Michael Soyka

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
  2. ncbi Outpatient alcohol detoxification: implementation efficacy and outcome effectiveness of a model project
    Michael Soyka
    Psychiatric Hospital, University Munich, Munich, Germany
    Eur Addict Res 10:180-7. 2004
  3. ncbi Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
  4. ncbi PET and SPECT findings in alcohol hallucinosis: case report and super-brief review of the pathophysiology of this syndrome
    M Soyka
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:215-8. 2000
  5. ncbi Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study
    Michael Soyka
    Psychiatric Hospital University of Munich, Munich, Germany
    Eur Addict Res 9:65-72. 2003
  6. ncbi [General practitioner plays a central role as case manager. Diagnosis and therapy of alcoholism]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen
    MMW Fortschr Med 145:40-2. 2003
  7. ncbi [Glutamatergic mechanisms in alcohol dependence--genetic, molecular-biological and neuropharmacological findings]
    M Soyka
    Psychiatrische Klinik der Universität München, Munich
    Fortschr Neurol Psychiatr 71:S45-50. 2003
  8. ncbi Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
  9. ncbi No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
  10. ncbi Delinquency and criminal offenses in former schizophrenic inpatients 7-12 years following discharge
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:289-94. 2004

Collaborators

Detail Information

Publications89

  1. ncbi New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
    ..Tricyclics have been found to be more effective than serotonin reuptake inhibitors in improving depressive symptoms in these patients...
  2. ncbi Outpatient alcohol detoxification: implementation efficacy and outcome effectiveness of a model project
    Michael Soyka
    Psychiatric Hospital, University Munich, Munich, Germany
    Eur Addict Res 10:180-7. 2004
    ..The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach...
  3. ncbi Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  4. ncbi PET and SPECT findings in alcohol hallucinosis: case report and super-brief review of the pathophysiology of this syndrome
    M Soyka
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:215-8. 2000
    ..Current IBZM SPECT data do not support a dopamine receptor dysfunction in alcohol hallucinosis but TRODAT SPECT showed reduced dopamine transporter binding. Possible implications of these findings are discussed...
  5. ncbi Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study
    Michael Soyka
    Psychiatric Hospital University of Munich, Munich, Germany
    Eur Addict Res 9:65-72. 2003
    ..Although the efficacy of flupenthixol as an anti-craving drug in dual diagnosis patients has to be explored in further studies, the drug may be considered a promising medication for these patients...
  6. ncbi [General practitioner plays a central role as case manager. Diagnosis and therapy of alcoholism]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen
    MMW Fortschr Med 145:40-2. 2003
    ..After successful treatment (abstinence)--prevention of relapse, where necessary using so-called anti-craving drugs such as acamprostate...
  7. ncbi [Glutamatergic mechanisms in alcohol dependence--genetic, molecular-biological and neuropharmacological findings]
    M Soyka
    Psychiatrische Klinik der Universität München, Munich
    Fortschr Neurol Psychiatr 71:S45-50. 2003
    ..A better understanding of the glutamatergic mechanisms in alcohol dependence may therefore also be of relevance for the development of new anti-craving-drugs and therapy-research...
  8. ncbi Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  9. ncbi No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  10. ncbi Delinquency and criminal offenses in former schizophrenic inpatients 7-12 years following discharge
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:289-94. 2004
    ..Previously, we reported a high prevalence of aggression in a large sample of schizophrenic patients treated between 1990-1995 in the psychiatric hospital of the University of Munich...
  11. ncbi [Aggression and violent crime associated with schizophrenia]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen
    Dtsch Med Wochenschr 127:1708-12. 2002
  12. ncbi Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen, Germany
    Eur Addict Res 6:57-63. 2000
    ..Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism...
  13. ncbi [Psychiatric examination of accused for the "United Nations International Tribunal for the prosecution of persons responsible for serious violations of International Humanitarian Law committed in the territory of the former Yugoslavia" (ICTY)]
    M Soyka
    Psychiatrische Klinik der Universität München
    Fortschr Neurol Psychiatr 70:84-7. 2002
    ..After a brief description of a case report relevant aspects of psychiatric evaluation of persons responsible for war crimes are outlined and possible implications for forensic research are discussed...
  14. ncbi Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Drugs R D 3:1-12. 2002
    ..To determine abstinence rates and to obtain safety data during the use of integrated therapy with acamprosate and the main established psychotherapeutic intervention programmes in the treatment of alcohol dependence...
  15. ncbi [Aggressiveness in schizophrenia: prevalence, psychopathological and sociodemographic correlates]
    M Soyka
    Psychiatrische Klinik der Universität München, Germany
    Fortschr Neurol Psychiatr 70:171-7. 2002
    ..Psychopathological symptoms significantly associated with aggression were e.p. delusional ideas and disorganized thinking. Possible risk factors for aggression in schizophrenia and clinical implications are discussed...
  16. ncbi [Therapeutic strategies and help in chronic alcoholism]
    M Soyka
    Psychiatrische Klinik, Universität Münchern
    Gesundheitswesen 63:347-53. 2001
    ..Anti-dipsotropics or so-called anti-craving-agents like acamprosate and naltrexone are primarily given to increase the rate of abstinence but could successfully be used in a harm reduction strategy (less drinking, shorter relapses)...
  17. ncbi Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
    M Soyka
    Psychiatric Hospital University of Munich, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur Neuropsychopharmacol 10:325-32. 2000
    ..Future studies should focus on dosing issues, the differentiation between short- and long-term effects and the identification of subgroups of patients with particular psychopathology...
  18. ncbi [Ambulatory detoxification of alcoholic patients. Results of a model project]
    M Soyka
    Psychiatrische Klinik und Poliklinik Klinikum Innenstadt der Universität München
    MMW Fortschr Med 142:38-40. 2000
    ..The concept behind the project and the clinical results achieved with the first 47 detoxified patients are presented and discussed...
  19. ncbi [Psychotherapy of alcohol addiction--principles and new findings of therapy research]
    M Soyka
    Psychiatrische Klinik der Universität München, Nussbaumstrasse 7, D 80336 MUnchen, Deutschland
    Wien Med Wochenschr 151:380-8; discussion 389. 2001
    ..A difficult question remains the allocation of patients to different treatments. Current concepts of treatment for alcoholics are described and results of different treatment studies are given...
  20. doi Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:699-703. 2008
    ..Selective attention improved in both patient groups during treatment. We propose that the improvement of attention may facilitate rehabilitation of drug-dependent patients...
  21. doi No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms
    Gabriele Koller
    Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany
    Addict Biol 14:506-8. 2009
    ..048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis...
  22. doi Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 11:641-53. 2008
    ..The intensity of withdrawal symptoms showed the strongest correlation with drop-out. Future studies are warranted to further address patient profiles and outcome under different substitution regimens...
  23. ncbi Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses
    Susanne Karch
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 42:734-45. 2008
    ..This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients...
  24. doi Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms
    Gabriele Koller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 36:1230-6. 2012
    ..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
  25. doi Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study
    Ulrich W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University, Halle Wittenberg, Julius Kühn Str 7, D 06112 Halle, Germany
    Addict Biol 16:323-33. 2011
    ....
  26. doi Criminal behaviour and violent crimes in former inpatients with affective disorder
    Christian Graz
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Affect Disord 117:98-103. 2009
    ..Several studies have reported criminal and violent behaviour in people with schizophrenia but few have investigated the association between affective disorders and violent behaviour...
  27. ncbi Outpatient alcoholism treatment: predictors of outcome after 3 years
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstr 7, 80336 Munich, Germany
    Drug Alcohol Depend 80:83-9. 2005
    ..This prospective study investigated predictors for relapse 3 years after completion of an intensive outpatient treatment programme for alcoholism...
  28. doi Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  29. ncbi Clinical correlates of later violence and criminal offences in schizophrenia
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 94:89-98. 2007
    ..Violence and criminality in patients with schizophrenia has been described in several studies but prediction of later criminal behavior is difficult...
  30. doi A comparison of cognitive function in patients under maintenance treatment with heroin, methadone, or buprenorphine and healthy controls: an open pilot study
    Michael Soyka
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Am J Drug Alcohol Abuse 37:497-508. 2011
    ..INTROduction: Cognitive impairment has been reported in drug-dependent patients under opioid maintenance treatment...
  31. ncbi Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Clin Psychopharmacol 25:490-3. 2005
    ..We assessed whether patients under buprenorphine, a partial mu-opioid agonist, perform better in cognitive tests measuring psychomotor performance as described in previous nonrandomized studies...
  32. ncbi Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilians University of Munich, Naussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 39:101-8. 2005
    ..Among patients with risperidone, seven patients (35%) passed all test parameters without major failures. Clinical implications of these findings are discussed...
  33. ncbi Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Addict Res 11:132-7. 2005
    ..In summary, results of this study indicate a favorable outcome of socially stable alcohol-dependent patients and patients with a lower degree of depression, anxiety and craving in an intensive outpatient rehabilitation program...
  34. doi The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 12:160-87. 2011
    ..To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence...
  35. ncbi A combination of carbamazepine/tiapride in outpatient alcohol detoxification. Results from an open clinical study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:197-200. 2002
    ..Results from this study suggest that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for outpatient alcohol detoxification in patients with moderate severity of withdrawal syndrome...
  36. doi Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
    ..Maintenance therapy is effective in the reduction in both narcotics-related and acquisition crime...
  37. ncbi Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine: results of a pooled analysis in 540 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, , Germany
    Eur Arch Psychiatry Clin Neurosci 256:395-401. 2006
    ..In line with previous research, the results from this study give further evidence that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for alcohol withdrawal treatment...
  38. doi Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    World J Biol Psychiatry 10:217-24. 2009
    ..2 to 39.8%. Withdrawal symptoms, craving and compliance improved significantly after transfer to (R)-methadone. We conclude that transfer from racemic to (R)-methadone is a safe and practical procedure...
  39. ncbi One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
    ..Taking into account the high comorbidity of opioid dependent patients and the severity of dependence, the mortality rate of approximately 1% confirms that maintenance treatment could be regarded as a fairly safe treatment...
  40. doi Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
    Susanne Rösner
    IFT, Institut für Therapieforschung, Munich, Germany
    J Psychopharmacol 22:11-23. 2008
    ..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
  41. ncbi Influence of anxiety on electrophysiological correlates of response inhibition capacities in alcoholism
    Susanne Karch
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:89-95. 2007
    ..The results emphasize the importance of monitoring trait anxiety in studies regarding cognitive functions in subjects with alcohol use disorder...
  42. ncbi Association of personality disorders with Type A and Type B alcoholics
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:55-61. 2006
    ..The impact of other personality disorders does not play a substantial role in subtyping alcoholics...
  43. doi Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
    ..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
  44. ncbi Impact of craving on alcohol relapse during, and 12 months following, outpatient treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Alcohol Alcohol 39:357-61. 2004
    ..1995) and relapse during and after completion of an intensive outpatient treatment programme...
  45. doi Association for methodology and documentation in psychiatry profiles predict later risk for criminal behavior and violent crimes in former inpatients with affective disorder
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 55:655-9. 2010
    ..As previously demonstrated in another sample of schizophrenic patients, the AMDP syndromes mania (and hostility) is associated with a higher risk of later criminal behavior...
  46. ncbi Suicidal behavior in alcohol-dependent subjects: the role of personality disorders
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Alcohol Clin Exp Res 30:866-77. 2006
    ....
  47. ncbi SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
    ..Further analysis are needed to confirm these results...
  48. doi Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:317-24. 2008
    ..Taking the substantial numbers of animal studies suggesting a possible role of CB1 antagonists for the treatment of alcohol dependence into account, it seems worthwhile to further test cannabinoid blockers in the treatment of alcoholism...
  49. ncbi Hyponatremia-induced seizure during carbamazepine treatment
    Bettina Holtschmidt-Taschner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 8:51-3. 2007
    ..CCT and ECG were normal. To our knowledge, this is the first description of a seizure related to hyponatremia in an adult carbamazepine-treated patient...
  50. doi Emerging drugs to treat alcoholism
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7 80336 Munich, Germany
    Expert Opin Emerg Drugs 15:695-711. 2010
    ..Alcoholism is a widespread disorder with substantial mortality and negative treatment outcomes. To date, few medications have been found to reduce relapse rates or drinking in alcohol-dependent patients...
  51. ncbi Impact of different personality dimensions (NEO Five-Factor Inventory) on the outcome of alcohol-dependent patients 6 and 12 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 136:61-7. 2005
    ..These results are in line with prior research on this topic...
  52. doi Prevalence of delusional jealousy in psychiatric disorders
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 56:450-2. 2011
    ..We conclude that delusional jealousy is a comparatively rare phenomenon that is most frequent in schizophrenia and related psychoses. Quite a number of affected patients are aggressive, which may indicate a risk of future violence...
  53. ncbi Co-consumption of benzodiazepines in heroin users, methadone-substituted and codeine-substituted patients
    Markus Backmund
    Kolner Platz 1, Munchen, 80804, Germany
    J Addict Dis 24:17-29. 2005
    ..05) were associated with concomitant daily consumption of BZDs in opioid dependent subjects. These finding underline the need to further explore the causes, interactions and consequences of concomitant BZD and opiate use...
  54. ncbi Effects of irritability on craving before and after cue exposure in abstinent alcoholic inpatients: experimental data on subjective response and heart rate
    Sonnig S W Chiang
    Psychiatric Hospital of Munich University, Munich, Germany
    Neuropsychobiology 46:150-60. 2002
    ..Irritability is often linked with problem drinking. The aim of this study is to examine the possible influence of irritability on craving induced by a cue-exposure paradigm...
  55. ncbi Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
    Hepatology 37:443-51. 2003
    ..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting...
  56. pmc Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study
    Peggy Schmidt
    Psychiatric Hospital, Ludwig Maximilians University, Nussbaumstr, 7, 80336 Munich, Germany
    Subst Abuse Treat Prev Policy 6:14. 2011
    ..The present study examined whether craving as measured by the obsessive-compulsive drinking scale (OCDS) predict long-term outcome in alcohol-dependent inpatients...
  57. ncbi Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  58. doi Nalmefene for treatment of alcohol dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7, D 80336 Munich, Germany
    Expert Opin Investig Drugs 19:1451-9. 2010
    ..Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge...
  59. ncbi Thalamic hypofunction in alcohol hallucinosis: FDG PET findings
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 139:259-62. 2005
    ..When the second patient was retested after clinical recovery, FDG PET findings were normalized, suggesting the probable thalamic dysfunction to be a functional rather than a structural abnormality...
  60. ncbi [Effectiveness of outpatient treatment for alcoholism - impact of personality disorders on course of treatment]
    Miriam Bottlender
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen, Germany
    Psychother Psychosom Med Psychol 53:384-9. 2003
    ..The present results indicate that patients with comorbid personality disorder can be successfully integrated into a high-structured outpatient therapy...
  61. doi OCDS craving scores predict 24-month outcome in alcoholic outpatients
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Am J Addict 19:264-9. 2010
    ..OCDS scores were higher in patients with a less favorable outcome. In line with previous findings, our results showed that the intensity of craving as measured by the OCDS may predict outcome in outpatient alcoholics...
  62. ncbi [Olfactory delusional syndrome and alcoholism]
    Marc Warnecke
    Psychiatrische Klinik und Poliklinik, der Ludwig Maximilians Universitat Munchen, Germany
    Psychiatr Prax 29:211-3. 2002
    ..This case report is about a 52 year old male suffering of alcoholism in addition. Aspects of this special comorbidity are discussed. Neuroleptic treatment with Risperidone led to a partial remission of the delusional syndrome...
  63. doi Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
    Gabi Koller
    Department of addiction research Clinic of Psychiatry LMU Munich Nussbaumstrasse 7 80336 Munich Germany
    Psychiatr Genet 18:59-63. 2008
    ..Higher serotonin levels among carriers of the S allele might exhibit increased liability of serotonin-mediated, psychopathology-like anxiety and depression and may impair social skills reflected by harm avoidance...
  64. pmc PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany Department of Psychiatry, Martin Luther University, Halle Wittenberg, Germany
    PLoS ONE 8:e78688. 2013
    ..The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach...
  65. ncbi Effects of haloperidol and atypical neuroleptics on psychomotor performance and driving ability in schizophrenic patients. Results from an experimental study
    Sabine Kagerer
    Psychiatric Hospital, Dtstion C4, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 47:212-8. 2003
    ..Only 1 (5%) subject passed all subtests without major failures and could be regarded as competent to drive. Among patients with atypical neuroleptics, 7 patients (24%) passed all test parameters without major failures...
  66. pmc Neurobiology of aggression and violence in schizophrenia
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Schizophr Bull 37:913-20. 2011
    ..Neuroimaging studies may well help further elucidate the interrelationship between neurocognitive functioning, personality traits, and antisocial and violent behavior...
  67. ncbi Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Am J Addict 12:S69-80. 2003
    ..Some centers suggest naltrexone not only for patients aiming for abstinence but also for patients for whom continued drinking is a therapeutic possibility or a clinical inevitability...
  68. doi Buprenorphine and buprenorphine/naloxone soluble-film for treatment of opioid dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7 Munich Munich, Germany
    Expert Opin Drug Deliv 9:1409-17. 2012
    ..A novel buprenorphine/naloxone film has been developed with improved pharmacokinetics and a hopefully lower risk of diversion and accidental intoxications...
  69. ncbi Opioid antagonists for alcohol dependence
    Susanne Rösner
    Psychiatric Hospital, University of Munich, Nußbaumstr 7, Munich, Germany, 80336
    Cochrane Database Syst Rev 12:CD001867. 2010
    ..Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene...
  70. doi Why should addiction medicine be an attractive field for young physicians?
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Addiction 104:169-72. 2009
    ..Yet, we believe that the medical specialties of addiction medicine/psychiatry are not attracting the interest and enthusiasm of young physicians. What can be done?..
  71. ncbi Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens
    Andre Tadic
    Dept of Psychiatry, University of Mainz, 55131 Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 255:129-35. 2005
    ..Moreover, we hypothesized that another genetic variation within GRIN2B (rs1806191) may have an effect in the etiology of alcoholism or withdrawal-related traits...
  72. ncbi The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Nat Med 11:35-42. 2005
    ..Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake...
  73. doi Feasibility and outcome of substitution treatment of heroin-dependent patients in specialized substitution centers and primary care facilities in Germany: a naturalistic study in 2694 patients
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzerstrasse 46, 01187 Dresden, Germany
    Drug Alcohol Depend 95:245-57. 2008
    ..Despite many short-term studies, little is known about the long-term (12-month) effects of these treatments in different settings, i.e. primary care-based (PMC) and specialized substitution centers (SSCs)...
  74. ncbi Alcohol consumption in heroin users, methadone-substituted and codeine-substituted patients--frequency and correlates of use
    Markus Backmund
    Addiction Medicine, General Hospital Munich Schwabing, Germany
    Eur Addict Res 9:45-50. 2003
    ..Alcohol consumption by opioid-addicted patients treated with methadone or DHC presents a serious medical problem. Co-abuse of alcohol will receive more attention...
  75. ncbi Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study
    Markus Gastpar
    Department of Psychiatry of the University of Essen, Germany
    J Clin Psychopharmacol 22:592-8. 2002
    ..Nevertheless, the question arises whether self-reports of drinking are more reliable than gamma-GT as a measure of recent alcohol consumption...
  76. ncbi [The qualified-detoxification-of-alcoholics procedure--in light of the development of guidelines for the treatment of substance-related disorders]
    Lutz G Schmidt
    Psychiatrische Klinik und Poliklinik der Johannes Gutenberg Universität Mainz
    Z Arztl Fortbild Qualitatssich 96:295-300. 2002
    ....
  77. ncbi Recent developments in the genetics of alcohol-related phenotypes
    Victor Hesselbrock
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, 06030 2103, USA
    Alcohol Clin Exp Res 29:1321-4. 2005
  78. ncbi Buprenorphine and methadone in the treatment of opioid dependence: methods and design of the COBRA study
    Hans Ulrich Wittchen
    Institut für Klinische Psychologie und Psychotherapie, TU Dresden, Germany
    Int J Methods Psychiatr Res 14:14-28. 2005
    ..The COBRA study provides a unique comprehensive database, informing about the natural allocation and intervention processes in routine care and about the course and outcome of patients treated with buprenorphine or methadone...
  79. doi World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  80. ncbi [Psychotherapeutic interventions of general practitioners in patients with alcohol problems]
    Michael Soyka
    Psychiatrische Klinik der Universität München, Privatklinik Meiringen, Schweiz
    MMW Fortschr Med 150:33-5. 2008
  81. doi Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior
    Gunter Schumann
    Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
    Arch Gen Psychiatry 65:826-38. 2008
    ..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models...
  82. ncbi The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a randomized, double-blind, placebo-controlled trial in 299 alcohol-dependent patients
    Stefan Bender
    Department of Psychiatry and Psychotherapy, Rhine State Hospital, University Hospital Essen, Germany
    Int J Neuropsychopharmacol 10:653-60. 2007
    ..Regarding the high success rate in the placebo group the influence of psychosocial treatment in studies investigating drug effects on the course of alcohol dependence has to be considered...
  83. ncbi [For and against: controlled drinking as useful and necessary treatment alternative]
    Joachim Körkel
    Ev Fachhochschule Nürnberg, Bärenschanzstrasse 4, 90429 Nürnberg
    Psychiatr Prax 32:324-6. 2005
  84. ncbi Antidepressants and driving ability: results from a clinical study
    Alexander Brunnauer
    District Hospital Gabersee, Academic Hospital of Psychiatry, Psychotherapy, and Neurology, Wasserburg Inn, Germany
    J Clin Psychiatry 67:1776-81. 2006
    ..The present study was designed to evaluate the effects of antidepressant monotherapy on psychomotor functions related to car-driving skills in depressive patients in a routine clinical setting...
  85. ncbi Hitler's missing psychiatric file
    Gerhard Koepf
    Eur Arch Psychiatry Clin Neurosci 257:245. 2007
  86. ncbi Delusional parasitosis associated with pemoline
    Till Krauseneck
    Psychopathology 38:103-4. 2005
  87. doi Long-term effects of heroin-assisted treatment in Germany
    Uwe Verthein
    Centre for Interdisciplinary Addiction Research of Hamburg University, CIAR, Hamburg, Germany
    Addiction 103:960-6; discussion 967-8. 2008
    ..The present study describes the association between 2 years of heroin treatment and improvements in health and social stabilization, as well as illicit drug use...
  88. ncbi Precontemplated and impulsive suicide attempts among individuals with alcohol dependence
    Kenneth R Conner
    Center for the Study and Prevention of Suicide and Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14620, USA
    J Stud Alcohol 67:95-101. 2006
    ..Some suicide attempts are precontemplated, whereas other attempts are impulsive. The purpose of this study was to compare characteristics and correlates of impulsive and precontemplated suicide attempts...
  89. ncbi [One drink, one drunk--controlled drinking by alcoholics? 3-year-outcome after intensive outpatient treatment]
    Miriam Bottlender
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen
    Psychother Psychosom Med Psychol 57:32-8. 2007
    ..In the present study we examined in a sample of alcohol-dependent patients whether or not controlled drinking is possible during a three years period following treatment...