R H G Schwinger

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in (Ca2+)-sensitivity or myosin ATPase-activity of the contractile proteins
    R H Schwinger
    Clinic III of Internal Medicine, University of Cologne, Germany
    Basic Res Cardiol 95:12-8. 2000
  2. ncbi request reprint Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently
    R H Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Germany
    J Cardiovasc Pharmacol 35:700-7. 2000
  3. ncbi request reprint Overexpression of sorcin enhances cardiac contractility in vivo and in vitro
    K F Frank
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmannstr 9, 50924 Köln, Germany
    J Mol Cell Cardiol 38:607-15. 2005
  4. ncbi request reprint Calcium and the failing heart: phospholamban, good guy or bad guy?
    Robert H G Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, Joseph Stelzmannstrasse, 50924 Köln, Germany
    Sci STKE 2003:pe15. 2003
  5. ncbi request reprint cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure
    R H Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Germany
    Ann N Y Acad Sci 853:240-50. 1998
  6. ncbi request reprint Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure
    R H Schwinger
    Klinik III für Innere Medizin der Universität zu Köln Germany
    Circulation 99:2105-12. 1999
  7. ncbi request reprint [If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency]
    R H Schwinger
    Klinik III fur Innere Medizin, Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Universitat Koln
    Dtsch Med Wochenschr 130:969-73. 2005
  8. ncbi request reprint The Na, K-ATPase in the failing human heart
    Robert H G Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Cardiovasc Res 57:913-20. 2003
  9. ncbi request reprint [Treatment of heart failure with beta-receptor-blockers]
    R H Schwinger
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Dtsch Med Wochenschr 127:682-8. 2002
  10. ncbi request reprint Chronic treatment with carvedilol improves Ca(2+)-dependent ATP consumption in triton X-skinned fiber preparations of human myocardium
    K Brixius
    Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany
    J Pharmacol Exp Ther 322:222-7. 2007

Detail Information

Publications87

  1. ncbi request reprint The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in (Ca2+)-sensitivity or myosin ATPase-activity of the contractile proteins
    R H Schwinger
    Clinic III of Internal Medicine, University of Cologne, Germany
    Basic Res Cardiol 95:12-8. 2000
    ..At the level of the regulation of crossbridge interaction, no adaptive or compensatory mechanisms have been initiated by ablation of phospholamban...
  2. ncbi request reprint Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently
    R H Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Germany
    J Cardiovasc Pharmacol 35:700-7. 2000
    ..In addition, WS 1442 improves the force-frequency relation in failing human myocardium...
  3. ncbi request reprint Overexpression of sorcin enhances cardiac contractility in vivo and in vitro
    K F Frank
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmannstr 9, 50924 Köln, Germany
    J Mol Cell Cardiol 38:607-15. 2005
    ..These results strengthen the notion that overexpression of SOR improves cardiac contractility independent of beta-adrenergic stimulation and may prove beneficial in the treatment of decreased cardiac output such as heart failure...
  4. ncbi request reprint Calcium and the failing heart: phospholamban, good guy or bad guy?
    Robert H G Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, Joseph Stelzmannstrasse, 50924 Köln, Germany
    Sci STKE 2003:pe15. 2003
    ..This Perspective discusses new advances in our understanding of the role of phospholamban in intracellular Ca(2+) handling and the development of human and murine cardiomyopathies...
  5. ncbi request reprint cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure
    R H Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Germany
    Ann N Y Acad Sci 853:240-50. 1998
    ..The altered regulation of the SR-CA(2+)-ATPase in human heart failure may offer an opportunity for an improvement in the therapy of heart failure...
  6. ncbi request reprint Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure
    R H Schwinger
    Klinik III für Innere Medizin der Universität zu Köln Germany
    Circulation 99:2105-12. 1999
    ..In patients with heart failure the sensitivity toward cardiac glycosides is enhanced...
