Ulrich Spengler

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo
    Ludger Leifeld
    Departments of Internal Medicine I, University of Bonn, Bonn, Germany
    Am J Pathol 168:778-85. 2006
  2. ncbi Antiretroviral drug toxicity -- a challenge for the hepatologist?
    Ulrich Spengler
    Department of General Internal Medicine I, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Hepatol 36:283-94. 2002
  3. ncbi Management of end-stage liver disease in HIV/hepatitis C virus co-infection
    Ulrich Spengler
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Curr Opin HIV AIDS 6:527-33. 2011
  4. ncbi HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Antivir Ther 10:95-107. 2005
  5. ncbi The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Hepatol 56:758-64. 2012
  6. ncbi Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Germany
    Immunol Invest 38:1-13. 2009
  7. ncbi Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
  8. ncbi Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Immunol Invest 38:284-96. 2009
  9. ncbi The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    J Hepatol 47:348-55. 2007
  10. ncbi Comparison of GB virus C, HIV, and HCV infection markers in hemophiliacs exposed to non-inactivated or inactivated factor concentrates
    Bernd Kupfer
    Institute of Medical Microbiology and Immunology, University of Bonn, Sigmund Freud Str. 25, D-53105 Bonn, Germany
    J Clin Virol 34:42-7. 2005

Detail Information

Publications101 found, 100 shown here

  1. ncbi Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo
    Ludger Leifeld
    Departments of Internal Medicine I, University of Bonn, Bonn, Germany
    Am J Pathol 168:778-85. 2006
    ..Moreover, selective expression of gelsolin in sinusoidal endothelial cells indicates a pivotal role for interactions between sinusoidal endothelial cells and liver parenchymal cells in Fas ligand-mediated liver failure...
  2. ncbi Antiretroviral drug toxicity -- a challenge for the hepatologist?
    Ulrich Spengler
    Department of General Internal Medicine I, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Hepatol 36:283-94. 2002
  3. ncbi Management of end-stage liver disease in HIV/hepatitis C virus co-infection
    Ulrich Spengler
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Curr Opin HIV AIDS 6:527-33. 2011
    ..Antiretroviral drugs do not directly interact with the hepatitis C virus (HCV), so that end-stage liver disease (ESLD) in HCV/HIV co-infected patients has become a leading clinical problem in many co-infected patients...
  4. ncbi HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Antivir Ther 10:95-107. 2005
    ..These results propose HIV-mediated up-regulation of HLA-E expression as an additional evasion strategy targeting the antiviral activities of NK cells, which may contribute to the capability of the virus in establishing chronic infection...
  5. ncbi The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Hepatol 56:758-64. 2012
    ..Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Here, we investigated whether the CXCL1 rs4074 polymorphism affects CXCL1 expression and progression of chronic hepatitis C virus (HCV) infection towards cirrhosis...
  6. ncbi Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Germany
    Immunol Invest 38:1-13. 2009
    ..Interruption of the CCR5 signalling pathway due to CCR5-n32 may potentially result in subtle reduction of HCV specific IFN-gamma responses in anti-HCV-positive haemophiliac patients...
  7. ncbi Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
    ..Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) serum levels in patients with different outcomes of HCV infection...
  8. ncbi Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Immunol Invest 38:284-96. 2009
    ..Interruption of the CCR5 signalling pathway due to CCR5-Delta32 may potentially result in subtle reduction of HCV specific IFN-gamma responses in anti-HCV-positive haemophiliac patients...
  9. ncbi The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    J Hepatol 47:348-55. 2007
    ..The G protein beta3 unit (GNB3) C825T polymorphism has been shown to affect treatment response in HCV mono-infection. Here, we analyzed the impact of the GNB3 genotype in the context of HCV/HIV co-infection...
  10. ncbi Comparison of GB virus C, HIV, and HCV infection markers in hemophiliacs exposed to non-inactivated or inactivated factor concentrates
    Bernd Kupfer
    Institute of Medical Microbiology and Immunology, University of Bonn, Sigmund Freud Str. 25, D-53105 Bonn, Germany
    J Clin Virol 34:42-7. 2005
    ..Despite repeated parenteral exposure more than 55% of hemophiliacs were not infected with GBV-C/HGV. Our findings indicate a high frequency of host factors preventing parenteral transmission of GBV-C/HGV...
  11. ncbi Regulation of NK cell trafficking by CD81
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Immunol 39:3447-58. 2009
    ..Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment...
