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Genomes and Genes | Edzard SchwedhelmSummaryAffiliation: University of Hamburg Country: Germany Publications
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Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohortEdzard Schwedhelm
Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Chem Lab Med 49:1907-10. 2011..Furthermore, recent work implicates SDMA in the pathogenesis of cardiovascular disease. To date, reference limits for SDMA plasma concentrations in healthy individuals are lacking...- A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuriaLatika Sibal
Newcastle University, Newcastle upon Tyne, UK
Cardiovasc Diabetol 8:27. 2009..The aim of the present study was to measure circulating ADMA, and define its association with endothelial dysfunction and endothelial markers in people with Type 1 diabetes with low likelihood of macrovascular disease... 
Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasmaEdzard Schwedhelm
Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Germany
Clin Chem 51:1268-71. 2005- Quantification of ADMA: analytical approachesEdzard Schwedhelm
Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Germany
Vasc Med 10:S89-95. 2005..This GC-MS approach has been further improved by Albsmeier et al by introducing labelled ADMA as an internal standard. As an alternative to existing methods, a commercially available ELISA kit has recently been developed and validated... - High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasmaEdzard Schwedhelm
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 851:211-9. 2007..37+/-0.07 microM in healthy humans (n=85), respectively, and 44+/-14, 0.72+/-0.23, and 0.19+/-0.06 microM in C57BL/6 mice. Also, the molar ratios of arginine to ADMA were different in man and mice, i.e. 166+/-50 and 85+/-22, respectively... 
Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohortEdzard Schwedhelm
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Chem 55:1539-45. 2009..Relatively small differences in ADMA concentrations between healthy individuals and those with disease underscore the need to formulate reference intervals that may aid risk stratification of individuals...- Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolismEdzard Schwedhelm
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg Eppendorf, Germany
Br J Clin Pharmacol 65:51-9. 2008..In contrast, L-citrulline is readily absorbed and at least in part converted to L-arginine. The aim of our study was to assess this metabolic conversion and its subsequent pharmacodynamic effects... - Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control studyEdzard Schwedhelm
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
Circulation 109:843-8. 2004..We tested the hypothesis that risk factors of CHD are associated with abundant systemic oxidative stress... - Application of gas chromatography-mass spectrometry for analysis of isoprostanes: their role in cardiovascular diseaseEdzard Schwedhelm
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
Clin Chem Lab Med 41:1552-61. 2003..Results from several clinical studies are included indicating the validity of isoprostanes as surrogate parameters of oxidative stress in cardiovascular disease... - Telmisartan improves endothelial function in patients with essential hypertensionRalf A Benndorf
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center, Hamburg Eppendorf, Germany
J Cardiovasc Pharmacol 50:367-71. 2007..We therefore investigated whether the new ARB telmisartan improves endothelial function and renal vascular resistance in patients with essential hypertension... - Reference intervals for plasma L-arginine and the L-arginine:asymmetric dimethylarginine ratio in the Framingham Offspring CohortNicole Lüneburg
Institute of Clinical Pharmacology and Toxicology, University Medical Center, Hamburg Eppendorf, Germany
J Nutr 141:2186-90. 2011..We report reference levels for plasma L-arginine and for the L-arginine:ADMA ratio that may be helpful for evaluation of the effects of L-arginine supplementation in participants with an impaired L-arginine/NO pathway... - Mobilization of putative high-proliferative-potential endothelial colony-forming cells during antihypertensive treatment in patients with essential hypertensionRalf A Benndorf
Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Stem Cells Dev 16:329-38. 2007.... - Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertensionMilica Bajcetic
Institute of Experimental and Clinical Pharmacology and Toxicology, Clinical Pharmacology Unit, University Hospital Hamburg Eppendorf, Martinistrasse 521, D 20246 Hamburg
J Clin Pharmacol 47:295-304. 2007..Larger crossover trials will have to establish these observations and investigate whether interaction of both drugs affects telmisartan efficacy and tolerability in clinical use... - Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemiaRenke Maas
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Clin Chem 54:292-300. 2008..It was the aim of this study to directly estimate and compare whole-body NO production in normo- and hypercholesterolemia by applying a nonradioactive stable isotope dilution technique in vivo... - Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertensionRalf A Benndorf
Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
Metabolism 55:1159-64. 2006..Future studies will demonstrate whether these telmisartan-induced effects may contribute to a blood pressure-independent reduction in cardiovascular morbidity... - Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic strokeFrank Leypoldt
