Michael Soyka

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
  2. doi request reprint Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
  3. doi request reprint Emerging drugs to treat alcoholism
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7 80336 Munich, Germany
    Expert Opin Emerg Drugs 15:695-711. 2010
  4. ncbi request reprint Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence
    M Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Pharmacopsychiatry 39:30-4. 2006
  5. doi request reprint OCDS craving scores predict 24-month outcome in alcoholic outpatients
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Am J Addict 19:264-9. 2010
  6. ncbi request reprint Fatal poisoning in methadone and buprenorphine treated patients -- are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Pharmacopsychiatry 39:85-7. 2006
  7. ncbi request reprint Thalamic hypofunction in alcohol hallucinosis: FDG PET findings
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 139:259-62. 2005
  8. ncbi request reprint Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study
    M Soyka
    Psychiatric Hospital of the University of Munich, Nussbaumstr 7, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 255:308-12. 2005
  9. ncbi request reprint [Alcohol hallucinosis and jealous delusion]
    M Soyka
    Psychiatrische Klinik der Universität München
    Fortschr Neurol Psychiatr 74:346-52; quiz 353-4. 2006
  10. ncbi request reprint GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 42:184-91. 2008

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
    ..Future studies on the role of different subtypes of alcoholics according to their genetic or psychological profile to explain or even predict the effects of opioid antagonists in the treatment of alcohol dependence are needed...
  2. doi request reprint Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
    ..Maintenance therapy is effective in the reduction in both narcotics-related and acquisition crime...
  3. doi request reprint Emerging drugs to treat alcoholism
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7 80336 Munich, Germany
    Expert Opin Emerg Drugs 15:695-711. 2010
    ..Alcoholism is a widespread disorder with substantial mortality and negative treatment outcomes. To date, few medications have been found to reduce relapse rates or drinking in alcohol-dependent patients...
  4. ncbi request reprint Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence
    M Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Pharmacopsychiatry 39:30-4. 2006
    ..Few medications have been tested for outpatient alcohol detoxification. Previously we had shown a combination of carbamazepine and tiapride to be effective in an open study. This database is an extension of our previous work...
  5. doi request reprint OCDS craving scores predict 24-month outcome in alcoholic outpatients
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Am J Addict 19:264-9. 2010
    ..OCDS scores were higher in patients with a less favorable outcome. In line with previous findings, our results showed that the intensity of craving as measured by the OCDS may predict outcome in outpatient alcoholics...
  6. ncbi request reprint Fatal poisoning in methadone and buprenorphine treated patients -- are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Pharmacopsychiatry 39:85-7. 2006
    ..Some recent studies have suggested a lower risk of fatal intoxications in drug-dependent patients under buprenorphine compared to methadone treatment...
  7. ncbi request reprint Thalamic hypofunction in alcohol hallucinosis: FDG PET findings
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 139:259-62. 2005
    ..When the second patient was retested after clinical recovery, FDG PET findings were normalized, suggesting the probable thalamic dysfunction to be a functional rather than a structural abnormality...
  8. ncbi request reprint Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study
    M Soyka
    Psychiatric Hospital of the University of Munich, Nussbaumstr 7, 80336, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 255:308-12. 2005
    ....
  9. ncbi request reprint [Alcohol hallucinosis and jealous delusion]
    M Soyka
    Psychiatrische Klinik der Universität München
    Fortschr Neurol Psychiatr 74:346-52; quiz 353-4. 2006
  10. ncbi request reprint GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 42:184-91. 2008
    ..These findings support and extend the three previous studies implicating a GABA-A receptor subunit as contributing to the genetic risk for alcohol dependence. Possible implications of these findings are discussed...
  11. ncbi request reprint [Insufficient involvement of psychiatrists in substitution treatment]
    M Soyka
    Psychiatrische Universität München, Nussbaumstrasse 7, 80336 Munchen
    Nervenarzt 77:1368-72. 2006
    ..Most psychiatrists engaged in substitution treatment work in specialized outpatient wards (51.3%), and few were operative in their own or private practice (7.2%). Implications of these critical findings are discussed...
