brain Res 135:409-17. 2002
    ..Concepts for memory storage and consolidation and mechanisms of plasticity concerning epileptic activity as well as modification of long-term potentiation for plasticity with regard to memory functions are also discussed...
  76. ncbi request reprint Influence of vagus nerve stimulation on histamine-induced itching
    A Kirchner
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 59:108-12. 2002
    ..To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans...
  77. ncbi request reprint Epileptogenesis and rational therapeutic strategies
    H Stefan
    Epilepsy Centre Neurological Clinic, University Erlangen Nuernberg, Erlangen, Germany
    Acta Neurol Scand 113:139-55. 2006
    ....
  78. ncbi request reprint Spatial intralobar correlation of spike and slow wave activity localisations in focal epilepsies: a MEG analysis
    M Kaltenhäuser
    Epilepsycenter ZEE, Department of Neurology, University of Erlangen Nurnberg, Schwabachanlage 16, D 91054 Erlangen, Germany
    Neuroimage 34:1466-72. 2007
    ..The localisation of slow wave dipole density yielded additional important information and may contribute to defining the irritative zone...
  79. ncbi request reprint Prediction of postoperative outcome with special respect to removal of hemosiderin fringe: a study in patients with cavernous haemangiomas associated with symptomatic epilepsy
    T Hammen
    Department of Neurology, Epilepsy Center, University of Erlangen Nuremberg, Germany
    Seizure 16:248-53. 2007
    ..In this study 30 patients with symptomatic epilepsy caused by cavernomas were investigated in a postoperative follow up study to assess predictors for postoperative outcome with respect to indications, time and approach of surgery...
  80. pmc Sex differences and lateral asymmetry in heart rate modulation in patients with temporal lobe epilepsy
    A Kirchner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurol Neurosurg Psychiatry 73:73-5. 2002
    ..24, df = 2.58/27, p < 0.001). These results confirm the right hemispheric lateralisation of sympathetic cardiac control in male patients...
  81. ncbi request reprint Fast activity as a surrogate marker of epileptic network function?
    S Rampp
    Epilepsy Center Erlangen, University of Erlangen Nuremberg, Germany
    Clin Neurophysiol 117:2111-7. 2006
    ..In this review, an overview of the electrophysiologic characteristics, putative cellular and network mechanisms in epilepsy is given. Recent studies are reviewed and interpreted in the context of a common hypothetical model...
  82. ncbi request reprint Identifying the affected hemisphere by (1)H-MR spectroscopy in patients with temporal lobe epilepsy and no pathological findings in high resolution MRI
    T Hammen
    Clinics of Neurology, Epilepsy Center ZEE, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Neurol 13:482-90. 2006
    ..22+/-0.17*, P=0.035). The results of our study show that (1)H-MRS is able to identify the affected hemisphere of MRI negative TLE patients and can be used as an additive tool in multimodal focus localization...
  83. ncbi request reprint [Ictal signs--cerebral localization and propagation]
    H Stefan
    Neurologische Klinik, Zentrum Epilepsie der Universität Erlangen Nuremberg, Erlangen
    Nervenarzt 74:527-35; quiz 536. 2003
    ..Limitations of so-called silent brain regions in this respect are also discussed. As a simple aid for clinical diagnosis, the nuclear shell structure model is demonstrated...
  84. doi request reprint Rapid loading of intravenous lacosamide: efficacy and practicability during presurgical video-EEG monitoring
    Wenjie Li
    Department of Neurology, University of Magdeburg, Magdeburg, Germany Neurological Clinic, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 54:75-80. 2013
    ..This study investigates immediate efficacy and safety of intravenous application of de novo lacosamide (LCM) as add-on therapy in patients with pharmacoresistant focal epilepsy...
  85. doi request reprint Ictal onset baseline shifts and infraslow activity
    Stefan Rampp
    Department of Neurology, Epilepsy Center, University Hospital Erlangen, Erlangen, Germany
    J Clin Neurophysiol 29:291-7. 2012
    ..It is concluded that ictal onset baseline shifts can be detected by commonly used EEG systems with an input filter of 0.1 Hz and may contribute to identify seizure onset and areas involved in seizure generation...
  86. ncbi request reprint Vagus nerve stimulation suppresses pain but has limited effects on neurogenic inflammation in humans
    Annette Kirchner
    Neurologische Klinik, University of Erlangen Nuremberg, Germany
    Eur J Pain 10:449-55. 2006
    ....
  87. doi request reprint Epilepsy monitoring for therapy: challenges and perspectives
    H Stefan
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Neurophysiol 120:653-8. 2009
    ..These methods can be of assistance, as essential and practical tools, in the decision making during diagnostic monitoring by providing more objective results...
  88. ncbi request reprint Autonomic auras: left hemispheric predominance of epileptic generators of cold shivers and goose bumps?
