Manfred Spitzer

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint Working memory capacity, indirect semantic priming, and stroop interference: pattern of interindividual prefrontal performance differences in healthy volunteers
    Markus Kiefer
    Department of Psychiatry, University of Ulm, Ulm, Germany
    Neuropsychology 19:332-44. 2005
  2. pmc Decade of the mind
    Manfred Spitzer
    Philos Ethics Humanit Med 3:7. 2008
  3. ncbi request reprint The neural signature of social norm compliance
    Manfred Spitzer
    University of Ulm, University Hospital for Psychiatry, Psychiatry III, Leimgrubenweg 1214, 89075, Ulm, Germany
    Neuron 56:185-96. 2007
  4. ncbi request reprint Side effects of transcranial magnetic stimulation biased task performance in a cognitive neuroscience study
    Birgit Abler
    Department of Psychiatry, University of Ulm, Germany
    Brain Topogr 17:193-6. 2005
  5. ncbi request reprint Cholinergic enhancement of episodic memory in healthy young adults
    Georg Gron
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075 Ulm, Germany
    Psychopharmacology (Berl) 182:170-9. 2005
  6. ncbi request reprint Semantic and syntactic processes during sentence comprehension in patients with schizophrenia: evidence from event-related potentials
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Schizophr Res 64:147-56. 2003
  7. ncbi request reprint Error processing and impulsiveness in normals: evidence from event-related potentials
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Brain Res Cogn Brain Res 24:317-25. 2005
  8. ncbi request reprint No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial working memory in schizophrenia
    Henrik Walter
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075, Ulm, Germany
    Schizophr Res 61:175-84. 2003
  9. ncbi request reprint Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia
    Carlos Schonfeldt-Lecuona
    Departments of Psychiatry III, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Neuroreport 15:1669-73. 2004
  10. ncbi request reprint Changes over time in frontotemporal activation during a working memory task in patients with schizophrenia
    Robert Christian Wolf
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Schizophr Res 91:141-50. 2007

Detail Information

Publications46

  1. ncbi request reprint Working memory capacity, indirect semantic priming, and stroop interference: pattern of interindividual prefrontal performance differences in healthy volunteers
    Markus Kiefer
    Department of Psychiatry, University of Ulm, Ulm, Germany
    Neuropsychology 19:332-44. 2005
    ..These findings suggest that working memory, executive control, and semantic retrieval are functionally related to some extent...
  2. pmc Decade of the mind
    Manfred Spitzer
    Philos Ethics Humanit Med 3:7. 2008
    ..Therefore, the proposal, which is scientifically interdisciplinary in nature, has to be politically international...
  3. ncbi request reprint The neural signature of social norm compliance
    Manfred Spitzer
    University of Ulm, University Hospital for Psychiatry, Psychiatry III, Leimgrubenweg 1214, 89075, Ulm, Germany
    Neuron 56:185-96. 2007
    ....
  4. ncbi request reprint Side effects of transcranial magnetic stimulation biased task performance in a cognitive neuroscience study
    Birgit Abler
    Department of Psychiatry, University of Ulm, Germany
    Brain Topogr 17:193-6. 2005
    ..We emphasize the importance of controlling side effects of the stimulation as a source of biasing effects in TMS studies...
  5. ncbi request reprint Cholinergic enhancement of episodic memory in healthy young adults
    Georg Gron
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075 Ulm, Germany
    Psychopharmacology (Berl) 182:170-9. 2005
    ..Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects...
  6. ncbi request reprint Semantic and syntactic processes during sentence comprehension in patients with schizophrenia: evidence from event-related potentials
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Schizophr Res 64:147-56. 2003
    ..These results suggest that patients with schizophrenia are not impaired in syntactic structure assignment as reflected by the ELAN, but show deficits in semantic-syntactic integration processes underlying the P600...
  7. ncbi request reprint Error processing and impulsiveness in normals: evidence from event-related potentials
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Brain Res Cogn Brain Res 24:317-25. 2005
    ..Moreover, present results argue for the necessity of careful control of impulsiveness when including normal comparison groups in the context of clinical studies...
  8. ncbi request reprint No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial working memory in schizophrenia
    Henrik Walter
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075, Ulm, Germany
    Schizophr Res 61:175-84. 2003
    ..We conclude that the finding of hypofrontality may depend on the medication of the patients and that there is prefrontal dysfunction even in the absence of hypofrontality...
  9. ncbi request reprint Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia
    Carlos Schonfeldt-Lecuona
    Departments of Psychiatry III, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Neuroreport 15:1669-73. 2004
    ..rTMS did not lead to a significant reduction of hallucination severity. Conclusively, rTMS has to be regarded critically as a possible novel tool for the treatment of hallucinations...
