Jurgen R Schwarz

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Functions of erg K+ channels in excitable cells
    Jurgen R Schwarz
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Cell Mol Med 8:22-30. 2004
  2. pmc KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier
    J R Schwarz
    Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Physiol 573:17-34. 2006
  3. doi request reprint Erg K+ channels modulate contractile activity in the bovine epididymal duct
    Marco Mewe
    Institute of Vegetative Physiology and Pathophysiology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Regul Integr Comp Physiol 294:R895-904. 2008
  4. doi request reprint Erg K+ currents modulate excitability in mouse mitral/tufted neurons
    Wiebke Hirdes
    Institut für Neurale Signalverarbeitung, ZMNH, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, 20246, Hamburg, Germany
    Pflugers Arch 459:55-70. 2009
  5. pmc Extracellular potassium effects are conserved within the rat erg K+ channel family
    Patrick Sturm
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Physiol 564:329-45. 2005
  6. doi request reprint Modulation of cardiac ERG1 K(+) channels by cGMP signaling
    Marco Mewe
    Institute of Pharmacology for Pharmacists, University Medical Center, Hamburg Eppendorf UKE, Martinistr 52, D 20246 Hamburg, Germany
    J Mol Cell Cardiol 49:48-57. 2010
  7. ncbi request reprint Biophysical properties of heteromultimeric erg K+ channels
    Sönke Wimmers
    Institut für Angewandte Physiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Pflugers Arch 445:423-30. 2002
  8. pmc Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells
    Günter Glassmeier
    Institut für Zelluläre und Integrative Physiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, D 20246, Hamburg, Germany
    Pflugers Arch 463:365-76. 2012
  9. pmc Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit
    Niklas M Kirchberger
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Physiol 571:27-42. 2006
  10. ncbi request reprint Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b
    Ralf Fliegert
    Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    FEBS J 274:704-13. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Functions of erg K+ channels in excitable cells
    Jurgen R Schwarz
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Cell Mol Med 8:22-30. 2004
    ..Changes in the resting potential are related to cell-specific functions like increase in hormone secretion, frequency adaptation or increase in contractility...
  2. pmc KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier
    J R Schwarz
    Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Physiol 573:17-34. 2006
    ..We conclude that the nodal I(Ks) current is mediated by KCNQ channels, which in large fibres of rat sciatic nerve appear to be KCNQ2 homomers...
  3. doi request reprint Erg K+ channels modulate contractile activity in the bovine epididymal duct
    Marco Mewe
    Institute of Vegetative Physiology and Pathophysiology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Regul Integr Comp Physiol 294:R895-904. 2008
    ..In summary, these data provide strong evidence for a physiological role of erg1 channels in regulating epididymal motility patterns...
  4. doi request reprint Erg K+ currents modulate excitability in mouse mitral/tufted neurons
    Wiebke Hirdes
    Institut für Neurale Signalverarbeitung, ZMNH, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, 20246, Hamburg, Germany
    Pflugers Arch 459:55-70. 2009
    ..A pharmacological block of erg channels depolarized the resting potential of M/T cells and clearly demonstrated the involvement of erg channels in the control of mitral cell excitability...
  5. pmc Extracellular potassium effects are conserved within the rat erg K+ channel family
    Patrick Sturm
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Physiol 564:329-45. 2005
    ..5-3) and erg3 (factor 2-2.5). The data demonstrate that most [K(+)](o)-dependent changes in the biophysical properties are well conserved within the erg K(+) channel family, despite gradual differences in the magnitude of the effects...
  6. doi request reprint Modulation of cardiac ERG1 K(+) channels by cGMP signaling
    Marco Mewe
    Institute of Pharmacology for Pharmacists, University Medical Center, Hamburg Eppendorf UKE, Martinistr 52, D 20246 Hamburg, Germany
    J Mol Cell Cardiol 49:48-57. 2010
    ..These findings provide first evidence that through heteromeric assembly ERG1 channels become a critical target of cGMP-PKG signaling linking cGMP accumulation to cardiac I(Kr) modulation...
  7. ncbi request reprint Biophysical properties of heteromultimeric erg K+ channels
    Sönke Wimmers
    Institut für Angewandte Physiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Pflugers Arch 445:423-30. 2002
    ..Thus, through heteromeric assembly erg channels may contribute significantly to different physiological functions such as setting and stabilizing the resting membrane potential and modulation of action potential frequency...
  8. pmc Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells
    Günter Glassmeier
    Institut für Zelluläre und Integrative Physiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, D 20246, Hamburg, Germany
    Pflugers Arch 463:365-76. 2012
    ....
  9. pmc Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit
    Niklas M Kirchberger
    Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Physiol 571:27-42. 2006
    ..Surprisingly, most effects of TRH on heteromeric rerg1 channels were dominated by the rerg1b subunit...
  10. ncbi request reprint Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b
    Ralf Fliegert
    Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    FEBS J 274:704-13. 2007
    ..In conclusion, in cells with a small negative membrane potential, such as HEK-293 cells, TRPM4b acts as a positive regulator of Ca(2+) entry...
  11. pmc Fast erg K+ currents in rat embryonic serotonergic neurones
    Wiebke Hirdes
    Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Physiol 564:33-49. 2005
    ..Our data suggest that the erg channels in rat embryonic rhombencephalon neurones are heteromultimers formed by different erg channel subunits...
  12. doi request reprint Gonadotropin-releasing hormone inhibits ether-à-go-go-related gene K+ currents in mouse gonadotropes
    Wiebke Hirdes
    Institute for Neural Signal Transduction, Center for Molecular Neurobiology, University Hospital Hamburg Eppendorf, Falkenried 94, D 20253 Hamburg, Germany
    Endocrinology 151:1079-88. 2010
    ..In addition, the erg channels are modulated by GnRH by an as-yet unknown signal cascade...
  13. doi request reprint Ancillary subunits associated with voltage-dependent K+ channels
    Olaf Pongs
    Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Hamburg, Germany
    Physiol Rev 90:755-96. 2010
    ..We critically review present knowledge on the physiological role of ancillary Kv channel subunits and their effects on Kv channel properties...
  14. ncbi request reprint Mechanisms regulating spontaneous contractions in the bovine epididymal duct
    Marco Mewe
    Institut für Anatomie II Experimentelle Morphologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, D 20246 Hamburg, Germany
    Biol Reprod 75:651-9. 2006
    ..ATM cells may provide electrical coupling between myofibroblasts, which is essential for the generation of regular myogenic activity...
  15. doi request reprint Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions
    Chong Wee Liew
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    FEBS Lett 583:49-54. 2009
    ..Interaction with MUPP1 enables the receptor to regulate transepithelial permeability in a pertussis toxin sensitive manner, suggesting that hSSTR3 can activate G-proteins locally at tight junctions...