Matthias Simon

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Alternative splicing of the p15 cdk inhibitor in glioblastoma multiforme
    M Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Germany
    Acta Neuropathol 102:167-74. 2001
  2. pmc Interinstitutional variance of postoperative radiotherapy and follow up for meningiomas in Germany: impact of changes of the WHO classification
    M Simon
    Neurochirurgische Universitatsklinik, Sigmund Freud Str 25, 53105 Bonn
    J Neurol Neurosurg Psychiatry 77:767-73. 2006
  3. ncbi request reprint Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system
    Matthias Simon
    Neurochirurgische Klinik and Institut für Klinische Biochemie, Universitatskliniken Bonn, Germany
    J Neurosurg 104:945-9. 2006
  4. pmc Genetic risk profiles identify different molecular etiologies for glioma
    Matthias Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Bonn, Germany
    Clin Cancer Res 16:5252-9. 2010
  5. ncbi request reprint Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas
    Matthias Simon
    Neurochirurgische Universitatsklinik, D 53105 Bonn, Germany
    Oncol Rep 16:127-32. 2006
  6. ncbi request reprint Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme
    Matthias Simon
    Department of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosurgery 59:1078-85; discussion 1085. 2006
  7. doi request reprint Surgical management of intracranial gliomas
    Matthias Simon
    Department of Neurosurgery, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    Recent Results Cancer Res 171:105-24. 2009
  8. ncbi request reprint Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression
    Matthias Simon
    Neurochirurgische Klinik, Universitat Bonn, Germany
    J Neurooncol 60:1-12. 2002
  9. ncbi request reprint Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression
    M Simon
    Neurochirurgische Universitatsklinik, Bonn, Germany
    J Neurooncol 55:149-58. 2001
  10. doi request reprint Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms
    Alexander Semmler
    Department of Neurology, University of Bonn, Bonn, Germany
    Cerebrovasc Dis 26:425-9. 2008

Detail Information

Publications55

  1. ncbi request reprint Alternative splicing of the p15 cdk inhibitor in glioblastoma multiforme
    M Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Germany
    Acta Neuropathol 102:167-74. 2001
    ..This novel mechanism of loss of p15 might complement alterations of the INK4a tumor suppressor gene in some glioblastomas, resulting in combined loss of p16, p15 and p14ARF...
  2. pmc Interinstitutional variance of postoperative radiotherapy and follow up for meningiomas in Germany: impact of changes of the WHO classification
    M Simon
    Neurochirurgische Universitatsklinik, Sigmund Freud Str 25, 53105 Bonn
    J Neurol Neurosurg Psychiatry 77:767-73. 2006
    ..To document and critically analyse the impact of the revised WHO 2000 histological classification for meningiomas on postoperative radiotherapy/radiosurgery indications and MRI follow up protocols...
  3. ncbi request reprint Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system
    Matthias Simon
    Neurochirurgische Klinik and Institut für Klinische Biochemie, Universitatskliniken Bonn, Germany
    J Neurosurg 104:945-9. 2006
    ..The authors studied whether sequence variations in ACVRL1 or ENG are associated with the development of clinically sporadic arteriovenous dysplasias and aneurysms of the CNS...
  4. pmc Genetic risk profiles identify different molecular etiologies for glioma
    Matthias Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Bonn, Germany
    Clin Cancer Res 16:5252-9. 2010
    ..Because gliomas are heterogeneous in histology, molecular alterations, and clinical behavior, we have investigated these polymorphisms for potential correlations with tumor histology and patient survival...
  5. ncbi request reprint Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas
    Matthias Simon
    Neurochirurgische Universitatsklinik, D 53105 Bonn, Germany
    Oncol Rep 16:127-32. 2006
    ..We would like to point out that such candidate genes which may code for potent growth suppressors (like p16) or even toxic gene products can be successfully investigated using the approach detailed in this manuscript...
  6. ncbi request reprint Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme
    Matthias Simon
    Department of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosurgery 59:1078-85; discussion 1085. 2006
    ..Patients with LFS experience a variety of cancers, including malignant astrocytomas. We investigated a potential role for a CHEK2 gene polymorphism in glioblastomas...