  7. ncbi request reprint [If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency]
    R H Schwinger
    Klinik III fur Innere Medizin, Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Universitat Koln
    Dtsch Med Wochenschr 130:969-73. 2005
  8. ncbi request reprint The Na, K-ATPase in the failing human heart
    Robert H G Schwinger
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Joseph Stelzmann Strasse 9, 50924, Cologne, Germany
    Cardiovasc Res 57:913-20. 2003
    ..Cardiac glycoside treatment is still the only safe inotropic drug for oral use that improves hemodynamics in patients with compromised cardiac function...
  9. ncbi request reprint [Treatment of heart failure with beta-receptor-blockers]
    R H Schwinger
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Dtsch Med Wochenschr 127:682-8. 2002
  10. ncbi request reprint Chronic treatment with carvedilol improves Ca(2+)-dependent ATP consumption in triton X-skinned fiber preparations of human myocardium
    K Brixius
    Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany
    J Pharmacol Exp Ther 322:222-7. 2007
    ..The more economic cross-bridge cycling in patients under carvedilol treatment may provide an explanation for the efficacy of carvedilol in the treatment of chronic heart failure patients...
  11. ncbi request reprint The increased angiotensin II (type 1) receptor density in myocardium of type 2 diabetic patients is prevented by blockade of the renin-angiotensin system
    H Reuter
    Laboratory of Muscle Research and Molecular Cardiology, Department III of Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, Cologne, Germany
    Diabetologia 49:3067-74. 2006
    ..In addition, we determined the effect of treatment with ACE inhibitors or AT1 receptor blockers on expression levels of the receptor in diabetic patients...
  12. ncbi request reprint Effects of the Ca2+ sensitizers EMD 57033 and CGP 48506 on myocardial contractility and Ca2+ transients in human ventricular and atrial myocardium
    K Brixius
    Laboratory of Muscle Research and Molecular Cardiology Clinic III of Internal Medicine, University of Cologne Joseph Stelzmann Str 9, 50924 Köln, Germany
    Z Kardiol 91:312-8. 2002
    ..The Ca2+ sensitizers EMD and CGP increase cAMP and Ca2+ independently from the force of contraction in the human myocardium. However, their therapeutic use in human heart failure may be limited as they impair relaxation...
  13. pmc The preferential beta3-adrenoceptor agonist BRL 37344 increases force via beta1-/beta2-adrenoceptors and induces endothelial nitric oxide synthase via beta3-adrenoceptors in human atrial myocardium
    C Pott
    Clinic III of Internal Medicine, Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Koln, Germany
    Br J Pharmacol 138:521-9. 2003
    ..In conclusion, this study shows that beta(3)-adrenergic stimulation is present in human atrium, but may not be functionally as significant as in the left ventricle...
  14. ncbi request reprint Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
    S Lee
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Physiol Res 59:679-89. 2010
    ..The decreased SERCA 2a activity following beta-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity...
  15. ncbi request reprint Nebivolol induces eNOS activation and NO-liberation in murine corpus cavernosum
    C Reidenbach
    Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University Cologne, Cologne, Germany
    Life Sci 80:2421-7. 2007
    ..Since cardiovascular diseases are often associated with the development of erectile dysfunction, the nebivolol-induced eNOS-activation in corpus cavernosum may be beneficial when treating patients suffering from cardiovascular disease...
  16. ncbi request reprint Beta3-adrenergic stimulation in the human heart: signal transduction, functional implications and therapeutic perspectives
    C Pott
    Laboratory for Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Germany
    Pharmazie 61:255-60. 2006
    ..In this context, the beta3-adrenoceptor is discussed as a novel target for the pharmacological therapy of heart failure...
  17. ncbi request reprint [Beta-adrenoceptor antagonists in the treatment of chronic heart failure]
    A Bundkirchen
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III für Innere Medizin der Universität zu Köln, Germany
    Pharmazie 59:83-92. 2004
    ..Based on the results of large clinical trials, experimental-pharmacological properties of beta-adrenoceptor blockers as well as the main aspects of its clinical use are discussed...
  18. ncbi request reprint Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
    M Flesch
    Klinik III fur Innere Medizin, Universitat Koln, Germany
    J Mol Med (Berl) 74:321-32. 1996
    ..The observed alterations are not dependent on the underlying cause of end-stage heart failure...
