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Genomes and GenesSpecies | V SchusterSummaryAffiliation: University of Leipzig Country: Germany Publications
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Publications
Plasminogen deficiencyV Schuster
Hospital for Children and Adolescents, Medical Faculty of Leipzig University, Liebigstrasse 20a, Leipzig, Germany
J Thromb Haemost 5:2315-22. 2007....
Immunogenicity and safety assessments after one and two doses of a refrigerator-stable tetravalent measles-mumps-rubella-varicella vaccine in healthy children during the second year of lifeVolker Schuster
Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
Pediatr Infect Dis J 27:724-30. 2008..This study (104389/NCT00127023) was undertaken to assess the immunogenicity and safety of a new refrigerator-stable tetravalent MMRV vaccine after 1 dose and after 2 doses administered during the second year of life...
Lasting immune memory against hepatitis B in children after primary immunization with 4 doses of DTPa-HBV-IPV/Hib in the first and 2nd year of lifeMichael Steiner
University Hospital for Children and Adolescents, Leipzig, Germany
BMC Infect Dis 10:9. 2010..We assessed antibody persistence and immune memory in children 4-5 years of age, previously vaccinated with four doses of combined hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix hexa)...- Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activityJürgen Klammt
Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
Thromb Haemost 105:454-60. 2011..Transmission of genetic and clinical data to the recently established Plasminogen Deficiency Registry should help to determine the prevalence of the disease and to develop more efficient treatment strategies... - Homozygous and compound-heterozygous type I plasminogen deficiency is a common cause of ligneous conjunctivitisV Schuster
Children s Hospital, University of Leipzig, Germany
Thromb Haemost 85:1004-10. 2001..Our results suggest that the Lys19-->Glu mutation is the most prevalent mutation in the plasminogen gene of patients with ligneous conjunctivitis... - [Gianotti-Crosti syndrome in an infant following immunization]N Schwerk
Universitätsklinik und Poliklinik für Kinder und Jugendliche Leipzig
Klin Padiatr 217:297-9. 2005..Our data and review of the literature suggest that GCS is rarely associated with immunizations, especially when performed with inactivated vaccines... - Decreased factor XIII activity during severe Henoch-Schoenlein purpura -- does it play a role?F Prenzel
Clinic for Pediatric and Adolescent Medicine, University Hospitals of Leipzig
Klin Padiatr 218:174-6. 2006..In patients with Henoch-Schoenlein purpura (HSP), particularly with severe gastrointestinal symptoms, an associated decrease of plasma factor XIII has been observed... - X-linked lymphoproliferative disease is caused by deficiency of a novel SH2 domain-containing signal transduction adaptor proteinV Schuster
Department of Pediatrics, Leipzig University School of Medicine, Germany
Immunol Rev 178:21-8. 2000..Further functional studies of the SH2D1A protein will probably provide new insights into the pathogenesis of severe infectious mononucleosis, malignant lymphomas and immunodeficiency in patients with XLP... - A hospital based study on inter- and intragenotypic diversity of human rotavirus A VP4 and VP7 gene segments, GermanyC Pietsch
Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany
J Clin Virol 50:136-41. 2011..A major challenge in immunisation is the vast inter- and intragenotypic diversity accomplished by circulating rotaviruses... - Lethal influenza B myocarditis in a child and review of the literature for pediatric age groupsH Frank
Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany
Infection 38:231-5. 2010..Cardiac arrest occurred suddenly, resuscitation efforts were not successful, and the patient died of congestive heart failure 24 h after admission to the hospital... - [Varicella vaccination: who should be vaccinated these days?]Boris Hugle
Universitätsklinik für Kinder und Jugendliche, Leipzig
