Helmut K Seitz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Alcohol metabolism and cancer risk
    Helmut K Seitz
    Center ofA lcohol Research, Liver Disease and Nutrition, Salem Medical Center, University ofHeidelberg, Heidelberg, Germany
    Alcohol Res Health 30:38-41, 44-7. 2007
  2. ncbi request reprint The relationship between alcohol metabolism, estrogen levels, and breast cancer risk
    Helmut K Seitz
    Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Germany
    Alcohol Res Health 30:42-3. 2007
  3. doi request reprint The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis
    Helmut K Seitz
    Centre of Alcohol Research, University of Heidelberg, Heidelberg, Germany
    Subcell Biochem 67:131-43. 2013
  4. pmc Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Genes Nutr 5:121-8. 2010
  5. doi request reprint Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012
    Helmut K Seitz
    Centre of Alcohol Research, University of Heidelberg, Germany
    Alcohol Alcohol 47:204-12. 2012
  6. ncbi request reprint Alcoholic liver disease in the elderly
    Helmut K Seitz
    Department of Medicine and Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, D 69121 Heidelberg, Germany
    Clin Geriatr Med 23:905-21, viii. 2007
  7. ncbi request reprint Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics
    Helmut K Seitz
    Laboratory of Alcohol Research, Liver Disease and Nutrition and Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Int J Cancer 108:483-7. 2004
  8. ncbi request reprint Molecular mechanisms of alcohol-mediated carcinogenesis
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, University of Heidelberg, Heidelberg, Germany
    Nat Rev Cancer 7:599-612. 2007
  9. ncbi request reprint Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, D 69121 Heidelberg, Germany
    Biol Chem 387:349-60. 2006
  10. ncbi request reprint Alcoholic liver disease: from pathophysiology to therapy
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1276-81. 2005

Detail Information

Publications52

  1. pmc Alcohol metabolism and cancer risk
    Helmut K Seitz
    Center ofA lcohol Research, Liver Disease and Nutrition, Salem Medical Center, University ofHeidelberg, Heidelberg, Germany
    Alcohol Res Health 30:38-41, 44-7. 2007
    ..Together with other factors related to chronic alcohol consumption, these metabolism-related factors may increase tumor risk in chronic heavy drinkers...
  2. ncbi request reprint The relationship between alcohol metabolism, estrogen levels, and breast cancer risk
    Helmut K Seitz
    Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Germany
    Alcohol Res Health 30:42-3. 2007
  3. doi request reprint The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis
    Helmut K Seitz
    Centre of Alcohol Research, University of Heidelberg, Heidelberg, Germany
    Subcell Biochem 67:131-43. 2013
    ..Thus, there is increasing evidence that CYP2E1 induced by chronic alcohol consumption plays an important role in alcohol mediated carcinogenesis...
  4. pmc Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Genes Nutr 5:121-8. 2010
    ..These studies underline the important role of acetaldehyde in ethanol-mediated carcinogenesis...
  5. doi request reprint Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012
    Helmut K Seitz
    Centre of Alcohol Research, University of Heidelberg, Germany
    Alcohol Alcohol 47:204-12. 2012
    ..To update epidemiological data on alcohol and breast cancer, with special emphasis on light alcohol consumption, and to review mechanisms of alcohol mediated mammary carcinogenesis...
  6. ncbi request reprint Alcoholic liver disease in the elderly
    Helmut K Seitz
    Department of Medicine and Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, D 69121 Heidelberg, Germany
    Clin Geriatr Med 23:905-21, viii. 2007
    ..In addition, chronic alcohol consumption may enhance drug associated liver disease and may also act as a cofactor in other liver diseases, such as viral hepatitis and nonalcoholic fatty liver disease...
  7. ncbi request reprint Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics
    Helmut K Seitz
    Laboratory of Alcohol Research, Liver Disease and Nutrition and Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Int J Cancer 108:483-7. 2004
  8. ncbi request reprint Molecular mechanisms of alcohol-mediated carcinogenesis
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, University of Heidelberg, Heidelberg, Germany
    Nat Rev Cancer 7:599-612. 2007
    ..Alcohol-related carcinogenesis may interact with other factors such as smoking, diet and comorbidities, and depends on genetic susceptibility...