  19. ncbi request reprint Coupling of M-cholinoceptors and A1 adenosine receptors in human myocardium
    M Bohm
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Am J Physiol 266:H1951-8. 1994
    ..It is concluded that stimulation of M-cholinoceptors but not A1 adenosine receptors is able to maximally activate a pool of G protein alpha-subunits.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint Force/shortening-frequency relationship in multicellular muscle strips and single cardiomyocytes of human failing and nonfailing hearts
    K Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III for Internal Medicine, University of Cologne, Cologne, Germany
    J Card Fail 7:335-41. 2001
    ..5 Hz; FOC, 180% basal; cell shortening, 129% basal). CONCLUSIONS: The negative force-frequency relationship measured in multicellular preparations of failing human myocardium results from alterations at the single cell level...
  21. ncbi request reprint Differential increase of CD34, KDR/CD34, CD133/CD34 and CD117/CD34 positive cells in peripheral blood of patients with acute myocardial infarction
    F Grundmann
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Clin Res Cardiol 96:621-7. 2007
    ..For potential therapeutic use, understanding the endogenous mechanisms after ischemia is inevitable. We investigated the absolute number, but also the subset composition of CD34+ CPC after AMI...
  22. ncbi request reprint Nebivolol, carvedilol and metoprolol do not influence cardiac Ca(2+) sensitivity
    A Bundkirchen
    , , Joseph-Stelzmann-Strasse 9, D-50924 Cologne, Lindenthal, Germany
    Eur J Pharmacol 422:175-80. 2001
    ..In conclusion, none of the investigated beta-adrenoceptor antagonists influenced Ca(2+) sensitivity of myofibrillar tension development in human failing myocardium...
  23. pmc Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium
    K Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Joseph-Stelzmann-Str. 9, , Germany
    Br J Pharmacol 133:1330-8. 2001
    ..These differences as well as the mode of extracardiac action may have an impact on outcome of patients treated with beta-adrenoceptor antagonists...
  24. ncbi request reprint Increased expression of isoform 1 of the sarcoplasmic reticulum Ca(2+)-release channel in failing human heart
    G Munch
    Laboratory of Muscle Research and Molecular Cardiology, Klinik III fur Innere Medizin, University of Cologne, Cologne, Germany
    Circulation 103:2739-44. 2001
    ....
  25. ncbi request reprint Calcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27
    H Diedrichs
    Laboratory for Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Mol Med (Berl) 82:688-95. 2004
    ..Thus GATA-4 seems to be a marker of hypertrophy independently of calcineurin activation, possibly activated by various pathways...
  26. ncbi request reprint The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass
    K Hekmat
    Department of Thoracic and Cardiovascular Surgery, University of Cologne, Germany
    Curr Med Res Opin 20:1429-35. 2004
    ..The purpose of this study was to examine the influence of APT therapy on haemorrhage and transfusion requirements in patients undergoing coronary artery bypass (CABG) on cardiopulmonary bypass (CPB)...
  27. pmc Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes
    C Herr
    Institute of Biochemistry I, University of Cologne, 50931 Cologne, Germany
    Mol Cell Biol 21:4119-28. 2001
    ..This suggests a function for annexin A7 in electromechanical coupling, probably through Ca(2+) homoeostasis...
  28. pmc Studies of the nucleoside transporter inhibitor, draflazine, in the human myocardium
    M Bohm
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Br J Pharmacol 112:137-42. 1994
    ..6. Draflazine could be a useful agent for cardio preservation because it does not produce cardio depressant effects. Thus, it may be possible to perfuse explanted hearts directly with this agent without the hazard of cardiodepression...
  29. ncbi request reprint Interference by cellular phones with permanent implanted pacemakers: an update
    K Hekmat
    Department of Cardiothoracic Surgery, University of Cologne, 50924 Cologne, Germany
    Europace 6:363-9. 2004
    ..The aim of this study was to test pacemakers with feedthru filters for interference with a digital cellular telephone...
