Bärbel Stecher

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Inflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms
    Lubov Petkova Nedialkova
    Max von Pettenkofer Institute, LMU Munich, Munich, Germany German Center for Infection research DZIF, partner site LMU Munich, Munich, Germany
    PLoS Pathog 10:e1003844. 2014
  2. pmc Salmonella transiently reside in luminal neutrophils in the inflamed gut
    Yvonne Loetscher
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e34812. 2012
  3. doi Colonization resistance and microbial ecophysiology: using gnotobiotic mouse models and single-cell technology to explore the intestinal jungle
    Bärbel Stecher
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, Munich, Germany
    FEMS Microbiol Rev 37:793-829. 2013
  4. doi Finding a sugary foothold: how antibiotics pave the way for enteric pathogens
    Bärbel Stecher
    Max von Pettenkofer Institute, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany German Center for Infection research DZIF, Inhoffenstrasse 7, 38124 Braunschweig, Germany Electronic address
    Cell Host Microbe 14:225-7. 2013
  5. doi Mechanisms controlling pathogen colonization of the gut
    Bärbel Stecher
    Max von Pettenkofer Institut, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Curr Opin Microbiol 14:82-91. 2011
  6. pmc Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Paulistrasse 10, HCI G413, CH 8093 Zurich, Switzerland
    Infect Immun 73:3228-41. 2005
  7. pmc Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice
    Siegfried Hapfelmeier
    Institute of Microbiology, ETH Zurich, CH 8092 Zurich, Switzerland
    Infect Immun 72:795-809. 2004
  8. pmc Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis
    Siegfried Hapfelmeier
    Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
    J Exp Med 205:437-50. 2008
  9. pmc Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
    Infect Immun 72:4138-50. 2004
  10. pmc Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1269-74. 2012

