D Schuppan

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening
    D Schuppan
    Medical Department I, University of Erlangen Nuernberg, Erlangen, Germany
    Eur J Gastroenterol Hepatol 13:635-7. 2001
  2. ncbi Hepatitis C and liver fibrosis
    D Schuppan
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    Cell Death Differ 10:S59-67. 2003
  3. ncbi Biomedicine. Gluten and the gut-lessons for immune regulation
    Detlef Schuppan
    First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Science 297:2218-20. 2002
  4. ncbi Matrix as a modulator of hepatic fibrogenesis
    D Schuppan
    Department of Gastroenterology, Hepatology and Infectiology, University of Erlangen Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Semin Liver Dis 21:351-72. 2001
  5. ncbi Innate immunity and coeliac disease
    Detlef Schuppan
    First Department of Medicine, University of Erlangen-Nuernberg, 91054, Erlangen, Germany
    Lancet 362:3-4. 2003
  6. ncbi Celiac disease and its link to type 1 diabetes mellitus
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Germany
    J Pediatr Endocrinol Metab 14:597-605. 2001
  7. ncbi Current concepts of celiac disease pathogenesis
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
    Gastroenterology 119:234-42. 2000
  8. ncbi [Endemic sprue (celiac disease)--diagnosis, associated diseases and therapy]
    D Schuppan
    Medizinische Klinik I, , Erlangen
    Dtsch Med Wochenschr 128:S69-71. 2003
  9. ncbi Fistulising Crohn's disease: MMPs gone awry
    D Schuppan
    Department of Medicine I, , Germany
    Gut 53:622-4. 2004
  10. ncbi Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1
    J D Jia
    Department of Gastroenterology and Hepatology, Friedrich-Alexander University, Erlangen-Nuernberg, Erlangen, Germany
    J Hepatol 35:392-8. 2001

Collaborators

Detail Information

Publications100

  1. ncbi IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening
    D Schuppan
    Medical Department I, University of Erlangen Nuernberg, Erlangen, Germany
    Eur J Gastroenterol Hepatol 13:635-7. 2001
    ..However, with an estimated prevalence of 1:100-1:200 of mostly atypical and subclinical coeliacs in Western populations, we are confronted with the question of how far mass screening is ethically feasible and cost effective...
  2. ncbi Hepatitis C and liver fibrosis
    D Schuppan
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    Cell Death Differ 10:S59-67. 2003
    ..Together with the evolving validation of serological markers of hepatic fibrogenesis and fibrolysis an effective and individualised treatment of liver fibrosis is anticipated...
  3. ncbi Biomedicine. Gluten and the gut-lessons for immune regulation
    Detlef Schuppan
    First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Science 297:2218-20. 2002
  4. ncbi Matrix as a modulator of hepatic fibrogenesis
    D Schuppan
    Department of Gastroenterology, Hepatology and Infectiology, University of Erlangen Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Semin Liver Dis 21:351-72. 2001
    ..Furthermore, certain peptides can be used as targeting structures to the fibrogenic lesion...
  5. ncbi Innate immunity and coeliac disease
    Detlef Schuppan
    First Department of Medicine, University of Erlangen-Nuernberg, 91054, Erlangen, Germany
    Lancet 362:3-4. 2003
  6. ncbi Celiac disease and its link to type 1 diabetes mellitus
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Germany
    J Pediatr Endocrinol Metab 14:597-605. 2001
    ..Apart from shared or adjacent HLA loci in both diseases, post-translational modification of potential autoantigens by enzymes such as tissue transglutaminase could play a role in the autoimmunity of type 1 DM...
  7. ncbi Current concepts of celiac disease pathogenesis
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
    Gastroenterology 119:234-42. 2000
    ..Long-standing untreated celiac disease, even if clinically silent, predisposes for other autoimmune diseases. Therefore, population screening for immunoglobulin A antibodies to tissue transglutaminase seems justified...
  8. ncbi [Endemic sprue (celiac disease)--diagnosis, associated diseases and therapy]
    D Schuppan
    Medizinische Klinik I, , Erlangen
    Dtsch Med Wochenschr 128:S69-71. 2003
  9. ncbi Fistulising Crohn's disease: MMPs gone awry
    D Schuppan
    Department of Medicine I, , Germany
    Gut 53:622-4. 2004
  10. ncbi Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1
    J D Jia
    Department of Gastroenterology and Hepatology, Friedrich-Alexander University, Erlangen-Nuernberg, Erlangen, Germany
    J Hepatol 35:392-8. 2001
    ..The serum procollagen type III propeptide level mirrors profibrogenic mRNA expression in the liver...
  11. ncbi Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis
    C Raetsch
    Department of Gastroenterology, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Gut 50:241-7. 2002
    ..CONCLUSIONS: We conclude that targeting pentoxifylline to the fibrogenic cells, thereby avoiding upregulation of TIMP-1, could become a potent antifibrogenic tool in chronic liver disease...
  12. ncbi Identification of the autoantigen of celiac disease
    D Schuppan
    Free University of Berlin, Klinikum Benjamin Franklin, Department of Gastroenterology, Germany
    Ann N Y Acad Sci 859:121-6. 1998
    ....
  13. ncbi Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease
    W Dieterich
    Department of Medicine I, University of Erlangen Nuernberg, Erlangen 91054, Germany
    Gut 55:478-84. 2006
    ..Therefore, our aim was to identify the reaction patterns of gluten peptides, intestinal extracellular matrix proteins, and tTG...
  14. ncbi Quantitative testing of liver function in patients with cirrhosis due to chronic hepatitis C to assess disease severity
    C Herold
    Dept of Medicine I, University of Erlangen Nuernberg, Germany
    Liver 21:26-30. 2001
    ..Quantitative testing of liver function (QTLF) may allow a prognostic assessment of patients with various liver diseases. However, there are insufficient data about patients with liver cirrhosis due to hepatitis C...
  15. ncbi Collagen type XVIII/endostatin is differentially expressed in primary and metastatic colorectal cancers and ovarian carcinomas
    U Guenther
    Department of Gastroenterology, Benjamin Franklin Hospital, Free University, Berlin, Germany
    Br J Cancer 85:1540-5. 2001
    ....
  16. ncbi Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease
    F Stickel
    I. Department of Medicine, University of Erlangen-Nurnberg, Erlangen, Germany
    Dig Dis Sci 46:2025-32. 2001
    ..The correlation between procollagen-III-N-propeptide and TGF-beta1 emphasizes its role in hepatic fibrogenesis...
  17. ncbi Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity
    W Dieterich
    Department of Medicine I, University of Erlangen-Nuernberg, Germany
    Gut 52:1562-6. 2003
    ..CONCLUSIONS: Despite a partial inhibitory effect of isolated anti-tTG autoantibodies from patients with CD, residual enzymatic activity remains sufficiently high to cast doubt on their in vivo relevance...
  18. ncbi Cocarcinogenic effects of alcohol in hepatocarcinogenesis
    F Stickel
    Department of Medicine I, Division of Hepatology, University of Erlangen Nuremberg, Germany
    Gut 51:132-9. 2002
    ..These include dietary or environmental carcinogens ingested along with alcoholic beverages, alcoholic cirrhosis as a precancerous condition, and the effects of alcohol metabolism...
  19. ncbi Screening for coeliac disease antigen source and performance of the anti-tissue transglutaminase ELISA
    T Freitag
    Division of Gastroenterology and Hepatology, Department of Medicine 1, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Dig Liver Dis 36:658-60. 2004
  20. ncbi Changes in hepatic hemodynamics after orthotopic liver transplantation: color Doppler sonography
    C Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr. 12, 91054 Erlangen, Germany
    Abdom Imaging 26:32-5. 2001
    ..These observations are of special interest after OLT, where liver circulation has an influence on therapy results...
  21. ncbi Complete primary structure of human collagen type XIV (undulin)
    M Bauer
    Free University of Berlin, Klinkum Benjamin Franklin, Department of Gastroenterology, Germany
    Biochim Biophys Acta 1354:183-8. 1997
    ....
  22. ncbi Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin)
    T Ehnis
    Free University of Berlin, Klinikum Benjamin Franklin, Department of Gastroenterology, Hindenburgdamm 30, D 12200 Berlin, Germany
    J Biol Chem 272:20414-9. 1997
    ..In addition, an auxiliary binding site located COOH-terminal to this fibronectin type III repeat interacted with the glycosaminoglycan component of decorin...
  23. ncbi Soluble collagen VI drives serum-starved fibroblasts through S phase and prevents apoptosis via down-regulation of Bax
    M Ruhl
    Department of Medicine I, Klinikum B Franklin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Biol Chem 274:34361-8. 1999
    ....
  24. ncbi Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer
    M Ocker
    Department of Medicine I, Friedrich Alexander University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    Gut 54:1298-308. 2005
    ..We therefore investigated how far siRNA specific for bcl-2 may serve as a therapeutic option for pancreatic cancer in vitro and in vivo...
  25. ncbi Antifibrotic properties of botanicals in chronic liver disease
    F Stickel
    Department of Medicine I, Division of Hepatology, Division of Complementary Medicine, University of Erlangen Nuremberg, Ulmenweg 18, D 91054 Erlangen, Germany
    Hepatogastroenterology 49:1102-8. 2002
    ..Herbal combinations, such as compound 861 and LIV.52 were advocated as antifibrotics or hepatoprotectives, but studies in humans have either been of questionable design or resulted in cessation of the trial due to adverse outcomes...
  26. ncbi Serum markers of matrix turnover as predictors for the evolution of colorectal cancer metastasis under chemotherapy
    B Hanke
    Department of Medicine I, University of Erlangen-Nuernberg, Germany
    Br J Cancer 88:1248-50. 2003
    ..0001). We conclude that serum MMP-2 appears to reflect tumour resorption, while serum TIMP-1 may mirror tumour expansion...
  27. ncbi Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells
    C Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, D 91054 Erlangen, Germany
    Br J Cancer 86:443-8. 2002
    ..Therefore, qualification of ciprofloxacin as adjunctive agent for colorectal cancer should be evaluated...
  28. ncbi Modulation of collagen XVIII/endostatin expression in lobular and biliary rat liver fibrogenesis
    J D Jia
    Department of Gastroenterology and Hepatology, University of Erlangen Nuernberg, Erlangen, Germany
    J Hepatol 35:386-91. 2001
    ..In human liver C18 is mainly expressed by hepatocytes. However, its quantitative and temporospatial expression patterns during liver fibrogenesis are unknown...
  29. ncbi Is gliadin harmful from the first morsel?
    W Dieterich
    Department of Medicine 1, University Erlangen Nuernberg, 91054 Erlangen, Germany
    Dig Liver Dis 39:917-21. 2007
  30. ncbi Coeliac disease and secondary autoimmunity
    D Schuppan
    First Department of Medicine, University of Erlangen-Nuernberg, Germany
    Dig Liver Dis 34:13-5. 2002
  31. ncbi Acute hepatitis induced by greater celandine (Chelidonium majus)
    J Benninger
    Department of Medicine I, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany
    Gastroenterology 117:1234-7. 1999
    ..Greater celandine has to be added to the list of herbs capable of inducing acute (cholestatic) hepatitis. A significant proportion of unexplained cases of hepatitis may be caused by greater celandine...
  32. ncbi Adrenomedullin is a novel marker of tumor progression in neuroendocrine carcinomas
    M E Pavel
    Division of Endocrinology, Department of Medicine I, Erlangen Nürnberg University Hospital, Germany
    Horm Metab Res 38:112-8. 2006
    ..Adrenomedullin might represent a useful prognostic marker in patients with neuroendocrine carcinomas...
  33. ncbi Acute hepatitis induced by Greater Celandine (Chelidonium majus)
    F Stickel
    Dept of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Scand J Gastroenterol 38:565-8. 2003
    ....
  34. ncbi Quantitative testing of liver function in relation to fibrosis in patients with chronic hepatitis B and C
    C Herold
    Dept. of Medicine I and Institute of Pathology, University of Erlangen-Nuernberg, Erlangen, Germany
    Liver 21:260-5. 2001
    ..Therefore, tests of metabolic liver function (aminopyrine breath test, galactose elimination capacity) should be useful to search for drugs that restore liver function in viral hepatitis irrespective of the fibrosis stage...
  35. ncbi Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica
    B Brinkhaus
    Department of Traditional and Complementary Medicine, Medical Department I, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Phytomedicine 7:427-48. 2000
    ..However, the therapeutic potential of this plant in terms of its efficacy and versatility is such that further detailed research would appear worthwhile...
  36. ncbi Serum antibodies in celiac disease
    W Dieterich
    Friedrich Alexander Universität Erlangen Nürnberg Medizinische Klinik I, Germany
    Clin Lab 46:361-4. 2000
    ..These serological tests, which are based on the detection of antibodies against gliadin and autoantibodies against components of the extracellular matrix, are described in this article...
  37. ncbi Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells
    Christoph Herold
    Department of Internal Medicine I, University Erlangen Nuernberg, Ullmenweg 18, D 91054 Erlangen, Germany
    Int J Oncol 23:751-6. 2003
    ..Due to their known safety profile, this justifies clinical trials for colorectal cancer using combinations of these biological response modifiers...
  38. ncbi [Alcoholic liver disease--established treatment and new therapeutic approaches]
    F Stickel
    Medizinische Klinik I und Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen
    Z Gastroenterol 41:333-42. 2003
    ..Silymarin has not been proven efficacious in alcoholic cirrhosis and clinical trials are ongoing which aim to elucidate its therapeutic value in less advanced stages of liver disease...
  39. ncbi [Review "Kava, kavapyrones and toxic liver injury" by R Teschke, Hanau Zeitschrift für Gastroenterologie 2003, 41:395-404]
    F Stickel
    Medizinische Klinik I mit Poliklinik, , Erlangen
    Z Gastroenterol 41:888-9. 2003
  40. ncbi Contrast-enhanced ultrasound improves hepatic vessel visualization after orthotopic liver transplantation
    C Herold
    Department of Medicine I, University of Erlangen-Nuernberg, Germany
    Abdom Imaging 26:597-600. 2001
    ..These findings are important because the early detection of blood flow through the liver after transplantation affects prognosis...
  41. ncbi Review article: Nutritional therapy in alcoholic liver disease
    F Stickel
    Department of Medicine I, University of Erlangen-Nuremberg, Germany
    Aliment Pharmacol Ther 18:357-73. 2003
    ....
  42. ncbi Combined in vitro anti-tumoral action of tamoxifen and retinoic acid derivatives in hepatoma cells
    C Herold
    Department of Medicine I, D 91054 Erlangen, Germany
    Int J Oncol 20:89-96. 2002
    ..Combination of TAM and CRA, but not ATRA, have an additive to synergistic anti-proliferative and pro-apoptotic effect on HCC cells. This justifies trials for HCC using combinations of these biological response modifiers...
  43. ncbi A chondroitin/dermatan sulfate form of CD44 is a receptor for collagen XIV (undulin)
    T Ehnis
    Klinikum Benjamin Franklin, Department of Gastroenterology, Free University of Berlin, Hindenburgdamm 30, Berlin, D 12200, Germany
    Exp Cell Res 229:388-97. 1996
    ....
  44. ncbi Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
    Michael Hopfner
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, 12200 Berlin, Germany
    Biochem Pharmacol 71:1435-48. 2006
    ..Thus, IGF-1R-TK inhibition may be a promising novel treatment approach in HCC...
  45. ncbi Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells
    Anja Schulze-Krebs
    Department of Medicine I, University of Erlangen-Nuremberg, Germany
    Gastroenterology 129:246-58. 2005
    ....
  46. ncbi Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis
    Felix Stickel
    Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
    Arch Intern Med 165:1835-40. 2005
    ..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC...
  47. ncbi Serum fibrosis markers as predictors of an antifibrotic effect of interferon alfa in children with chronic hepatitis B
    Dariusz M Lebensztejn
    IIIrd Dept of Pediatrics, Medical University, Bialystok, Poland
    Eur J Gastroenterol Hepatol 17:843-8. 2005
    ..The evolution of serum fibrosis markers suggests they may be more sensitive to detect minor antifibrotic effects than semiquantitative follow-up histology...
  48. ncbi Helicobacter pylori upregulates prion protein expression in gastric mucosa: a possible link to prion disease
    Peter C Konturek
    Department of Medicine I, University Erlangen Nuremberg, Germany
    World J Gastroenterol 11:7651-6. 2005
    ....
  49. ncbi Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional management
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nutr Clin Care 8:54-69. 2005
    ..Current research focuses on non-dietary therapies and treatment of refractory (diet-unresponsive) CD...
  50. ncbi Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor
    Andreas P Sutter
    , Campus Benjamin Franklin, Medical Clinic I, Berlin, Germany
    J Hepatol 43:808-16. 2005
    ..CONCLUSIONS: Our data shed light on the signaling cascades mediating statin-induced growth inhibition of HCC cells. Moreover, PBR ligands sensitized HCC cells to statins, suggesting a new strategy to treat HCC...
  51. ncbi Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantation
    Suleyman Yedibela
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Liver Int 25:717-22. 2005
    ..The aim of this study was to evaluate the safety and efficacy of interferon (IFN)-alpha2b plus ribavirin (RIBA) in the treatment of recurrent HCV after OLT over the long term...
  52. ncbi The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha
    Christina Lohwasser
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    J Invest Dermatol 126:291-9. 2006
    ..We conclude that in HFFs, AGE-RAGE interactions may influence the process of skin aging through mild stimulation of ECM gene expression...
  53. ncbi Efficacy and tolerability of pegylated IFN-alpha in patients with neuroendocrine gastroenteropancreatic carcinomas
    Marianne E Pavel
    Department of Medicine I, University Hospital Erlangen Nuremberg, 91054 Erlangen, Germany
    J Interferon Cytokine Res 26:8-13. 2006
    ..Better tolerability of PEG-IFN-alpha2b improved patients' compliance, justifying its use in patients who do not tolerate conventional IFN-alpha treatment...
  54. ncbi Monitoring nonresponsive patients who have celiac disease
    Norbert Krauss
    Department of Medicine I Gastroenterology, Hepatology, Pneumonology and Endocrinology, University Hospital, Ulmenweg 18, Erlangen 91054, Germany
    Gastrointest Endosc Clin N Am 16:317-27. 2006
    ..At present there is no effective treatment for type II RCD.Fig. 3 presents a proposed algorithm for monitoring patients who have ce-liac disease...
  55. ncbi Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    Hepatology 43:1354-63. 2006
    ..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
  56. ncbi No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
    ..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
  57. ncbi Liver cirrhosis
    Detlef Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 371:838-51. 2008
    ..This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments...
  58. ncbi Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    Yury Popov
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 48:453-64. 2008
    ..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis...
  59. ncbi Turning swords into plowshares: transglutaminase to detoxify gluten
    Detlef Schuppan
    Gastroenterology 133:1025-8. 2007
  60. ncbi Etiologies and predictors of diagnosis in nonresponsive celiac disease
    Daniel A Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 5:445-50. 2007
    ..The aim of this study was to determine the common etiologies of NRCD in a tertiary referral center...
  61. ncbi Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2)
    Daniel Rost
    Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Hepatol 46:482-91. 2007
    ..Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial...
  62. ncbi Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells
    Viola Baradari
    , Campus Benjamin Franklin, Berlin, Germany
    Endocr Relat Cancer 13:1237-50. 2006
    ..To conclude, our data show that HDAC inhibition is a promising new approach in the treatment of NET disease, which should be evaluated in clinical studies...
  63. ncbi Synthesis of collagen I in collagenous sprue
    Severin Daum
    Department of Medicine I, Gastroenterology, Infectious Diseases and Rheumatology, Universitatsmedizin Berlin, Berlin, Germany
    Clin Gastroenterol Hepatol 4:1232-6. 2006
    ..We studied the expression patterns of genes involved in fibrogenesis and fibrolysis and analyzed the composition of the subepithelial collagen band in CS compared with untreated celiac diseases (CDs)...
  64. ncbi Monitoring non-responsive patients with celiac disease
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gastrointest Endosc Clin N Am 16:593-603. 2006
    ..At present the prognosis of RCd type II or EATL is poor due to lack of effective therapies. However, treatments that effectively target the aberrant lymphocytes can be anticipated...
  65. ncbi Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases
    Johannes Hansler
    Department of Medicine, Friedrich Alexander University, Erlangen Nuremberg, Germany
    World J Gastroenterol 12:3716-21. 2006
    ..CONCLUSION: Patients with primary and secondary tumors of the liver show a significant tumor-specific cytotoxic T-cell stimulation with a dramatically increased tumor specific cytolytic activity of CD8(+) T cells after RFA...
  66. ncbi Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: recent advances and future perspectives
    Michael Hopfner
    World J Gastroenterol 14:2461-73. 2008
    ..e. combining growth factor (receptor)-targeting agents with chemo- or biotherapeutics or with other novel anticancer drugs such as HDAC or proteasome inhibitors will be taken into account...
  67. ncbi Iron, HCV, and liver cancer: hard metal setting the pace?
    Sebastian Mueller
    Gastroenterology 130:2229-34. 2006
  68. ncbi Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha
    Dariusz-Marek Lebensztejn
    IIIrd Department of Pediatrics, Medical University of Bialystok, Poland
    World J Gastroenterol 12:3338-43. 2006
    ..CONCLUSION: Tenascin reflects hepatic fibrogenesis and inflammation which decreases during IFN treatment of children with chronic hepatitis B. TIMP-1 correlates with nonresponse and hyaluronan with histological fibrosis...
  69. ncbi Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
    Eleonora Patsenker
    Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Gastroenterology 135:660-70. 2008
    ..Because its role in liver fibrosis is unknown, we studied alphavbeta6 function in vitro and explored the antifibrotic potential of the specific alphavbeta6 antagonist EMD527040...
  70. ncbi Hepatocellular carcinomas do not compromise quantitative tests of liver function
    Marion Ganslmayer
    Department of Internal Medicine I, University of Erlangen-Nuernberg, Germany
    Hepatogastroenterology 52:881-4. 2005
    ..Since these parameters are not affected by the occurrence of hepatocellular carcinoma, the emergence of hepatic neoplasia in cirrhotics does not appear to be determined by the degree of hepatic functional deterioration...
  71. ncbi TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Medical University of Vienna, Austria
    Cytokine 31:142-8. 2005
    ..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg...
  72. ncbi Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells
    Benjamin Schaefer
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:1771-80. 2003
    ..Overall, these findings strongly support the notion that alpha1(I) collagen and matrix metalloproteinase-13 mRNAs are reciprocally modulated...
  73. ncbi A molecular warhead and its target: tissue transglutaminase and Celiac Sprue
    Detlef Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Chem Biol 10:199-201. 2003
    ..DON-modified peptides could be useful for the study and therapy of celiac sprue...
  74. ncbi Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 38:419-25. 2003
    ..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology...
  75. ncbi Inducibility of microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve
    Chirstoph Herold
    Department of Medicine I, Unviersity of Erlangen Nuernberg, Erlangen Germany
    J Gastroenterol Hepatol 18:445-9. 2003
    ..Quantitative tests of liver function (QTLF) can be modulated by enzyme-inducing agents. The objective of the study was to examine changes in QTLF after treatment with Phenobarbital, a potent cytochrome P450-inducing agent...
  76. ncbi Portal vein arterialisation as a technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigs
    Rudolf Ott
    Department of Surgery, University of Leipzig, Leipzig, Germany
    Liver Int 23:54-62. 2003
    ..Arterialisation of the portal vein has been propagated as a technical variant in liver transplantation. However, the consequences of this unphysiological vascular supply are insufficiently known...
  77. ncbi Hemochromatosis (HFE) gene mutations and response to chloroquine in porphyria cutanea tarda
    Ulrich Stölzel
    Department of Medicine II, Klinikum Chemnitz, Germany
    Arch Dermatol 139:309-13. 2003
    ..To examine the role of hemochromatosis (HFE) gene mutations, which are associated with porphyria cutanea tarda (PCT), in the therapeutic response to chloroquine...
  78. ncbi Can quantitative tests of liver function discriminate between different etiologies of liver cirrhosis?
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    Dig Dis Sci 47:2669-73. 2002
    ..In conclusion, QTLF in ALC and VIC patients was more reduced than in patients with PBC. This may be due to saturation of enzymes in ALC and ongoing inflammation in VIC...
  79. ncbi Hepatic fibrosis: from bench to bedside
    Detlef Schuppan
    Department of Medicine I, Division of Gastroenterology, Hepatology and Infectiology, University of Erlangen Nuernberg, Germany
    J Gastroenterol Hepatol 17:S300-5. 2002
    ..Combined with the evolving validation of serological markers of fibrogenesis and fibrolysis an effective and individualized treatment of liver fibrosis can be anticipated...
  80. ncbi [Prevalence of circulating autoantibodies in healthy individuals]
    Andreas Teubner
    , Klinikum Chemnitz gGmbH, , Chemnitz
    Med Klin (Munich) 97:645-9. 2002
    ..01). Since at least one in three or four healthy individuals tested positive for ANA or ASMA, the positive predictive value of these autoantibodies is low, and clinical interpretation should include additional information...
  81. ncbi Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Exp Cell Res 278:184-97. 2002
    ..Our study shows that inhibition of histone deacetylases by TSA reduces expression of fibrosis-related genes in skin fibroblasts and this coincides by alterations in the TGF-beta(1) signaling pathway...
  82. ncbi Changes in hepatic perfusion after administration of hydroxyethyl starch in intensive care patients assessed using color-coded Doppler sonography
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, 91054, Germany
    Clin Imaging 26:173-6. 2002
    ..CCDS is suitable to assess liver perfusion in intensive care patients. Since HES enhances splanchnic perfusion, its application improves hepatic perfusion in intensive care patients...
  83. ncbi Autoimmunity and HCV infection in porphyria cutanea tarda: a controlled study
    Ulrich Stölzel
    Department of Gastroenterology, Medizinische Klinik II, Klinikum Chernitz GmbH, Teaching Hospital of the University of Leipzig, Germany
    Cell Mol Biol (Noisy-le-grand) 48:43-7. 2002
    ..However, a higher prevalence of HCV infection and systemic lupus erythematosus in patients with porphyria cutanea tarda was confirmed...
  84. ncbi Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre
    Christoph Herold
    Department of Medicine I, Department of Surgery, Institute for Medical Statistics, Biometry and Epidemiology, University of Erlangen Nuernberg, Germany
    Liver 22:23-8. 2002
    ..Only a few follow up data are available for patients with hepatocellular carcinoma (HCC) in Europe and the USA. Therefore, we analysed all HCC patients admitted to our hospital between 1988 and 1999...
  85. ncbi Hepatitis induced by Kava (Piper methysticum rhizoma)
    Felix Stickel
    Department of Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, D 91054 Erlangen, Germany
    J Hepatol 39:62-7. 2003
    ..Kava root (Piper methysticum rhizoma), used frequently in Europe as a remedy against anxiety, contains kavapyrones with sedative effects. Seven case reports suggested the development of hepatitis after the intake of Kava...