  10. ncbi request reprint Changes over time in frontotemporal activation during a working memory task in patients with schizophrenia
    Robert Christian Wolf
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Schizophr Res 91:141-50. 2007
    ....
  11. pmc From uncertainty to reward: BOLD characteristics differentiate signaling pathways
    Birgit Abler
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    BMC Neurosci 10:154. 2009
    ....
  12. ncbi request reprint The effect of erroneous responses on response monitoring in patients with major depressive disorder: a study with event-related potentials
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Ulm, Germany
    Psychophysiology 41:833-40. 2004
    ..This result might reflect impaired response monitoring processes in major depressive disorder resulting from an underactivity in a central reward pathway and/or a deficit in strategic reasoning...
  13. ncbi request reprint Evidence for quantitative domain dominance for verbal and spatial working memory in frontal and parietal cortex
    Henrik Walter
    Department of Psychiatry, University of Ulm, Germany
    Cortex 39:897-911. 2003
    ..The concept of domain dominance is discussed in the light of recent theories of prefrontal cortex function...
  14. ncbi request reprint Emotional context modulates subsequent memory effect
    Susanne Erk
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Neuroimage 18:439-47. 2003
    ..These results contribute to the understanding of the interaction of emotion and cognition and moreover are of general relevance for studies of episodic memory...
  15. doi request reprint Increased unconscious semantic activation in schizophrenia patients with formal thought disorder
    Markus Kiefer
    University of Ulm, Department of Psychiatry, Section for Cognitive Electrophysiology, Leimgrubenweg 12, 89075 Ulm, Germany
    Schizophr Res 114:79-83. 2009
    ..Increased unconscious activation of several related concepts may interfere with conscious goal-directed thinking in TD patients...
  16. doi request reprint Neural correlates of error monitoring modulated by atomoxetine in healthy volunteers
    Heiko Graf
    Department of Psychiatry, Ulm University Hospital, Ulm University, Ulm, Germany
    Biol Psychiatry 69:890-7. 2011
    ..We investigated the effects of atomoxetine (80 mg) on error monitoring as a second key component of cognitive control...
  17. ncbi request reprint Add-on rTMS for treatment of depression: a pilot study using stereotaxic coil-navigation according to PET data
    Uwe Herwig
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, D 89070 Ulm, Germany
    J Psychiatr Res 37:267-75. 2003
    ..In a double-blind, randomized, sham-controlled pilot study we investigated the efficacy of neuronavigated rTMS, guided according to the prefrontal metabolic state determined by positron emission tomography (PET)...
  18. ncbi request reprint Prediction error as a linear function of reward probability is coded in human nucleus accumbens
    Birgit Abler
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Neuroimage 31:790-5. 2006
    ..We therefore identify two different covariates that model activity in the Nac: specific properties of a psychological task and individual character traits...
  19. ncbi request reprint Transcranial magnetic stimulation in motor conversion disorder: a short case series
    Carlos Schonfeldt-Lecuona
    Department of Psychiatry III, University of Ulm, Ulm, Germany
    J Clin Neurophysiol 23:472-5. 2006
    ..The potential benefit of rTMS in motor conversion disorder should be evaluated in larger, controlled samples...
  20. ncbi request reprint Electrophysiological correlates of error processing in borderline personality disorder
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, D 89075 Ulm, Germany
    Biol Psychol 72:133-40. 2006
    ..No between-group differences were observed for the early and late Pe components. ERP measures appear to be a suitable tool to study clinical time courses in BPD...
  21. doi request reprint Neuroplasticity of semantic representations for musical instruments in professional musicians
    Klaus Hoenig
    University of Ulm, Department of Psychiatry, Section for Cognitive Electrophysiology, Ulm, Germany
    Neuroimage 56:1714-25. 2011
    ..These findings highlight the eminent importance of sensory and motor experience for acquiring rich concepts...
  22. ncbi request reprint Aerobic endurance exercise improves executive functions in depressed patients
    Sabine Kubesch
    Department of Psychiatry, University of Ulm, Ulm, Germany
    J Clin Psychiatry 64:1005-12. 2003
    ..We tested the hypothesis that a 30-minute individually customized endurance exercise program has the potential to enhance executive functions in patients with major depressive disorder...
  23. doi request reprint Aerobic endurance exercise benefits memory and affect in young adults
    Sanna Stroth
    Transfercenter for Neuroscience and Learning, University of Ulm, Germany
    Neuropsychol Rehabil 19:223-43. 2009
    ..We conclude that physical activity can possibly serve as a means to improve positively valenced aspects of affect and benefit visuospatial but not verbal memory in young adults...