MMW Fortschr Med 147:31-2, 34-5. 2005..Experience gained in the United States show that widespread introduction of VZV vaccination results in a decrease in both the incidence of varicella and concomitant complications including herpes zoster... - Simultaneous manifestation of fulminant infectious mononucleosis with haemophagocytic syndrome and B-cell lymphoma in X-linked lymphoproliferative diseaseBoris Hugle
Department of Pediatrics, University of Leipzig, Oststrasse 21 25, Leipzig, Germany
Eur J Pediatr 166:589-93. 2007..Fatal EBV infection in male infants is highly indicative of XLP. Virus-associated haemophagocytic syndrome and B-cell lymphoma can occur concomitantly and may be difficult to distinguish due to their similar histological pictures... - Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patientsKatrin Tefs
Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, D 04317 Leipzig, Germany
Blood 108:3021-6. 2006..These results demonstrate impaired secretion of mutant PLG proteins as a common molecular pathomechanism in type I PLG deficiency... - A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotypeWolfram Heinritz
Institute of Human Genetics, University of Leipzig Medical Faculty, Leipzig, Germany
Am J Med Genet A 140:1223-7. 2006..We report on the clinical findings in a 2(1/2)-year-old boy with some aspects out of the MWS-spectrum in addition to unusual anomalies and a novel missense mutation in the ZFHX1B gene... - Addison's disease and severe encephalopathy in an infant with HIV infectionSkadi Beblo
Universitätsklinik und Poliklinik für Kinder und Jugendliche, Universitat Leipzig, Leipzig, Germany
J Pediatr Endocrinol Metab 23:297-302. 2010..To discuss the overlapping clinical spectrum of encephalopathy due to Addison's disease and HIV infection... - Pyogenic osteomyelitis of the vertebral arch in childrenMartin Reiss-Zimmermann
University Hospital Leipzig, Department of Pediatric Radiology, Liebigstr 20a, 04103 Leipzig, Germany
J Pediatr Surg 45:1737-40. 2010..Antibiotic therapy with or without surgical intervention provided successful management. With the recurrence observed in 1 child, the most optimal treatment of this condition might still be unknown... - Unusual presentation of congenital disorder of glycosylation type 1a: congenital persistent thrombocytopenia, hypertrophic cardiomyopathy and hydrops-like aspect due to marked peripheral oedemaVera Noelle
University Children s Hospital, Oststrasse 21 25, 04317 Leipzig, Germany
Eur J Pediatr 164:223-6. 2005..CONCLUSION: Congenital thrombocytopenia, unspecific macrophage activation and a hydrops-like aspect without a real hydrops fetalis broaden the already wide phenotypic spectrum of congenital disorder of glycosylation syndrome type 1a... - Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease--report of three casesB Hugle
Hospital for Children and Adolescents, University of Leipzig, 04317 Leipzig, Germany
J Clin Immunol 24:515-22. 2004..Development of persistent hypogammaglobulinemia after severe primary EBV infection seems to be a specific diagnostic sign for XLP even in males with unremarkable family history... - A K19E missense mutation in the plasminogen gene is a common cause of familial hypoplasminogenaemiaKatrin Tefs
Children's Hospital, University of Leipzig, Germany
Blood Coagul Fibrinolysis 14:411-6. 2003..In conclusion, the K19E mutation in the plasminogen gene is a common cause of hypoplasminogenaemia in Scotland, with an estimated prevalence of around 0.14%... - Characterization of plasminogen variants in healthy subjects and plasminogen mutants in patients with inherited plasminogen deficiency by isoelectric focusing gel electrophoresisKatrin Tefs
Children's Hospital, University of Leipzig, Germany
Thromb Haemost 92:352-7. 2004..In conclusion, plg phenotyping by IEF in combination with molecular analysis of the plg gene seems to be a useful method for characterization of plg variants and mutants... - Limited sequence heterogeneity of Epstein-Barr virus nuclear antigen 1 in benign and malignant EBV-associated disordersV Schuster
Children s Hospital, University of Leipzig, Germany