    H Stefan
    Department of Neurology Center Epilepsy, University of Erlangen Nurnberg, Germany
    Epilepsia 43:41-5. 2002
    ..Autonomic seizures in temporal lobe epilepsies associated with "cold shivers and goose bumps" as a principal ictal sign or aura have only rarely been studied...
  89. ncbi request reprint 1H-MR spectroscopy: a promising method in distinguishing subgroups in temporal lobe epilepsy?
    Th Hammen
    Department of Neurology, Center Epilepsy, Neurologische Klinik mit Poliklinik, University Erlangen Nurnberg, ZEE Zentrum Epilepsie Erlangen Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neurol Sci 215:21-5. 2003
    ..Our results reveal that 1H-MRS is able to distinguish between mesiobasal and lateral pathologies in patients with TLE and represents a useful tool for noninvasive TLE classification...
  90. ncbi request reprint Changes of seizures activity during rapid withdrawal of lamotrigine
    Y Wang-Tilz
    Department of Neurology, Center of Epilepsy ZEE, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Neurol 12:280-8. 2005
    ..This study justified the withdrawal in pre-surgical localization, rationalized precautions for possible accompanying risks, and also aroused attentions in clinical anticonvulsant trials and substitutions involving withdrawal process...
  91. ncbi request reprint An efficient, robust and fast method for the offline detection of epileptic seizures in long-term scalp EEG recordings
    R Hopfengärtner
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Neurophysiol 118:2332-43. 2007
    ..It is aimed for seizure detection with high sensitivity and low number of false detections in long-term EEG data without a priori information...
  92. ncbi request reprint Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome
    Jie Mu
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China Electronic address
    Seizure 23:553-9. 2014
    ..To evaluate the value of magnetoencephalography (MEG) source localization in localization of epileptic activities and predicting surgical outcome in frontal lobe epilepsies (FLE)...
  93. ncbi request reprint Somatotopic organization of the ventral and dorsal finger surface representations in human primary sensory cortex evaluated by magnetoencephalography
    Katrin Druschky
    Department of Neurology, University of Erlangen Nuernberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroimage 15:182-9. 2002
    ....
  94. doi request reprint Detection of epileptic spikes by magnetoencephalography and electroencephalography after sleep deprivation
    M Heers
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Seizure 19:397-403. 2010
    ....
  95. ncbi request reprint Comparison of clonidine to sleep deprivation in the potential to induce spike or sharp-wave activity
    B Kettenmann
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Neurophysiol 116:905-12. 2005
    ..This study aimed to investigate previously observed side effects, i.e. increased epileptic activity during clonidine medication. The safety and effectiveness of clonidine as spike inducing agent compared to sleep deprivation were tested...
  96. ncbi request reprint Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated by [(123)I]metaiodobenzylguanidine-SPECT
    A Druschky
    Department of Neurology, University of Erlangen-Nuremberg, Germany
    Brain 124:2372-82. 2001
    ..MIBG-SPECT demonstrates altered post-ganglionic cardiac sympathetic innervation. This dysfunction might carry an increased risk of cardiac abnormalities...
  97. ncbi request reprint Influence of levetiracetame on ictal and postictal EEG in patients with partial seizures
    C Tilz
    Department of Neurology, Epilepsy Center Erlangen, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Eur J Neurol 13:1352-8. 2006
    ..03). This study demonstrated that LEV not only prevented the seizure pattern propagation but also helped the speedy recovery of the postictal background activity in the EEG...
  98. doi request reprint [Current clinical-neurophysiological findings in absence epilepsies]
    H Stefan
    Epilepsiezentrum Erlangen Neurologie, Universitatsklinik, Erlangen, Germany
    Nervenarzt 80:378-85. 2009
    ..These must be distinguished from a pure culture of focal frontal lobe epilepsies, which can also be accompanied by the lead symptom of absences...
  99. doi request reprint Epilepsy outcomes in elderly treated with topiramate
    H Stefan
    Epilepsy Center, University of Erlangen, Germany
    Acta Neurol Scand 118:164-74. 2008
    ..To explore effectiveness, tolerability and quality of life in elderly patients with epilepsy treated with topiramate...
  100. ncbi request reprint Microdysgenesis in mesial temporal lobe epilepsy: a clinicopathological study
    Burkhard S Kasper
    Epilepsy Center, Department of Neurology, University of Erlangen, Erlangen, Germany
    Ann Neurol 54:501-6. 2003
    ..Their suggested fundamental role as dysplastic factor within development of hippocampal sclerosis and MTLE is not confirmed...
  101. doi request reprint [Cognition and epilepsies]
    H Stefan
    Epilepsiezentrum Neurologische Klinik, Universitatsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    Nervenarzt 79:77-91; quiz 92. 2008
    ..The need of individual assessment of cognitive side effects draws increasing attention as a precondition for treatment optimized to each patient...