  9. ncbi request reprint Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, D 69121 Heidelberg, Germany
    Biol Chem 387:349-60. 2006
    ..Finally, chronic alcohol abuse interferes with methyl group transfer and may thereby alter gene expression...
  10. ncbi request reprint Alcoholic liver disease: from pathophysiology to therapy
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1276-81. 2005
  11. ncbi request reprint Alcohol consumption and cancer of the gastrointestinal tract
    Helmut K Seitz
    Department of Medicine, Salem Medical Centre and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany
    Dig Dis 23:297-303. 2005
    ..Nutritional deficiencies, i.e. lack of folic and retinoic acid, as well as malnutrition itself may also contribute to the development of gastrointestinal cancer...
  12. ncbi request reprint Dharam Pal Agarwal (1938-2003)
    Helmut K Seitz
    Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    Alcohol Alcohol 38:393. 2003
  13. ncbi request reprint Alcohol and cancer
    H K Seitz
    Laboratory of Alcohol Research, Liver Disease and Nutrition, and Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 25:137S-143S. 2001
    ..Seitz...
  14. doi request reprint Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions
    Gunda Millonig
    Department of Medicine, Salem Medical Centre and Centre of Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 128:533-40. 2011
    ..Our data demonstrate for the first time an induction of CYP2E1 in the esophageal mucosa by ethanol in a dose dependent manner in man and may explain, at least in part, the generation of carcinogenic DNA lesions in this target organ...
  15. ncbi request reprint From alcohol toxicity to treatment
    Helmut K Seitz
    Department of Medicine, Salem Medical Center and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1341-50. 2005
    ..Lieber (USA) discussed the development of the understanding of the pathophysiology of alcoholic liver disease in the last 50 years. He emphasized the role of pathophysiology as an important prerequisite for better treatment strategies...
  16. doi request reprint High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mutat Res 683:23-8. 2010
    ....
  17. ncbi request reprint The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract
    Helmut K Seitz
    Laboratory of Alcohol Research, Liver Disease and Nutrition, Department of Medicine, Salem Medical Center Heidelberg and University of Heidelberg, Heidelberg, Germany
    Novartis Found Symp 285:110-9; discussion 119-4, 198-9. 2007
    ....
  18. ncbi request reprint The role of acetaldehyde in upper digestive tract cancer in alcoholics
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
    Transl Res 149:293-7. 2007
    ..AA seems to be an important factor in alcohol-associated carcinogenesis of the UADT...
  19. ncbi request reprint Alcohol and cancer: genetic and nutritional aspects
    Gudrun Pöschl
    Laboratory of Alcohol Research, Liver Disease and Nutrition and Department of Medicine, Salem Medical Center, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    Proc Nutr Soc 63:65-71. 2004
    ....
  20. pmc Alcoholic liver disease and hepatitis C: a frequently underestimated combination
    Sebastian Mueller
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    World J Gastroenterol 15:3462-71. 2009
    ..For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs...
  21. ncbi request reprint Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease
    Ying Wang
    Center of Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Germany
    Hepatology 50:453-61. 2009
    ..CMZ blocked the generation of etheno-DNA adducts by 70%-90% (P < 0.01)...
  22. doi request reprint Contribution of alcohol and tobacco use in gastrointestinal cancer development
    Helmut K Seitz
    Department of Medicine, Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Methods Mol Biol 472:217-41. 2009
    ....
  23. ncbi request reprint Age, alcohol metabolism and liver disease
    Patrick Meier
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
    Curr Opin Clin Nutr Metab Care 11:21-6. 2008
    ..Alcohol consumption among the elderly has increased. Alcohol metabolism changes with age and the elderly are more sensitive to the toxic effects; this increased consumption is therefore of great clinical relevance...
  24. doi request reprint [Hereditary hyperferritinemia cataract syndrome--the first family in Germany]
    G Millonig
    Alkoholforschungszentrum Universität Heidelberg und Medizinische Klinik, KH Salem, Heidelberg, Germany
    Z Gastroenterol 47:1211. 2009
    ..Thus, in gastroenterological practice, HHCS should be added as a differential diagnosis of hyperferritinemia in Germany. Importantly, patients with HHCS can be spared from invasive diagnostics such as liver biopsy...
