Research Topics
Genomes and GenesSpecies | Andrej Nikolai SpiessSummaryAffiliation: University Medical Center Hamburg-Eppendorf Country: Germany Publications
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Detail Information
Publications
A biopsy sample reduction approach to identify significant alterations of the testicular transcriptome in the presence of Y-chromosomal microdeletions that are independent of germ cell compositionHeike Cappallo-Obermann
Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Hum Genet 128:421-31. 2010..We conclude that the deletion of Y-chromosomal genes has a significant effect on spermatogenesis by modulating the transcriptional network of the germ cell and somatic compartment...
Screening for biomarkers of spermatogonia within the human testis: a whole genome approachKathrein von Kopylow
Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Hum Reprod 25:1104-12. 2010....
Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like responseAndrej Nikolai Spiess
Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Hum Reprod 22:2936-46. 2007..The molecular basis of human testicular dysfunction is largely unknown. Global gene expression profiling of testicular biopsies might reveal an expression signature of spermatogenic failure in azoospermic men...- Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruptionBen Davies
CCR Institute of Pharmacology and Toxicology, Charite University Medicine, Berlin, and IHF Institute for Hormone and Fertility Research, University Hospital Hamburg Eppendorf, Germany
Mol Reprod Dev 74:539-53. 2007..The cloned cDNA sequences predicted hydrophobic polytopic membrane proteins containing the DUF716 motif. Protein expression was shown in the rodent caput epididymidis but remained uncertain in primates... - Radiation rescue: mesenchymal stromal cells protect from lethal irradiationClaudia Lange
Clinic for Stem Cell Transplantation, Department of Cell and Gene Therapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 6:e14486. 2011..Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals... - Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogoniaKathrein von Kopylow
Department of Andrology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Reproduction 143:45-57. 2012..Conversely, exosome component 10 (EXOSC10) was found to accumulate within the rarefaction zones, which points to a possible role of this nuclear domain in RNA processing... - Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicineClaudia Lange
Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Cell Physiol 213:18-26. 2007..In summary, we have established a GMP-compatible protocol for safe and accelerated expansion of hMSC to be used in cell and tissue therapy... - A highly efficient method for long-chain cDNA synthesis using trehalose and betaineAndrej Nikolai Spiess
Institute for Hormone and Fertility Research, Grandweg 64, Hamburg, 22529, Germany
Anal Biochem 301:168-74. 2002..The application of betaine in combination with trehalose should prove useful in all laboratory methods relying on full-length cDNA. (USA)... - Highly purified spermatozoal RNA obtained by a novel method indicates an unusual 28S/18S rRNA ratio and suggests impaired ribosome assemblyHeike Cappallo-Obermann
Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
Mol Hum Reprod 17:669-78. 2011....