  12. doi request reprint Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:699-703. 2008
    ..Selective attention improved in both patient groups during treatment. We propose that the improvement of attention may facilitate rehabilitation of drug-dependent patients...
  13. doi request reprint The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 12:160-87. 2011
    ..To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence...
  14. doi request reprint Cognitive function in short- and long-term substitution treatment: are there differences?
    Michael Soyka
    Private Hospital Meiringen, Willigen, Meiringen, Switzerland
    World J Biol Psychiatry 11:400-8. 2010
    ..More longitudinal research and studies controlling for the effects of dosage and duration of opioid addiction are necessary to examine whether cognitive ability may improve under long-term MMT...
  15. ncbi request reprint Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses
    Susanne Karch
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 42:734-45. 2008
    ..This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients...
  16. doi request reprint No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms
    Gabriele Koller
    Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany
    Addict Biol 14:506-8. 2009
    ..048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis...
  17. ncbi request reprint Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Clin Psychopharmacol 25:490-3. 2005
    ..We assessed whether patients under buprenorphine, a partial mu-opioid agonist, perform better in cognitive tests measuring psychomotor performance as described in previous nonrandomized studies...
  18. ncbi request reprint Outpatient alcohol detoxification: implementation efficacy and outcome effectiveness of a model project
    Michael Soyka
    Psychiatric Hospital, University Munich, Munich, Germany
    Eur Addict Res 10:180-7. 2004
    ..The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach...
  19. doi request reprint Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 11:641-53. 2008
    ..The intensity of withdrawal symptoms showed the strongest correlation with drop-out. Future studies are warranted to further address patient profiles and outcome under different substitution regimens...
  20. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  21. doi request reprint A comparison of cognitive function in patients under maintenance treatment with heroin, methadone, or buprenorphine and healthy controls: an open pilot study
    Michael Soyka
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Am J Drug Alcohol Abuse 37:497-508. 2011
    ..INTROduction: Cognitive impairment has been reported in drug-dependent patients under opioid maintenance treatment...
  22. doi request reprint Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  23. ncbi request reprint Clinical correlates of later violence and criminal offences in schizophrenia
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 94:89-98. 2007
    ..Violence and criminality in patients with schizophrenia has been described in several studies but prediction of later criminal behavior is difficult...
  24. ncbi request reprint One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
    ..Taking into account the high comorbidity of opioid dependent patients and the severity of dependence, the mortality rate of approximately 1% confirms that maintenance treatment could be regarded as a fairly safe treatment...
  25. ncbi request reprint Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine: results of a pooled analysis in 540 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, , Germany
    Eur Arch Psychiatry Clin Neurosci 256:395-401. 2006
    ..In line with previous research, the results from this study give further evidence that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for alcohol withdrawal treatment...
  26. ncbi request reprint A combination of carbamazepine/tiapride in outpatient alcohol detoxification. Results from an open clinical study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:197-200. 2002
    ..Results from this study suggest that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for outpatient alcohol detoxification in patients with moderate severity of withdrawal syndrome...
  27. doi request reprint Criminal behaviour and violent crimes in former inpatients with affective disorder
    Christian Graz
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Affect Disord 117:98-103. 2009
    ..Several studies have reported criminal and violent behaviour in people with schizophrenia but few have investigated the association between affective disorders and violent behaviour...
  28. ncbi request reprint Outpatient alcoholism treatment: predictors of outcome after 3 years
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstr 7, 80336 Munich, Germany
    Drug Alcohol Depend 80:83-9. 2005
    ..This prospective study investigated predictors for relapse 3 years after completion of an intensive outpatient treatment programme for alcoholism...
