Ulrich S Schwarz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Oscillations of Min-proteins in micropatterned environments: a three-dimensional particle-based stochastic simulation approach
    Max Hoffmann
    BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    Soft Matter 10:2388-96. 2014
  2. pmc Stochastic dynamics of virus capsid formation: direct versus hierarchical self-assembly
    Johanna E Baschek
    Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany
    BMC Biophys 5:22. 2012
  3. pmc United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction
    Ulrich S Schwarz
    BioQuant and Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany
    J Cell Sci 125:3051-60. 2012
  4. doi request reprint Developmental biology: a growing role for computer simulations
    Ulrich S Schwarz
    BioQuant and Institute for Theoretical Physics, University of Heidelberg, Philosophenweg 19, 69118 Heidelberg, Germany
    Curr Biol 22:R441-3. 2012
  5. pmc Environmental constraints guide migration of malaria parasites during transmission
    Janina Kristin Hellmann
    Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany
    PLoS Pathog 7:e1002080. 2011
  6. pmc Filamentous network mechanics and active contractility determine cell and tissue shape
    Ilka B Bischofs
    University of Heidelberg, Bioquant 0013, D 69120 Heidelberg, Germany
    Biophys J 95:3488-96. 2008
  7. doi request reprint Modeling cytoskeletal flow over adhesion sites: competition between stochastic bond dynamics and intracellular relaxation
    Benedikt Sabass
    BIOQUANT, University of Heidelberg, Heidelberg, Germany
    J Phys Condens Matter 22:194112. 2010
  8. doi request reprint Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites
    Sylvia Münter
    Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Im Neuenheimer Feld 324, University of Heidelberg, 69120 Heidelberg, Germany
    Cell Host Microbe 6:551-62. 2009
  9. doi request reprint Reconstructing the orientation distribution of actin filaments in the lamellipodium of migrating keratocytes from electron microscopy tomography data
    Julian Weichsel
    BIOQUANT, Heidelberg University, Heidelberg 69120, Germany
    Cytometry A 81:496-507. 2012
  10. ncbi request reprint Viscoelastic response of contractile filament bundles
    Achim Besser
    University of Heidelberg, BIOQUANT, Im Neuenheimer Feld 267, Heidelberg
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051902. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint Oscillations of Min-proteins in micropatterned environments: a three-dimensional particle-based stochastic simulation approach
    Max Hoffmann
    BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    Soft Matter 10:2388-96. 2014
    ....
  2. pmc Stochastic dynamics of virus capsid formation: direct versus hierarchical self-assembly
    Johanna E Baschek
    Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany
    BMC Biophys 5:22. 2012
    ..abstract:..
  3. pmc United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction
    Ulrich S Schwarz
    BioQuant and Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany
    J Cell Sci 125:3051-60. 2012
    ..Physical limits of stability emerge as one important element of the cellular response that complements the structural changes affected by regulatory systems in response to mechanical processes...
  4. doi request reprint Developmental biology: a growing role for computer simulations
    Ulrich S Schwarz
    BioQuant and Institute for Theoretical Physics, University of Heidelberg, Philosophenweg 19, 69118 Heidelberg, Germany
    Curr Biol 22:R441-3. 2012
    ....
  5. pmc Environmental constraints guide migration of malaria parasites during transmission
    Janina Kristin Hellmann
    Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany
    PLoS Pathog 7:e1002080. 2011
    ..This may explain their delay in infecting the host. The flexibility of sporozoite adaption to different environments and a favorable speed for optimal dispersal ensures efficient host switching during malaria transmission...
  6. pmc Filamentous network mechanics and active contractility determine cell and tissue shape
    Ilka B Bischofs
    University of Heidelberg, Bioquant 0013, D 69120 Heidelberg, Germany
    Biophys J 95:3488-96. 2008
    ..Our model in conjunction with actomyosin inhibition experiments further suggests that cell shape is regulated by two different control modes related to motor contractility and structural changes in the actin cytoskeleton...
  7. doi request reprint Modeling cytoskeletal flow over adhesion sites: competition between stochastic bond dynamics and intracellular relaxation
    Benedikt Sabass
    BIOQUANT, University of Heidelberg, Heidelberg, Germany
    J Phys Condens Matter 22:194112. 2010
    ..At low internal dissipation, stochastic bond dynamics lead to a regime of irregular stick-and-slip motion. High internal dissipation effectively suppresses cooperative effects among bonds and hence stabilizes the adhesion...
  8. doi request reprint Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites
    Sylvia Münter
    Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Im Neuenheimer Feld 324, University of Heidelberg, 69120 Heidelberg, Germany
    Cell Host Microbe 6:551-62. 2009
    ..Further, we show that the essential sporozoite surface protein TRAP is critical for the regulated formation and rupture of adhesion sites but is dispensable for retrograde capping...
  9. doi request reprint Reconstructing the orientation distribution of actin filaments in the lamellipodium of migrating keratocytes from electron microscopy tomography data
    Julian Weichsel
    BIOQUANT, Heidelberg University, Heidelberg 69120, Germany
    Cytometry A 81:496-507. 2012
    ..For the lamellipodium at the leading edge of slow moving cells as well as for the lamellipodium at the flanks of fast moving cells, one broad peak around 0 degree dominates the distribution...