  30. ncbi request reprint Effect of epinine on tension of human renal arteries
    R H Schwinger
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Naunyn Schmiedebergs Arch Pharmacol 354:343-7. 1996
    ..The present study aimed to characterize the effects of epinine, the active metabolite of ibopamine on tension development in human renal arteries...
  31. ncbi request reprint [Therapy of heart failure in the elderly]
    Carsten Zobel
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III für Innere Medizin der Universität zu Köln
    Med Klin (Munich) 101:47-50. 2006
    ..However, side effects and interactions between drugs are more frequent and require special attention. The majority of concomitant diseases are no contraindication to heart failure treatment...
  32. ncbi request reprint Ca2+-sensitisers--a promising option to treat heart failure?
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne
    Cardiovasc Drugs Ther 19:423-8. 2005
    ..This review provides a survey on the molecular mechanisms and the therapeutic effectiveness of Ca(2+)-sensitisers for the treatment of human heart failure...
  33. ncbi request reprint eNOS translocation but not eNOS phosphorylation is dependent on intracellular Ca2+ in human atrial myocardium
    Christian Pott
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Institutsgebäude 1, 9 OG, Carl Diem Weg 6, Rm 911, D 50933 Cologne, Germany
    Am J Physiol Cell Physiol 290:C1437-45. 2006
    ..3) Although Ca(2+) dependent, eNOS translocation and NO release could not be mimicked by adenylate cyclase activation as a mediator of beta-adrenergic stimulation...
  34. ncbi request reprint [Mesenchymal stem cells for cardiac regeneration]
    Benjamin Krausgrill
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III für Innere Medizin der Universität zu Köln
    Med Klin (Munich) 101:202-6. 2006
    ..Thus, MSC show promising experimental results, and may be of therapeutic value for heart disease in the future. However, there are many unanswered questions and problems, which need to be resolved before...
  35. ncbi request reprint Reduced sarcoplasmic reticulum Ca2+ -ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium
    Holger M Nef
    Department of Cardiology, Kerckhoff Heart Centre, Benekestr 2 8, Bad Nauheim 61231, Germany
    Mol Cell Biochem 282:53-63. 2006
    ..In HHM a decreased activity of SERCA2a due to an impaired phosphorylation of PLN contributes to contractile dysfunction. The increase in the relative ratio of PLN/SERCA2a leads to a decreased calcium affinity of SERCA2a...
  36. ncbi request reprint [Reverse remodeling of the intracellular Ca(2+)-homeostasis: new concepts of pathophysiology and therapy of heart failure]
    Klara Brixius
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III fur Innere Medizin, Koln
    Wien Med Wochenschr 156:209-15. 2006
    ..In addition, new therapeutic options will be introduced which may be of importance for the treatment of heart failure patients...
  37. ncbi request reprint ENOS is not activated by nebivolol in human failing myocardium
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Germany
    Life Sci 79:1234-41. 2006
    ..This mode of action may be of advantage when treating heart failure patients...
  38. ncbi request reprint Mesenchymal stem cells induce endothelial activation via paracine mechanisms
    Dennis Ladage
    Laboratory for Muscle Research and Molecular Cardiology, Department III of Internal Medicine, University of Cologne, Carl Diem Weg 6, 50933 Cologne, Germany
    Endothelium 14:53-63. 2007
    ..Concluding, the authors postulate that MSCs emit soluble factors that alter the NO and calcium levels of endothelial cells and may be important for facilitate crossing the endothelial barrier...
  39. ncbi request reprint Alterations of tension-dependent ATP utilization in a transgenic rat model of hypertrophic cardiomyopathy
    Norbert Frey
    Department of Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    J Biol Chem 281:29575-82. 2006
    ..Taken together, our data support the hypothesis of energy compromise as a contributing factor in the pathogenesis of FHC...
  40. ncbi request reprint Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Germany
    Can J Physiol Pharmacol 84:1051-60. 2006
    ..These pathways are used in a regional-dependent manner. beta3-adrenergic oxygen-derived free radical production might be important in situations of enhanced beta3-adrenoceptor activation, as has been described in human heart failure...