  7. doi request reprint Surgical management of intracranial gliomas
    Matthias Simon
    Department of Neurosurgery, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    Recent Results Cancer Res 171:105-24. 2009
    ..There will be an increasing pressure on neurosurgeons to justify the costs involved by showing that patients will actually benefit from complex treatments in highly specialized centers...
  8. ncbi request reprint Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression
    Matthias Simon
    Neurochirurgische Klinik, Universitat Bonn, Germany
    J Neurooncol 60:1-12. 2002
    ..Loss of pRB following p16 expression might severely limit the potential benefit of p16 gene therapy for glioblastoma...
  9. ncbi request reprint Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression
    M Simon
    Neurochirurgische Universitatsklinik, Bonn, Germany
    J Neurooncol 55:149-58. 2001
    ..Inactivation of p16/p15- and pl4ARF-dependent pathways possibly in conjunction with telomerase activation might be critical steps for a meningioma cell towards escape from senescence, that is, immortalization...
  10. doi request reprint Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms
    Alexander Semmler
    Department of Neurology, University of Bonn, Bonn, Germany
    Cerebrovasc Dis 26:425-9. 2008
    ..We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms...
  11. doi request reprint Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Delia Kurzwelly
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    J Neurooncol 100:187-92. 2010
    ..Our results suggest the hypothesis that folate and methionine metabolism is relevant to susceptibility to PCNSL...
  12. doi request reprint Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas
    Tim Muller
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Am J Pathol 181:675-83. 2012
    ..0122). Our data suggest that the loss of 5hmC is a frequent event in gliomas, independent of IDH1 mutation, and may be influenced by the nuclear exclusion of TET1 from the nuclei of glioma cells...
  13. doi request reprint NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri
    Martin Glas
    Division of Clinical Neuro oncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
    Ann Neurol 70:445-53. 2011
    ....
  14. pmc The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 10:548-52. 2008
    ..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients...
  15. doi request reprint Insular gliomas: the case for surgical management
    Matthias Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Klinikum rechts der Isar, Munchen, Germany
    J Neurosurg 110:685-95. 2009
    ..Treatment for insular (paralimbic) gliomas is controversial. In this report the authors summarize their experience with microsurgical resection of insular tumors...
  16. doi request reprint Tumor recurrence and malignant progression of gangliogliomas
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Cancer 113:3355-63. 2008
    ..Most gangliogliomas (GGs) are benign tumors, but tumor recurrence and malignant progression are observed in some patients...
  17. ncbi request reprint Combined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade III
    Rudolf A Kristof
    Department of Neurosurgery, University of Bonn, Germany
    J Neurooncol 59:231-7. 2002
    ..This is in accordance with results in patients treated by surgery with adjuvant radiation alone. The efficacy of additional adjuvant PCV chemotherapy in prolonging TTP and TTD has to be verified in prospective controlled studies...
  18. pmc Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 11:2-8. 2009
    ..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies...
  19. doi request reprint Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation
    Wolfgang Wick
    From the Departments of Neuro oncology W W, M P, A s, B W, M Weiler and Neuropathology A v D, University of Heidelberg German Cancer Consortium DKTK W W, B W, M Weiler, Clinical Cooperation Unit Neuro oncology and Clinical Cooperation Unit Neuropathology A v D, German Cancer Research Center, Heidelberg Department of Medical Biometry C M, University of Tübingen Institute for Medical Informatics, Statistics and Epidemiology B H, M L, University Leipzig Departments of Neurosurgery M C S and Neuropathology G R, Heinrich Heine University and DKTK G R, Düsseldorf Department of Neurology S K, University of Essen Medical School Department of Neurosurgery R K, Saarland University, Homburg, Germany Department of Neurology G T, D G, M Weller, University Hospital Zurich, Switzerland Department of Neurosurgery M Westphal, University Clinic Hamburg Eppendorf, Hamburg Department of Neurosurgery G S and DKTK G S, Technical University Dresden and Department of Neurosurgery M S, University of Bonn, Germany
    Neurology 81:1515-22. 2013
    ....