  29. doi request reprint Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
    Susanne Rösner
    IFT, Institut für Therapieforschung, Munich, Germany
    J Psychopharmacol 22:11-23. 2008
    ..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
  30. ncbi request reprint Role of aggressivity on reactivity and craving before and after cue exposure in recently detoxified alcoholics: results from an experimental study
    S S Chiang
    Psychiatric Hospital of Munich University, Munich, Germany
    Eur Addict Res 7:184-92. 2001
    ..007. The results were discussed in the context of the Classical, Operant Conditioning Theory, the Cognitive Craving Theory of Tiffany, Gilbert's STAR Model, and the Self-Medication Hypothesis...
  31. ncbi request reprint [Pharmacotherapy of alcohol dependence]
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen
    MMW Fortschr Med 150:22-4. 2008
  32. ncbi request reprint Delinquency and criminal offenses in former schizophrenic inpatients 7-12 years following discharge
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:289-94. 2004
    ..Previously, we reported a high prevalence of aggression in a large sample of schizophrenic patients treated between 1990-1995 in the psychiatric hospital of the University of Munich...
  33. doi request reprint Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms
    Gabriele Koller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 36:1230-6. 2012
    ..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
  34. ncbi request reprint Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Addict Res 11:132-7. 2005
    ..In summary, results of this study indicate a favorable outcome of socially stable alcohol-dependent patients and patients with a lower degree of depression, anxiety and craving in an intensive outpatient rehabilitation program...
  35. doi request reprint Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
    ..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
  36. doi request reprint Association for methodology and documentation in psychiatry profiles predict later risk for criminal behavior and violent crimes in former inpatients with affective disorder
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 55:655-9. 2010
    ..As previously demonstrated in another sample of schizophrenic patients, the AMDP syndromes mania (and hostility) is associated with a higher risk of later criminal behavior...
  37. doi request reprint Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    World J Biol Psychiatry 10:217-24. 2009
    ..2 to 39.8%. Withdrawal symptoms, craving and compliance improved significantly after transfer to (R)-methadone. We conclude that transfer from racemic to (R)-methadone is a safe and practical procedure...
  38. ncbi request reprint Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilians University of Munich, Naussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 39:101-8. 2005
    ..Among patients with risperidone, seven patients (35%) passed all test parameters without major failures. Clinical implications of these findings are discussed...
  39. ncbi request reprint New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
    ..Tricyclics have been found to be more effective than serotonin reuptake inhibitors in improving depressive symptoms in these patients...
  40. ncbi request reprint Influence of anxiety on electrophysiological correlates of response inhibition capacities in alcoholism
    Susanne Karch
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:89-95. 2007
    ..The results emphasize the importance of monitoring trait anxiety in studies regarding cognitive functions in subjects with alcohol use disorder...
  41. ncbi request reprint Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Biol Psychiatry 50:636-9. 2001
    ..A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample...
  42. ncbi request reprint Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:232-8. 2001
    ..Implications for the self-medication hypothesis for substance use in schizophrenia and future research in this area are discussed...
  43. ncbi request reprint Prevalence of alcohol and drug abuse in schizophrenic inpatients
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 242:362-72. 1993
    ..Dual diagnosis" schizophrenics had a significantly higher rate of suicide attempts and were less likely to be married. Possible clinical implications of these findings are discussed...
  44. doi request reprint High rehospitalization rate in alcohol-induced psychotic disorder
    Michael Soyka
    Private Hospital Meiringen, Willigen, 3860 Meiringen, Switzerland
    Eur Arch Psychiatry Clin Neurosci 263:309-13. 2013
    ..More follow-up studies are needed to elucidate this syndrome...
  45. ncbi request reprint Impact of craving on alcohol relapse during, and 12 months following, outpatient treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Alcohol Alcohol 39:357-61. 2004
    ..1995) and relapse during and after completion of an intensive outpatient treatment programme...
  46. ncbi request reprint Association of personality disorders with Type A and Type B alcoholics
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:55-61. 2006
    ..The impact of other personality disorders does not play a substantial role in subtyping alcoholics...
  47. ncbi request reprint Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study
    Michael Soyka
    Psychiatric Hospital University of Munich, Munich, Germany
    Eur Addict Res 9:65-72. 2003
    ..Although the efficacy of flupenthixol as an anti-craving drug in dual diagnosis patients has to be explored in further studies, the drug may be considered a promising medication for these patients...