  41. ncbi request reprint Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes
    Erol Saygili
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Kerpenerstr 62, 50924 Cologne, Germany
    Am J Physiol Heart Circ Physiol 292:H2898-905. 2007
    ..This prevented the stretch-induced abbreviation of action potential duration. Prevention of stretch-induced electrical remodeling might contribute to the clinical effects of losartan against AF...
  42. ncbi request reprint Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Cardiology 107:281-90. 2007
    ....
  43. ncbi request reprint Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Germany
    Cardiovasc Res 76:257-68. 2007
    ..We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-))...
  44. ncbi request reprint Altered tension cost in (TG(mREN-2)27) rats overexpressing the mouse renin gene
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur J Appl Physiol 99:121-32. 2007
    ..The present study demonstrates that cardiac hypertrophy, induced by an activation of the renin-angiotensin system, leads to adapting alterations on the level of the contractile filaments, which reduce tension cost...
  45. ncbi request reprint Genetically changed mice with chronic deficiency or overexpression of the beta-adrenoceptors--what can we learn for the therapy of heart failure?
    Samuel Lee
    Laboratory of Muscle Research and Molecular Cardiology, Department III for Internal Medicine, University of Cologne, Cologne, Germany
    Pflugers Arch 455:767-74. 2008
    ....
  46. ncbi request reprint Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients
    Hannes Reuter
    Laboratory of Muscle Research and Molecular Cardiology, Department III of Internal Medicine, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Mol Cell Biochem 308:141-9. 2008
    ..This defective Ca(2+) release may represent an early stage of ventricular dysfunction in type 2 diabetes and would favor the abnormal response to exercise frequently observed in asymptomatic diabetic patients...
  47. ncbi request reprint A simple device to apply equibiaxial strain to cells cultured on flexible membranes
    Obaida R Rana
    Univ Hospital RWTH Aachen, Dept I of Internal Medicine, Division of Cardiology, Pulmonary and Vascular Diseases, Pauwelsstrasse 30, Aachen, Germany
    Am J Physiol Heart Circ Physiol 294:H532-40. 2008
    ..The simple and low-cost device presented here might be applied to a wide range of experimental settings in different fields of research...
  48. ncbi request reprint [On the function of beta3-adrenoceptors in the human heart: signal transduction, inotropic effect and therapeutic prospects]
    Christian Pott
    Universitatsklinikum Munster, Medizinische Klinik und Poliklinik C für Kardiologie und Angiologie, Munster, Germany
    Wien Med Wochenschr 156:451-8. 2006
    ..For this reason, the beta3-adrenoceptor is discussed as a possible target for the pharmacological therapy of heart failure...
  49. ncbi request reprint Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic beta3-adrenoceptor deficiency
    Christoph Ziskoven
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Pflugers Arch 453:443-53. 2007
    ..Thus, beta(3)-adrenergic depression may be a therapeutic aim in situations of impaired SERCA 2a activity, e.g. for the treatment of heart failure...
  50. ncbi request reprint Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction
    Jochen Müller-Ehmsen
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Kerpener Str 62, 50937 Koln, Germany
    J Mol Cell Cardiol 41:876-84. 2006
    ..Organ distribution was independent from injection time. The low survival of grafted cells may limit their therapeutic impact, while their distribution to other organs must be considered in all cell therapy applications...
  51. ncbi request reprint Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells
    Dennis Ladage
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Clin Exp Pharmacol Physiol 33:720-4. 2006
    ..These characteristics of NEB may be beneficial not only when treating patients suffering from cardiovascular disease, but may also prevent further deterioration of endothelial dysfunction...
  52. ncbi request reprint Phosphodiesterase type 5 inhibitor sildenafil citrate does not potentiate the vasodilative properties of nebivolol in rat aorta
    Stephan Rosenkranz
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Life Sci 78:1103-7. 2006
    ....