  86. ncbi Serum hyaluronate correlates with histological progression in alcoholic liver disease
    Felix Stickel
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Gastroenterol Hepatol 15:945-50. 2003
    ..In addition, serum hyaluronate was determined in 40 non-cirrhotic alcoholic patients with either a normal serum aspartate aminotransferase (AST) or an AST elevated at least two-fold...
  87. ncbi Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Hepatol 42:914-9. 2005
    ..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC...
  88. ncbi Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas
    Marianne E Pavel
    Department of Medicine I, University Hospital Erlangen Nuernberg, Ulmensweg 18, 91054 Erlangen, Germany
    Clin Endocrinol (Oxf) 62:434-43. 2005
    ..The aim of our study was to investigate whether tumour growth could be correlated with the release of proangiogenic factors into the circulation...
  89. ncbi The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells
    Matthias Ocker
    Department of Medicine I, University of Erlangen Nuernberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Cancer Res Clin Oncol 131:385-94. 2005
    ..The use of the triple combination could optimize treatment results in vivo and needs further evaluation...
  90. ncbi Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential
    Zili Dan
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany
    FASEB J 19:845-7. 2005
    ..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
  91. ncbi Matrix metalloproteinase pattern in celiac duodenal mucosa
    Rachele Ciccocioppo
    Gastroenterology Unit, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Lab Invest 85:397-407. 2005
    ..In conclusion, our results show the presence of a peculiar MMP pattern in active CD strongly dominated by MMP-12, correlating either with IFN-gamma or the degree of mucosal damage...
  92. ncbi Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
    Michael Hopfner
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
    J Hepatol 41:1008-16. 2004
    ..We therefore studied the antineoplastic potency of gefitinib in human HCC cells...
  93. ncbi Serum markers detect the presence of liver fibrosis: a cohort study
    William M C Rosenberg
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
    Gastroenterology 127:1704-13. 2004
    ..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...
  94. ncbi Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1
    Andreas P Sutter
    Medical Clinic I, , Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Hepatol 41:799-807. 2004
    ..CONCLUSIONS: This is the first report on the induction of apoptosis and cell cycle arrest by PBR ligands in HCC cells. Moreover, PBR ligands sensitized HCC cells to taxans and doxorubicin...
  95. ncbi Potentiated anticancer effects on hepatoma cells by the retinoid adapalene
    Matthias Ocker
    Department of Internal Medicine I, University Erlangen-Nuernberg, Ulmenweg 18, D-91054 Erlangen, Germany
    Cancer Lett 208:51-8. 2004
    ..3 in hepatoma cells. ADA inhibits hepatoma cell growth in vitro and is a powerful inducer of hepatoma cell apoptosis...
  96. ncbi A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells
    Marion Ganslmayer
    Medical Department I, University of Erlangen-Nuernberg, D-91054 Erlangen, Germany
    Oncol Rep 11:943-50. 2004
    ..While the single substances were not effective on hepatoma cells in tolerable doses, their combination significantly increases anti-tumoral efficacy. Combination therapy with biomodulators is a promising treatment option for HCC...
  97. ncbi The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac disease
    Tobias Freitag
    Medical Department I, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Autoimmun Rev 3:13-20. 2004
    ..Although no intestinal lesions were found, this observation lends support to the concept that the development of autoimmunity against TGase 2 is a pathological event that might ultimately lead to organ damage...
  98. ncbi Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
    Gernot Sellge
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Immunol 172:260-7. 2004
    ..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis...
  99. ncbi Pathomechanisms in celiac disease
    Walburga Dieterich
    Medical Department I, , Erlangen, Germany
    Int Arch Allergy Immunol 132:98-108. 2003
    ....
  100. ncbi The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
    Christoph Herold
    Department of Medicine I, University of Erlangen-Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Hepatol 36:233-40. 2002
    ..Its anti-proliferative activity is paralleled by a comparable rate of apoptosis. TSA may be a promising agent for treatment of hepatocellular carcinoma in vivo...