  12. ncbi Hepatitis C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A+CD8+ T cells
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Germany
    J Infect Dis 198:213-7. 2008
    ..Thus, CCR5 is likely to exert immunoregulatory effects in hepatitis C virus infection by preferentially recruiting CD8(+) T cells bearing the inhibitory NKG2A receptor to the liver...
  13. ncbi The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells
    Daniela Schulte
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 200:1397-401. 2009
    ..038). Moreover, we found that the HLA-E(R) allelic variant confers protection against chronic infection with HCV genotypes 2 and 3. Taken together, our data indicate an important immunomodulating function of HLA-E in hepatitis C...
  14. ncbi TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients
    Christian Korner
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str, 25, 53127 Bonn, Germany
    BMC Cancer 12:85. 2012
    ....
  15. ncbi Cytotoxic capacity of hepatitis C virus (HCV)--specific lymphocytes after in vitro immunization with HCV-derived lipopeptides
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    Cytometry A 65:59-68. 2005
    ....
  16. ncbi Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rs12979860 polymorphism of the IL28B gene
    P Lutz
    Department of Internal Medicine I, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 16:335-41. 2011
    ..Our aim was to clarify by non-invasive techniques if this polymorphism affects fibrosis progression in HIV/HCV co-infection...
  17. ncbi The transforming growth factor-beta high-producer genotype is associated with response to hepatitis C virus-specific therapy in HIV-positive patients with acute hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    AIDS 22:1287-92. 2008
    ..Here, we studied whether transforming growth factor-beta gene polymorphisms affect treatment response in HCV/HIV coinfection...
  18. ncbi Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Vaccine 24:3066-75. 2006
    ..In contrast, numbers of HLA-A2-pentamer-positive CD8+ T cells and granzyme B-secreting T cells remained unchanged. Thus, up-regulation of TLR2 during immunization with DC enhances functions of CD4+ T cells but not CD8+ T cells...
  19. ncbi The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Am J Pathol 166:443-53. 2005
    ..Our data indicate the existence of T cell epitopes that can be recognized by HLA-A2 and HLA-E. This dual recognition may contribute to viral persistence in hepatitis C...
  20. ncbi Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study
    Golo Ahlenstiel
    Medizinische Klinik u Poliklinik 1, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    World J Gastroenterol 11:7631-8. 2005
    ..RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore, these mutations may also affect the course of HIV/HCV coinfection...
  21. ncbi Frequent detection of cell-associated HIV-1 RNA in patients with plasma viral load <50 copies/ml
    Bernd Kupfer
    Institute of Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany
    J Med Virol 79:1440-5. 2007
    ..Since these replication events could lead to ongoing viral evolution it should be considered to optimize antiretroviral therapy in order to minimize the development of drug resistance...
  22. ncbi Effect of the interleukin-6 C174G gene polymorphism on treatment of acute and chronic hepatitis C in human immunodeficiency virus coinfected patients
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 46:1016-25. 2007
    ..CONCLUSION: Response rates to HCV-specific treatment are higher in HCV/HIV-positive patients carrying the IL-6 HP genotype, which might be because of IL-6 mediated STAT3 activation...
  23. ncbi Clinical outcomes of HIV-HCV co-infection in a large cohort of hemophiliac patients
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, 53105 Bonn, Germany
    J Infect 50:221-8. 2005
    ..To determine the disease progression of HIV-HCV co-infected hemophiliacs in a large cohort of patients (n = 288) cared for at a single medical institution...
  24. ncbi Hepatitis C-associated autoimmunity in patients coinfected with HIV
    Rainer P Woitas
    Department of Internal Medicine I, University of Bonn, 53105 Bonn, Germany
    Liver Int 25:1114-21. 2005
    ..Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection...
  25. ncbi Effects of HCV co-infection on apoptosis of CD4+ T-cells in HIV-positive patients
    Christian Korner
    Department of Internal Medicine I, University of Bonn, Germany, Sigmund Freud Str 25, Bonn 53127, Germany
    Clin Sci (Lond) 116:861-70. 2009
    ..The results of the present study suggest that HCV co-infection sensitizes CD4+ T-cells towards apoptosis in untreated HIV-positive patients. However, this effect is rapidly lost under effective antiretroviral therapy...
  26. ncbi Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2
    Martin Coenen
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:1375-82. 2011
    ..Manipulating the TLR2 pathway may thus provide a new approach for antifibrotic therapies in HCV infection...