  53. ncbi request reprint The mobilization of CD34 positive mononuclear cells after myocardial infarction is abolished by revascularization of the culprit vessel
    Jochen Müller-Ehmsen
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 24, 50924 Köln, Germany
    Int J Cardiol 103:7-11. 2005
    ..Here, we evaluated the influence of an acute percutaneous coronary intervention (PCI) of the occluded artery on the mobilization of CD34+ in acute MI...
  54. ncbi request reprint Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia
    Frank Callies
    Department of Endocrinology, Medical University Hospital Wuerzburg, 97080 Wuerzburg, Germany
    Endocrinology 144:4478-83. 2003
    ..In conclusion, administration of testosterone significantly improves recovery from global ischemia. These beneficial effects are associated with an attenuation of reperfusion induced [Ca2+]i overload...
  55. ncbi request reprint The cardiac sodium pump: structure and function
    Alicia A McDonough
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 1333 San Pablo Street, Los Angeles, CA 90089 9142, USA
    Basic Res Cardiol 97:I19-24. 2002
    ....
  56. ncbi request reprint Ser16-, but not Thr17-phosphorylation of phospholamban influences frequency-dependent force generation in human myocardium
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Pflugers Arch 447:150-7. 2003
    ..Cross talk signaling of Ser16/Thr17-PLB phosphorylation after beta-adrenergic stimulation exists in non-failing, but not in failing human myocardium. The Ca(2+)-dependent CaM-kinase activity may be altered in human heart failure...
  57. ncbi request reprint Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium
    Andreas Bundkirchen
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Eur J Pharmacol 476:97-105. 2003
    ..This and the finding that nebivolol and its D-enantiomer improve the frequency-dependent force generation may be of particular advantage when treating patients with already compromised cardiac function...
  58. ncbi request reprint Sodium pump isoform expression in heart failure: implication for treatment
    Jochen Müller-Ehmsen
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III for Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Basic Res Cardiol 97:I25-30. 2002
    ..Therefore, the isoforms of human Na,K-ATPase are not exchangeable and targeting specific isoforms by drugs or gene therapy may promise therapeutic benefit in diseases like heart failure or atrial fibrillation...
  59. ncbi request reprint Reduced length-dependent cross-bridge recruitment in skinned fiber preparations of human failing myocardium
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Eur J Appl Physiol 89:249-56. 2003
    ..We concluded that, in human failing myocardium, the length-dependent force generation may be blunted due to an already increased Ca(2+) affinity of troponin C as well as an impairment of length-dependent cross-bridge recruitment...
  60. ncbi request reprint [Increased myocardial blood flow after spinal cord stimulation in patients with refractory angina pectoris]
    Holger Diedrichs
    Klinik III fur Innere Medizin, Universitat zu Koln, Cologne
    Med Klin (Munich) 98:146-50. 2003
    ..In spite of great progresses in surgical and catheter interventional techniques there is an increasing number of patients with coronary heart disease not suitable for these conventional treatment strategies...
  61. ncbi request reprint Longer term effects of ouabain on the contractility of rat isolated cardiomyocytes and on the expression of Ca and Na regulating proteins
    Jochen Müller-Ehmsen
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Basic Res Cardiol 98:90-6. 2003
    ..Whether such regulation can be found in human cardiomyocytes and the resulting consequences in the clinical setting remain to be determined...
  62. ncbi request reprint Modulation of SERCA: implications for the failing human heart
    Konrad F Frank
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III for Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, 50924 Kö1n, Germany
    Basic Res Cardiol 97:I72-8. 2002
    ..This review summarizes recent advances in the understanding how SERCA is modulated under physiological and pathophysiological conditions...
  63. ncbi request reprint Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation
    Konrad F Frank
    Clinic III of Internal Medicine, Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Cologne, Germany
    Cardiovasc Res 57:20-7. 2003
    ....
  64. ncbi request reprint Isometric force kinetics upon rapid activation and relaxation of mouse, guinea pig and human heart muscle studied on the subcellular myofibrillar level
    Robert Stehle
    Institute of Physiology, Universitat zu Koln, Robert Koch Str 39, 50931 Koln, Germany
    Basic Res Cardiol 97:I127-35. 2002
    ..The kinetics of isometric relaxation of skinned trabeculae (i.e., multicellular preparations), therefore, do not reflect the kinetics of force relaxation at the cardiac myofibrillar level...