  20. doi request reprint Surgery for spinal cord ependymomas: outcome and prognostic factors
    Azize Boström
    Department of Neurosurgery University Hospital Bonn Medical Center, Bonn, Germany
    Neurosurgery 68:302-8; discussion 309. 2011
    ..Spinal cord tumors account for 5% to 10% of all primary central nervous system tumors. The most common intramedullary neoplasms are ependymomas, composing 50% to 60% of spinal neuroepithelial tumors in adults...
  21. doi request reprint Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation
    Achim Temme
    Department of Neurosurgery, Section Experimental Neurosurgery Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neuropathol Exp Neurol 69:632-42. 2010
    ..These results suggest that loss of p53 function and dysregulated Aurora B protein levels might represent factors that drive the development of multinucleated cells in gcGB...
  22. doi request reprint Phenotypical analysis, relation to malignancy and prognostic relevance of ICOS+T regulatory and dendritic cells in patients with gliomas
    Konstantinos Gousias
    Department of Neurosurgery, University Hospital of Bonn, Sigmund Freud Strasse 25, 53105, Germany Electronic address
    J Neuroimmunol 264:84-90. 2013
    ..Higher CD4+ cell counts (≥225 cells/μl, median) were associated with improved survival in glioblastomas...
  23. pmc RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas
    Anna von dem Knesebeck
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Neoplasia 14:526-34. 2012
    ..We conclude that RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas...
  24. doi request reprint uPA/PAI-1 expression and uPA promoter methylation in meningiomas
    Julia Annabel Kandenwein
    Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    J Neurooncol 103:533-9. 2011
    ..Our data suggest PAI-1 (and possibly to a lesser degree uPA) as potential prognostic markers in meningiomas. uPA expression in meningiomas might, in part, be controlled by promoter methylation...
  25. pmc End-of-life caregivers' perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey
    Oliver Heese
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 15:1251-6. 2013
    ..To obtain information about this period, we surveyed caregivers of patients who were registered in the German Glioma Network and who died from the disease...
  26. doi request reprint Unusual clinico-pathological features in primary Hodgkin's lymphomas of the central nervous system
    Marco Gessi
    Institute of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Acta Neurochir (Wien) 155:19-24. 2013
    ..The third case occurred as a temporal lesion in the settings of a Richter transformation of a chronic lymphocytic leukemia...
  27. doi request reprint Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro
    Céline Lugnier
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuropathol Exp Neurol 68:1136-46. 2009
    ..Future studies will be needed to characterize the roles of these TSC1 sequence variants in the genesis of dysplastic epileptogenic developmental brain lesions...
  28. doi request reprint Surgical treatment of choroid plexus tumors
    Azize Boström
    Department of Neurosurgery, University Hospital of Bonn Medical Center, Germany
    Acta Neurochir (Wien) 153:371-6. 2011
    ..The purpose of this study is to evaluate the results of microsurgical treatment for choroid plexus tumors (CPT) in adult patients...
  29. ncbi request reprint Frequent recurrence and progression in pilocytic astrocytoma in adults
    Carsten Stuer
    Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany
    Cancer 110:2799-808. 2007
    ..To the authors' knowledge, the literature contains only scarce data regarding piloA in adults...
  30. ncbi request reprint Long-term survival with glioblastoma multiforme
    Dietmar Krex
    Department of Neurosurgery, Carl Gustav Carus University Hospital, University of Technology, Dresden, Germany
    Brain 130:2596-606. 2007
    ....
  31. ncbi request reprint The diagnostic utility of human papillomavirus-testing in combination with immunohistochemistry in advanced gynaecologic pelvic tumours: a new diagnostic approach
    Tjoung Won Park
    Departmetn of Obstetrics and Gynaecology, University of Bonn, D 53105 Bonn, Germany
    Int J Oncol 24:829-36. 2004
    ..The proposed diagnostic approach is helpful in the identification and management of pelvic tumours of unknown primary origin...
