Reinhard Sittl

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double-blind, placebo-controlled trial
    Reinhard Sittl
    University of Erlangen, Pain Clinic, Erlangen, Germany
    Clin Ther 25:150-68. 2003
  2. ncbi request reprint Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 27:225-37. 2005
  3. ncbi request reprint Transdermal buprenorphine in cancer pain and palliative care
    Reinhard Sittl
    Department of Anaesthesiology, Pain Therapy, University of Erlangen Nuremberg, Krankenhausstr 12, D 91054 Erlangen, Germany
    Palliat Med 20:s25-30. 2006
  4. ncbi request reprint Transdermal buprenorphine in the treatment of chronic pain
    Reinhard Sittl
    University of Erlangen, Pain Clinic, Krankenhausstr, 91054 Erlangen, Germany
    Expert Rev Neurother 5:315-23. 2005
  5. ncbi request reprint Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
    Wolfgang Koppert
    Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 118:15-22. 2005
  6. ncbi request reprint The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 108:148-53. 2004
  7. ncbi request reprint Effects of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentrations in chronic pain patients treated with transdermal buprenorphine
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Eur J Pain 10:743-8. 2006
  8. ncbi request reprint Patterns of dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: a retrospective data analysis in Germany
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 28:1144-54. 2006
  9. ncbi request reprint Changes in the prescribed daily doses of transdermal fentanyl and transdermal buprenorphine during treatment of patients with cancer and noncancer pain in Germany: results of a retrospective cohort study
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 27:1022-31. 2005
  10. ncbi request reprint Long-term management of chronic pain with transdermal buprenorphine: a multicenter, open-label, follow-up study in patients from three short-term clinical trials
    Rudolf Likar
    Pain Clinic, General Hospital Klagenfurt, Klagenfurt, Austria, and Pain Clinic, University of Erlangen Nurnberg, Germany
    Clin Ther 28:943-52. 2006