  65. ncbi request reprint TNF and congestive heart failure: therapeutic possibilities
    Jochen Müller-Ehmsen
    University of Cologne, Department of Internal Medicine III, Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Expert Opin Ther Targets 8:203-9. 2004
    ....
  66. ncbi request reprint Increased Ca2+-sensitivity of myofibrillar tension in heart failure and its functional implication
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III for Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Basic Res Cardiol 97:I111-7. 2002
    ..Alterations of myofilament function occur at very early stages of heart failure and may be species dependent, or dependent on intracellular free Ca2+-levels...
  67. ncbi request reprint Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes
    Birgit Bölck
    Laboratory of Muscle Research and Molecular Cardiology, Dept of Internal Medicine III, Univ of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Am J Physiol Heart Circ Physiol 287:H1435-45. 2004
    ..e., in conditions with enhanced [Na(+)](i). At low stimulation rates, increased NCX expression enhances both intracellular systolic Ca(2+) and contraction amplitude...
  68. ncbi request reprint Beneficial effects of the Ca(2+) sensitizer levosimendan in human myocardium
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, D 50924 Koln, Germany
    Am J Physiol Heart Circ Physiol 282:H131-7. 2002
    ..In conclusion, levosimendan improves contraction in failing human myocardium under conditions with already increased intracellular Ca(2+)...
  69. ncbi request reprint Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction coupling
    Hannes Reuter
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Cardiovasc Res 67:198-207. 2005
    ....
  70. ncbi request reprint Letters regarding article by Wojakowski et al, "mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infar
    Jochen Müller-Ehmsen
    Circulation 111:e307; author reply e307-8. 2005
  71. ncbi request reprint Ouabain-like compound changes rapidly on physical exercise in humans and dogs: effects of beta-blockade and angiotensin-converting enzyme inhibition
    Natali Bauer
    Clinic for Small Animal Internal Medicine and Forensic Affairs, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Germany
    Hypertension 45:1024-8. 2005
    ..We conclude that OLC changes rapidly during exercise and is under the control of norepinephrine and angiotensin II...
  72. ncbi request reprint Bucindolol exerts agonistic activity on the propranolol-insensitive state of beta1-adrenoceptors in human myocardium
    Andreas Bundkirchen
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III für Innere Medizin der Universität zu Köln, Koln, Germany
    J Pharmacol Exp Ther 300:794-801. 2002
    ..Thus, the agonistic activity of bucindolol may influence outcome in heart failure patients...
  73. ncbi request reprint Altered hetero- and homeometric autoregulation in the terminally failing human heart
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, Joseph Stelzmann Str 9, 50924 Cologne Lindenthal, Germany
    Eur J Heart Fail 7:29-35. 2005
    ..In addition, morphological studies (van Giesson Trichrome staining, electron microscopy) were performed...
  74. ncbi request reprint Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium
    Götz Münch
    Laboratory of Muscle Research and Molecular Cardiology, Klinik III fur Innere Medizin, University of Cologne, Germany
    J Mol Cell Cardiol 34:321-34. 2002
    ..Increased calcineurin activity contributes to the impaired V(max) of SERCA 2a in failing human myocardium and the disorder in Ca(2+)-handling in heart failure...
  75. ncbi request reprint [Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan]
    Carsten Zobel
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III für Innere Medizin der Universität zu Köln, Joseph Stelzmann Strasse 9, 50924, Koln
    Med Klin (Munich) 99:742-6. 2004
    ..Although these drugs result in an improvement of the acute hemodynamic situation, they have no positive in. uence on survival in the long run...
  76. ncbi request reprint Ouabain increases myofibrillar Ca2+ sensitivity but does not influence the Ca2+ release in human skinned fibres
    Njde Hambarchian
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Eur J Pharmacol 492:225-31. 2004
    ..In conclusion, ouabain increases myofibrillar Ca(2+) sensitivity possibly due to an increase in the cooperativity of the thick and thin myofilaments. This mechanism may additionally contribute to the positive inotropic effect of ouabain...