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 4:e7337. 2009..ADMA is a predictor of cardiovascular events and mortality in humans. It is eliminated primarily by enzymatic activity of dimethylarginine dimethylaminohydrolase (DDAH)... - Extensive characterization of the human DDAH1 transgenic miceEdzard Schwedhelm
Institute of Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
Pharmacol Res 60:494-502. 2009.... - Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgeryRenke Maas
University Hospital Hamburg Eppendorf, Institute of Experimental and Clinical Pharmacology and Toxicology, Hamburg, Germany
Crit Care Med 35:1876-81. 2007..We aimed to investigate elevated plasma ADMA concentrations as a prospective risk marker for adverse events in patients undergoing noncardiac surgery... - Symmetric dimethylarginine predicts all-cause mortality following ischemic strokeFriedrich Schulze
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Atherosclerosis 208:518-23. 2010..ADMA is a predictor of cardiovascular events and mortality in diverse populations... - Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the communityRainer H Boger
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Circulation 119:1592-600. 2009..Although elevated ADMA has been associated with an increased risk of cardiovascular disease events and death in referral samples, the prognostic significance of ADMA in the community has not been adequately evaluated... - L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglyceridesFriedrich Schulze
Center for Experimental Medicine, Institute for Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany
Nutr Res 29:291-7. 2009..We conclude from our data that L-arginine enhances the effects of simvastatin on lipid metabolism, but it has no triglyceride-lowering effects when given alone... - FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantationTobias Deuse
Department of Cardiovascular Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany
J Heart Lung Transplant 24:1844-54. 2005..The anti-proliferative potency of FK778 on SMC may be an important mechanism of action. Combination regimens showed favorable drug interaction and allowed dose reduction of both agents to achieve maximal immunosuppressive efficacy... - Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's diseaseSönke Arlt
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Dement Geriatr Cogn Disord 26:58-64. 2008..Concerning Alzheimer's disease (AD), there are reports on altered cerebral NO metabolism, but only few studies on ADMA concentrations in plasma and cerebrospinal fluid (CSF)... - Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometryRainer H Boger
Institute of Clinical Pharmacology, Medical School, Hannover, Germany Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
Nitric Oxide 11:1-8. 2004.... - Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicityChi Un Choe
Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Neurochem 110:1766-73. 2009..Taken together, our data indicate that HNO might worsen cerebral ischemia-reperfusion injury by increasing oxidative stress and decreasing brain perfusion at concentrations shown to be cardioprotective in vivo... - Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger TrialTanja K Rudolph
Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Am J Clin Nutr 86:334-40. 2007..High-fat meals have negative effects on endothelial function, but vitamin-rich side orders may prevent these negative effects... - Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxRalf A Benndorf
Clinical Pharmacology Unit, Department of Pharmacology, University Hospital Hamburg, Hamburg, Germany
Circ Res 103:1037-46. 2008..By this mechanism, isoprostanes may contribute directly to exacerbation of coronary heart disease and to capillary rarefaction in disease states of increased oxidative stress... - Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal functionNicole Lüneburg
Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Germany
Clin Sci (Lond) 122:105-11. 2012..Our results strengthen the prognostic value of renal function in patients with stroke and confirm the hypothesis that SDMA is a promising marker for renal function... - Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assayFriedrich Schulze
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, Center for Experimental Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Clin Chem Lab Med 42:1377-83. 2004..For human plasma we found a mean of 0.65 micromol/l in healthy subjects. In the plasma of mice and rats we found mean concentrations of 1.05 and 1.09 micromol/l, respectively... - Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effectsThomas Heitzer
Universitäres Herzzentrum Hamburg, Universitatsklinikum Hamburg Eppendorf, Germany
Arterioscler Thromb Vasc Biol 26:1648-52. 2006.... - Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemiaRenke Maas
Clinical Pharmacology Unit, Institute for Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Atherosclerosis 191:211-9. 2007..To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function... - Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der RegiRenke Maas
Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Clin Chem 53:693-701. 2007..We investigated the association between plasma concentrations of ADMA and risk in initially healthy smoking and nonsmoking men... - Myeloperoxidase deficiency preserves vasomotor function in humansTanja K Rudolph
Cardiovascular Research Center and Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
Eur Heart J 33:1625-34. 2012..Observational studies have suggested a mechanistic link between the leucocyte-derived enzyme myeloperoxidase (MPO) and vasomotor function. Here, we tested whether MPO is systemically affecting vascular tone in humans... - Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginineGerhild I Böger