  48. doi request reprint Prevalence of delusional jealousy in psychiatric disorders
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 56:450-2. 2011
    ..We conclude that delusional jealousy is a comparatively rare phenomenon that is most frequent in schizophrenia and related psychoses. Quite a number of affected patients are aggressive, which may indicate a risk of future violence...
  49. ncbi request reprint Alcoholism-related phenotypes and genetic variants of the CB1 receptor
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003
    ..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
  50. ncbi request reprint No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics
    G Koller
    Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 Munchen, Germany
    Alcohol Alcohol 38:31-4. 2003
    ..We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits...
  51. pmc Outpatient alcoholism treatment--24-month outcome and predictors of outcome
    Michael Soyka
    Private Hospital Meiringen, PO Box 612, CH 3860 Meiringen, Switzerland
    Subst Abuse Treat Prev Policy 4:15. 2009
    ..To study the value of demographic and alcohol-related variables for predicting 24-month treatment outcome in an outpatient setting...
  52. pmc Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study
    Peggy Schmidt
    Psychiatric Hospital, Ludwig Maximilians University, Nussbaumstr, 7, 80336 Munich, Germany
    Subst Abuse Treat Prev Policy 6:14. 2011
    ..The present study examined whether craving as measured by the obsessive-compulsive drinking scale (OCDS) predict long-term outcome in alcohol-dependent inpatients...
  53. ncbi request reprint Co-consumption of benzodiazepines in heroin users, methadone-substituted and codeine-substituted patients
    Markus Backmund
    Kolner Platz 1, Munchen, 80804, Germany
    J Addict Dis 24:17-29. 2005
    ..05) were associated with concomitant daily consumption of BZDs in opioid dependent subjects. These finding underline the need to further explore the causes, interactions and consequences of concomitant BZD and opiate use...
  54. doi request reprint Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:317-24. 2008
    ..Taking the substantial numbers of animal studies suggesting a possible role of CB1 antagonists for the treatment of alcohol dependence into account, it seems worthwhile to further test cannabinoid blockers in the treatment of alcoholism...
  55. ncbi request reprint Hyponatremia-induced seizure during carbamazepine treatment
    Bettina Holtschmidt-Taschner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 8:51-3. 2007
    ..CCT and ECG were normal. To our knowledge, this is the first description of a seizure related to hyponatremia in an adult carbamazepine-treated patient...
  56. doi request reprint Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral results
    W M Wong
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 41:72-8. 2008
    ..Furthermore we wanted to know whether functional polymorphisms (5-HTTLPR and 5HT2C Ser23Cys), have any influence on this responsivity...
  57. ncbi request reprint Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Drugs R D 3:1-12. 2002
    ..To determine abstinence rates and to obtain safety data during the use of integrated therapy with acamprosate and the main established psychotherapeutic intervention programmes in the treatment of alcohol dependence...
  58. doi request reprint Nalmefene for treatment of alcohol dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7, D 80336 Munich, Germany
    Expert Opin Investig Drugs 19:1451-9. 2010
    ..Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge...
  59. ncbi request reprint [Effectiveness of outpatient treatment for alcoholism - impact of personality disorders on course of treatment]
    Miriam Bottlender
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen, Germany
    Psychother Psychosom Med Psychol 53:384-9. 2003
    ..The present results indicate that patients with comorbid personality disorder can be successfully integrated into a high-structured outpatient therapy...
  60. doi request reprint Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
    Gabi Koller
    Department of addiction research Clinic of Psychiatry LMU Munich Nussbaumstrasse 7 80336 Munich Germany
    Psychiatr Genet 18:59-63. 2008
    ..Higher serotonin levels among carriers of the S allele might exhibit increased liability of serotonin-mediated, psychopathology-like anxiety and depression and may impair social skills reflected by harm avoidance...
