Heidi Schwarzenbach

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1032-8. 2009
  2. ncbi request reprint Detection of tumor-specific DNA in blood and bone marrow plasma from patients with prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Int J Cancer 120:1465-71. 2007
  3. pmc Predictive diagnostics in colorectal cancer: impact of genetic polymorphisms on individual outcomes and treatment with fluoropyrimidine-based chemotherapy
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    EPMA J 1:485-94. 2010
  4. pmc LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival
    Jan Dominik Kuhlmann
    Department of Gynecology and Obstetrics, University Hospital of Essen, Hufelandstrasse 55, Essen, D 45122, Germany
    BMC Cancer 12:325. 2012
  5. doi request reprint Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression
    Heidi Schwarzenbach
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 18:5719-30. 2012
  6. doi request reprint Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients
    Heidi Schwarzenbach
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Breast Cancer Res Treat 134:933-41. 2012
  7. doi request reprint Circulating nucleic acids and protease activities in blood of tumor patients
    Heidi Schwarzenbach
    University Medical Center Hamburg Eppendorf, Department of Tumor Biology, Martinistrase 52, 20246 Hamburg, Germany
    Expert Opin Biol Ther 12:S163-9. 2012
  8. pmc Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    Breast Cancer Res 11:R71. 2009
  9. doi request reprint Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 127:881-8. 2010
  10. doi request reprint Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    J Cancer Res Clin Oncol 137:811-9. 2011