  32. doi request reprint Residual tumor cells are unique cellular targets in glioblastoma
    Martin Glas
    Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Germany
    Ann Neurol 68:264-9. 2010
    ..Our findings suggest a need for characterization of residual tumor cells to optimize diagnosis and treatment of GBM...
  33. ncbi request reprint Low-grade gliomas -- current concepts
    J Schramm
    Department of Neurosurgery, University of Bonn, Bonn, Germany
    Zentralbl Neurochir 67:55-66. 2006
    ..e., classification and neuropathology, MR imaging, stereotactic biopsy, microsurgery, interstitial radiotherapy/brachytherapy, radiotherapy, wait and see strategy)...
  34. ncbi request reprint Stroke prevention during surgery for deep-seated gliomas
    G Neuloh
    Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
    Neurophysiol Clin 37:383-9. 2007
    ..This study determines the feasibility and clinical utility of MEP monitoring for ischemic complication avoidance during surgery for deep-seated, specifically insular gliomas...
  35. ncbi request reprint Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression
    M Simon
    Neurochirurgische Universitätsklinik und Neuropathologisches Institut der Universität, Bonn, Germany
    J Neurosurg 92:832-40. 2000
    ..The authors have investigated a series of benign, atypical, and anaplastic/malignant meningiomas for telomerase activity and expression of the telomerase catalytic subunit human telomerase reverse transcriptase (hTERT)...
  36. ncbi request reprint Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas
    M Simon
    Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Acta Neuropathol 98:444-52. 1999
    ..Therefore, homozygous co-deletions of CDKN2A and CDKN2B rather than mutations targeting individual transcripts are frequently selected for in these tumors...
  37. doi request reprint Evaluation of an institutional guideline for the treatment of cerebrospinal fluid shunt-associated infections
    Christian von der Brelie
    Department of Neurosurgery, University Hospital Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Acta Neurochir (Wien) 154:1691-7. 2012
    ..Cerebrospinal fluid (CSF) shunt-associated infection is one of the most frequent complications of CSF shunt surgery. We evaluated our institutional guideline for the treatment of shunt-associated infections...
  38. ncbi request reprint The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse, 25, 53105 Bonn, Germany
    Cancer Epidemiol Biomarkers Prev 15:2314-6. 2006
    ..72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed...
  39. doi request reprint Extent of resection and survival in supratentorial infiltrative low-grade gliomas: analysis of and adjustment for treatment bias
    Konstantinos Gousias
    Department of Neurosurgery, University Hospital of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Acta Neurochir (Wien) 156:327-37. 2014
    ..The present study investigates the potential impact of this type of treatment bias on survival in a series of patients with low-grade gliomas treated at the authors' institution...
  40. doi request reprint Surgical management of intracranial subependymomas
    Julia Annabel Kandenwein
    Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Acta Neurochir (Wien) 153:1469-75. 2011
    ..Intracranial subependymomas are rare, slow-growing and usually non-invasive tumors. The aim of this study was to analyze our experience with the surgical treatment of intracranial subependymomas...
  41. doi request reprint Computer-based assessment of cognitive functions in brain tumor patients
    Klaus Fliessbach
    Department of Epileptology, University of Bonn, Bonn, Germany
    J Neurooncol 100:427-37. 2010
    ..It can be carried out within a short period of time by non-academic personnel and is therefore applicable to large cohorts, e.g., within clinical trials...
  42. ncbi request reprint Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation-induced human meningiomas
    T Joachim
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 94:218-21. 2001
    ..Our data suggest that, while there is a certain overlap in the mutational spectrum, NF2 mutations may not play such a prominent role in the pathogenesis of radiation-induced compared to sporadic meningiomas...
  43. doi request reprint Anticancer effects of niclosamide in human glioblastoma
    Anja Wieland
    Stem Cell Pathologies, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn Medical Center, Bonn, Germany
    Clin Cancer Res 19:4124-36. 2013
    ..Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need...
  44. doi request reprint Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
    Martin Glas
    Stem Cell Pathologies, University of Bonn Medical Center, Bonn, Germany
    Stem Cells 31:1064-74. 2013
    ....
