Genomes and Genes
Affiliation: University of Heidelberg
- Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammationMarkus Sperandio
Children s Hospital, University of Heidelberg, Heidelberg, Germany
Eur J Immunol 36:3207-15. 2006....
- Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestationMarkus Sperandio
Division of Neonatology, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
Pediatrics 116:1361-6. 2005..Optimizing the pharmacologic treatment could offer an interesting approach to reduce the number of infants who need surgical closure of the duct...
- Selectins and glycosyltransferases in leukocyte rolling in vivoMarkus Sperandio
University Children s Hospital Heidelberg, Division of Neonatal Medicine, University of Heidelberg, Germany
FEBS J 273:4377-89. 2006..In addition, modifications, such as carbohydrate or tyrosine sulfation, were also found to contribute to the synthesis of functional selectin ligands...
- Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammationDavid Frommhold
Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
J Exp Med 205:1435-46. 2008..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...
- RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent mannerDavid Frommhold
Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
BMC Immunol 12:56. 2011....
- RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivoDavid Frommhold
Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
Blood 116:841-9. 2010....
- Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency IIChristina C Hellbusch
Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
J Biol Chem 282:10762-72. 2007..The diversity of these phenotypic aspects demonstrates the broad general impact of fucosylation in the mammalian organism...
- Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activationDavid Frommhold
Department of Neonatology, University Children s Hospital, Heidelberg, Germany
Am J Pathol 179:2637-50. 2011..We conclude that during acute inflammation and sepsis, PC is a fast acting and effective therapeutic approach to block leukocyte recruitment and improve survival...
- Analysis of leukocyte rolling in vivo and in vitroMarkus Sperandio
Children s Hospital, Division of Neonatology, University of Heidelberg, Germany
Methods Enzymol 416:346-71. 2006....
- Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivoDavid Frommhold
Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
BMC Immunol 8:31. 2007..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
- Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and NilotinibFalk Dillmann
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
Leuk Lymphoma 50:1676-86. 2009....
- P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flowLijun Xia
Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Clin Invest 109:939-50. 2002..The residual PSGL-1-/- leukocytes that tethered rolled with slow velocities equivalent to those of PSGL-1+/+ leukocytes. These results reveal a novel function for PSGL-1 in tethering leukocytes to E-selectin under flow...
- Sialyltransferase specificity in selectin ligand formationLesley G Ellies
Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, and Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093, USA
Blood 100:3618-25. 2002..Our findings indicate a high degree of functional specificity among sialyltransferases and a substantial role for ST3Gal-IV in selectin ligand formation...
- P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venulesMarkus Sperandio
University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg, Rm 1013, P O Box 801 394, Charlottesville, VA 22908 1394, USA
J Exp Med 197:1355-63. 2003..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice...
- Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIcSviatlana Yakubenia
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Blood 112:1472-81. 2008..Taken together, Slc35c1(-/-) mice show strongly defective leukocyte trafficking but normal lymphocyte homing to the spleen, which may explain normal lymphocyte functions in LAD II...
- Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosisAlma Zernecke
Institute for Molecular Cardiovascular Research, Rheinisch Westfalische Technische Hochschule, Aachen University, Germany
Circ Res 102:209-17. 2008..Disrupting Cxcl12/Cxcr4 thus promotes lesion formation through deranged neutrophil homeostasis, indicating that Cxcl12/Cxcr4 controls the important contribution of neutrophils to atherogenesis in mice...
- Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectinMichael L Smith
Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
J Leukoc Biol 76:985-93. 2004..The unexpected synergism between E- and P-selectins explains why neutrophil recruitment is enhanced when both selectins are expressed...
- The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migrationJurgen Schymeinsky
Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
Blood 108:3919-27. 2006..These findings indicate that Syk is critical for beta(2) integrin-mediated neutrophil migration in vitro and plays a fundamental role in neutrophil recruitment during the inflammatory response in vivo...