H Schweikl

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Mutagenic activity of structurally related oxiranes and siloranes in Salmonella typhimurium
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Mutat Res 521:19-27. 2002
  2. doi request reprint Salivary protein adsorption and Streptococccus gordonii adhesion to dental material surfaces
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg Medical Centre, 93042 Regensburg, Germany Electronic address
    Dent Mater 29:1080-9. 2013
  3. doi request reprint Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Biomaterials 29:1377-87. 2008
  4. ncbi request reprint Proliferation of osteoblasts and fibroblasts on model surfaces of varying roughness and surface chemistry
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, Regensburg 93053, Germany
    J Mater Sci Mater Med 18:1895-905. 2007
  5. ncbi request reprint Genetic and cellular toxicology of dental resin monomers
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    J Dent Res 85:870-7. 2006
  6. ncbi request reprint Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Dent Mater 23:688-95. 2007
  7. ncbi request reprint The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Biomaterials 26:4111-8. 2005
  8. ncbi request reprint Cytotoxic and mutagenic effects of dental composite materials
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg D 93042, Germany
    Biomaterials 26:1713-9. 2005
  9. ncbi request reprint The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    J Dent Res 83:17-21. 2004
  10. ncbi request reprint Toxicity parameters for cytotoxicity testing of dental materials in two different mammalian cell lines
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Eur J Oral Sci 104:292-9. 1996

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Mutagenic activity of structurally related oxiranes and siloranes in Salmonella typhimurium
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Mutat Res 521:19-27. 2002
    ..typhimurium strains. All compounds will be further analyzed for the formation of chromosomal aberrations in mammalian cell cultures...
  2. doi request reprint Salivary protein adsorption and Streptococccus gordonii adhesion to dental material surfaces
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg Medical Centre, 93042 Regensburg, Germany Electronic address
    Dent Mater 29:1080-9. 2013
    ....
  3. doi request reprint Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Biomaterials 29:1377-87. 2008
    ..The coordinated induction of genes coding for oxidative stress response and antioxidant proteins is a critical mechanism of protection against TEGDMA-induced cell damage...
  4. ncbi request reprint Proliferation of osteoblasts and fibroblasts on model surfaces of varying roughness and surface chemistry
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, Regensburg 93053, Germany
    J Mater Sci Mater Med 18:1895-905. 2007
    ..The different surface roughnesses and topographies were recognized by MG-63 osteoblasts. The cells spread well on smooth surfaces but appeared smaller on a rough and unique pyramid-shaped surface and on a rough sandblasted surface...
  5. ncbi request reprint Genetic and cellular toxicology of dental resin monomers
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    J Dent Res 85:870-7. 2006
    ..Pathways regulating cellular homeostasis, dentinogenesis, or tissue repair may be modified by monomers at concentrations well below those which cause acute cytotoxicity...
  6. ncbi request reprint Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Dent Mater 23:688-95. 2007
    ..In addition, we analyzed the effects of TEGDMA and HEMA on the normal cell cycle in the presence of NAC...
  7. ncbi request reprint The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    Biomaterials 26:4111-8. 2005
    ..From these results, we conclude that TEGDMA may influence physiological processes like cell growth and differentiation of human pulp cells in vivo...
  8. ncbi request reprint Cytotoxic and mutagenic effects of dental composite materials
    Helmut Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg D 93042, Germany
    Biomaterials 26:1713-9. 2005
    ..Our findings suggest that mutagenic components of biologically active composite resins should be replaced by more biocompatible substances to avoid risk factors for the health of patients and dental personnel...
  9. ncbi request reprint The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042 Regensburg, Germany
    J Dent Res 83:17-21. 2004
    ..Est-Ep and Eth-Ep also induced gene mutations. Our analyses indicated low mutagenic potentials of siloranes; however, some oxiranes induced strong effects at two genetic endpoints...
  10. ncbi request reprint Toxicity parameters for cytotoxicity testing of dental materials in two different mammalian cell lines
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Eur J Oral Sci 104:292-9. 1996
    ....