Detail Information

Publications27

  1. ncbi request reprint Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double-blind, placebo-controlled trial
    Reinhard Sittl
    University of Erlangen, Pain Clinic, Erlangen, Germany
    Clin Ther 25:150-68. 2003
    ..Buprenorphine is a potent opioid analgesic that is available in sublingual and parenteral formulations. A new formulation, buprenorphine transdermal delivery system (TDS), has been developed...
  2. ncbi request reprint Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 27:225-37. 2005
    ..Growing evidence from clinical practice, in which much lower doses of buprenorphine are used, suggests that this conversion ratio may be too high...
  3. ncbi request reprint Transdermal buprenorphine in cancer pain and palliative care
    Reinhard Sittl
    Department of Anaesthesiology, Pain Therapy, University of Erlangen Nuremberg, Krankenhausstr 12, D 91054 Erlangen, Germany
    Palliat Med 20:s25-30. 2006
    ....
  4. ncbi request reprint Transdermal buprenorphine in the treatment of chronic pain
    Reinhard Sittl
    University of Erlangen, Pain Clinic, Krankenhausstr, 91054 Erlangen, Germany
    Expert Rev Neurother 5:315-23. 2005
    ..Most adverse events were either local reactions to the patch that generally subsided within 24 h or systemic events typical of treatment with opioid analgesics, such as nausea, vomiting and constipation...
  5. ncbi request reprint Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
    Wolfgang Koppert
    Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 118:15-22. 2005
    ..It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization...
  6. ncbi request reprint The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 108:148-53. 2004
    ..Thus, besides its well-known effects on inflamed peripheral tissues, inhibition of central COX provides an important mechanism of NSAID-mediated antihyperalgesia in humans...
  7. ncbi request reprint Effects of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentrations in chronic pain patients treated with transdermal buprenorphine
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Eur J Pain 10:743-8. 2006
    ..Furthermore, hemodialysis did not affect buprenorphine plasma levels, leading to stable analgesic effects during the therapy...
  8. ncbi request reprint Patterns of dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: a retrospective data analysis in Germany
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 28:1144-54. 2006
    ..However, no information concerning the relationship between qualitative and quantitative dose changes is available...
  9. ncbi request reprint Changes in the prescribed daily doses of transdermal fentanyl and transdermal buprenorphine during treatment of patients with cancer and noncancer pain in Germany: results of a retrospective cohort study
    Reinhard Sittl
    Pain Clinic, University of Erlangen, Erlangen, Germany
    Clin Ther 27:1022-31. 2005
    ....
  10. ncbi request reprint Long-term management of chronic pain with transdermal buprenorphine: a multicenter, open-label, follow-up study in patients from three short-term clinical trials
    Rudolf Likar
    Pain Clinic, General Hospital Klagenfurt, Klagenfurt, Austria, and Pain Clinic, University of Erlangen Nurnberg, Germany
    Clin Ther 28:943-52. 2006
    ..Long-term data are essential to determining the performance of an analgesic in the management of chronic pain...
  11. ncbi request reprint Transdermal buprenorphine in clinical practice--a post-marketing surveillance study in 13,179 patients
    Norbert Griessinger
    Department of Anaesthesiology, Pain Clinic, University of Erlangen Nuernberg, Erlangen, Germany
    Curr Med Res Opin 21:1147-56. 2005
    ..The objective of this post-marketing surveillance study was to collect effectiveness and safety data on the labelled use of buprenorphine transdermal patches (Transtec*) under routine clinical conditions...
  12. ncbi request reprint Intravenous morphine consumption in outpatients with cancer during their last week of life--an analysis based on patient-controlled analgesia data
    Christine Schiessl
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Support Care Cancer 16:917-23. 2008
    ..Mostly oral opioids were used. Due to the pharmacokinetic properties of opioids, it is rather difficult to get a reliable estimate of the true opioid need from those results...
  13. doi request reprint Long-term treatment of neuropathic pain with a 5% lidocaine medicated plaster
    Ilca Ricarda Wilhelm
    Department of Anaesthesiology, University Hospital Erlangen, Erlangen, Germany
    Eur J Anaesthesiol 27:169-73. 2010
    ..This study examined the efficacy and tolerability of long-term treatment with the 5% lidocaine medicated plaster in patients with localized neuropathic pain conditions...
  14. ncbi request reprint Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Erlangen, Germany
    Anesth Analg 98:1050-5, table of contents. 2004
    ....
  15. ncbi request reprint Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Clinic of Erlangen, Germany
    Anesthesiology 99:152-9. 2003
    ....
  16. ncbi request reprint Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 106:91-9. 2003
    ....
  17. doi request reprint Effectiveness of an intensive multidisciplinary headache treatment program
    Birgit Gunreben-Stempfle
    The Pain Center, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen D 91054, Germany
    Headache 49:990-1000. 2009
    ..To investigate if the effectiveness of a 96-hour multidisciplinary headache treatment program exceeds the effectiveness of a 20-hour program and primary care...
  18. ncbi request reprint The role of opioid analgesics in rheumatoid disease in the elderly population
    Norbert Griessinger
    Department of Anesthesiology, University Erlangen Nurnberg, Erlangen, Germany
    Drugs Aging 20:571-83. 2003
    ..This opens the way to new therapeutic options in the future through the development of systemic peripherally selective opioids without CNS adverse effects...
  19. doi request reprint Transdermal buprenorphine in chronic pain: indications and clinical experience
    Stefan Kusnik
    Pain Centre and Pain Outpatients Clinic, University Hospital of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany and Department of Pediatrics, University Hospital of Erlangen, Loschgestrasse 15, 91054 Erlangen, Germany
    Expert Rev Clin Pharmacol 1:729-36. 2008
    ..Most notably, it appears to be effective in treating hyperalgesic states and syndromes characterized by pronounced central sensitization. ..
  20. ncbi request reprint [Transdermal buprenorphine for treatment of chronic tumor and non-tumor pain]
    Rudolf Likar
    Landeskrankenhaus Klagenfurt, Abteilung für Anästhesiologie und Intensivmedizin, Schmerzambulanz, St Veiter Strasse 47, A 9020 Klagenfurt
    Wien Med Wochenschr 153:317-22. 2003
    ....
  21. ncbi request reprint Pharmacokinetic and pharmacodynamic properties of tramadol IR and SR in elderly patients: a prospective, age-group-controlled study
    Rudolf Likar
    Interdisciplinary Pain Clinic, General Hospital Klagen furt, Klagen furt, Austria
    Clin Ther 28:2022-39. 2006
    ..Although age-related differences in pharmacologic responsiveness are to be expected, the pharmacodynamic and pharmacokinetic (PK) properties of tramadol have not been systematically compared between patients of various ages...
  22. ncbi request reprint Transdermal buprenorphine patches applied in a 4-day regimen versus a 3-day regimen: a single-site, Phase III, randomized, open-label, crossover comparison
    Rudolf Likar
    Interdisciplinary Pain Clinic, General Hospital Klagenfurt, Klagenfurt, Austria
    Clin Ther 29:1591-606. 2007
    ..The primary recommendation contained in the prescribing information was that transdermal patches be worn for a 3-day period before application of a new patch...
  23. ncbi request reprint High doses of topically applied lidocaine in a cancer patient
    Ilca Ricarda Wilhelm
    J Pain Symptom Manage 30:203-4. 2005
  24. doi request reprint Use of patient-controlled analgesia for pain control in dying children
    Christine Schiessl
    Department of Palliative Medicine, University Hospital Cologne, Kerpener Strasse 62, 50924, Cologne, Germany
    Support Care Cancer 16:531-6. 2008
    ..In the last week of life, the daily opioid dose in children is highly variable, making the use of patient-controlled analgesia (PCA) a useful therapy option. Scientific data on the use of PCA in paediatric palliative care are rare...
  25. ncbi request reprint Transdermal buprenorphine in the treatment of chronic pain: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study
    Jürgen Sorge
    Department of Anesthesiology, Surgical Intensive Care and Pain Therapy, Peine District Hospital, Virchowstrasse 8h, 31221 Peine, Germany
    Clin Ther 26:1808-20. 2004
    ..In 2001, the buprenorphine transdermal delivery system (TES) was introduced at 3 release rates (35, 52.5, and 70 microg/h) for the treatment of chronic cancer and noncancer pain...
  26. ncbi request reprint Transdermal buprenorphine for treating nociceptive and neuropathic pain: four case studies
    Rudolf Likar
    Pain Clinic, General Hospital Klagenfurt, St Veither Strasse 47, 9026 Klagenfurt, Austria
    Anesth Analg 100:781-5, table of contents. 2005
    ..In each case, sufficient pain relief was obtained and no problems were encountered in switching from prior analgesic therapy with larger doses of other opioids...
  27. ncbi request reprint On the role of the kidneys in the pathogenesis of edema formation during permanent morphine application/an experimental study in rats
    Sabine Supanz
    Institute of Pathophysiology, Med University of Graz, Graz, Austria
    Arzneimittelforschung 54:259-64. 2004
    ..The histological examination of kidneys revealed no differences among the various groups. These data indicate a role of the kidney in the induction of peripheral edema during permanent morphine administration...