  27. ncbi p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ
    Birgit Terjung
    Department of Internal Medicine, University of Bonn, Sigmund Freud Strasse 25, Bonn D 53105, Germany
    Gut 59:808-16. 2010
    ....
  28. ncbi The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation
    Jacob Nattermann
    Department of Internal Medicine, University of Bonn, Bonn, Germany
    J Hepatol 55:1201-6. 2011
    ..Here, we investigated the relative genetic contributions of the CCR5Δ32 deletion and the IL28B rs12979860 polymorphisms to spontaneous clearance of hepatitis C in a single-source outbreak...
  29. ncbi The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Int J Cancer 130:1470-5. 2012
    ..05). Our data suggest the TLR2 -196 to -174 del allele to affect HCV viral loads and to increase the risk for HCC in HCV genotype1-infected patients...
  30. ncbi Orthotopic liver transplantation in human immunodeficiency virus (HIV)-positive patients: outcome of 7 patients from the Bonn cohort
    Martin Vogel
    Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
    Liver Transpl 11:1515-21. 2005
    ..In conclusion, even though preliminary, our data suggest that outcomes after liver transplantation of HIV-infected patients can be improved...
  31. ncbi Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C
    Golo Ahlenstiel
    Medizinische Klinik u. Poliklinik I, Allgemeine Innere Medizin, , Sigmund-Freud-Strasse 25, D-53105, Bonn, Germany
    J Hepatol 39:245-52. 2003
    ..However, interferon/ribavirin combination treatment may overcome this negative effect of CCR5-Delta32...
  32. ncbi Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 203:595-601. 2011
    ..Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C...
  33. ncbi Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma
    Georg Feldmann
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Clin Cancer Res 12:4491-8. 2006
    ..To clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis of HCV-associated MC or B-NHL...
  34. ncbi The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    AIDS 24:2001-7. 2010
    ..Here, we analyzed the potential impact of the CTLA4 polymorphisms on response to hepatitis C virus (HCV)-specific treatment in HIV(+) patients co-infected with HCV...
  35. ncbi Semiquantitative analysis of intrahepatic CC-chemokine mRNas in chronic hepatitis C
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Mediators Inflamm 13:357-9. 2004
    ..021) were significantly lower in HCV liver samples while MCP-2 expression was similar in all groups analyzed. CONCLUSION: The data support the concept of chemokines as mediators of liver cell injury in chronic hepatitis C...
  36. ncbi NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner
    Andreas Glässner
    Department of Internal Medicine I, University of Bonn, Germany
    Lab Invest 92:967-77. 2012
    ..Here we demonstrate that NK cells from HCV-infected patients are highly efficient in inducing apoptosis of activated HSCs. Thus, NK cells may have an important anti-fibrotic role in chronic hepatitis C...
  37. ncbi The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 6:e27087. 2011
    ..I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC)...
  38. ncbi Early up-regulation of chemokine expression in fulminant hepatic failure
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Germany
    J Pathol 199:335-44. 2003
    ..The data indicate that an abundant intrahepatic release of CC-chemokines is an early and pivotal step in the pathogenesis of FHF...
  39. ncbi Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI- versus NNRTI-containing HAART
    Jan Christian Wasmuth
    Department of Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Antiviral Res 61:207-12. 2004
    ..A moderate decrease of RANTES was observed in both treatment groups. The data suggest that HAART regimens containing either NNRTI or PI are not equivalent with regard to modification of CC chemokine mRNA profiles...
  40. ncbi Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, 53105 Bonn, Germany
    Clin Vaccine Immunol 14:1266-73. 2007
    ..As several of the HLA-associated mutations lie at positions associated with drug resistance, our results indicate possible negative effects of HLA genotypes on the development of HIV-1 drug resistance...
  41. ncbi Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42094. 2012
    ..Our in vitro data suggest that--in addition to its immunostimulatory effects on TH1 cells--ribavirin can inhibit functions of HCV-specific Tregs and thus reverses Treg-mediated suppression of T effector cells in chronic hepatitis C...
  42. ncbi Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures
    Hans Dieter Nischalke
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42141. 2012
    ..Here we analyze whether determination of target gene mRNA levels in intraductal brush cytology specimens may be used to improve the diagnosis of bile duct carcinoma...
  43. ncbi Host genetic factors and treatment of hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Curr Mol Pharmacol 1:171-80. 2008
    ....