Infection 28:137-42. 2000..EBNA-1 is suggested to be oncogenic in vivo since its expression induces B-cell neoplasia in transgenic mice... - A season of aseptic meningitis in Germany: epidemiologic, clinical and diagnostic aspectsAntje Böttner
Children s Hospital, University of Leipzig, Germany
Pediatr Infect Dis J 21:1126-32. 2002.... - Ligneous conjunctivitisVolker Schuster
Department of Pediatrics, Leipzig University Medical School, Leipzig, Germany
Surv Ophthalmol 48:369-88. 2003.... - Difficulties in mutation screening of the plasminogen (PLG) gene in patients with ligneous conjunctivitis and severe hypoplasminogenemiaKatrin Tefs
Arch Ophthalmol 125:1303; author reply 1303. 2007 - Ligneous conjunctivitis, hydrocephalus, hydrocele, and pulmonary involvement in a child with homozygous type I plasminogen deficiencyErgin Ciftci
Department of Paediatric Infectious Diseases, University of Ankara Medical School, 06100 Dikimevi Ankara, Turkey
Eur J Pediatr 162:462-5. 2003..CONCLUSION: Ligneous conjunctivitis related to type I plasminogen deficiency is relatively common in the Turkish population, however, mutations are heterogeneous and a common founder is unlikely... - Hypoplasminogenemia with ligneous periodontitis: a failed local therapeutic approachIdil Kurtulus
Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
J Periodontol 78:1164-75. 2007..Pseudomembranes may develop on the gingivae, and there may be periodontal involvement... - [MMW questions colleagues about prescriptions. How to manage children with otitis media? (interview by Thomas Meissner)]Karl Bernd Huttenbrink
MMW Fortschr Med 145:12-3. 2003 - Therapeutic approaches in the treatment of ligneous conjunctivitis, the most common clinical manifestation of a systemic disease, caused by severe type I plasminogen deficiencyKatrin Tefs
Am J Ophthalmol 138:699; author reply 699-700. 2004 - Mutation spectrum of human SLC39A4 in a panel of patients with acrodermatitis enteropathicaSebastien Kury
Laboratoire d Etude du Polymorphisme de l ADN, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
Hum Mutat 22:337-8. 2003..850G>A (p.Glu284Lys) and c.193-113T>C] were also observed at homozygous state in a French family formerly described. This study brings to 21 the number of reported SLC39A4 mutations in AE families... - A nucleic acid exchange in Intron F (Intron F-14T>G) in the human plasminogen gene is only a common polymorphism and not a true mutationKatrin Tefs
Thromb Haemost 91:830-1; author reply 832. 2004 - Immunogenicity and reactogenicity of a trivalent influenza split vaccine in previously unvaccinated children aged 6-9 and 10-13 yearsRuprecht Schmidt-Ott
GlaxoSmithKline, Theresienhöhe 11, 80339 Munich, Germany
Vaccine 26:32-40. 2007.... - Bladder exstrophy and Epstein type congenital macrothrombocytopenia: evidence for a common cause?Boris Utsch
Department of Pediatrics, University of Erlangen Nuremberg, Erlangen, Germany
Am J Med Genet A 140:2251-3. 2006 - Inherited plasminogen deficiency presenting as ligneous vaginitis: a case report with molecular correlation and review of the literatureTamara L Lotan
Pathology, University of Chicago, Chicago, IL 60637, USA
Hum Pathol 38:1569-75. 2007..Recently, replacement therapy with plasminogen has been shown to significantly improve systemic symptoms, making ligneous mucositis a serious but treatable condition... - Ligneous inflammation involving the female genital tractAbdullah Karaer
Department of Obstetrics and Gynecology, Dr Zekai Tahir Burak Women s Health Education and Reserach Hospital, Ankara, Turkey
J Obstet Gynaecol Res 33:581-4. 2007..However, the histology of lesions is characteristic and a diagnosis can be made quite easily once it has been considered... - Ligneous (pseudomembranous) inflammation involving the female genital tract associated with type-1 plasminogen deficiencyLiron Pantanowitz
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Int J Gynecol Pathol 23:292-5. 2004..We present a patient with ligneous inflammation of her genital, middle ear, and oral mucosa that was associated with type-1 homozygous plasminogen deficiency due to a novel missense mutation in the plasminogen gene...