Ruth Sittl

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi [Update on preemptive analgesia : options and limits of preoperative pain therapy]
    R Sittl
    Klinikum der Universitat Munchen, Nussbaumstr 20, 80336, Munchen, Deutschland
    Anaesthesist 62:789-96. 2013
  2. pmc Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons
    Alexandra B Klinger
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstraße 17, 91054 Erlangen, Germany
    Mol Pain 8:69. 2012
  3. doi The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve
    Ruth Sittl
    Institute of Physiology, University of Munich, Munich, Germany
    J Peripher Nerv Syst 15:63-72. 2010
  4. doi Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, Pettenkoferstr 12, Munich, Germany
    Neurotoxicology 31:694-700. 2010
  5. pmc Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 109:6704-9. 2012
  6. pmc Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial
    Johannes Fleckenstein
    Department of Anaesthesiology, University of Munich, Munich, Germany
    J Transl Med 11:34. 2013
  7. doi Sustained increase in the excitability of myelinated peripheral axons to depolarizing current is mediated by Nav1.6
    Ruth Sittl
    Institute of Physiology, University of Munich, Pettenkoferstr 12, D 80336 Munich, Germany
    Neurosci Lett 492:129-33. 2011
  8. pmc GABA increases electrical excitability in a subset of human unmyelinated peripheral axons
    Richard W Carr
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 5:e8780. 2010

Collaborators

Detail Information

Publications8

  1. ncbi [Update on preemptive analgesia : options and limits of preoperative pain therapy]
    R Sittl
    Klinikum der Universitat Munchen, Nussbaumstr 20, 80336, Munchen, Deutschland
    Anaesthesist 62:789-96. 2013
    ..g. epidural) to reduce nociceptive input to the spinal cord as well as opioids, N-methyl-D-aspartate (NMDA) antagonists, antidepressants and anticonvulsants, all of which have an inhibitory influence on the central nervous system...
  2. pmc Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons
    Alexandra B Klinger
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstraße 17, 91054 Erlangen, Germany
    Mol Pain 8:69. 2012
    ..Here, we investigated if ATX-II induces resurgent currents in sensory neurons of the dorsal root ganglion (DRGs) and how this may translate into human sensations...
  3. doi The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve
    Ruth Sittl
    Institute of Physiology, University of Munich, Munich, Germany
    J Peripher Nerv Syst 15:63-72. 2010
    ..This indicates that neuropathies with abnormal nerve excitability parameters corresponding to those affected by flupirtine may benefit from activation of axonal Kv7 potassium channels...
  4. doi Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, Pettenkoferstr 12, Munich, Germany
    Neurotoxicology 31:694-700. 2010
    ..The data indicate that activation of slow potassium channels in the A-fibres of peripheral nerve may attenuate the acute neuropathy associated with oxaliplatin in humans...
  5. pmc Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 109:6704-9. 2012
    ..6 plays a central role in mediating acute cooling-exacerbated symptoms following oxaliplatin, and that enhanced resurgent and persistent sodium currents may provide a general mechanistic basis for cold-aggravated symptoms of neuropathy...
  6. pmc Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial
    Johannes Fleckenstein
    Department of Anaesthesiology, University of Munich, Munich, Germany
    J Transl Med 11:34. 2013
    ..Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expected to reduce axonal excitability and potentially contribute to flupirtine's clinical profile...
  7. doi Sustained increase in the excitability of myelinated peripheral axons to depolarizing current is mediated by Nav1.6
    Ruth Sittl
    Institute of Physiology, University of Munich, Pettenkoferstr 12, D 80336 Munich, Germany
    Neurosci Lett 492:129-33. 2011
    ..These data reveal the specific functional role of an identified subtype of voltage-gated sodium channel (Nav1.6) in mediating the depolarizing threshold electrotonus response of peripheral myelinated nerve fibers...
  8. pmc GABA increases electrical excitability in a subset of human unmyelinated peripheral axons
    Richard W Carr
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 5:e8780. 2010
    ..However, the effect of GABA on human peripheral unmyelinated axons has not been established...