B Siebers

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi Carbohydrate metabolism in Thermoproteus tenax: in vivo utilization of the non-phosphorylative Entner-Doudoroff pathway and characterization of its first enzyme, glucose dehydrogenase
    B Siebers
    FB 9 Mikrobiologie, Universität GH Essen, Universitatsstrasse 5, D 45117 Essen, Germany
    Arch Microbiol 168:120-7. 1997
  2. ncbi Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax by use of genomic and biochemical data
    Bettina Siebers
    Department of Microbiology, Universitat Duisburg Essen, 45117 Essen, Germany
    J Bacteriol 186:2179-94. 2004
  3. ncbi Archaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type class I aldolase
    B Siebers
    Department of Microbiology, Universitat Essen, 45117 Essen, Germany
    J Biol Chem 276:28710-8. 2001
  4. ncbi PPi-dependent phosphofructokinase from Thermoproteus tenax, an archaeal descendant of an ancient line in phosphofructokinase evolution
    B Siebers
    FB 9 Mikrobiologie, Universität GH Essen, Germany
    J Bacteriol 180:2137-43. 1998
  5. ncbi Pyruvate kinase of the hyperthermophilic crenarchaeote Thermoproteus tenax: physiological role and phylogenetic aspects
    A Schramm
    Department of Microbiology, Universität GH Essen, D 45117 Essen, Germany
    J Bacteriol 182:2001-9. 2000
  6. ncbi NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties
    N A Brunner
    Department of Microbiology, FB 9, Universit t GH Essen, Universit tsstrasse 5, 45117 Essen, Germany
    J Biol Chem 273:6149-56. 1998
  7. ncbi Embden-Meyerhof-Parnas and Entner-Doudoroff pathways in Thermoproteus tenax: metabolic parallelism or specific adaptation?
    H Ahmed
    Department of Microbiology, University of Duisburg Essen, Universitatsstrasse 5, 45117 Essen, Germany
    Biochem Soc Trans 32:303-4. 2004
  8. ncbi Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level
    N A Brunner
    Department of Microbiology, Universität GH Essen, Germany
    Extremophiles 5:101-9. 2001
  9. ncbi Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes
    Daniel Kehrer
    Department of Biology and Geography, Institute of Biology, Microbiology I, Universitat Duisburg Essen, Universitatsstr, 5, 45117 Essen, Germany
    BMC Genomics 8:301. 2007
  10. ncbi DNA microarray analysis of central carbohydrate metabolism: glycolytic/gluconeogenic carbon switch in the hyperthermophilic crenarchaeum Thermoproteus tenax
    Melanie Zaparty
    Department of Biology and Geography, Institute of Biology, Microbiology I, University of Duisburg Essen, Universitätsstr 5, 45117 Essen, Germany
    J Bacteriol 190:2231-8. 2008