  44. ncbi Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection
    Nazifa Qurishi
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lancet 362:1708-13. 2003
    ..This survival benefit seems to outweigh by far the associated risks of severe hepatotoxicity...
  45. ncbi Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)
    Jacob Nattermann
    Department of General Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Hepatol 42:499-504. 2005
    ..Antibodies mediating ADCC are usually directed against viral envelope proteins. As cell surface expression of the HCV envelope E2 protein has been shown, the HCV E2 protein is an especially promising candidate target for ADCC...
  46. ncbi Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Clin Sci (Lond) 119:97-109. 2010
    ..Thus HCV core-specific Treg-cells may contribute to the immunoregulatory balance in chronic hepatitis C...
  47. ncbi Elevated soluble tumor necrosis factor receptor 75 concentrations identify patients with liver cirrhosis at risk of death
    Frank Grunhage
    Department of Internal Medicine I, University Hospital Bonn, University of Bonn, Bonn, Germany
    Clin Gastroenterol Hepatol 6:1255-62. 2008
    ..Thus, we compared sTNF-R 75 with the Model for End-Stage Liver Disease (MELD), CTP, and the sTNF-R 75/55 ratio...
  48. ncbi Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients with fatal liver disease
    Mathias Lichterfeld
    Department of General Internal Medicine, Universitatsklinikum Bonn, Germany
    J Gastroenterol Hepatol 20:739-45. 2005
    ..Here, histopathological features of fatal liver disease in HIV-HCV co-infected patients were comparatively assessed...
  49. ncbi Regulation of CC chemokine receptor 5 in hepatitis G virus infection
    Jacob Nattermann
    Department of General Internal Medicine, , Bonn, Germany
    AIDS 17:1457-62. 2003
    ..This mechanism might contribute to the delayed progression of HIV-infection in HGV-coinfected patients...
  50. ncbi CC-chemokine receptor 5 (CCR5) in hepatitis C--at the crossroads of the antiviral immune response?
    Golo Ahlenstiel
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Antimicrob Chemother 53:895-8. 2004
    ..This article will summarize and discuss the available data with respect to possibly altered disease susceptibility, clinical course and treatment outcomes associated with the CCR5-Delta32 mutation in hepatitis C...
  51. ncbi Hepatitis C coinfection enhances sensitization of CD4(+) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients
    Christian Korner
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Antivir Ther 16:1047-55. 2011
    ..Since this effect might be attributed to changes in receptor-induced apoptosis, we studied expression and function of Fas ligand (FasL) and its death receptor Fas on CD4(+) T-cells in HIV/HCV coinfection...
  52. ncbi The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Immunol 107:55-9. 2003
    ..Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS...
  53. ncbi Management of drug-to-drug interactions between cyclosporine A and the protease-inhibitor lopinavir/ritonavir in liver-transplanted HIV-infected patients
    Martin Vogel
    Department of Internal Medicine I, University of Bonn, Germany
    Liver Transpl 10:939-44. 2004
    ..Because of the flat absorption/elimination profiles under ritonavir-boosted HAART cyclosporine A, dosing could be reliably monitored long term by measuring cyclosporine A trough-levels...
  54. ncbi Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Germany
    J Immunol Methods 306:161-8. 2005
    ..Thus, the particular choice of a cytotoxicity assay must be carefully adapted to the experimental situation under study...
  55. ncbi Intrahepatic activation of caspases in human fulminant hepatic failure
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Germany
    Liver Int 26:872-9. 2006
    ..Apoptosis has been implicated in the pathogenesis of fulminant hepatic failure (FHF) potentially involving caspases. Thus far, apoptosis in FHF has mainly been studied in animal models while human data are sparse...
  56. ncbi Transient elastography discloses identical distribution of liver fibrosis in chronic hepatitis C between HIV-negative and HIV-positive patients on HAART
    F Grunhage
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    Eur J Med Res 15:139-44. 2010
    ..Highly active antiretroviral therapy (HAART) efficiently restores and preserves immune functions and has recently been demonstrated to also result in reduced liver-related mortality in HIV/HCV-co-infected patients...
  57. ncbi Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 56:1201-13. 2012
    ..Conclusions: NKp46(High) expression defines a specific NK-cell subset that may be involved in both the suppression of HCV replication and HCV-associated liver damage underpinning the role of NK cells in the immunopathogenesis of HCV...