  77. ncbi request reprint Isoform-specific downregulation of peroxiredoxin in human failing myocardium
    Klara Brixius
    Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University, Germany
    Life Sci 81:823-31. 2007
    ..The selective downregulation of peroxiredoxin 3-6 isoforms may point towards a subcellular specific dysregulation of the antioxidative defence during the development of DCM...
  78. ncbi request reprint Calcium and the failing heart
    Robert H G Schwinger
    Basic Res Cardiol 97:I1-3. 2002
  79. ncbi request reprint Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies
    Andreas Bundkirchen
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III of Internal Medicine, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Eur J Pharmacol 460:19-26. 2003
    ..It is concluded that nebivolol is approximately 3.5 times more beta(1)-adrenoceptor-selective than bisoprolol in the human myocardium. Furthermore, in vivo metabolized nebivolol retains beta(1)-adrenoceptor selectivity...
  80. ncbi request reprint Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Clin Exp Pharmacol Physiol 32:708-13. 2005
    ....
  81. ncbi request reprint Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure
    Holger Diedrichs
    Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Eur J Heart Fail 6:3-9. 2004
    ..As reported from animal experiments, the Ca(2+)-calmodulin activated phosphatase calcineurin and its downstream transcriptional effector NFAT have been implicated as transducers of the hypertrophic response...
  82. ncbi request reprint Mesenchymal stem cells transmigrate over the endothelial barrier
    Annette Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Carl Diem Weg 6, D 50933 Cologne, Germany
    Eur J Cell Biol 85:1179-88. 2006
    ..This work demonstrates the capability of MSCs for transendothelial migration. Moreover we showed that the vast majority of MSCs migrated within 30 min, an important finding for the exposure times in clinical settings...
  83. ncbi request reprint Basic fibroblast growth factor controls migration in human mesenchymal stem cells
    Annette Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne
    Stem Cells 24:1750-8. 2006
    ..This ambivalent effect of bFGF provides the possibility to a purposeful routing of MSCs...
  84. ncbi request reprint Crataegus special extract WS 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177
    Klara Brixius
    Laboratory of Muscle Research and Molecular Cardiology, Clinic III for Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, D 50924, Cologne, Germany, Robert
    Cardiovasc Drugs Ther 20:177-84. 2006
    ..This study investigates the influence of WS(R) 1442, a special extract of Crataegus leaves with flowers, on the relaxation of rat aorta and human mammarian artery (coronary bypass patients)...
  85. ncbi request reprint [The basis for treatment of cardiovascular diseases: cellular and molecular mechanisms of Crataegus extract]
    Klara Brixius
    Labor für Herzmuskelphysiologie und Molekulare Kardiologie, Klinik III fur Innere Medizin, Universitat Koln
    Pharm Unserer Zeit 34:48-51. 2005
  86. ncbi request reprint Role of erythropoietin for angiogenesis and vasculogenesis: from embryonic development through adulthood
    Jochen Müller-Ehmsen
    Dept of Internal Medicine III, University of Cologne, Germany
    Am J Physiol Heart Circ Physiol 290:H331-40. 2006
    ..They provide additional and further evidence for a strong interrelation between hematopoiesis and vasculogenesis/angiogenesis (sharing the same pathways), which may be important in many physiological and pathophysiological conditions...
  87. ncbi request reprint Effect of prophylactic bisoprolol plus magnesium on the incidence of atrial fibrillation after coronary bypass surgery: results of a randomized controlled trial
    Saeid Behmanesh
    Department of Cardiothoracic Surgery, University of Cologne, Joseph Stelzman Strasse 9, 50924 Cologne, Germany
    Curr Med Res Opin 22:1443-50. 2006
    ..Therefore the aim of this study was to evaluate the efficacy of bisoprolol plus magnesium (Mg) in the prophylaxis of AF after coronary artery bypass graft (CABG) surgery...