Research Topics
Genomes and Genes
| Jurgen R SchwarzSummaryAffiliation: University of Hamburg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Functions of erg K+ channels in excitable cellsJurgen R Schwarz
Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
J Cell Mol Med 8:22-30. 2004..Changes in the resting potential are related to cell-specific functions like increase in hormone secretion, frequency adaptation or increase in contractility...
KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of RanvierJ R Schwarz
Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
J Physiol 573:17-34. 2006..We conclude that the nodal I(Ks) current is mediated by KCNQ channels, which in large fibres of rat sciatic nerve appear to be KCNQ2 homomers...
Erg K+ channels modulate contractile activity in the bovine epididymal ductMarco Mewe
Institute of Vegetative Physiology and Pathophysiology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
Am J Physiol Regul Integr Comp Physiol 294:R895-904. 2008..In summary, these data provide strong evidence for a physiological role of erg1 channels in regulating epididymal motility patterns...- Erg K+ currents modulate excitability in mouse mitral/tufted neuronsWiebke Hirdes
Institut für Neurale Signalverarbeitung, ZMNH, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, 20246, Hamburg, Germany
Pflugers Arch 459:55-70. 2009..A pharmacological block of erg channels depolarized the resting potential of M/T cells and clearly demonstrated the involvement of erg channels in the control of mitral cell excitability... - Modulation of cardiac ERG1 K(+) channels by cGMP signalingMarco Mewe
Institute of Pharmacology for Pharmacists, University Medical Center, Hamburg Eppendorf UKE, Martinistr 52, D 20246 Hamburg, Germany
J Mol Cell Cardiol 49:48-57. 2010..These findings provide first evidence that through heteromeric assembly ERG1 channels become a critical target of cGMP-PKG signaling linking cGMP accumulation to cardiac I(Kr) modulation... - Biophysical properties of heteromultimeric erg K+ channelsSönke Wimmers
Institut für Angewandte Physiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Pflugers Arch 445:423-30. 2002..Thus, through heteromeric assembly erg channels may contribute significantly to different physiological functions such as setting and stabilizing the resting membrane potential and modulation of action potential frequency... - Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cellsGünter Glassmeier
Institut für Zelluläre und Integrative Physiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistr 52, D 20246, Hamburg, Germany
Pflugers Arch 463:365-76. 2012.... - Modulation of Ca2+ entry and plasma membrane potential by human TRPM4bRalf Fliegert
Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
FEBS J 274:704-13. 2007..In conclusion, in cells with a small negative membrane potential, such as HEK-293 cells, TRPM4b acts as a positive regulator of Ca(2+) entry... - Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunitNiklas M Kirchberger
Institut für Angewandte Physiologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Physiol 571:27-42. 2006..Surprisingly, most effects of TRH on heteromeric rerg1 channels were dominated by the rerg1b subunit... - Fast erg K+ currents in rat embryonic serotonergic neuronesWiebke Hirdes
Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
J Physiol 564:33-49. 2005..Our data suggest that the erg channels in rat embryonic rhombencephalon neurones are heteromultimers formed by different erg channel subunits... - Gonadotropin-releasing hormone inhibits ether-à-go-go-related gene K+ currents in mouse gonadotropesWiebke Hirdes
Institute for Neural Signal Transduction, Center for Molecular Neurobiology, University Hospital Hamburg Eppendorf, Falkenried 94, D 20253 Hamburg, Germany
Endocrinology 151:1079-88. 2010..In addition, the erg channels are modulated by GnRH by an as-yet unknown signal cascade... - Ancillary subunits associated with voltage-dependent K+ channelsOlaf Pongs
Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Hamburg, Germany
Physiol Rev 90:755-96. 2010..We critically review present knowledge on the physiological role of ancillary Kv channel subunits and their effects on Kv channel properties... - Mechanisms regulating spontaneous contractions in the bovine epididymal ductMarco Mewe
Institut für Anatomie II Experimentelle Morphologie, Zentrum für Experimentelle Medizin, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, D 20246 Hamburg, Germany
Biol Reprod 75:651-9. 2006..ATM cells may provide electrical coupling between myofibroblasts, which is essential for the generation of regular myogenic activity... - Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctionsChong Wee Liew
Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
FEBS Lett 583:49-54. 2009..Interaction with MUPP1 enables the receptor to regulate transepithelial permeability in a pertussis toxin sensitive manner, suggesting that hSSTR3 can activate G-proteins locally at tight junctions...