  25. ncbi request reprint Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease
    R Urbaschek
    Institute for Medical Microbiology and Hygiene, Klinikum Mannheim, University of Heidelberg, Germany
    Alcohol Clin Exp Res 25:261-8. 2001
    ..A second aim was to identify correlations between these latter parameters, endotoxin, and cytokines, especially IL-10...
  26. doi request reprint Gastrointestinal stromal tumor in a patient with undiagnosed neurofibromatosis type I: an uncommon cause of extrahepatic cholestasis
    G Millonig
    Department of Internal Medicine, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Z Gastroenterol 48:479-81. 2010
    ..Tumor resection failed because of cardiac decompensation due to a Takotsubo cardiomyopathy during induction of anesthesia. The patient has been started on imatinib instead and shows so far a stable disease over 6 months...
  27. doi request reprint Assessment of renal allograft fibrosis by transient elastography
    Claudia Sommerer
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Transpl Int 26:545-51. 2013
    ..The heterogeneous kidney morphology and several other confounding factors negatively affect measurability of KS by TE. Further technical modifications are required to improve applicability of TE for kidney assessment...
  28. ncbi request reprint Update on pancreatic cancer and alcohol-associated risk
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastroenterol Hepatol 21:S69-75. 2006
    ....
  29. ncbi request reprint Enhanced urinary excretion of cysteinyl leukotrienes in patients with acute alcohol intoxication
    M Uemura
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Gastroenterology 118:1140-8. 2000
    ..We examined the metabolic derangement of leukotriene inactivation by ethanol in humans in vivo...
  30. ncbi request reprint Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens
    C Coutelle
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
    Int J Oncol 25:1127-32. 2004
    ....
  31. ncbi request reprint The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis
    Hong Lei Weng
    Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Germany
    Hepatology 50:230-43. 2009
    ..TGF-beta1 predominance is detected in HBV-related liver fibrogenesis and IL-13 predominance in chronic HCV infection. In some instances, the underlying fibrogenic mediator remains enigmatic...
  32. ncbi request reprint LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimens
    Andrea Faller
    Institute of Legal and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Anal Bioanal Chem 401:1163-6. 2011
    ..It could be shown that the determination of PEth species in DBS is as reliable as in whole blood samples. This assay may facilitate monitoring of alcohol misuse...
  33. ncbi request reprint Effect of aging on in vivo and in vitro ethanol metabolism and its toxicity in F344 rats
    H K Seitz
    Department of Medicine, University of Heidelberg, Federal Republic of Germany
    Gastroenterology 97:446-56. 1989
    ....
  34. ncbi request reprint Alcohol and cancer
    G Pöschl
    Department of Medicine, Salem Medical Centre, Heidelberg, Germany
    Alcohol Alcohol 39:155-65. 2004
    ..Also, an alcohol-mediated increase in oestradiols may be at least in part responsible for breast cancer risk. Thus, all these mechanisms functioning in concert actively modulate carcinogenesis leading to its stimulation...
  35. pmc Increased rectal cell proliferation following alcohol abuse
    U A Simanowski
    Laboratory of Alcohol Research, Liver Disease and Nutrition, and Department of Medicine, Salem Medical Centre, Heidelberg, Germany
    Gut 49:418-22. 2001
    ..CONCLUSION: Chronic alcohol abuse leads to rectal mucosal hyperproliferation in humans, a condition associated with an increased cancer risk...
  36. ncbi request reprint Vitamin A-induced cholestatic hepatitis: a case report
    P Becker
    Department of Medicine, Salem Medical Center, Heidelberg
    Z Gastroenterol 45:1063-6. 2007
    ..There were no signs of intrahepatic metastasis or liver cirrhosis. Treatment with ursodeoxycholic acid rapidly improved the cholestasis and led to a total recovery after three weeks...
  37. ncbi request reprint Inhibition of alcohol-associated colonic hyperregeneration by alpha-tocopherol in the rat
    P Vincon
    Laboratory of Alcohol Research, Liver Disease and Nutrition and Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 27:100-6. 2003
    ..We wondered whether alpha-tocopherol supplementation may prevent ethanol-induced colorectal cell cycle behavior and whether these changes were related to alterations in protein synthesis...
