Markus Sperandio

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
  2. pmc Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Blood 121:e118-28. 2013
  3. doi request reprint The expanding role of α2-3 sialylation for leukocyte trafficking in vivo
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Ann N Y Acad Sci 1253:201-5. 2012
  4. pmc Glycosylation in immune cell trafficking
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Immunol Rev 230:97-113. 2009
  5. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
  6. doi request reprint RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
  7. ncbi request reprint Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation
    Markus Sperandio
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:3207-15. 2006
  8. pmc Neutrophil and endothelial adhesive function during human fetal ontogeny
    Claudia Nussbaum
    Walter Brendel Centre of Experimental Medicine, Perinatal Center at Department of Gynecology and Obstetrics, University Children s Hospital, Ludwig Maximilians Universitat, Munich, Germany
    J Leukoc Biol 93:175-84. 2013
  9. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
  10. ncbi request reprint Analysis of leukocyte rolling in vivo and in vitro
    Markus Sperandio
    Children s Hospital, Division of Neonatology, University of Heidelberg, Germany
    Methods Enzymol 416:346-71. 2006

Collaborators

Detail Information

Publications21

  1. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
    ..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...
  2. pmc Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Blood 121:e118-28. 2013
    ..Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life...
  3. doi request reprint The expanding role of α2-3 sialylation for leukocyte trafficking in vivo
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Ann N Y Acad Sci 1253:201-5. 2012
    ..These findings make ST3Gal-IV an interesting drug target for modulating leukocyte trafficking in human disorders, including autoimmune diseases and cancer...
  4. pmc Glycosylation in immune cell trafficking
    Markus Sperandio
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Immunol Rev 230:97-113. 2009
    ..Advancing the knowledge on glycan function into appropriate pathology models is likely to suggest interesting new therapeutic strategies in the treatment of immune- and inflammation-mediated diseases...
  5. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
    ....
  6. doi request reprint RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
    ....
  7. ncbi request reprint Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation
    Markus Sperandio
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:3207-15. 2006
    ....
  8. pmc Neutrophil and endothelial adhesive function during human fetal ontogeny
    Claudia Nussbaum
    Walter Brendel Centre of Experimental Medicine, Perinatal Center at Department of Gynecology and Obstetrics, University Children s Hospital, Ludwig Maximilians Universitat, Munich, Germany
    J Leukoc Biol 93:175-84. 2013
    ..Thus, PMN recruitment and EC adhesion-related functions are ontogenetically regulated in the fetus, which might contribute significantly to the high risk of life-threatening infections in premature infants...
  9. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
    ..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
  10. ncbi request reprint Analysis of leukocyte rolling in vivo and in vitro
    Markus Sperandio
    Children s Hospital, Division of Neonatology, University of Heidelberg, Germany
    Methods Enzymol 416:346-71. 2006
    ....
  11. doi request reprint Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response
    Sascha M Jakob
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Blood 121:4184-94. 2013
    ..In summary, our results indicate that HPK1 is critically involved in LFA-1-mediated PMN trafficking during acute inflammation...
  12. ncbi request reprint Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II
    Christina C Hellbusch
    Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Biol Chem 282:10762-72. 2007
    ..The diversity of these phenotypic aspects demonstrates the broad general impact of fucosylation in the mammalian organism...
  13. ncbi request reprint Selectins and glycosyltransferases in leukocyte rolling in vivo
    Markus Sperandio
    University Children s Hospital Heidelberg, Division of Neonatal Medicine, University of Heidelberg, Germany
    FEBS J 273:4377-89. 2006
    ..In addition, modifications, such as carbohydrate or tyrosine sulfation, were also found to contribute to the synthesis of functional selectin ligands...
  14. doi request reprint The molecular basis of leukocyte recruitment and its deficiencies
    Sarah Schmidt
    Walter Brendel Center for Experimental Medicine, Ludwig Maximilians Universitat, Munich, Germany
    Mol Immunol 55:49-58. 2013
    ..Finally, LAD-III, also known as LAD-I variant, is caused by impaired integrin activation due to mutations within the kindlin-3 gene. This review provides an overview on the molecular basis of leukocyte adhesion and its deficiencies...
  15. doi request reprint Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease
    Claudia Nussbaum
    Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Antioxid Redox Signal 18:692-713. 2013
    ..Despite advances in unraveling the complex action of MPO and MPO-derived oxidants, further research is warranted to determine the precise nature and biological role of MPO in inflammation...
  16. doi request reprint Innate immune cell recruitment in the fetus and neonate
    Claudia Nussbaum
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians Universitat, Marchioninistr 27, 81377 Munich, Germany
    J Reprod Immunol 90:74-81. 2011
    ..In this review, an overview will be given of the developmental aspects of innate immune cell recruitment including a discussion of controversial findings and open questions...
  17. doi request reprint The mammalian actin-binding protein 1 (mAbp1): a novel molecular player in leukocyte biology
    Jurgen Schymeinsky
    Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Trends Cell Biol 21:247-55. 2011
    ..Here, we review the current understanding of the molecular and cellular functions of mAbp1 with a focus on its impact in leukocyte biology...
  18. ncbi request reprint SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization
    Georg Stachel
    Medizinische Klinik und Poliklinik I, Klinikum Groshadern, Ludwig Maximilians University and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
    Stem Cells 31:1795-805. 2013
    ..Recombinant versions of S1FG applied via catheters in combination with progenitor cell mobilization may be useful in the treatment of chronic ischemic syndromes requiring improved perfusion...
  19. ncbi request reprint Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication
    Yvonne Döring
    From Institute for Cardiovascular Prevention Y D, M M, B K, C N, D L, M D, R T A M, M L, H H, O S, C W, and Walter Brendel Centre of Experimental Medicine M S, Ludwig Maximilians University, Munich, Germany Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany H N, P V T, W T Center for Nanomedicine, Sanford Burnham Medical Research Institute, University of California, Santa Barbara, CA J D M DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany M S, O S, C W Academic Medical Center, Amsterdam, the Netherlands O S and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands R T A M, C W
    Circ Res 114:976-81. 2014
    ..Recent evidence suggests that sialylation also affects the binding of chemokines to their corresponding receptor...
  20. doi request reprint High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis
    Christopher Höhne
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 136:1746-59. 2013
    ..Because persistent inflammation contributes to meningitis-associated brain damage, high mobility group box 1 may represent a promising target for adjunctive therapy of this disease...
  21. doi request reprint Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib
    Falk Dillmann
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Leuk Lymphoma 50:1676-86. 2009
    ....