  11. ncbi request reprint The induction of micronuclei in vitro by unpolymerized resin monomers
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    J Dent Res 80:1615-20. 2001
    ..Since it has been shown that TEGDMA also caused gene mutations and DNA sequence deletions in mammalian cells, the activity of this substance should be analyzed in vivo...
  12. ncbi request reprint The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Mutat Res 415:119-30. 1998
    ..typhimurium. In contrast, the compound induced a dose-dependent rise in mutant frequencies in V79 cell cultures. It is concluded that TEGDMA acted through a clastogenic mechanism which is not detected by Ames tester strains...
  13. ncbi request reprint Triethylene glycol dimethacrylate induces large deletions in the hprt gene of V79 cells
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, D 93042, Regensburg, Germany
    Mutat Res 438:71-8. 1999
    ..Therefore, we conclude by analogy that the induction of large DNA sequence deletions as shown here with the reactive dimethacrylate, triethylene glycol dimethacrylate, is probably common for acrylates and methacrylates...
  14. ncbi request reprint The induction of micronuclei in V79 cells by the root canal filling material AH plus
    H Schweikl
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Biomaterials 21:939-44. 2000
    ..Therefore, we provide evidence for the induction of chromosomal mutations by freshly mixed AH Plus under experimental conditions...
  15. ncbi request reprint Epithelium-fibroblast co-culture for assessing mucosal irritancy of metals used in dentistry
    G Schmalz
    Department of Operative Dentistry and Periodontology, University of Regenburg, Germany
    Eur J Oral Sci 105:86-91. 1997
    ..The PGE2 determination proved to be a non-destructive method for continuous monitoring of cell reactions in the same culture. The model used seems promising for evaluating the time-dependent mucosal irritancy of dental cast alloys...
  16. ncbi request reprint Responses of L929 mouse fibroblasts, primary and immortalized bovine dental papilla-derived cell lines to dental resin components
    B Thonemann
    Department of Operative Dentistry and Periodontology, University of Regensburg, 93042, Germany
    Dent Mater 18:318-23. 2002
    ....
  17. doi request reprint TEGDMA reduces mineralization in dental pulp cells
    K M Galler
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Dent Res 90:257-62. 2011
    ..These findings indicate that even low TEGDMA concentrations might inhibit mineralization induced by dental pulp cells, thus impairing reparative dentin formation after pulp capping with dentin bonding agents...
  18. ncbi request reprint Release of prostaglandin E2, IL-6 and IL-8 from human oral epithelial culture models after exposure to compounds of dental materials
    G Schmalz
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Eur J Oral Sci 108:442-8. 2000
    ..Therefore, the measurement of this cytokine may be included as another parameter in evaluating the biological activity of dental materials under nontoxic experimental conditions in vitro...
  19. ncbi request reprint Adhesion of eukaryotic cells and Staphylococcus aureus to silicon model surfaces
    R Muller
    Institute of Physical and Theoretical Chemistry, University of Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    J Biomed Mater Res A 84:817-27. 2008
    ..These findings provide evidence that the PEG-modified surfaces showed selective bioactivity, preventing the attachment of a microbial pathogen but supporting the adhesion of eukaryotic cells...
  20. doi request reprint Toll-like receptors, LPS, and dental monomers
    G Schmalz
    Department of Operative Dentistry and Periodontology, University Medical Centre Regensburg, Germany
    Adv Dent Res 23:302-6. 2011
    ..Furthermore, the cell type played a decisive role. Inhibition of the immune response may result in a decrease in inflammatory symptoms and/or a reduced defense capacity against bacteria...
  21. doi request reprint Influence of TEGDMA on the mammalian cell cycle in comparison with chemotherapeutic agents
    Alexander Eckhardt
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Dent Mater 26:232-41. 2010
    ..Therefore, the influence of TEGDMA on the cell cycle was analyzed in comparison with the chemotherapeutic agents adriamycin and mitomycin C (MMC), which arrest the cell cycle through different mechanisms...
