Andrej Nikolai Spiess

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. pmc A biopsy sample reduction approach to identify significant alterations of the testicular transcriptome in the presence of Y-chromosomal microdeletions that are independent of germ cell composition
    Heike Cappallo-Obermann
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Hum Genet 128:421-31. 2010
  2. doi request reprint Screening for biomarkers of spermatogonia within the human testis: a whole genome approach
    Kathrein von Kopylow
    Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Reprod 25:1104-12. 2010
  3. ncbi request reprint Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response
    Andrej Nikolai Spiess
    Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Reprod 22:2936-46. 2007
  4. ncbi request reprint Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption
    Ben Davies
    CCR Institute of Pharmacology and Toxicology, Charite University Medicine, Berlin, and IHF Institute for Hormone and Fertility Research, University Hospital Hamburg Eppendorf, Germany
    Mol Reprod Dev 74:539-53. 2007
  5. pmc Radiation rescue: mesenchymal stromal cells protect from lethal irradiation
    Claudia Lange
    Clinic for Stem Cell Transplantation, Department of Cell and Gene Therapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e14486. 2011
  6. doi request reprint Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia
    Kathrein von Kopylow
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Reproduction 143:45-57. 2012
  7. ncbi request reprint Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine
    Claudia Lange
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 213:18-26. 2007
  8. ncbi request reprint A highly efficient method for long-chain cDNA synthesis using trehalose and betaine
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, Grandweg 64, Hamburg, 22529, Germany
    Anal Biochem 301:168-74. 2002
  9. doi request reprint Highly purified spermatozoal RNA obtained by a novel method indicates an unusual 28S/18S rRNA ratio and suggests impaired ribosome assembly
    Heike Cappallo-Obermann
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Mol Hum Reprod 17:669-78. 2011

Collaborators

Detail Information

Publications9

  1. pmc A biopsy sample reduction approach to identify significant alterations of the testicular transcriptome in the presence of Y-chromosomal microdeletions that are independent of germ cell composition
    Heike Cappallo-Obermann
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Hum Genet 128:421-31. 2010
    ..We conclude that the deletion of Y-chromosomal genes has a significant effect on spermatogenesis by modulating the transcriptional network of the germ cell and somatic compartment...
  2. doi request reprint Screening for biomarkers of spermatogonia within the human testis: a whole genome approach
    Kathrein von Kopylow
    Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Reprod 25:1104-12. 2010
    ....
  3. ncbi request reprint Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response
    Andrej Nikolai Spiess
    Department of Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Reprod 22:2936-46. 2007
    ..The molecular basis of human testicular dysfunction is largely unknown. Global gene expression profiling of testicular biopsies might reveal an expression signature of spermatogenic failure in azoospermic men...
  4. ncbi request reprint Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption
    Ben Davies
    CCR Institute of Pharmacology and Toxicology, Charite University Medicine, Berlin, and IHF Institute for Hormone and Fertility Research, University Hospital Hamburg Eppendorf, Germany
    Mol Reprod Dev 74:539-53. 2007
    ..The cloned cDNA sequences predicted hydrophobic polytopic membrane proteins containing the DUF716 motif. Protein expression was shown in the rodent caput epididymidis but remained uncertain in primates...
  5. pmc Radiation rescue: mesenchymal stromal cells protect from lethal irradiation
    Claudia Lange
    Clinic for Stem Cell Transplantation, Department of Cell and Gene Therapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e14486. 2011
    ..Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals...
  6. doi request reprint Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia
    Kathrein von Kopylow
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Reproduction 143:45-57. 2012
    ..Conversely, exosome component 10 (EXOSC10) was found to accumulate within the rarefaction zones, which points to a possible role of this nuclear domain in RNA processing...
  7. ncbi request reprint Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine
    Claudia Lange
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 213:18-26. 2007
    ..In summary, we have established a GMP-compatible protocol for safe and accelerated expansion of hMSC to be used in cell and tissue therapy...
  8. ncbi request reprint A highly efficient method for long-chain cDNA synthesis using trehalose and betaine
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, Grandweg 64, Hamburg, 22529, Germany
    Anal Biochem 301:168-74. 2002
    ..The application of betaine in combination with trehalose should prove useful in all laboratory methods relying on full-length cDNA. (USA)...
  9. doi request reprint Highly purified spermatozoal RNA obtained by a novel method indicates an unusual 28S/18S rRNA ratio and suggests impaired ribosome assembly
    Heike Cappallo-Obermann
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Mol Hum Reprod 17:669-78. 2011
    ....