Markus Sperandio

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation
    Markus Sperandio
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:3207-15. 2006
  2. ncbi Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation
    Markus Sperandio
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Pediatrics 116:1361-6. 2005
  3. ncbi Selectins and glycosyltransferases in leukocyte rolling in vivo
    Markus Sperandio
    University Children s Hospital Heidelberg, Division of Neonatal Medicine, University of Heidelberg, Germany
    FEBS J 273:4377-89. 2006
  4. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
  5. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
  6. doi RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
  7. ncbi Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II
    Christina C Hellbusch
    Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Biol Chem 282:10762-72. 2007
  8. pmc Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation
    David Frommhold
    Department of Neonatology, University Children s Hospital, Heidelberg, Germany
    Am J Pathol 179:2637-50. 2011
  9. ncbi Analysis of leukocyte rolling in vivo and in vitro
    Markus Sperandio
    Children s Hospital, Division of Neonatology, University of Heidelberg, Germany
    Methods Enzymol 416:346-71. 2006
  10. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007

Collaborators

Detail Information

Publications18

  1. ncbi Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation
    Markus Sperandio
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:3207-15. 2006
    ....
  2. ncbi Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation
    Markus Sperandio
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Pediatrics 116:1361-6. 2005
    ..Optimizing the pharmacologic treatment could offer an interesting approach to reduce the number of infants who need surgical closure of the duct...
  3. ncbi Selectins and glycosyltransferases in leukocyte rolling in vivo
    Markus Sperandio
    University Children s Hospital Heidelberg, Division of Neonatal Medicine, University of Heidelberg, Germany
    FEBS J 273:4377-89. 2006
    ..In addition, modifications, such as carbohydrate or tyrosine sulfation, were also found to contribute to the synthesis of functional selectin ligands...
  4. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
    ..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...
  5. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
    ....
  6. doi RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
    ....
  7. ncbi Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II
    Christina C Hellbusch
    Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Biol Chem 282:10762-72. 2007
    ..The diversity of these phenotypic aspects demonstrates the broad general impact of fucosylation in the mammalian organism...
  8. pmc Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation
    David Frommhold
    Department of Neonatology, University Children s Hospital, Heidelberg, Germany
    Am J Pathol 179:2637-50. 2011
    ..We conclude that during acute inflammation and sepsis, PC is a fast acting and effective therapeutic approach to block leukocyte recruitment and improve survival...
  9. ncbi Analysis of leukocyte rolling in vivo and in vitro
    Markus Sperandio
    Children s Hospital, Division of Neonatology, University of Heidelberg, Germany
    Methods Enzymol 416:346-71. 2006
    ....
  10. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
    ..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
  11. doi Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib
    Falk Dillmann
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Leuk Lymphoma 50:1676-86. 2009
    ....
  12. pmc P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow
    Lijun Xia
    Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 109:939-50. 2002
    ..The residual PSGL-1-/- leukocytes that tethered rolled with slow velocities equivalent to those of PSGL-1+/+ leukocytes. These results reveal a novel function for PSGL-1 in tethering leukocytes to E-selectin under flow...
  13. ncbi Sialyltransferase specificity in selectin ligand formation
    Lesley G Ellies
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, and Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093, USA
    Blood 100:3618-25. 2002
    ..Our findings indicate a high degree of functional specificity among sialyltransferases and a substantial role for ST3Gal-IV in selectin ligand formation...
  14. pmc P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules
    Markus Sperandio
    University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg, Rm 1013, P O Box 801 394, Charlottesville, VA 22908 1394, USA
    J Exp Med 197:1355-63. 2003
    ..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice...
  15. doi Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc
    Sviatlana Yakubenia
    Max Planck Institute for Molecular Biomedicine, Munster, Germany
    Blood 112:1472-81. 2008
    ..Taken together, Slc35c1(-/-) mice show strongly defective leukocyte trafficking but normal lymphocyte homing to the spleen, which may explain normal lymphocyte functions in LAD II...
  16. ncbi Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Rheinisch Westfalische Technische Hochschule, Aachen University, Germany
    Circ Res 102:209-17. 2008
    ..Disrupting Cxcl12/Cxcr4 thus promotes lesion formation through deranged neutrophil homeostasis, indicating that Cxcl12/Cxcr4 controls the important contribution of neutrophils to atherogenesis in mice...
  17. ncbi Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin
    Michael L Smith
    Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
    J Leukoc Biol 76:985-93. 2004
    ..The unexpected synergism between E- and P-selectins explains why neutrophil recruitment is enhanced when both selectins are expressed...
  18. ncbi The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
    Blood 108:3919-27. 2006
    ..These findings indicate that Syk is critical for beta(2) integrin-mediated neutrophil migration in vitro and plays a fundamental role in neutrophil recruitment during the inflammatory response in vivo...