  24. ncbi request reprint Electroconvulsive therapy in the treatment of depression in a former ecstasy user
    Roland W Freudenmann
    Department of Psychiatry, University of Ulm, Ulm, Germany
    J Psychopharmacol 20:860-2. 2006
    ..5 years. Add-on ECT could be a treatment option in former ecstasy users with severe depressive disorders that fail to respond to SSRI and/or SNRI. Clinical trials are needed to evaluate further the usefulness of ECT in this patient group...
  25. ncbi request reprint Measuring attachment representation in an FMRI environment: a pilot study
    Anna Buchheim
    Department of Psychosomatic Medicine and Psychotherapy, University of Ulm, Ulm, Germany
    Psychopathology 39:144-52. 2006
    ..These results are discussed in relation to assessing attachment in an fMRI environment and future research in this area...
  26. ncbi request reprint Functional principal component analysis of fMRI data
    Roberto Viviani
    Department of Psychiatry III, University of Ulm, 89075 Ulm, Germany
    Hum Brain Mapp 24:109-29. 2005
    ..We discuss the rationale and advantages of the proposed approach relative to other exploratory methods, such as clustering or independent component analysis, as well as the differences from methods based on expanded design matrices...
  27. ncbi request reprint Intracortical excitability is modulated by a norepinephrine-reuptake inhibitor as measured with paired-pulse transcranial magnetic stimulation
    Uwe Herwig
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89070 Ulm, Germany
    Psychopharmacology (Berl) 164:228-32. 2002
    ..The reuptake-inhibition of norepinephrine, known as an excitatory neuromodulator and neurotransmitter, was postulated to enhance cortical excitability through increased facilitation and reduced inhibition as measured with ppTMS...
  28. ncbi request reprint Transcranial magnetic stimulation in the reversal of motor conversion disorder
    Carlos Schonfeldt-Lecuona
    Department of Psychiatry, University of Ulm, Germany
    Psychother Psychosom 72:286-8. 2003
    ..We tested the therapeutic potential of high-frequency repetitive transcranial magnetic stimulation (rTMS) in a 20-year-old patient suffering from a conversion paralysis of the right arm...
  29. ncbi request reprint Accuracy of stereotaxic positioning of transcranial magnetic stimulation
    Carlos Schonfeldt-Lecuona
    Department of Psychiatry, University of Ulmn, Germany
    Brain Topogr 17:253-9. 2005
    ..It is therefore a precise method for TMS brain mapping studies or for repeated TMS treatments, with the need of topographically exact stimulation...
  30. ncbi request reprint Error processing in major depressive disorder: evidence from event-related potentials
    Martin Ruchsow
    Department of Psychiatry at the University of Ulm, Leimgrubenweg, D 89075 Ulm, Germany
    J Psychiatr Res 40:37-46. 2006
    ..This result might reflect impaired response monitoring processes in major depressive disorder resulting from an impaired activation of a central reward pathway and/or a deficit in strategic reasoning...
  31. ncbi request reprint The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA)
    Roland W Freudenmann
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075 Ulm, Germany
    CNS Drug Rev 10:89-116. 2004
    ..Such challenge studies should directly compare individual RSAs. They will represent the most viable and fruitful approach to the resolution of the highly controversial issues of serotonergic neurotoxicity and its functional consequences...
  32. doi request reprint Neural correlates of attachment trauma in borderline personality disorder: a functional magnetic resonance imaging study
    Anna Buchheim
    Department of Psychosomatic Medicine and Psychotherapy, University Ulm, Am Hochstraess 8, 89081 Ulm, Germany
    Psychiatry Res 163:223-35. 2008
    ..e. fearful and painful intolerance of aloneness, hypersensitivity to social environment, and reduced positive memories of dyadic interactions...
  33. ncbi request reprint Phonological deficit in school children is reflected in the Mismatch Negativity
    Ulrich Bitz
    Transfercenter for Neuroscience and Learning ZNL, University of Ulm, Ulm, Germany
    Neuroreport 18:911-5. 2007
    ..The deficit was speech specific, because there were significant group differences only with syllables but not with pure tones...
  34. pmc Increased resting-state perfusion after repeated encoding is related to later retrieval of declarative associative memories
    Georg Groen
    Section for Neuropsychology and Functional Imaging, Department of Psychiatry, Ulm University, Ulm, Germany
    PLoS ONE 6:e19985. 2011
    ..We suggest that the observed rCBF increases might reflect processes that possibly contribute to the long-term persistence of memory traces...