Collaborators

Detail Information

Publications31

  1. pmc Inflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms
    Lubov Petkova Nedialkova
    Max von Pettenkofer Institute, LMU Munich, Munich, Germany German Center for Infection research DZIF, partner site LMU Munich, Munich, Germany
    PLoS Pathog 10:e1003844. 2014
    ..In conclusion, this study uncovers a so-far unappreciated role of inflammation-inflicted blooms as an environment favouring ColIb-dependent competition of pathogenic and commensal representatives of the Enterobacteriaceae family. ..
  2. pmc Salmonella transiently reside in luminal neutrophils in the inflamed gut
    Yvonne Loetscher
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e34812. 2012
    ..Here, we analyzed the interaction of gut luminal neutrophils with S. enterica serovar Typhimurium (S. Tm) in a mouse colitis model...
  3. doi Colonization resistance and microbial ecophysiology: using gnotobiotic mouse models and single-cell technology to explore the intestinal jungle
    Bärbel Stecher
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, Munich, Germany
    FEMS Microbiol Rev 37:793-829. 2013
    ....
  4. doi Finding a sugary foothold: how antibiotics pave the way for enteric pathogens
    Bärbel Stecher
    Max von Pettenkofer Institute, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany German Center for Infection research DZIF, Inhoffenstrasse 7, 38124 Braunschweig, Germany Electronic address
    Cell Host Microbe 14:225-7. 2013
    ..In a recent study, Ng et al. (2013) demonstrate that antibiotic-mediated disruption of the microbial food web gives rise to free microbiota-liberated monosaccharides in the gut, which can promote growth of enteropathogenic bacteria...
  5. doi Mechanisms controlling pathogen colonization of the gut
    Bärbel Stecher
    Max von Pettenkofer Institut, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Curr Opin Microbiol 14:82-91. 2011
    ..We are discussing recent progress in deciphering the underlying molecular mechanisms in health and disease...
  6. pmc Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Paulistrasse 10, HCI G413, CH 8093 Zurich, Switzerland
    Infect Immun 73:3228-41. 2005
    ..One obvious difference was more pronounced damage and reduced regenerative response of the cecal epithelium in GF mice. Overall, StrSPF mice and GF mice provide similar but not identical models for Salmonella serovar Typhimurium colitis...
  7. pmc Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice
    Siegfried Hapfelmeier
    Institute of Microbiology, ETH Zurich, CH 8092 Zurich, Switzerland
    Infect Immun 72:795-809. 2004
    ....
  8. pmc Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis
    Siegfried Hapfelmeier
    Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
    J Exp Med 205:437-50. 2008
    ..These results establish that pathogen sampling by DCs is a discrete, and MyD88-independent, step during the initiation of a mucosal innate immune response to bacterial infection in vivo...
  9. pmc Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
    Infect Immun 72:4138-50. 2004
    ..This effect is mostly attributable to chemotaxis. Recognition of flagellar subunits (i.e., flagellin) by innate immune receptors (i.e., Toll-like receptor 5) may be less important...
  10. pmc Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1269-74. 2012
    ..These blooms may favor reassortment of plasmid-encoded genes between pathogens and commensals fostering the spread of fitness-, virulence-, and antibiotic-resistance determinants...
  11. pmc Bacterial colitis increases susceptibility to oral prion disease
    Christina J Sigurdson
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    J Infect Dis 199:243-52. 2009
    ..Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE...
  12. pmc O-antigen-negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonization but elicits colitis in streptomycin-treated mice
    Karin Ilg
    Institut fur Mikrobiologie, Eidgenossische Technische Hochschule, ETH Zurich, Zurich, Switzerland
    Infect Immun 77:2568-75. 2009
    ..Our experiments prove that the presence of complete LPS is not essential for in vitro invasion or for triggering acute colitis...
  13. pmc Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000711. 2010
    ..This might be of relevance for human enteropathogen infections as well as therapeutic use of probiotic commensal bacteria...
  14. pmc The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea
    Kathrin Endt
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1001097. 2010
    ..This has implications for curing S. typhimurium diarrhea and for preventing transmission...
  15. pmc Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
    Bärbel Stecher
    Institute of Microbiology, Swiss Institute of Technology Zurich, Zurich, Switzerland
    PLoS Biol 5:2177-89. 2007
    ..Triggering the host's immune defence can shift the balance between the protective microbiota and the pathogen in favour of the pathogen...
  16. pmc Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection
    Pascal Songhet
    Institute of Microbiology D BIOL, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    PLoS ONE 6:e22459. 2011
    ..Thus IFN-γR-signaling influences different mucosal responses to infection, including not only pathogen restriction in the lamina propria, but, as shown here, also goblet cell function...
  17. pmc Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Infect Immun 74:5047-57. 2006
    ..We propose that streptomycin-pretreated 129Sv/Ev mice provide a robust murine model for chronic enteric salmonellosis including complications such as cholangitis...
  18. doi The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response
    Patrick Kaiser
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
    Immunol Rev 245:56-83. 2012
    ..Finally, we discuss the general need for defined assay conditions when using animal models for enteric infections and the central importance of littermate controls...
  19. doi Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathway
    Rina Käppeli
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Int J Med Microbiol 301:117-24. 2011
    ..This establishes a novel virulence phenotype for spvB in the alternative pathway of S. Typhimurium colitis...
  20. doi Motility allows S. Typhimurium to benefit from the mucosal defence
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Cell Microbiol 10:1166-80. 2008
    ..Thus, nutrient availability contributes to enhanced pathogen growth in the inflamed intestine. Strategies interfering with bacterial motility or nutrient availability might offer starting points for therapeutic approaches...
  21. pmc A simple screen to identify promoters conferring high levels of phenotypic noise
    Nikki E Freed
    Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
    PLoS Genet 4:e1000307. 2008
    ..Typhimurium genome. This approach can be applied to many other bacterial and eukaryotic systems as a simple method for identifying genes with noisy expression...
  22. doi 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution
    Bärbel Stecher
    German Centre for Infection Research and the Max von Pettenkofer Institut, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9, 80336 Munich, Germany
    Nat Rev Microbiol 11:277-84. 2013
    ..Here, we present evidence suggesting that dysbiosis fuels horizontal gene transfer between members of this ecosystem, facilitating the transfer of virulence and antibiotic resistance genes and thereby promoting pathogen evolution...
  23. doi TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice
    Simon Heidegger
    Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    J Immunol 190:5313-20. 2013
    ..Our data identify a mechanism that excludes noncognate CD8(+) T cells from selected immune compartments during TLR-induced systemic inflammation...
  24. pmc InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium
    Kristin Ehrbar
    Institute of Microbiology, ETH Zurich, 8092 Zurich, Switzerland
    J Bacteriol 186:1215-9. 2004
    ..We found that the chaperone InvB binds to SopA and slightly stabilizes it in the bacterial cytosol and that it is required for its transport via the SPI-1 TTSS...
  25. pmc Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking
    Benjamin Misselwitz
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    Infect Immun 79:330-41. 2011
    ..Typhimurium helper strain. Our data show that binding to HeLa cells is mediated by at least two different mechanisms and that both can lead to invasion if actin rearrangements are triggered...
  26. ncbi Self-destructive cooperation mediated by phenotypic noise
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, 8092 Zurich, Switzerland
    Nature 454:987-90. 2008
    ....
  27. ncbi The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms
    Siegfried Hapfelmeier
    Institute of Microbiology, D BIOL, Eidgenössiche Technische Hochschule, Zurich, Switzerland
    J Immunol 174:1675-85. 2005
    ....
  28. pmc Real-time imaging of type III secretion: Salmonella SipA injection into host cells
    Markus C Schlumberger
    Institute of Microbiology, Eidgenossische Technische Hochschule, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:12548-53. 2005
    ..Similar observations were made for the effector protein SopE. This visualization of type III secretion in real time explains the efficiency of host cell manipulation by means of this virulence system...
  29. doi The role of microbiota in infectious disease
    Bärbel Stecher
    Institute of Microbiology, Eidgenoessische Technische Hochschule ETH Zürich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Trends Microbiol 16:107-14. 2008
    ..Thus, some pathogens can benefit from inflammatory defenses. This new paradigm will enable the study of host factors enhancing or inhibiting bacterial growth in health and disease...
  30. doi The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease
    Hans Joachim Anders
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    Kidney Int 83:1010-6. 2013
    ....
  31. doi Microbiota-derived hydrogen fuels salmonella typhimurium invasion of the gut ecosystem
    Lisa Maier
    Institute of Microbiology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell Host Microbe 14:641-51. 2013
    ..Tm growth. Thus, H2 is an Achilles' heel of microbiota metabolism that can be subverted by pathogens and might offer opportunities to prevent infection. ..