  58. ncbi The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C
    Marianne Eisenhardt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e38846. 2012
    ..Here, we analyzed phenotype and function of CXCR3 expressing NK cells in chronic hepatitis C...
  59. ncbi Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
    Vaccine 22:1441-7. 2004
    ..Thus, HCV lipopeptides are more immunogenic than unmodified peptides and can induce HCV-reactive B lymphocytes in antigen-naïve lymphocytes...
  60. ncbi Successful transplantation of a liver from a donor with fatal ethylene glycol poisoning
    Martin Wolff
    Department of Surgery, University of Bonn, Germany
    Liver Transpl 11:990-2. 2005
  61. ncbi Fifteen years of env C2V3C3 evolution in six individuals infected clonally with human immunodeficiency virus type 1
    Bernd Kupfer
    Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany
    J Med Virol 79:1629-39. 2007
    ..These common changes within the V3 loop are likely to be enforced by HIV-1 specific immune response...
  62. ncbi Hepatitis C virus-derived lipopeptides differentially induce epitope-specific immune responses in vitro
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 189:248-53. 2004
    ..IFN-gamma sfcs could only be induced with lipopeptide aa 20-44 but not by conventional antigens, which indicates that lipopeptides may alter T cell functions, depending on the epitope...
  63. ncbi Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure
    Volker Schmitz
    Medizinische Klinik und Poliklinik I, Universitat Bonn, Bonn, Germany
    Hepatology 44:430-9. 2006
    ..This model suggests involvement of the CD40-CD40L system in FHF and might have important implications for future pathophysiological studies of this condition...
  64. ncbi Differential expansion of T-cell receptor variable beta subsets after antigenic stimulation in patients with different outcomes of hepatitis C infection
    Rainer P Woitas
    Department of Internal Medicine, University of Bonn, Germany
    Immunology 106:419-27. 2002
    ..58-0.98, P<0.01). Thus, differential involvement of selected TCR BV subsets may be related to the outcome of HCV infection...
  65. ncbi Immunopathogenesis in hepatitis C virus cirrhosis
    Ulrich Spengler
    Department of Internal Medicine 1, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Clin Sci (Lond) 112:141-55. 2007
    ..A clear understanding of these processes will eventually help to develop novel treatment strategies for HCV liver disease, independent from direct inhibition of HCV replication...
  66. ncbi Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Infect Dis 185:1803-7. 2002
    ..Thus, chronic hepatitis C, but not hepatitis B, infection alters surface expression of distinct CCRs, resulting in lower CC chemokine responsiveness...
  67. ncbi Acenocoumarol is not a safe alternative for anticoagulation in phenprocoumon-induced hepatic failure. Report of two cases
    Markus Neef
    Department of General Internal Medicine, University of Bonn, Bonn, Germany
    Digestion 67:100-4. 2003
    ..Thus, acenocoumarol may not be a safe therapeutic alternative for patients who survived severe phenprocoumon-induced hepatotoxicity...
  68. ncbi Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) expression in fulminant hepatic failure
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Hepatol 37:613-9. 2002
    ..Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) have important functions in inflammation and vasoregulation but their role in fulminant hepatic failure (FHF) is not well understood...
  69. ncbi Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany
    Markus Neibecker
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    J Med Virol 83:685-94. 2011
    ..These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV-C...
  70. ncbi Estimation of glomerular filtration rates after orthotopic liver transplantation: Evaluation of cystatin C-based equations
    Thomas Gerhardt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Transpl 12:1667-72. 2006
    ..2%) formula, albeit not significantly different from MDRD (64.4% and 83.1%). Taken together, these data show the best overall performance for GFR estimates derived from the Hoek equation with respect to bias, precision, and accuracy...
  71. ncbi Bleeding complications after percutaneous liver biopsy. An analysis of risk factors
    Birgit Terjung
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Digestion 67:138-45. 2003
    ..Considering these predictors before liver biopsy will aid to reduce the rate of bleeding complications...
  72. ncbi Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
    M Vogel
    Department of Internal Medicine I, Bonn University, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 16:101-7. 2011
    ..To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy...
  73. ncbi Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction
    Thomas Kuntzen
    Department of Internal Medicine I, Rheinische Friedrich-Wilhelms-Universitaet Bonn, Bonn, Germany
    Eur J Gastroenterol Hepatol 17:1131-4. 2005
    ..High-dose immunosuppression led to dramatic improvements over the past year...
  74. ncbi Atypical p-ANCA in PSC and AIH: a hint toward a "leaky gut"?
    Birgit Terjung
    Department of Internal Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Clin Rev Allergy Immunol 36:40-51. 2009
    ....
  75. ncbi HIV and hepatitis C virus co-infection
    Jürgen Kurt Rockstroh
    HIV Outpatient Clinic, and Department of Medicine I, University of Bonn, Bonn, Germany
    Lancet Infect Dis 4:437-44. 2004
    ..Owing to the high rates of HIV and HCV co-infection worldwide, new improved treatment strategies and guidelines for the management of co-infection remain a major future goal...
  76. ncbi Hepatic microcirculation: a critical but neglected factor for the outcome of viral hepatitis
    Ulrich Spengler
    University of Bonn, Department of Internal Medicine I, Sigmund Freud Strasse 25, Bonn, Germany
    J Hepatol 50:631-3. 2009
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  77. ncbi Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B
    Ludger Leifeld
    Department of Internal Medicine I, University of Bonn, Germany
    Hepatology 36:1001-8. 2002
    ..This cytokine imbalance may play an important role in promoting inflammatory reactions leading to massive liver damage in fulminant hepatitis B...
  78. ncbi Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction
    Hans Dieter Nischalke
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, D 53105 Bonn, Germany
    AIDS Res Hum Retroviruses 20:750-4. 2004
    ..We have established a new real-time PCR protocol, which enables fast, cost-saving, and reliable CCR5 genotyping...
  79. ncbi GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4(+) T-cells
    Carolynne Schwarze-Zander
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Antivir Ther 15:745-52. 2010
    ....
  80. ncbi [Non adherence - non response in transplantation medicine]
    Ulrich Spengler
    Medizinische Klinik I, Universitatsklinikum Bonn
    Ther Umsch 67:317-22. 2010
    ..This review summarizes types and risk factors of non adherent behavior in transplanted patients and outlines possible strategies to improve patient adherence...
  81. ncbi Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C
    Rainer P Woitas
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Gastroenterology 122:1721-8. 2002
    ..However, the role of this mutation in other infections, such as hepatitis C virus (HCV) infection, has not been defined...
  82. ncbi Bolus ingestion but not regular consumption of native or dealcoholized red wine modulates selected immunological functions of leukocytes in healthy volunteers
    Sabine Ellinger
    FraunhoferInstitute for Molecular Biology and Applied Ecology and Institute of Biology VII Molecular Biotechnology, RWTH Aachen, Aachen, Germany
    Ann Nutr Metab 52:288-95. 2008
    ..Since immunological mechanisms involved in CHD were modulated by RW polyphenols in vitro, we investigated whether consumption of native or dealcoholized RW (DRW) affects selected immunological parameters in healthy adults ex vivo...
  83. ncbi HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C
    Rainer P Woitas
    Department of Internal Medicine I, University of Bonn, D 53105 Bonn, Germany
    World J Gastroenterol 8:562-6. 2002
    ..Therefore, we studied hepatitis C virus (HCV)-specific induction of interleukins-1 beta, -10, -12 (IL-1 beta, IL-10, IL-12), and tumor necrosis factor-alpha (TNF-alpha) in monocytes...
  84. ncbi Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Hepatology 44:945-54. 2006
    ..In conclusion, migration of DC is markedly affected by interaction of HCV E2 with CD81. Failure of DC to recirculate to lymphoid tissue may be critically involved in impaired T cell priming during HCV infection...
  85. ncbi Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines
    Franz Ludwig Dumoulin
    Department of Medicine I, University of Bonn, Sigmund Freud Strasse 25, Germany
    Virology 305:260-6. 2003
    ..The inhibitory effect of HCV NS2 on liver and non-liver-specific promoters and enhancer elements might be relevant for the pathogenesis of chronic HCV infection...
  86. ncbi Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)--core protein is mediated by toll like receptors (TLRs) 2 and 4
    Uta Düesberg
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Immunol Lett 84:89-95. 2002
    ..Thus, lipopeptides but not their corresponding free peptides can activate cells via TLRs 2 and 4. This activation is apparently affected by the amino acid sequence of the peptide moiety...
  87. ncbi Role of auto-antibodies for the diagnosis of chronic cholestatic liver diseases
    Birgit Terjung
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Clin Rev Allergy Immunol 28:115-33. 2005
    ..Additionally, auto-antibodies in these disorders usually do not contribute to the immunopathogenesis of the disease...
  88. ncbi Bacteremia caused by a novel helicobacter species in a 28-year-old man with X-linked agammaglobulinemia
    Carolynne Schwarze-Zander
    Department of Internal Medicine I, University Hospital Bonn, Institut of Medical Microbiology and Immunology, Bonn University, Bonn, Germany
    J Clin Microbiol 48:4672-6. 2010
    ..This is the first report of bacteremia caused by this fastidious organism. Further investigations are necessary to determine the potential role of this species as a pathogen of bloodstream infections...
  89. ncbi ROC analysis comparison of three assays for the detection of antibodies against double-stranded DNA in serum for the diagnosis of systemic lupus erythematosus
    Jan-Christian Wasmuth
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Clin Chem 50:2169-71. 2004
  90. ncbi Phospholipid autoantibodies and the antiphospholipid antibody syndrome: diagnostic accuracy of 23 methods studied by variation in ROC curves with number of clinical manifestations
    Jan-Christian Wasmuth
    Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
    Clin Chem 48:1004-10. 2002
    ....
  91. ncbi Antiviral therapy for hepatitis C virus recurrence after liver transplantation in HIV-infected patients: outcome in the Bonn cohort
    Kamila Wojcik
    Department of Infectious Diseases and Hepatology, Medical University of Lodz, 91 347 Lodz, Poland
    AIDS 21:1363-5. 2007
    ..At experienced centres interferon treatment is a valuable option for recurrent hepatitis C in HIV-positive patients...
  92. ncbi Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection
    Michael von Wagner
    Johann Wolfgang Goethe Universitat, Frankfurt, Main, Germany
    Hepatology 48:1404-11. 2008
    ..CONCLUSION: In this large placebo-controlled multicenter study, amantadine even at a dose of 400 mg/day did not improve virological response rates of peginterferon alfa-2a and ribavirin in patients with chronic genotype HCV-1 infection...
  93. ncbi Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 38:218-29. 2003
    ..Hepatology 2003;38:218-229)...
  94. ncbi Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    AIDS 22:203-10. 2008
    ..This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines...
  95. ncbi Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Eur J Immunol 34:1164-74. 2004
    ..These observations suggest an important role for the CXCL12/CXCR4 pathway in recruitment and retention of immune cells in the liver during chronic HCV and HBV infection...
  96. ncbi Risk of hepatitis C after immunoadsorption
    Rolf Kaiser
    Institute of Medical Microbiology and Immunology, University of Bonn, Germany
    Infect Control Hosp Epidemiol 23:342-3. 2002
    ..This incident illustrates that policies for the prevention of nosocomial transmission of blood-borne pathogens, especially in cohort treatment units, may need to be reassessed...
  97. ncbi Extended treatment duration for hepatitis C virus type 1: comparing 48 versus 72 weeks of peginterferon-alfa-2a plus ribavirin
    Thomas Berg
    Universitatsklinikum Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
    Gastroenterology 130:1086-97. 2006
    ..The extension of treatment duration beyond 48 weeks is one possible strategy to address this problem...
  98. ncbi Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a placebo-controlled trial
    Thomas Berg
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Hepatology 37:1359-67. 2003
    ....
  99. ncbi Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy
    Florian van Bömmel
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Hepatology 44:318-25. 2006
    ..No side effects were reported. In conclusion, these preliminary observations strongly suggest that TDF might be a highly effective rescue drug for HBV-infected patients with altered responsiveness to treatment with lamivudine and ADV...
  100. ncbi Efficacy of amantadine on quality of life in patients with chronic hepatitis C treated with interferon-alpha and ribavirin: results from a randomized, placebo-controlled, double-blind trial
    Bernd Kronenberger
    Department of Medicine I, Johann Wolfgang Goethe University Medical Center, Frankfurt M, Germany
    Eur J Gastroenterol Hepatol 19:639-46. 2007
    ..The aim of this study was to investigate whether amantadine reduces deterioration of quality of life in patients with chronic hepatitis C during and after treatment with interferon-alpha (IFN-alpha) and ribavirin...
  101. ncbi Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection
    Tobias Mueller
    Charite, Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt, Hepatologie und Gastroenterologie, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatol 41:652-8. 2004
    ..We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/deletion) and the 3'-UTR (1188-A/C), which have been reported to influence IL-12 synthesis, are associated with the outcome of HCV infection...