  61. ncbi request reprint [Olfactory delusional syndrome and alcoholism]
    Marc Warnecke
    Psychiatrische Klinik und Poliklinik, der Ludwig Maximilians Universitat Munchen, Germany
    Psychiatr Prax 29:211-3. 2002
    ..This case report is about a 52 year old male suffering of alcoholism in addition. Aspects of this special comorbidity are discussed. Neuroleptic treatment with Risperidone led to a partial remission of the delusional syndrome...
  62. ncbi request reprint Effects of cue exposure on the subjective perception of alcohol dependents with different types of cue reactivity
    S S W Chiang
    Psychiatric Hospital, Munich University, Munich, Germany
    J Neural Transm 112:1275-8. 2005
    ....
  63. doi request reprint [Evidence-based treatments in the inpatient rehabilitation of alcoholics]
    P Schmidt
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München, Nussbaumstrasse 7, Munich
    Fortschr Neurol Psychiatr 76:86-90. 2008
    ..We examined the analogy of both treatment elements used in inpatient rehabilitation of alcohol dependents and the published knowledge concerning the effectiveness of therapy elements...
  64. ncbi request reprint No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  65. ncbi request reprint [Is the European Addiction Severity Index a useful tool in the diagnostic routines of alcohol dependence?]
    P Schmidt
    Psychiatrische Klinik der Ludwig Maximilians Universität München, Nussbaumstrasse 7, 80336 Munich, Germany
    Fortschr Neurol Psychiatr 75:541-8. 2007
    ..To study the validity of the EuropASI in the patient allocation context and to measure the alcohol severity changes with treatment...
  66. ncbi request reprint Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoh
    B Hock
    Psychiatric Clinic of Ludwig Maximilian University, Munich, Germany
    Addiction 100:1477-86. 2005
    ....
  67. ncbi request reprint Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 6:34-41. 2006
    ..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
  68. ncbi request reprint Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals
    G Koller
    Substitutionsambulanz, Pestalozzistrasse 2, 80469 München, Germany
    Addict Biol 10:269-73. 2005
    ..Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals...
  69. ncbi request reprint [Zoophilia between pathology and normality. Presentation of 3 case reports and an internet survey]
    S Dittert
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Klinikum der Universitat Munchen, Munchen
    Nervenarzt 76:61-7. 2005
    ..The authors are optimistic over the possibilities offered by this Internet research methodology...
  70. ncbi request reprint [Ambulatory detoxification of alcoholic patients. Results of a model project]
    M Soyka
    Psychiatrische Klinik und Poliklinik Klinikum Innenstadt der Universität München
    MMW Fortschr Med 142:38-40. 2000
    ..The concept behind the project and the clinical results achieved with the first 47 detoxified patients are presented and discussed...
  71. ncbi request reprint Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
    M Soyka
    Psychiatric Hospital University of Munich, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur Neuropsychopharmacol 10:325-32. 2000
    ..Future studies should focus on dosing issues, the differentiation between short- and long-term effects and the identification of subgroups of patients with particular psychopathology...
  72. ncbi request reprint [Glutamatergic mechanisms in alcohol dependence--genetic, molecular-biological and neuropharmacological findings]
    M Soyka
    Psychiatrische Klinik der Universität München, Munich
    Fortschr Neurol Psychiatr 71:S45-50. 2003
    ..A better understanding of the glutamatergic mechanisms in alcohol dependence may therefore also be of relevance for the development of new anti-craving-drugs and therapy-research...
  73. ncbi request reprint Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
    Psychiatry Res 96:51-61. 2000
    ..K(D) might be influenced by duration of alcohol dependence, but not sufficiently to yield differences between alcohol-dependent and control subjects...
  74. ncbi request reprint Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Neuropsychobiology 43:186-91. 2001
    ..Alcohol dependents were investigated because these personality disorders and impulsive behavior are very frequent in alcohol dependence anf of clinical relevance...