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, Hamburg, Germany
J Am Coll Cardiol 49:2274-82. 2007..We hypothesized that the level of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide (NO) synthase (eNOS), might determine the endothelial effects of statins... - Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunctionRenke Maas
Institut fur Experimentelle und Klinische Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Germany
Eur Urol 48:1004-11; discussion 1011-2. 2005.... - Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertensionRenke Maas
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University, Erlangen Nuremberg, Germany
Pharmacol Res 60:488-93. 2009..The mechanisms of this association need further investigation... - Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortalityRainer H Boger
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Clin Chem Lab Med 43:1124-9. 2005..Recently, advances have been made in the development of analytical methods that are reliable and fast enough to allow determination of ADMA in clinical routine... - A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissueRenke Maas
Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 851:220-8. 2007..9% and 10% for mouse kidney and liver, respectively. The present DDAH activity assay allows for the first time to simultaneously determine DDAH activity and endogenous formation of ADMA, SDMA, and L-arginine in tissue... - Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidaseEike Christin von Leitner
Department of Interventional Cardiology, Hamburg University Heart Center, Hamburg, Germany
Circulation 124:2735-45. 2011..The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO... - Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency roomFriedrich Schulze
University Hospital Hamburg Eppendorf, Institute for Experimental and Clinical Pharmacology and Toxicology, Hamburg, Germany
Clin Chim Acta 401:20-4. 2009..We investigated the predictive value of asymmetric dimethylarginine (ADMA) in unselected patients attending an internal medicine ER regarding outcome of the patients and duration of stay in the hospital... - ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI studyRainer H Boger
Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
Vasc Med 10:S97-102. 2005.... - Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) studyFriedrich Schulze
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, Center of Experimental Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
Am Heart J 152:493.e1-8. 2006..It has been shown that ADMA predicts cardiovascular mortality in patients who have coronary heart disease (CHD). However, the question whether ADMA is an independent risk factor for CHD still remains unresolved... - The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsiaRainer H Boger
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf Martinistrasse 52, DE 20246 Hamburg, Germany boeger uke uni hamburg de
Gynecol Obstet Invest 69:1-13. 2010..Recently, diagnostic assays for ADMA, e.g. by ELISA, have become available, which render ADMA a possible biomarker to identify pregnant women at risk of developing preeclampsia... - Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertensionKarsten Sydow
Department of Interventional Cardiology, Hamburg University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 7:e48150. 2012.... - ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitaminsKarsten Sydow
Department of Cardiology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
Cardiovasc Res 57:244-52. 2003..We investigated whether oral treatment with B vitamins or L-arginine normalizes endothelium-dependent, flow-dependent vasodilation (FDD) in patients with peripheral arterial occlusive disease (PAOD) and hyperhomocyst(e)inemia... - Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular riskRainer H Boger
Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Germany
Pharmacol Res 60:481-7. 2009.... - Determination of NG,NG-dimethyl-L-arginine, an endogenous NO synthase inhibitor, by gas chromatography-mass spectrometryJennifer Albsmeier
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 809:59-65. 2004..This method is fast, rugged and an alternative to high performance liquid chromatography (HPLC) analysis of ADMA in cell culture supernatants and small volumes of human plasma... - AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney diseaseChristoph Fraune
Div of Nephrology, Dept of Medicine, Universitatsklinikum Hamburg Eppendorf, Martinistraβe 52, 20246 Hamburg, Germany
Am J Physiol Renal Physiol 303:F1037-48. 2012..These observations underscore the pivotal role of targeting ANG II to reduce renal injury... - Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitusMaike Anderssohn
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Diab Vasc Dis Res 7:105-18. 2010..Anticipated advances in clinical and experimental investigation will help us to better understand this complex interrelationship between diabetes, eNOS, DDAH and ADMA... - P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery diseaseAnneke Bierend
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Br J Clin Pharmacol 65:540-7. 2008.... - Stable isotope dilution assay for liquid chromatography-tandem mass spectrometric determination of L-homoarginine in human plasmaDorothee Atzler
Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 879:2294-8. 2011..4 ± 4.5% (±SD) for 0.1-50 μmol/L and 7.5 ± 2.0% for 2 and 5 μmol/L, respectively. Applying this method, a mean plasma concentration of L-homoarginine of 2.5 ± 1.0 μmol/L was determined in 136 healthy humans... - Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stressEdzard Schwedhelm
Institute of Experimental and Clinical Pharmacology, Clinical Pharmacology Unit, University Hospital of Hamburg Eppendorf, Hamburg, Germany
Clin Pharmacokinet 42:437-59. 2003..Catechins are degraded to several gamma-valerolactone derivatives and phase II conjugates have also been identified. Only limited clinical pharmacokinetic data for other polyphenols such as resveratrol have been reported to date... - The L-Arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathyMaike Anderssohn
Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Card Fail 18:904-11. 2012..Asymmetric dimethylarginine (ADMA) is associated with increased mortality in patients with chronic heart failure but it remains unclear if the etiology of heart failure influences the prognostic value of dimethylarginines... - Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's diseaseSönke Arlt
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Alzheimers Dis 31:751-8. 2012..Functional and interventional studies are needed to further proof this hypothesis... - The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular functionRenke Maas
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Vasc Med 7:213-25. 2002..Likewise, the role of endothelium-derived factors mediating NO-independent pathways is evaluated... - Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanismGuido Eisele
Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Germany
J Cardiovasc Pharmacol 43:514-21. 2004..For ASA, the observed inhibition of monocyte adhesion was accomplished with concentrations that can be reached after single oral doses of 500 mg of ASA... - FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studiesTobias Deuse
Department of Cardiovascular Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Transplantation 78:71-7. 2004..CONCLUSION: Besides its inhibitory effect on pyrimidine synthesis, FK778 directly reduces endothelial adhesion molecule upregulation and attenuates lymphocyte-endothelium interaction, which is a critical step in graft rejection... - Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in miceRalf A Benndorf
Clinical Pharmacology Unit, Institute of Experimental and Clinical Toxicology and Pharmacology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Kidney Int 75:1039-49. 2009..Whether activation of the AT2 receptor will have therapeutic benefit in chronic kidney disease will require further study... - The role of asymmetric and symmetric dimethylarginines in renal diseaseEdzard Schwedhelm
Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Nat Rev Nephrol 7:275-85. 2011..The biochemical pathways that regulate ADMA and SDMA, and the pathways that transduce their biological function, could be targeted to treat renal disease in the future... - Impact of atorvastatin treatment on platelet-activating factor acetylhydrolase and 15-F(2trans)-isoprostane in hypercholesterolaemic patientsGhainsom D Kom
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Br J Clin Pharmacol 63:672-9. 2007..We investigated the effect of atorvastatin on PLA(2)s and PAF-AH activity and the urinary excretion of 15-F(2trans)-isoprostane (15-F(2t)-IsoP, 8-iso-PGF(2alpha), iPF(2alpha)-III)... - Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery diseaseBernhard Schieffer
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
J Am Coll Cardiol 44:362-8. 2004..We evaluated whether renin-angiotensin system (RAS) blockade attenuates cardiovascular events... - Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndromeRonald G Garcia
Int J Cardiol 122:176-8. 2007..Ethnic-specific or environmental differences in the etiologic mechanisms of metabolic syndrome need to be elucidated in further studies... - AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery diseaseAscan Warnholtz
Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Atherosclerosis 194:439-45. 2007..Since reduced FMD of the brachial artery has been shown to be associated with a high-cardiovascular event rate, improvement of FMD by IRB may lead to better prognosis of patients with CAD... - Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alDimitrios Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, D 30625 Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 794:237-55. 2003..We assume that ent-15(S)-8-iso-PGF(2alpha) is also contributing by approximately 50% to urinary 8-iso-PGF(2alpha). This finding may have methodological, mechanistic and clinical implications... - Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosisJean Luc Cracowski
INSERM ESPRI HP2 Laboratory, EA 3745, Grenoble Medical School, Grenoble, France
Free Radic Biol Med 40:1732-7. 2006..Whether oxygen free radicals initiate the vascular dysfunction or whether there is an initial trigger that initiates both processes will need to be further clarified in future studies... - Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serumFriedrich Schulze
J Chromatogr B Analyt Technol Biomed Life Sci 831:333. 2006 - Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsiaRenke Maas
JAMA 291:823-4. 2004 - Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular systemDimitrios Tsikas
Circ Res 90:E70. 2002 - Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometryDimitrios Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 784:77-90. 2003..9+/-3.1 for NO(2)Tyr and 1.2+/-0.2 for NO(2)TyrALB/TyrALB. The present GC-tandem MS method provides accurate values of NO(2)Tyr and NO(2)TyrALB in human plasma... - Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditionsDimitrios Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
J Chromatogr A 1067:337-45. 2005..The unique CID behavior of C6F5CH2--NO2 can be utilized to unequivocally identify and accurately quantify nitrite in biological fluids by GC-tandem MS...