  10. ncbi request reprint Viscoelastic response of contractile filament bundles
    Achim Besser
    University of Heidelberg, BIOQUANT, Im Neuenheimer Feld 267, Heidelberg
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051902. 2011
    ..Imposing cyclic varying boundary forces allows us to calculate the complex modulus of a single stress fiber...
  11. ncbi request reprint Stochastic force generation by small ensembles of myosin II motors
    Thorsten Erdmann
    BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    Phys Rev Lett 108:188101. 2012
    ....
  12. ncbi request reprint Effect of adhesion geometry and rigidity on cellular force distributions
    Ilka B Bischofs
    BIOQUANT, University of Heidelberg, 69120 Heidelberg, Germany
    Phys Rev Lett 103:048101. 2009
    ..Softer substrates result in smaller forces. Our predictions agree well with experimental force patterns measured on pillar assays...
  13. ncbi request reprint Unifying autocatalytic and zeroth-order branching models for growing actin networks
    Julian Weichsel
    BioQuant and Institute for Theoretical Physics, University of Heidelberg, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 87:040701. 2013
    ..Together, these mechanisms allow cells to grow stable actin networks over a large range of different conditions...
  14. pmc Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment
    Raja Paul
    BIOQUANT, University of Heidelberg, Heidelberg, Germany
    Biophys J 94:1470-82. 2008
    ..The same effect can be obtained also by internally generated force, suggesting a mechanism by which cells can control their migration morphologies...
  15. pmc Two competing orientation patterns explain experimentally observed anomalies in growing actin networks
    Julian Weichsel
    BIOQUANT, and Institute for Theoretical Physics, Heidelberg University, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 107:6304-9. 2010
    ..Thus a simple generic model can explain the experimentally observed anomalies, with far reaching consequences for cell migration...
  16. ncbi request reprint Probing cellular microenvironments and tissue remodeling by atomic force microscopy
    Thomas Ludwig
    Group Microenvironment of Tumor Cell Invasion, German Cancer Research Center, BIOQUANT Zentrum BQ 0009 NWG Ludwig, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    Pflugers Arch 456:29-49. 2008
    ..To achieve a more complete understanding of the processes underlying the interaction of cells with their environments, the combination of AFM force spectroscopy experiments will be essential...
  17. ncbi request reprint Force localization in contracting cell layers
    Carina M Edwards
    University of Heidelberg, BIOQUANT, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    Phys Rev Lett 107:128101. 2011
    ..We also show that anisotropic extracellular stiffness can lead to force localization in the stiffer direction, as observed experimentally...
  18. pmc A kinetic model for RNA-interference of focal adhesions
    Max Hoffmann
    BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    BMC Syst Biol 7:2. 2013
    ..adhesome.org). First RNAi-screens have been performed for focal adhesions and the effect of knockdown of many of these components on the number, size, shape and location of focal adhesions has been reported...
  19. ncbi request reprint Role of anisotropy for protein-protein encounter
    Jakob Schluttig
    University of Heidelberg, Institut fur Theoretische Physik, Philosophenweg 19, 69120 Heidelberg, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 81:030902. 2010
    ..Calculating analytically the crossover times from anisotropic to isotropic diffusion in three dimensions, we find that they are much smaller than typical protein encounter times, in agreement with our numerical results...
  20. doi request reprint Stochastic simulations of cargo transport by processive molecular motors
    Christian B Korn
    University of Heidelberg, Bioquant 0013, Im Neuenheimer Feld 267, D 69120 Heidelberg, Germany
    J Chem Phys 131:245107. 2009
    ..Cooperativity in the sense of equal load sharing only occurs for high values for viscosity and attachment time...
  21. doi request reprint A quantitative measure for alterations in the actin cytoskeleton investigated with automated high-throughput microscopy
    Julian Weichsel
    BIOQUANT, University of Heidelberg, Heidelberg, Germany
    Cytometry A 77:52-63. 2010
    ..We then tested the influence of HIV-1 infection on actin coherency, but observed no significant differences between uninfected and infected cells...
  22. pmc Hysteresis in the cell response to time-dependent substrate stiffness
    Achim Besser
    BIOQUANT, University of Heidelberg, Heidelberg, Germany
    Biophys J 99:L10-2. 2010
    ..Using the full dynamical model, we predict that rate-dependent hysteresis will occur in the cellular traction forces when cells are exposed to substrates of time-dependent stiffness...
  23. doi request reprint Stochastic dynamics of small ensembles of non-processive molecular motors: the parallel cluster model
    Thorsten Erdmann
    BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany and Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, 69120 Heidelberg, Germany
    J Chem Phys 139:175104. 2013
    ..For increasing stiffness of the external spring, there is a sharp transition beyond which myosin II can no longer perform the power stroke. Slow unbinding from the pre-power-stroke state protects the ensembles against detachment. ..
  24. pmc High resolution traction force microscopy based on experimental and computational advances
    Benedikt Sabass
    University of Heidelberg, Heidelberg, Germany
    Biophys J 94:207-20. 2008
    ..Third, we combine these advances and for the first time reconstruct fibroblast traction with a spatial resolution of approximately 1 microm...
  25. ncbi request reprint Collective effects in cellular structure formation mediated by compliant environments: a Monte Carlo study
    Ilka B Bischofs
    University of Heidelberg, Im Neuenheimer Feld 293, D 69120 Heidelberg, Germany
    Acta Biomater 2:253-65. 2006
    ....