  75. ncbi request reprint [Therapeutic strategies and help in chronic alcoholism]
    M Soyka
    Psychiatrische Klinik, Universität Münchern
    Gesundheitswesen 63:347-53. 2001
    ..Anti-dipsotropics or so-called anti-craving-agents like acamprosate and naltrexone are primarily given to increase the rate of abstinence but could successfully be used in a harm reduction strategy (less drinking, shorter relapses)...
  76. ncbi request reprint [Psychotherapy of alcohol addiction--principles and new findings of therapy research]
    M Soyka
    Psychiatrische Klinik der Universität München, Nussbaumstrasse 7, D 80336 MUnchen, Deutschland
    Wien Med Wochenschr 151:380-8; discussion 389. 2001
    ..A difficult question remains the allocation of patients to different treatments. Current concepts of treatment for alcoholics are described and results of different treatment studies are given...
  77. ncbi request reprint [Psychiatric examination of accused for the "United Nations International Tribunal for the prosecution of persons responsible for serious violations of International Humanitarian Law committed in the territory of the former Yugoslavia" (ICTY)]
    M Soyka
    Psychiatrische Klinik der Universität München
    Fortschr Neurol Psychiatr 70:84-7. 2002
    ..After a brief description of a case report relevant aspects of psychiatric evaluation of persons responsible for war crimes are outlined and possible implications for forensic research are discussed...
  78. ncbi request reprint [General practitioner plays a central role as case manager. Diagnosis and therapy of alcoholism]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen
    MMW Fortschr Med 145:40-2. 2003
    ..After successful treatment (abstinence)--prevention of relapse, where necessary using so-called anti-craving drugs such as acamprostate...
  79. ncbi request reprint [Aggression and violent crime associated with schizophrenia]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen
    Dtsch Med Wochenschr 127:1708-12. 2002
  80. ncbi request reprint PET and SPECT findings in alcohol hallucinosis: case report and super-brief review of the pathophysiology of this syndrome
    M Soyka
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:215-8. 2000
    ..Current IBZM SPECT data do not support a dopamine receptor dysfunction in alcohol hallucinosis but TRODAT SPECT showed reduced dopamine transporter binding. Possible implications of these findings are discussed...
  81. ncbi request reprint No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Alcohol Alcohol 37:174-8. 2002
    ..The negative results in this study question the role of these polymorphisms in the pathogenesis of alcohol withdrawal-induced seizures and delirium tremens...
  82. ncbi request reprint [Aggressiveness in schizophrenia: prevalence, psychopathological and sociodemographic correlates]
    M Soyka
    Psychiatrische Klinik der Universität München, Germany
    Fortschr Neurol Psychiatr 70:171-7. 2002
    ..Psychopathological symptoms significantly associated with aggression were e.p. delusional ideas and disorganized thinking. Possible risk factors for aggression in schizophrenia and clinical implications are discussed...
  83. ncbi request reprint Impulsivity and aggression as predictors of suicide attempts in alcoholics
    G Koller
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:155-60. 2002
    ..Furthermore, the potential influence of concurrent personality disorders and depressive conditions were assessed...
  84. ncbi request reprint [Factor structure and validity of a german version of the barratt impulsiveness scale]
    U W Preuss
    Psychiatrische Klinik und Poliklinik Ludwig Maximilians Universität München
    Fortschr Neurol Psychiatr 71:527-34. 2003
    ..The aim of this study is to evaluate the BIS-5 in two German psychiatric inpatient samples and healthy controls proving the originally proposed four-factor structure as well as convergent and discriminate validity...
  85. ncbi request reprint Dementia associated with vitamin B(12) deficiency: presentation of two cases and review of the literature
    N Goebels
    Department of Psychiatry, University of Munich, Germany
    J Neuropsychiatry Clin Neurosci 12:389-94. 2000
    ..The literature concerning the pathophysiology and the diagnostic and therapeutic aspects of cobalamin deficiency is reviewed...
  86. ncbi request reprint Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  87. ncbi request reprint Chronological relationship between antisocial personality disorder and alcohol dependence
    M Bahlmann
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Eur Addict Res 8:195-200. 2002
    ..This finding suggests that in patients with ASPD, alcohol dependence might be a secondary syndrome as suggested by previous research...
