T Siessmeier

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Parametric mapping of binding in human brain of D2 receptor ligands of different affinities
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Nucl Med 46:964-72. 2005
  2. pmc Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome
    T Siessmeier
    Department of Nuclear Medicine, Johannes Gutenberg University, Mainz, Germany
    J Neurol Neurosurg Psychiatry 74:922-8. 2003
  3. ncbi request reprint [18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors
    G Grunder
    Department of Psychiatry, University of Mainz, Germany
    Eur J Nucl Med 28:1463-70. 2001
  4. ncbi request reprint The unpleasantness of tonic pain is encoded by the insular cortex
    M Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Neurology 64:1175-83. 2005
  5. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
  6. ncbi request reprint High opiate receptor binding potential in the human lateral pain system
    Ulf Baumgartner
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr 21 D 55099 Mainz, Germany
    Neuroimage 30:692-9. 2006
  7. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
  8. ncbi request reprint Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Germany
    Eur J Neurosci 24:305-13. 2006
  9. ncbi request reprint 18F-labeling of peptides by means of an organosilicon-based fluoride acceptor
    Ralf Schirrmacher
    Klinik und Poliklinik fur Nuklearmedizin, Johannes Gutenberg Universitat Mainz, 55131 Mainz, Germany
    Angew Chem Int Ed Engl 45:6047-50. 2006
  10. ncbi request reprint Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study
    Konrad J Werhahn
    Department of Neurology, Johannes Gutenberg University, Rhineland Palatinate, Germany
    Epilepsia 47:1392-6. 2006

Detail Information

Publications27

  1. ncbi request reprint Parametric mapping of binding in human brain of D2 receptor ligands of different affinities
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Nucl Med 46:964-72. 2005
    ..However, the in vivo kinetics of these compounds and the quantification approaches for parametric mapping of their specific bindings have not been systematically compared...
  2. pmc Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome
    T Siessmeier
    Department of Nuclear Medicine, Johannes Gutenberg University, Mainz, Germany
    J Neurol Neurosurg Psychiatry 74:922-8. 2003
    ....
  3. ncbi request reprint [18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors
    G Grunder
    Department of Psychiatry, University of Mainz, Germany
    Eur J Nucl Med 28:1463-70. 2001
    ....
  4. ncbi request reprint The unpleasantness of tonic pain is encoded by the insular cortex
    M Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Neurology 64:1175-83. 2005
    ..This study was conducted to identify the brain regions associated with the affective-motivational component of tonic skin and muscle pain...
  5. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
    ..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding...
  6. ncbi request reprint High opiate receptor binding potential in the human lateral pain system
    Ulf Baumgartner
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr 21 D 55099 Mainz, Germany
    Neuroimage 30:692-9. 2006
    ....
  7. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
    ..The stimulation of DDC cannot be excluded due to insufficient statistical power in the estimation of k3(D) changes...
  8. ncbi request reprint Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Germany
    Eur J Neurosci 24:305-13. 2006
    ....
  9. ncbi request reprint 18F-labeling of peptides by means of an organosilicon-based fluoride acceptor
    Ralf Schirrmacher
    Klinik und Poliklinik fur Nuklearmedizin, Johannes Gutenberg Universitat Mainz, 55131 Mainz, Germany
    Angew Chem Int Ed Engl 45:6047-50. 2006
  10. ncbi request reprint Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study
    Konrad J Werhahn
    Department of Neurology, Johannes Gutenberg University, Rhineland Palatinate, Germany
    Epilepsia 47:1392-6. 2006
    ..Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing...
  11. ncbi request reprint 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Hum Brain Mapp 28:931-9. 2007
    ..005; putamen: -0.870, P < 0. 001). Thus, the present findings reveal a strong correlation between dopamine synthesis capacity in striatum of healthy volunteers and performance of cognitive tasks linked to the prefrontal cortex...
  12. ncbi request reprint Asymmetry in dopamine D(2/3) receptors of caudate nucleus is lost with age
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 34:870-8. 2007
    ..Because ventral striatal dopamine neurotransmission is involved in cognitive processes, this loss of physiological asymmetry in NC dopamine transmission during aging might be involved in age-related declines of cognitive performance...
  13. ncbi request reprint Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 27:8080-7. 2007
    ....
  14. ncbi request reprint Validating the DemTect with 18-fluoro-2-deoxy-glucose positron emission tomography as a sensitive neuropsychological screening test for early alzheimer disease in patients of a memory clinic
    Armin Scheurich
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 20:271-7. 2005
    ..The first study to validate the diagnostic value of the DemTect, a short neuropsychological screening test for dementia (8-10 min), using 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) in patients of a memory clinic...
  15. ncbi request reprint Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients
    Andreas Heinz
    Central Institute of Mental Health, Mannheim, Germany
    Am J Psychiatry 162:1515-20. 2005
    ..In this study, positron emission tomography (PET) was used to compare dopamine synthesis capacity in the striatum in alcoholic patients and healthy comparison subjects...
  16. ncbi request reprint Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Nucl Med 44:109-16. 2003
    ..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers...
  17. ncbi request reprint Persistence of disturbed thalamic glucose metabolism in a case of Wernicke-Korsakoff syndrome
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Psychiatry Res 124:105-12. 2003
    ..1% (anterior cingulate, left) and 23.5% (parietal, left) in cortical areas during a 9-month remission period, thalamic glucose metabolism remained severely disturbed over time (change: left +0.2%, right +0.3%)...
  18. ncbi request reprint Increased cerebellar PET glucose metabolism corresponds to ataxia in Wernicke-Korsakoff syndrome
    Andreas Fellgiebel
    Departments of Psychiatry and Nuclear Medicine, University Hospital of Mainz, Mainz, Germany
    Alcohol Alcohol 39:150-3. 2004
    ..To investigate a possible relationship between cerebellar glucose metabolism and recovery from ataxia in the first months of acute Wernicke-Korsakoff syndrome...
  19. ncbi request reprint The dopamine D2 receptor ligand 18F-desmethoxyfallypride: an appropriate fluorinated PET tracer for the differential diagnosis of parkinsonism
    Mathias Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, 55101, Mainz, Germany
    Eur J Nucl Med Mol Imaging 31:1128-35. 2004
    ..Based on these first clinical results, we consider 18F-DMFP to be an appropriate PET tracer for the differential diagnosis of parkinsonian syndromes, with the advantage of better clinical availability than 11C-labelled D2 radioligands...
  20. ncbi request reprint Acute alcohol effects on neuronal and attentional processing: striatal reward system and inhibitory sensory interactions under acute ethanol challenge
    Mathias Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Neuropsychopharmacology 29:1527-37. 2004
    ..Modality specific reciprocal inhibition of sensory cortex activity seems to be relevant for attentional performance during acute alcohol impact...
  21. ncbi request reprint The thalamus as the generator and modulator of EEG alpha rhythm: a combined PET/EEG study with lorazepam challenge in humans
    Mathias Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Neuroimage 22:637-44. 2004
    ..Purpose of this study was to investigate the functional relationship between electroencephalographic (EEG) alpha power and cerebral glucose metabolism before and after pharmacological alpha suppression by lorazepam...
  22. ncbi request reprint Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Biol Psychiatry 56:279-83. 2004
    ....
  23. ncbi request reprint Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving
    Andreas Heinz
    Department of Psychiatry, Charite, Campus Mitte, Berlin, Germany
    Am J Psychiatry 161:1783-9. 2004
    ..Prolonged D(2) receptor dysfunction in the ventral striatum may interfere with a dopamine-dependent error detection signal and bias the brain reward system toward excessive attribution of incentive salience to alcohol-associated stimuli...
  24. ncbi request reprint High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
    Ingo Vernaleken
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Int J Neuropsychopharmacol 7:421-30. 2004
    ..However, our data show high striatal D2-like receptor occupancies under rising plasma concentrations. Using the full range of recommended amisulpride dosage, striatal occupancies up to 90% can be measured...
  25. doi request reprint Baseline [18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 40:1222-31. 2008
    ..We hypothesize that these effects may be driven by D(1)-receptor mediated transmission during D(2) blockade...
  26. ncbi request reprint Reduced cerebral fluoro-L-dopamine uptake in adult patients suffering from phenylketonuria
    Christian Landvogt
    Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    J Cereb Blood Flow Metab 28:824-31. 2008
    ..The linear graphical analysis shows reduced k3S in striatum, indicating reduced DOPA decarboxylase activity...
  27. doi request reprint Ratio of dopamine synthesis capacity to D2 receptor availability in ventral striatum correlates with central processing of affective stimuli
    Thorsten Kienast
    Department of Psychiatry and Psychotherapy of the Charité University Medical Center, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Eur J Nucl Med Mol Imaging 35:1147-58. 2008
    ..We investigated the dopaminergic neurotransmission in the ventral and dorsal striatum with respect to central processing of affective stimuli in healthy subjects...