Detail Information

Publications34

  1. doi request reprint Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1032-8. 2009
    ..Circulating cell-free DNA in the blood of cancer patients harbors tumor-specific aberrations. Here, we investigated whether this DNA might also reflect the presence of circulating tumor cells (CTC)...
  2. ncbi request reprint Detection of tumor-specific DNA in blood and bone marrow plasma from patients with prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Int J Cancer 120:1465-71. 2007
    ..These data demonstrate, for the first time, the presence of free tumor-specific DNA in blood and BM of PCa patients and suggest a possible relationship to BM micrometastasis...
  3. pmc Predictive diagnostics in colorectal cancer: impact of genetic polymorphisms on individual outcomes and treatment with fluoropyrimidine-based chemotherapy
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    EPMA J 1:485-94. 2010
    ....
  4. pmc LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival
    Jan Dominik Kuhlmann
    Department of Gynecology and Obstetrics, University Hospital of Essen, Hufelandstrasse 55, Essen, D 45122, Germany
    BMC Cancer 12:325. 2012
    ....
  5. doi request reprint Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression
    Heidi Schwarzenbach
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 18:5719-30. 2012
    ..As identification of LOH on cell-free DNA is impeded by the prevalence of wild type DNA in blood of cancer patients, we fractionated plasma DNA, and determined the diagnostic and prognostic value of both fractions...
  6. doi request reprint Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients
    Heidi Schwarzenbach
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Breast Cancer Res Treat 134:933-41. 2012
    ..Since PTEN is an important target gene of miR-214, this finding could also have potential implications for therapeutic approaches...
  7. doi request reprint Circulating nucleic acids and protease activities in blood of tumor patients
    Heidi Schwarzenbach
    University Medical Center Hamburg Eppendorf, Department of Tumor Biology, Martinistrase 52, 20246 Hamburg, Germany
    Expert Opin Biol Ther 12:S163-9. 2012
    ..One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells...
  8. pmc Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    Breast Cancer Res 11:R71. 2009
    ..Here we investigated whether the detection of this DNA is related to bone marrow (BM) micrometastasis and tumor recurrence in breast cancer patients...
  9. doi request reprint Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 127:881-8. 2010
    ..Our data provide insight into the molecular diversity of the regulation of the TS gene expression. This is the first study that compares multi-variant TS genotypes in different clinical specimens...
  10. doi request reprint Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    J Cancer Res Clin Oncol 137:811-9. 2011
    ..MS-MLPA detects genetic and epigenetic aberrations of 37 tumor suppressor genes (TSG) in a single reaction and might, therefore, avoid the cumbersome single gene analyses...
  11. doi request reprint Impact of physical activity and doping on epigenetic gene regulation
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Drug Test Anal 3:682-7. 2011
    ....
  12. doi request reprint Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease
    Heidi Schwarzenbach
    Department of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, Hamburg, Germany
    Mol Biosyst 7:2848-54. 2011
    ..In conclusion, the quantification of cell-free tumour DNA had diagnostic and prognostic values in breast cancer patients, and DNA loss at the region 13q31-33 may be an indication of lymphatic tumour cell spread...
  13. doi request reprint Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann N Y Acad Sci 1137:190-6. 2008
    ..02). Quantitative analysis demonstrates that elevated DNA levels can be detected in blood of patients with colorectal cancer and may be a useful tool in combination with other tumor markers for detection of colorectal cancer...
  14. doi request reprint Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Centre, Hamburg Eppendorf, Germany
    BJU Int 102:253-8. 2008
    ..To investigate whether a high frequency of allelic imbalance (AI) is associated with clinicopathological variables of patients with prostate cancer...
  15. pmc A critical evaluation of loss of heterozygosity detected in tumor tissues, blood serum and bone marrow plasma from patients with breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 9:R66. 2007
    ..The aim of the study was to perform a comparative analysis of LOH (loss of heterozygosity) in primary tumors as well as peripheral blood and bone marrow (BM) of patients with breast cancer (BCa)...
  16. ncbi request reprint Detection and characterization of circulating microsatellite-DNA in blood of patients with breast cancer
    Heidi Schwarzenbach
    Institut of Tumor Biology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Ann N Y Acad Sci 1022:25-32. 2004
    ..Thus, screening for circulating tumor DNA may provide additional diagnostic information...
  17. ncbi request reprint Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer
    Felix K H Chun
    Department of Urology, University Hospital Hamburg Epppendorf, Hamburg, Germany
    BJU Int 98:544-8. 2006
    ..To investigate whether preoperative plasma levels of free DNA can discriminate between men with localized prostate cancer and benign prostatic hyperplasia (BPH)...
  18. pmc Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications
    Imke Müller
    Department of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 10:297. 2010
    ....
  19. ncbi request reprint Comparison of genetic alterations detected in circulating microsatellite DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia
    Imke Müller
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Ann N Y Acad Sci 1075:222-9. 2006
    ..These results indicate that microsatellite analysis using plasma DNA may be an interesting tool for molecular screening of PCa patients...
  20. pmc Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 12:R90. 2010
    ..Here we evaluated, for the first time, the feasibility and clinical utility of circulating miRs as biomarkers for the detection and staging of breast cancer...
  21. pmc Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors
    Carina Roth
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e38248. 2012
    ....
  22. doi request reprint Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements
    Imke Müller
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Clin Chem 54:688-96. 2008
    ..However, plasma DNA may harbor tumor-specific genetic alterations and could therefore be an interesting target for noninvasive examinations of tumor DNA...
  23. ncbi request reprint Microsatellite analysis in serum DNA as a diagnostic tool for distinction of patients with unknown pancreatic masses
    Robin Wachowiak
    University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Diagn Mol Pathol 16:174-8. 2007
    ..These data suggest that LOH analysis may be a substantial help for diagnosing pancreatic masses. An extension of the panel, perhaps in combination with a better selection of markers may further improve this assay...
  24. pmc Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    BMC Cancer 11:4. 2011
    ....
  25. doi request reprint Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Mol Oncol 5:281-91. 2011
    ....
  26. ncbi request reprint Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters
    Frank Wischnewski
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinstrasse 52, 20246 Hamburg, Germany
    Mol Cancer Res 5:749-59. 2007
    ..In conclusion, these data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE-A genes...
  27. doi request reprint Monitoring of loss of heterozygosity in serum microsatellite DNA among patients with gastrointestinal stromal tumors indicates tumor recurrence
    Tamina Rawnaq
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Surg Res 169:31-5. 2011
    ..In the current study, the aim was to investigate whether the frequency of loss of heterozygosity (LOH) on cell-free DNA in blood may reflect tumor stage and recurrent disease of these patients...
  28. pmc Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung
    Tatyana Kalinina
    Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg, Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 10:295. 2010
    ..Therefore new models are urgently needed to investigate this deadly disease. As a part of this process we have established and characterized a new human pancreatic cancer cell line...
  29. doi request reprint Cell-free nucleic acids as biomarkers in cancer patients
    Heidi Schwarzenbach
    Institute of Tumour Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany
    Nat Rev Cancer 11:426-37. 2011
    ..In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers...
  30. ncbi request reprint Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis
    Robin Wachowiak
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Anticancer Res 27:477-81. 2007
    ..The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility...
  31. ncbi request reprint Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells
    Frank Wischnewski
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Mol Cancer Res 4:339-49. 2006
    ..In conclusion, our data show for the first time that not only hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE gene silencing...
  32. ncbi request reprint Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients
    Viacheslav N Kalinin
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
    World J Gastroenterol 12:5352-6. 2006
    ..To verify and expand the known spectrum of serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in chronic pancreatitis...
  33. doi request reprint Clinical relevance of circulating cell-free microRNAs in cancer
    Heidi Schwarzenbach
    Department of Tumour Biology, Centre of Experimental Medicine, University Cancer Centre, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Nat Rev Clin Oncol 11:145-56. 2014
    ..This Review article considers the latest developments in the use of circulating microRNAs as prognostic and predictive biomarkers and discusses their utility in personalized medicine. ..
  34. ncbi request reprint A diagnostic tool for monitoring multidrug resistance expression in human tumor tissues
    Heidi Schwarzenbach
    Department C on Internal Medicine, Kantonsspital, St Gallen, Switzerland
    Anal Biochem 308:26-33. 2002
    ..Based on the results obtained, this multiplex/nested PCR approach may provide a base for quantitative analyses of MDR1, MRP, and topoisomerase IIalpha mRNA expression in clinical tumor biopsies...