  22. doi request reprint The anti-adherence activity and bactericidal effect of microparticulate silver additives in composite resin materials
    Ralf Burgers
    Department of Prosthetic Dentistry, Regensburg University Medical Centre, 93042 Regensburg, Germany
    Arch Oral Biol 54:595-601. 2009
    ..The aim of the present in vitro study was to evaluate the antibacterial activity of a resin composite material loaded with silver microparticles against Streptococcus mutans...
  23. doi request reprint TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases
    Alexander Eckhardt
    Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany
    Biomaterials 30:2006-14. 2009
    ..Signaling through ATM indicates oxidative DNA damage and the activation of MAPK pathways indicates oxidative stress-induced regulation of cell survival and apoptosis...
  24. doi request reprint Influences of protein films on antibacterial or bacteria-repellent surface coatings in a model system using silicon wafers
    Rainer Müller
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Biomaterials 30:4921-9. 2009
    ..As a conclusion we propose that future approaches should combine the protein- and bacteria-repellent properties of PEG-coatings with the bactericidal function of charged cationic groups...
  25. doi request reprint Resin monomer-induced differential activation of MAP kinases and apoptosis in mouse macrophages and human pulp cells
    Stephanie Krifka
    Department of Operative Dentistry and Periodontology, University of Regensburg, University Medical Center, Regensburg, Germany
    Biomaterials 31:2964-75. 2010
    ..The direct causal correlation of these phenomena, however, requires further investigation...
  26. ncbi request reprint Cytotoxicity of low pH dentin-bonding agents in a dentin barrier test in vitro
    Gottfried Schmalz
    Clinic of Operative Dentistry and Periodontology, University of Regensburg, Germany
    J Endod 28:188-92. 2002
    ..Because low pH bonding agents did not show toxic reactions in this dentin barrier test, pulp damage caused by the tested substance is unlikely if a dentin layer protects the pulp...
  27. doi request reprint Inhibition of cytokine and surface antigen expression in LPS-stimulated murine macrophages by triethylene glycol dimethacrylate
    Alexander Eckhardt
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Biomaterials 30:1665-74. 2009
    ..Thus, the ability of macrophages to induce an appropriate immune response is inhibited by TEGDMA which reduces cytokine production and expression of surface antigens...
  28. ncbi request reprint Human pulp-derived cells immortalized with Simian Virus 40 T-antigen
    Kerstin M Galler
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Eur J Oral Sci 114:138-46. 2006
    ..Transfection of human pulp-derived cells resulted in an immortalized cell line retaining many of the phenotypic characteristics observed in primary cells...
  29. doi request reprint Effect of 2-hydroxyethyl methacrylate on human pulp cell survival pathways ERK and AKT
    Gianrico Spagnuolo
    Department of Oral and Maxillofacial Sciences and Interdisciplinary Research Centre on Biomaterials CRIB, University of Naples Federico II, Naples, Italy
    J Endod 34:684-8. 2008
    ..Our findings demonstrated that HEMA exposure modulates the ERK and AKT pathways in different manners, and that in turn, they function in parallel to mediate pro-survival signaling in pulp cells subjected to HEMA cytotoxicity...
  30. ncbi request reprint Toxicity potentiation by H2O2 with components of dental restorative materials on human oral cells
    Franz Xaver Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Goethestr 33, 80336 Munich, Germany
    Arch Toxicol 82:21-8. 2008
    ..06 or 0.1 mmol/l), as compared to that UDMA EC(50) value without H(2)O(2) addition. The addition of H(2)O(2) (0.06 or 0.1 mmol/l) resulted in a toxicity potentiation of TEGDMA and UDMA, but not of HEMA and BisGMA, on HGF or HPF...
  31. ncbi request reprint Effect of N-acetyl-L-cysteine on ROS production and cell death caused by HEMA in human primary gingival fibroblasts
    Gianrico Spagnuolo
    Department of Oral and Maxillofacial Sciences, University of Naples Federico II via S Pansini 5, 80131 Naples, Italy
    Biomaterials 27:1803-9. 2006
    ..05). In conclusion, our results suggest that high NAC concentrations protect HGF against HEMA cytotoxicity by reducing the induced ROS levels...