  38. ncbi request reprint Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase
    Carl M Oneta
    Division of Gastroenterology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois CHUV et Policlinique Médicale Universitaire PMU, Lausanne, Switzerland
    J Hepatol 36:47-52. 2002
    ..However, the amount and duration of alcohol intake associated with CYP2E1 induction is not known but limited information is available on the disappearance of CYP2E1 following alcohol withdrawal...
  39. ncbi request reprint Alcohol metabolism: role in toxicity and carcinogenesis
    Thomas M Badger
    Arkansas Children s Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA
    Alcohol Clin Exp Res 27:336-47. 2003
    ....
  40. doi request reprint No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
    ..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
  41. ncbi request reprint Mean corpuscular volume and ADH1C genotype in white patients with alcohol-associated diseases
    Leimin Sun
    Department of Medicine I, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
    Alcohol Clin Exp Res 29:788-93. 2005
    ....
  42. ncbi request reprint Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential
    Zili Dan
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 19:845-7. 2005
    ..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
  43. ncbi request reprint [Effects of alcohol. Besides its harmful health impact, are there any positive aspects of chronic alcohol consumption?]
    Patrick Meier
    Medizinische Klinik and Zentrum für Alkoholforschung, Lebererkrankungen und Ernährung, Krankenhaus Salem, und Universität Heidelberg, Germany
    Med Klin (Munich) 101:891-7; quiz 898-9. 2006
    ..In addition, a regular daily administration of alcohol should not be recommended...
  44. ncbi request reprint Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    Nils Homann
    Department of Medicine I, University of Lubeck, Germany
    Int J Cancer 118:1998-2002. 2006
    ..11-4.36), respectively. The data identify genotype ADH1C*1/1 as an independent risk factor for the development of alcohol-associated tumors among heavy drinkers, indicating a genetic predisposition of individuals carrying this genotype...
  45. doi request reprint Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease
    Christoph H Osterreicher
    Department of Medicine, University of California, San Diego, Leichtag Building, Room 349 I, 9500 Gilman Drive, 0702, La Jolla, CA 92093 0702, USA
    Cytokine 42:18-23. 2008
    ..Its contribution to the progression of ALD has not been investigated sufficiently so far...
  46. ncbi request reprint Additive effects of moderate drinking and obesity on serum gamma-glutamyl transferase
    Helmut K Seitz
    Am J Clin Nutr 83:1252-3. 2006
  47. ncbi request reprint Serum hyaluronate correlates with histological progression in alcoholic liver disease
    Felix Stickel
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Gastroenterol Hepatol 15:945-50. 2003
    ..In addition, serum hyaluronate was determined in 40 non-cirrhotic alcoholic patients with either a normal serum aspartate aminotransferase (AST) or an AST elevated at least two-fold...
  48. ncbi request reprint Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis
    Alexander Frank
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 25:1027-31. 2004
    ..In cancer-prone liver diseases (fatty liver, cirrhosis/fibrosis) such damage may act as a driving force towards malignancy...
  49. ncbi request reprint Alcohol and exocrine pancreatic function during pregnancy: the role of folate
    Felix Stickel
    Nutrition 19:812. 2003
  50. ncbi request reprint Chronic alpha-tocopherol supplementation in rats does not ameliorate either chronic or acute alcohol-induced changes in muscle protein metabolism
    Michael Koll
    Department of Nutrition and Dietetics, King s College London, Franklin Wilkins Building, Stamford Street, London SE1 9NN, UK
    Clin Sci (Lond) 104:287-94. 2003
    ..alpha-Tocopherol supplementation is not protective against the deleterious effects of alcohol on protein metabolism in skeletal muscle...
  51. ncbi request reprint Health risks of chronic moderate and heavy alcohol consumption: how much is too much?
    Dieter J Meyerhoff
    Department of Radiology, University of California, San Francisco, 94121, USA
    Alcohol Clin Exp Res 29:1334-40. 2005
    ....
  52. ncbi request reprint Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats
    Chun Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Alcohol Clin Exp Res 26:1703-9. 2002
    ..This study investigated whether treatment with chlormethiazole, a CYP inhibitor, restores vitamin A in the livers of ethanol-fed rats...