  88. ncbi request reprint Gene therapy and medical genetics on Internet
    O Seemann
    Psychiatrische Universitätsklinik LMU, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur J Med Res 3:443-8. 1998
    ..Finally, some of the ethical, legal and social implications of the links between gene therapy and the Intemet are considered...
  89. ncbi request reprint [Communication on the Internet. Possibilities and risks of the Internet for psychiatry]
    O Seemann
    Psychiatrische Klinik der LMU, Munchen
    Fortschr Neurol Psychiatr 66:483-6. 1998
    ..Useful and established possibilities are discussed. Finally, the risks of this kind of communication are shown and listed...
  90. ncbi request reprint [Catamnestic study on the efficacy of an intensive outpatient treatment programme for alcohol-dependent patients: impact of participation in AA on the abstinence rates]
    M Bottlender
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Deutschland
    Fortschr Neurol Psychiatr 73:150-5. 2005
    ..Results indicate the predictive value of AA attendance for relapse prevention after controlling for confounding variables. The value of self-help-groups in the network of alcoholism treatment is discussed...
  91. ncbi request reprint [Where are the 1.9 million patients dependent on legal drugs hiding?]
    M Soyka
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat, Munchen
    Nervenarzt 76:72-7. 2005
    ..Although the number of patients dependent on legal drugs is estimated to be as high as 1.9 million, very few are in clinical treatment. Research deficits in this area are evident...
  92. ncbi request reprint GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
    ..These findings support the hypothesis that the GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. This novel finding warrants replication...
  93. ncbi request reprint Phytohemagglutinin-stimulated calcium signal in lymphocytes of alcoholics before, during and after detoxification
    B Bondy
    Psychiatric Clinic, University of Munich, Munchen, Germany
    Psychiatry Res 81:157-62. 1998
    ..05), and especially for the sustained influx at the end of the observation period (P = 0.001). The detailed mechanisms of this disturbed calcium homeostasis need further investigation...
  94. ncbi request reprint Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  95. ncbi request reprint [Treatment of cocaine dependence. Intoxication, withdrawal and prevention of relapse]
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen
    Fortschr Neurol Psychiatr 68:224-38. 2000
    ..A short review of new experimental therapies in the treatment of cocaine-dependence is shown...
  96. ncbi request reprint Psybertherapy on the Internet and its implications for psychiatry, psychotherapy, and psychosomatics
    O Seemann
    Psychiatrische Klinik, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur J Med Res 3:571-6. 1998
    ..The systematic review gives access to the most important fields of mental health on the Internet. Finally, some of the risks of this kind of communication for therapy and society are visible...
  97. ncbi request reprint [Considerations in the combination of clozapine and benzodiazepines]
    R Rupprecht
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München, Munchen, Deutschland
    Nervenarzt 75:857-60. 2004
    ..Moreover, the formulation of such guidelines would help with forensic issues in case of serious adverse events occurring during this combination therapy...
  98. ncbi request reprint Late auditory evoked potentials (P300) do not discriminate between subgroups of alcohol-dependent patients defined by family history and antisocial personality traits
    U W Preuss
    Dept of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur J Med Res 4:114-20. 1999
    ..In conclusion, auditory P300 had a low discriminative power with regards to subgroups of inpatient alcoholics defined by family history and antisocial personality traits. Reasons for the negative findings in this study are discussed...
  99. ncbi request reprint Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen, Germany
    Eur Addict Res 6:57-63. 2000
    ..Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism...
  100. doi request reprint Effects of alcohol consumption on iron metabolism
    M Lieb
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Am J Drug Alcohol Abuse 37:68-73. 2011
    ..Here, vitamin B12 and folic acid state were assessed. Results on iron metabolism in patients with alcohol dependence in comparison with social drinkers are presented...
  101. pmc PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany Department of Psychiatry, Martin Luther University, Halle Wittenberg, Germany
    PLoS ONE 8:e78688. 2013
    ..The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach...