Affiliation: University of Kiel
Bruhs A, Haarmann Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A. Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol. 2015;135:435-444 pubmed publisher
..Thus, AhR agonists may represent an alternative to suppress the immune system like UVR but without causing the adverse effects of UVR including DNA damage. ..
Bruhs A, Schwarz T, Schwarz A. Prevention and Mitigation of Experimental Autoimmune Encephalomyelitis by Murine Î²-Defensins via Induction of Regulatory T Cells. J Invest Dermatol. 2016;136:173-81 pubmed publisher
..Thus, defensins may represent candidates worth being further pursued for the therapy of multiple sclerosis. ..
Schwarz A, Bruhs A, Schwarz T. The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. J Invest Dermatol. 2017;137:855-864 pubmed publisher
Bruhs A, Schwarz T. Ultraviolet Radiation-Induced Immunosuppression: Induction of Regulatory T Cells. Methods Mol Biol. 2017;1559:63-73 pubmed publisher
..In this protocol we describe a method for the UV-induced suppression of the induction of contact hypersensitivity and the adoptive transfer of immune response. ..
Navid F, Bruhs A, Schuller W, Fritsche E, Krutmann J, Schwarz T, et al
. The Aryl hydrocarbon receptor is involved in UVR-induced immunosuppression. J Invest Dermatol. 2013;133:2763-2770 pubmed publisher
..Activation of the AhR might represent an alternative to modulate the immune system in a similar manner like UVR but without causing the adverse effects of UVR, including DNA damage. ..
Bruhs A, Proksch E, Schwarz T, Schwarz A. Disruption of the Epidermal Barrier Induces Regulatory T Cells via IL-33 in Mice. J Invest Dermatol. 2018;138:570-579 pubmed publisher
..These results demonstrate that epidermal barrier disruption, in addition to danger signals, induces regulatory events that prevent exaggerated skin inflammation and that IL-33 appears to be critically involved in this process. ..