  45. doi request reprint Richter syndrome and brain involvement: low-grade lymphoma relapsing as cerebral high-grade lymphoma
    Moritz Stuplich
    Department of Neurology, Division of Clinical Neurooncology, University of Bonn Medical Center, Germany
    Acta Haematol 127:93-5. 2012
    ..This report extends the literature of central nervous system RS and particularly highlights the importance of a thorough diagnostic evaluation of patients with low-grade NHL presenting with neurological symptoms...
  46. ncbi request reprint Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105, Bonn, Germany
    Acta Neuropathol 112:715-25. 2006
    ..Future studies need to determine the origin of insulin pathway activation upstream of TSC1/TSC2 in FCD(IIb)...
  47. ncbi request reprint Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions
    V Schick
    Department of Neuropathology, University of Bonn Medical Centre, Bonn, Germany
    Neuropathol Appl Neurobiol 33:152-62. 2007
    ..However, a potential functional significance of lower expression for the cell-size and cell-cycle regulators CDK1 and cyclinA2 in FCD(IIb) composed of large dysplastic neurones and balloon cells needs to be further resolved...
  48. ncbi request reprint Seizures in patients with low-grade gliomas--incidence, pathogenesis, surgical management, and pharmacotherapy
    D Kurzwelly
    Schwerpunkt Klinische Neuroonkologie, Neurologische Klinik, Universitatskliniken Bonn, Bonn, Germany
    Adv Tech Stand Neurosurg 35:81-111. 2010
    ..Overall 60-70% of patients may experience recurrent epilepsy during long-term follow-up. Recurrent seizures (not infrequently heralding tumor recurrence) after surgery continue to pose significant clinical problems...
  49. doi request reprint Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation
    Alexander Semmler
    Department of Neurology, University Hospital of Bonn, Germany
    J Neurosurg 108:999-1004. 2008
    ..The authors investigated the association of 7 functional polymorphisms of methionine metabolism with meningioma formation...
  50. ncbi request reprint Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
    Michael Weller
    Department of General Neurology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 13:6933-7. 2007
    ..Importantly, the possible effect of combined 1p/19q loss has not been studied in patients who were not treated with radiotherapy or chemotherapy...
  51. ncbi request reprint NF2 mutations in secretory and other rare variants of meningiomas
    Christian Hartmann
    Department of Neuropathology, Charite, Universitatsmedizin Berlin, Germany
    Brain Pathol 16:15-9. 2006
    ..In the control group of 25 fibroblastic meningiomas, 11 cases were identified to carry an NF2 mutation. These results support the concept of different molecular subgroups of meningiomas which overlap with histological variants...
  52. ncbi request reprint Diagnostic and molecular pathology of meningiomas
    Christian Hartmann
    Institut für Neuropathologie der Charité, Augustenburger Platz 1, 13353 Berlin, Germany
    Expert Rev Neurother 6:1671-83. 2006
    ..Implementing these advances in our daily clinical routine holds the promise of improving diagnostic accuracy...
  53. doi request reprint Comprehensive characterization of genomic aberrations in gangliogliomas by CGH, array-based CGH and interphase FISH
    Alexander Hoischen
    Department of Human Genetics, Rheinische Friedrich Wilhelms University of Zürich, Zurich, Switerland
    Brain Pathol 18:326-37. 2008
    ..In summary, genomic profiling in a large series of gangliogliomas could distinguish genetic subgroups even in this low-grade tumor...
  54. ncbi request reprint Fine mapping of chromosome 22q tumor suppressor gene candidate regions in astrocytoma
    Christian Hartmann
    Department of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburgerplatz 1, D 13353 Berlin, Germany
    Int J Cancer 108:839-44. 2004
    ..We already performed mutation analysis on 4 candidate genes from these regions (MYO18B, DJ1042K10.2, MKL1 and EP300), but did not find any mutations in astrocytic tumors...
  55. ncbi request reprint Molecular genetics of meningiomas: from basic research to potential clinical applications
    Matthias Simon
    Neurosurgery 60:787-98; discussion 787-98. 2007
    ....