  35. ncbi request reprint Spatial congruence of neuronavigated transcranial magnetic stimulation and functional neuroimaging
    Uwe Herwig
    Department of Psychiatry III, University of Ulm, Leimgrubenweg 12, D 89075, Ulm, Germany
    Clin Neurophysiol 113:462-8. 2002
    ..Therefore, it is crucial to know whether the area of a certain function as identified by fMRI corresponds to the area where the TMS should be placed in order to influence this function...
  36. ncbi request reprint Human anterior cingulate cortex is activated by negative feedback: evidence from event-related potentials in a guessing task
    Martin Ruchsow
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Neurosci Lett 325:203-6. 2002
    ..The observation of the ERN/N(e) following negative feedback during guessing suggests that this ERP component mirrors response evaluation processes comparing expected and actual response outcome rather than response conflict...
  37. ncbi request reprint Dissociating a common working memory network from different neural substrates of phonological and spatial stimulus processing
    Bartosz Zurowski
    Department of Psychiatry, University of Ulm, 89075 Ulm, Germany
    Neuroimage 15:45-57. 2002
    ..We propose a stimulus-independent role for the bilateral pSFS and its vicinity for maintenance and manipulation of different context-dependent information within working memory...
  38. ncbi request reprint Working memory dysfunction in schizophrenia compared to healthy controls and patients with depression: evidence from event-related fMRI
    Henrik Walter
    Department of Psychiatry, Friedrich Wilhelms University, Bonn, Germany
    Neuroimage 35:1551-61. 2007
    ..However, superior temporal cortex dysfunction in patients with schizophrenia may be regarded as schizophrenia-specific finding in terms of psychiatric diagnosis specificity...
  39. ncbi request reprint Cultural objects modulate reward circuitry
    Susanne Erk
    Diagnostic Radiology, University Clinic Ulm, Leimgrubenweg 12, 89075 Ulm, Germany
    Neuroreport 13:2499-503. 2002
    ..We could thus demonstrate that artificial cultural objects associated with wealth and social dominance elicit activation in reward-related brain areas...
  40. ncbi request reprint Cognitive inhibition and thought disorder in schizophrenia
    Daniela Roesch-Ely
    Department of Psychiatry, University of Heidelberg, Heidelberg, Germany
    Psychopathology 36:23-32. 2003
    ..No influence of the course of disease or medication was found. Our results are in line with recent studies, where patients, irrespective of TD, show normal performance in the NP...
  41. ncbi request reprint Semantic hyperpriming in thought-disordered patients with schizophrenia: state or trait?--a longitudinal investigation
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, Technical University of Aachen RWTH, Pauwelsstrasse 30, D 5205, Aachen, Germany
    Schizophr Res 65:65-73. 2003
    ..In conclusion, semantic hyperpriming in TD patients with schizophrenia appears to be clearly state-dependent and might be viewed as an episode marker of psychosis with TD...
  42. doi request reprint Impulsiveness and ERP components in a Go/Nogo task
    Martin Ruchsow
    Department of Psychiatry, Christophsbad Göppingen, Goppingen, Germany
    J Neural Transm 115:909-15. 2008
    ..Therefore, different levels of impulsiveness in control groups should be carefully taken into account in further ERP studies...
  43. ncbi request reprint Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric, performance-controlled fMRI study
    Henrik Walter
    Department of Psychiatry, Division of Medical Psychology, University Clinic Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Affect Disord 101:175-85. 2007
    ..We applied a newly developed WM task to investigate the neural correlates of executive processes with functional magnetic resonance imaging (fMRI) at comparable performance levels analyzing correct trials only...
  44. ncbi request reprint Enantioselective quantitation of the ecstasy compound (R)- and (S)-N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma and urine
    Jochen Buechler
    Department of Pharmaceutical Analysis, University of Tuebingen, Auf der Morgenstelle 8, D 72076, Tuebingen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 793:207-22. 2003
    ..9 vs. 4.0 h). In contrast, the stereochemical disposition of the MDE metabolites HME and MDA was reversed. Concentrations of the (S)-metabolites in plasma of volunteers were much higher than those of the (R)-enantiomers...
  45. ncbi request reprint Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol
    Carlos Schonfeldt-Lecuona
    J Clin Psychopharmacol 24:97-8. 2004
  46. ncbi request reprint [Low-grade virtual reality. Small children and electronic media]
    Manfred Spitzer
    Abt Psychiatrie III, Psychiatrische Klinik der Universität Ulm
    Kinderkrankenschwester 23:489-91. 2004