Collaborators

Detail Information

Publications21

  1. ncbi Carbohydrate metabolism in Thermoproteus tenax: in vivo utilization of the non-phosphorylative Entner-Doudoroff pathway and characterization of its first enzyme, glucose dehydrogenase
    B Siebers
    FB 9 Mikrobiologie, Universität GH Essen, Universitatsstrasse 5, D 45117 Essen, Germany
    Arch Microbiol 168:120-7. 1997
    ....
  2. ncbi Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax by use of genomic and biochemical data
    Bettina Siebers
    Department of Microbiology, Universitat Duisburg Essen, 45117 Essen, Germany
    J Bacteriol 186:2179-94. 2004
    ..Almost all genes necessary for glycogen and trehalose metabolism were identified in the T. tenax genome...
  3. ncbi Archaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type class I aldolase
    B Siebers
    Department of Microbiology, Universitat Essen, 45117 Essen, Germany
    J Biol Chem 276:28710-8. 2001
    ..Because this new family shows no significant sequence similarity to classical Class I and II enzymes, a new name is proposed, archaeal type Class I FBP aldolases (FBP aldolase Class IA)...
  4. ncbi PPi-dependent phosphofructokinase from Thermoproteus tenax, an archaeal descendant of an ancient line in phosphofructokinase evolution
    B Siebers
    FB 9 Mikrobiologie, Universität GH Essen, Germany
    J Bacteriol 180:2137-43. 1998
    ..tenax and Amycolatopsis methanolica and the ATP-PFK from Streptomyces coelicolor. Comparative analyses of the pattern of conserved active-site residues strongly suggest that the group III PFKs originally bound PPi as a cosubstrate...
  5. ncbi Pyruvate kinase of the hyperthermophilic crenarchaeote Thermoproteus tenax: physiological role and phylogenetic aspects
    A Schramm
    Department of Microbiology, Universität GH Essen, D 45117 Essen, Germany
    J Bacteriol 182:2001-9. 2000
    ....
  6. ncbi NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties
    N A Brunner
    Department of Microbiology, FB 9, Universit t GH Essen, Universit tsstrasse 5, 45117 Essen, Germany
    J Biol Chem 273:6149-56. 1998
    ..tenax. Its regulatory properties substitute for those lacking in the reversible nonregulated pyrophosphate-dependent phosphofructokinase in this variant of the Embden-Meyerhof-Parnas pathway...
  7. ncbi Embden-Meyerhof-Parnas and Entner-Doudoroff pathways in Thermoproteus tenax: metabolic parallelism or specific adaptation?
    H Ahmed
    Department of Microbiology, University of Duisburg Essen, Universitatsstrasse 5, 45117 Essen, Germany
    Biochem Soc Trans 32:303-4. 2004
    ..An overview of the three different pathways is presented and the physiological function of the variants is discussed...
  8. ncbi Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level
    N A Brunner
    Department of Microbiology, Universität GH Essen, Germany
    Extremophiles 5:101-9. 2001
    ..The different regulation of the two counteracting glyceraldehyde-3-phosphate dehydrogenases is discussed with respect to the flux control of the T. tenax-specific EMP variant...
  9. ncbi Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes
    Daniel Kehrer
    Department of Biology and Geography, Institute of Biology, Microbiology I, Universitat Duisburg Essen, Universitatsstr, 5, 45117 Essen, Germany
    BMC Genomics 8:301. 2007
    ..In the T. tenax genome, a gene homolog with similarity to putative hydroxypyruvate reductase/glycerate dehydrogenase and glycerate kinase was identified...
  10. ncbi DNA microarray analysis of central carbohydrate metabolism: glycolytic/gluconeogenic carbon switch in the hyperthermophilic crenarchaeum Thermoproteus tenax
    Melanie Zaparty
    Department of Biology and Geography, Institute of Biology, Microbiology I, University of Duisburg Essen, Universitätsstr 5, 45117 Essen, Germany
    J Bacteriol 190:2231-8. 2008
    ..A transcriptional analysis comparing heterotrophic growth on glucose versus autotrophic growth on CO2-H2 was performed...
  11. ncbi Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax
    Anuschka Pauluhn
    Swiss Light Source, Paul Scherrer Institut, CH 5232 Villigen PSI, Switzerland
    Proteins 72:35-43. 2008
    ....
  12. ncbi A novel trehalose synthesizing pathway in the hyperthermophilic Crenarchaeon Thermoproteus tenax: the unidirectional TreT pathway
    Theresa Kouril
    Department of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg Essen, Lotharstr, MF Building, 47057 Duisburg, Germany
    Arch Microbiol 190:355-69. 2008
    ..Here we present a new pathway exclusively involved in trehalose synthesis--the unidirectional TreT pathway--and discuss its physiological role as well as its phylogenetic distribution...
  13. ncbi CC1, a novel crenarchaeal DNA binding protein
    Xiao Luo
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Bacteriol 189:403-9. 2007
    ..tenax. This protein binds single- and double-stranded DNAs with similar affinities. These properties are consistent with a role for CC1 as a crenarchaeal chromatin protein...
  14. ncbi Unusual pathways and enzymes of central carbohydrate metabolism in Archaea
    Bettina Siebers
    , Campus Essen, FB Biologie und Geografie, Mikrobiologie, , D-45117 Essen, Germany
    Curr Opin Microbiol 8:695-705. 2005
    ..Recent major advances in deciphering the complexity of archaeal central carbohydrate metabolism were gained by combination of classical biochemical and genomic-based approaches...
  15. ncbi Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates
    Esben Lorentzen
    European Molecular Biology Laboratory, Hamburg Outstation, Germany
    Biochemistry 44:4222-9. 2005
    ..The structure thus allows for the first time the catalytic mechanism of ring opening to be unraveled...
  16. ncbi Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins
    Esben Lorentzen
    European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, D 22603 Hamburg, Germany
    J Biol Chem 278:47253-60. 2003
    ..Structural comparisons, furthermore, establish an evolutionary link to the triosephosphate isomerases, a superfamily hitherto considered independent from the superfamily of aldolases...
  17. ncbi The hexokinase of the hyperthermophile Thermoproteus tenax. ATP-dependent hexokinases and ADP-dependent glucokinases, teo alternatives for glucose phosphorylation in Archaea
    Christine Dörr
    Department of Microbiology, Universitat Duisburg Essen, Essen 45117, Germany
    J Biol Chem 278:18744-53. 2003
    ..The distribution of the two types of sugar kinases, differing in their cosubstrate as well as substrate specificity, within Archaea is discussed on the basis of physiological constraints of the respective organisms...
  18. ncbi The central carbohydrate metabolism of the hyperthermophilic crenarchaeote Thermoproteus tenax: pathways and insights into their regulation
    Melanie Zaparty
    Department of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg Essen, Lotharstrasse, 47057 Duisburg, Germany
    Arch Microbiol 190:231-45. 2008
    ..The CCM pathways in T. tenax and the current understanding of their regulation are presented...
  19. ncbi Phosphoenolpyruvate synthetase and pyruvate, phosphate dikinase of Thermoproteus tenax: key pieces in the puzzle of archaeal carbohydrate metabolism
    Britta Tjaden
    Department of Microbiology, Universitat Duisburg Essen, 45117 Essen, Germany
    Mol Microbiol 60:287-98. 2006
    ..Comparative genomic analyses indicate the coexistence of PEPS, PPDK and PK in other Archaea as well, suggesting a similar regulation of the carbohydrate metabolism in these organisms...
  20. ncbi The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) of Sulfolobus solfataricus: a key-enzyme of the semi-phosphorylative branch of the Entner-Doudoroff pathway
    Thijs J G Ettema
    Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvagen 18C, 752 36 Uppsala, Sweden
    Extremophiles 12:75-88. 2008
    ..This work suggests an important role of GAPN in the regulation of carbon degradation via modifications of the EMP and the branched ED pathway in hyperthermophilic Archaea...
  21. ncbi The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation
    Hatim Ahmed
    Department of Microbiology, University Duisburg Essen, Campus Essen, Universitätsstr 5, 45117 Essen, Germany
    Biochem J 390:529-40. 2005
    ..tenax and S. solfataricus. The existence of this branched ED pathway is yet another example of the versatility and flexibility of the central carbohydrate metabolic pathways in the archaeal domain...